2020 ICD-10-CM Diagnosis Code D59.5

Paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli]

    2016 2017 2018 2019 2020 Billable/Specific Code
  • D59.5 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2020 edition of ICD-10-CM D59.5 became effective on October 1, 2019.
  • This is the American ICD-10-CM version of D59.5 - other international versions of ICD-10 D59.5 may differ.
Type 1 Excludes
Type 1 Excludes Help
A type 1 excludes note is a pure excludes. It means "not coded here". A type 1 excludes note indicates that the code excluded should never be used at the same time as D59.5. A type 1 excludes note is for used for when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • hemoglobinuria NOS (
    ICD-10-CM Diagnosis Code R82.3

    Hemoglobinuria

      2016 2017 2018 2019 2020 Billable/Specific Code
    Type 1 Excludes
    • hemoglobinuria due to hemolysis from external causes NEC (D59.6)
    • hemoglobinuria due to paroxysmal nocturnal [Marchiafava-Micheli] (D59.5)
    R82.3
    )
The following code(s) above D59.5 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to D59.5:
  • D50-D89
    2020 ICD-10-CM Range D50-D89

    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

    Type 2 Excludes
    • autoimmune disease (systemic) NOS (M35.9)
    • certain conditions originating in the perinatal period (P00-P96)
    • complications of pregnancy, childbirth and the puerperium (O00-O9A)
    • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
    • endocrine, nutritional and metabolic diseases (E00-E88)
    • human immunodeficiency virus [HIV] disease (B20)
    • injury, poisoning and certain other consequences of external causes (S00-T88)
    • neoplasms (C00-D49)
    • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
Approximate Synonyms
  • Paroxsymal nocturia hemoglobinuria
  • Paroxysmal nocturnal hemoglobinuria
Clinical Information
  • A rare acquired hematologic disorder characterized by hemolytic anemia, dark-colored urine due to the release of hemoglobin in the blood, and thrombosis. The episodes of hemolysis tend to occur at night. It is caused by a somatic mutation in the glycosylphosphatidylinositol biosynthesis gene.
  • A rare disorder in which red blood cells are easily destroyed by certain immune system proteins. Symptoms include blood clots, and red or brownish urine in the morning. Aplastic anemia (decreased production of blood cells) may lead to pnh, and people with pnh are at increased risk of acute myelogenous leukemia.
  • Disorder characterized by intravascular hemolysis and hemoglobinuria; some cases occur on exposure to cold and are due to the presence of an autohemolysin in the serum; other cases are more marked during or immediately after sleep and are considered to be due to an acquired intracorpuscular defect.
ICD-10-CM D59.5 is grouped within Diagnostic Related Group(s) (MS-DRG v37.0):
  • 791 Prematurity with major problems
  • 793 Full term neonate with major problems
  • 808 Major hematological and immunological diagnoses except sickle cell crisis and coagulation disorders with mcc
  • 809 Major hematological and immunological diagnoses except sickle cell crisis and coagulation disorders with cc
  • 810 Major hematological and immunological diagnoses except sickle cell crisis and coagulation disorders without cc/mcc

Convert D59.5 to ICD-9-CM

Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
Code annotations containing back-references to D59.5:
  • Type 1 Excludes: R82.3
    ICD-10-CM Diagnosis Code R82.3

    Hemoglobinuria

      2016 2017 2018 2019 2020 Billable/Specific Code
    Type 1 Excludes
    • hemoglobinuria due to hemolysis from external causes NEC (D59.6)
    • hemoglobinuria due to paroxysmal nocturnal [Marchiafava-Micheli] (D59.5)

Diagnosis Index entries containing back-references to D59.5:
  • Hematuria R31.9
    ICD-10-CM Diagnosis Code R31.9

    Hematuria, unspecified

      2016 2017 2018 2019 2020 Billable/Specific Code
  • Hemoglobinemia D59.9
    ICD-10-CM Diagnosis Code D59.9

    Acquired hemolytic anemia, unspecified

      2016 2017 2018 2019 2020 Billable/Specific Code
    Applicable To
    • Idiopathic hemolytic anemia, chronic
    • paroxysmal D59.6
      ICD-10-CM Diagnosis Code D59.6

      Hemoglobinuria due to hemolysis from other external causes

        2016 2017 2018 2019 2020 Billable/Specific Code
      Applicable To
      • Hemoglobinuria from exertion
      • March hemoglobinuria
      • Paroxysmal cold hemoglobinuria
      Type 1 Excludes
      • hemoglobinuria NOS (R82.3)
      Use Additional
      • code (Chapter 20) to identify external cause
      • nocturnal D59.5
  • Hemoglobinuria R82.3
    ICD-10-CM Diagnosis Code R82.3

    Hemoglobinuria

      2016 2017 2018 2019 2020 Billable/Specific Code
    Type 1 Excludes
    • hemoglobinuria due to hemolysis from external causes NEC (D59.6)
    • hemoglobinuria due to paroxysmal nocturnal [Marchiafava-Micheli] (D59.5)
    • paroxysmal (cold) D59.6
      ICD-10-CM Diagnosis Code D59.6

      Hemoglobinuria due to hemolysis from other external causes

        2016 2017 2018 2019 2020 Billable/Specific Code
      Applicable To
      • Hemoglobinuria from exertion
      • March hemoglobinuria
      • Paroxysmal cold hemoglobinuria
      Type 1 Excludes
      • hemoglobinuria NOS (R82.3)
      Use Additional
      • code (Chapter 20) to identify external cause
      • nocturnal D59.5
    • nocturnal D59.5 (paroxysmal)
  • Marchiafava-Micheli syndrome D59.5

ICD-10-CM Codes Adjacent To D59.5
D58.1 Hereditary elliptocytosis
D58.2 Other hemoglobinopathies
D58.8 Other specified hereditary hemolytic anemias
D58.9 Hereditary hemolytic anemia, unspecified
D59 Acquired hemolytic anemia
D59.0 Drug-induced autoimmune hemolytic anemia
D59.1 Other autoimmune hemolytic anemias
D59.2 Drug-induced nonautoimmune hemolytic anemia
D59.3 Hemolytic-uremic syndrome
D59.4 Other nonautoimmune hemolytic anemias
D59.5 Paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli]
D59.6 Hemoglobinuria due to hemolysis from other external causes
D59.8 Other acquired hemolytic anemias
D59.9 Acquired hemolytic anemia, unspecified
D60 Acquired pure red cell aplasia [erythroblastopenia]
D60.0 Chronic acquired pure red cell aplasia
D60.1 Transient acquired pure red cell aplasia
D60.8 Other acquired pure red cell aplasias
D60.9 Acquired pure red cell aplasia, unspecified
D61 Other aplastic anemias and other bone marrow failure syndromes
D61.0 Constitutional aplastic anemia

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.