ICD-10-CM Codes
D50-D89 Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
D60-D64 Aplastic and other anemias and other bone marrow failure syndromes
D61- Other aplastic anemias and other bone marrow failure syndromes
2021 ICD-10-CM Diagnosis Code D61.1

2021 ICD-10-CM Diagnosis Code D61.1

Drug-induced aplastic anemia

2016

2017

2018

2019

2020

2021

Billable/Specific Code

D61.1 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
The 2021 edition of ICD-10-CM D61.1 became effective on October 1, 2020.
This is the American ICD-10-CM version of D61.1 - other international versions of ICD-10 D61.1 may differ.

Use Additional

Use Additional Help

Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. For such conditions the ICD-10-CM has a coding convention that requires the underlying condition be sequenced first followed by the manifestation. Wherever such a combination exists there is a "use additional code" note at the etiology code, and a "code first" note at the manifestation code. These instructional notes indicate the proper sequencing order of the codes, etiology followed by manifestation. In most cases the manifestation codes will have in the code title, "in diseases classified elsewhere." Codes with this title are a component of the etiology/manifestation convention. The code title indicates that it is a manifestation code. "In diseases classified elsewhere" codes are never permitted to be used as first listed or principle diagnosis codes. They must be used in conjunction with an underlying condition code and they must be listed following the underlying condition.

code for adverse effect, if applicable, to identify drug (T36-T50
ICD-10-CM Range T36-T50
Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances
Code First
- , for adverse effects, the nature of the adverse effect, such as:
- adverse effect NOS (T88.7)
- aspirin gastritis (K29.-)
- blood disorders (D56-D76)
- contact dermatitis (L23-L25)
- dermatitis due to substances taken internally (L27.-)
- nephropathy (N14.0-N14.2)
Includes
- adverse effect of correct substance properly administered
- poisoning by overdose of substance
- poisoning by wrong substance given or taken in error
- underdosing by (inadvertently) (deliberately) taking less substance than prescribed or instructed
Note
- The drug giving rise to the adverse effect should be identified by use of codes from categories T36-T50 with fifth or sixth character 5.
Type 1 Excludes
- toxic reaction to local anesthesia in pregnancy (O29.3-)
Type 2 Excludes
- abuse and dependence of psychoactive substances (F10-F19)
- abuse of non-dependence-producing substances (F55.-)
- immunodeficiency due to drugs (D84.821)
- drug reaction and poisoning affecting newborn (P00-P96)
- pathological drug intoxication (inebriation) (F10-F19)
Use Additional
- code(s) to specify:
- manifestations of poisoning
- underdosing or failure in dosage during medical and surgical care (Y63.6, Y63.8-Y63.9)
- underdosing of medication regimen (Z91.12-, Z91.13-)
- T36 Poisoning by, adverse effect of and unde...
- T37 Poisoning by, adverse effect of and unde...
- T38 Poisoning by, adverse effect of and unde...
- T39 Poisoning by, adverse effect of and unde...
- T40 Poisoning by, adverse effect of and unde...
- T41 Poisoning by, adverse effect of and unde...
- T42 Poisoning by, adverse effect of and unde...
- T43 Poisoning by, adverse effect of and unde...
- T44 Poisoning by, adverse effect of and unde...
- T45 Poisoning by, adverse effect of and unde...
- T46 Poisoning by, adverse effect of and unde...
- T47 Poisoning by, adverse effect of and unde...
- T48 Poisoning by, adverse effect of and unde...
- T49 Poisoning by, adverse effect of and unde...
- T50 Poisoning by, adverse effect of and unde...
with fifth or sixth character 5)

The following code(s) above D61.1 contain annotation back-references

Annotation Back-References

In this context, annotation back-references refer to codes that contain:

Applicable To annotations, or
Code Also annotations, or
Code First annotations, or
Excludes1 annotations, or
Excludes2 annotations, or
Includes annotations, or
Note annotations, or
Use Additional annotations

that may be applicable to D61.1:

D50-D89
2021 ICD-10-CM Range D50-D89
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
Type 2 Excludes
- autoimmune disease (systemic) NOS (M35.9)
- certain conditions originating in the perinatal period (P00-P96)
- complications of pregnancy, childbirth and the puerperium (O00-O9A)
- congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
- endocrine, nutritional and metabolic diseases (E00-E88)
- human immunodeficiency virus [HIV] disease (B20)
- injury, poisoning and certain other consequences of external causes (S00-T88)
- neoplasms (C00-D49)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
D61
ICD-10-CM Diagnosis Code D61
Other aplastic anemias and other bone marrow failure syndromes
Type 2 Excludes
- neutropenia (D70.-)
Other aplastic anemias and other bone marrow failure syndromes

Approximate Synonyms

Anemia, drug induced aplastic
Aplastic anemia due to chemotherapy
Aplastic anemia due to drugs

Clinical Information

A state of bone marrow suppression and failure that is caused by a cytotoxic or adverse immunologic response to a drug treatment, leading to a failure of production of red blood cells, white cells and platelets.

ICD-10-CM D61.1 is grouped within Diagnostic Related Group(s) (MS-DRG v38.0):

808 Major hematological and immunological diagnoses except sickle cell crisis and coagulation disorders with mcc
809 Major hematological and immunological diagnoses except sickle cell crisis and coagulation disorders with cc
810 Major hematological and immunological diagnoses except sickle cell crisis and coagulation disorders without cc/mcc

Convert D61.1 to ICD-9-CM

Code History

2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
2017 (effective 10/1/2016): No change
2018 (effective 10/1/2017): No change
2019 (effective 10/1/2018): No change
2020 (effective 10/1/2019): No change
2021 (effective 10/1/2020): No change

Code annotations containing back-references to D61.1:

Type 1 Excludes: D63.0
, D64.81

ICD-10-CM Diagnosis Code D63.0
Anemia in neoplastic disease
Code First
- neoplasm (C00-D49)
Type 1 Excludes
- aplastic anemia due to antineoplastic chemotherapy (D61.1)
Type 2 Excludes
- anemia due to antineoplastic chemotherapy (D64.81)
ICD-10-CM Diagnosis Code D64.81
Anemia due to antineoplastic chemotherapy
Applicable To
- Antineoplastic chemotherapy induced anemia
Type 1 Excludes
- aplastic anemia due to antineoplastic chemotherapy (D61.1)
Type 2 Excludes
- anemia in neoplastic disease (D63.0)
Type 2 Excludes: D46
, D61.810
, D61.811

ICD-10-CM Diagnosis Code D46
Myelodysplastic syndromes
Type 2 Excludes
- drug-induced aplastic anemia (D61.1)
Use Additional
- code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)
ICD-10-CM Diagnosis Code D61.810
Antineoplastic chemotherapy induced pancytopenia
Type 2 Excludes
- aplastic anemia due to antineoplastic chemotherapy (D61.1)
ICD-10-CM Diagnosis Code D61.811
Other drug-induced pancytopenia
Type 2 Excludes
- aplastic anemia due to drugs (D61.1)

Diagnosis Index entries containing back-references to D61.1:

Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) D64.9
ICD-10-CM Diagnosis Code D64.9
Anemia, unspecified
- aplastic D61.9
  ICD-10-CM Diagnosis Code D61.9
  Aplastic anemia, unspecified
  2016 2017 2018 2019 2020 2021 Billable/Specific Code
  Applicable To
  Hypoplastic anemia NOS
  Medullary hypoplasia
  - due to
    - drugs D61.1
  - drug-induced D61.1

ICD-10-CM Codes Adjacent To D61.1

D59.9 Acquired hemolytic anemia, unspecified

D60 Acquired pure red cell aplasia [erythroblastopenia]

D60.0 Chronic acquired pure red cell aplasia

D60.1 Transient acquired pure red cell aplasia

D60.8 Other acquired pure red cell aplasias

D60.9 Acquired pure red cell aplasia, unspecified

D61 Other aplastic anemias and other bone marrow failure syndromes

D61.0 Constitutional aplastic anemia

D61.01 Constitutional (pure) red blood cell aplasia

D61.09 Other constitutional aplastic anemia

D61.1 Drug-induced aplastic anemia

D61.2 Aplastic anemia due to other external agents

D61.3 Idiopathic aplastic anemia

D61.8 Other specified aplastic anemias and other bone marrow failure syndromes

D61.81 Pancytopenia

D61.810 Antineoplastic chemotherapy induced pancytopenia

D61.811 Other drug-induced pancytopenia

D61.818 Other pancytopenia

D61.82 Myelophthisis

D61.89 Other specified aplastic anemias and other bone marrow failure syndromes

D61.9 Aplastic anemia, unspecified

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.

2021 ICD-10-CM Diagnosis Code D61.1

Drug-induced aplastic anemia

Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances

Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

Other aplastic anemias and other bone marrow failure syndromes

Anemia in neoplastic disease

Anemia due to antineoplastic chemotherapy

Myelodysplastic syndromes

Antineoplastic chemotherapy induced pancytopenia

Other drug-induced pancytopenia

Anemia, unspecified

Aplastic anemia, unspecified