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ICD-10-CM Codes
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D50-D89
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
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D60-D64
Aplastic and other anemias and other bone marrow failure syndromes
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D61-
Other aplastic anemias and other bone marrow failure syndromes
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2022 ICD-10-CM Diagnosis Code D61.81
2022 ICD-10-CM Diagnosis Code D61.81
Pancytopenia
2016 2017 2018 2019 2020 2021 2022 Non-Billable/Non-Specific Code
- D61.81 should not be used for reimbursement purposes as there are multiple codes below it that contain a greater level of detail.
- The 2022 edition of ICD-10-CM D61.81 became effective on October 1, 2021.
- This is the American ICD-10-CM version of D61.81 - other international versions of ICD-10 D61.81 may differ.
Type 1 ExcludesType 1 Excludes Help
A type 1 excludes note is a pure excludes. It means "not coded here". A type 1 excludes note indicates that the code excluded should never be used at the same time as D61.81. A type 1 excludes note is for used for when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
- pancytopenia (due to) (with) aplastic anemia (
ICD-10-CM Diagnosis Code D61.9
Aplastic anemia, unspecified
2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
Applicable To- Hypoplastic anemia NOS
- Medullary hypoplasia
D61.9) - pancytopenia (due to) (with) bone marrow infiltration (
ICD-10-CM Diagnosis Code D61.82
Myelophthisis
2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
Applicable To- Leukoerythroblastic anemia
- Myelophthisic anemia
- Panmyelophthisis
Code Also- the underlying disorder, such as:
- malignant neoplasm of breast (C50.-)
- tuberculosis (A15.-)
Type 1 Excludes- idiopathic myelofibrosis (D47.1)
- myelofibrosis NOS (D75.81)
- myelofibrosis with myeloid metaplasia (D47.4)
- primary myelofibrosis (D47.1)
- secondary myelofibrosis (D75.81)
D61.82) - pancytopenia (due to) (with) congenital (pure) red cell aplasia (
ICD-10-CM Diagnosis Code D61.01
Constitutional (pure) red blood cell aplasia
2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
Applicable To- Blackfan-Diamond syndrome
- Congenital (pure) red cell aplasia
- Familial hypoplastic anemia
- Primary (pure) red cell aplasia
- Red cell (pure) aplasia of infants
Type 1 Excludes- acquired red cell aplasia (D60.9)
D61.01) - pancytopenia (due to) (with) hairy cell leukemia (
ICD-10-CM Diagnosis Code C91.4
Hairy cell leukemia
2016 2017 2018 2019 2020 2021 2022 Non-Billable/Non-Specific Code
Applicable To- Leukemic reticuloendotheliosis
C91.4-) - pancytopenia (due to) (with) human immunodeficiency virus disease (
ICD-10-CM Diagnosis Code B20
- B20 Human immunodeficiency virus [HIV] disease
B20.-) - pancytopenia (due to) (with) leukoerythroblastic anemia (
ICD-10-CM Diagnosis Code D61.82
Myelophthisis
2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
Applicable To- Leukoerythroblastic anemia
- Myelophthisic anemia
- Panmyelophthisis
Code Also- the underlying disorder, such as:
- malignant neoplasm of breast (C50.-)
- tuberculosis (A15.-)
Type 1 Excludes- idiopathic myelofibrosis (D47.1)
- myelofibrosis NOS (D75.81)
- myelofibrosis with myeloid metaplasia (D47.4)
- primary myelofibrosis (D47.1)
- secondary myelofibrosis (D75.81)
D61.82) - pancytopenia (due to) (with) myeloproliferative disease (
ICD-10-CM Diagnosis Code D47.1
Chronic myeloproliferative disease
2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
Applicable To- Chronic neutrophilic leukemia
- Myeloproliferative disease, unspecified
Type 1 Excludes- atypical chronic myeloid leukemia BCR/ABL-negative (C92.2-)
- chronic myeloid leukemia BCR/ABL-positive (C92.1-)
- myelofibrosis NOS (D75.81)
- myelophthisic anemia (D61.82)
- myelophthisis (D61.82)
- secondary myelofibrosis NOS (D75.81)
D47.1)
Type 2 ExcludesType 2 Excludes Help
A type 2 excludes note represents "not included here". A type 2 excludes note indicates that the condition excluded is not part of the condition it is excluded from but a patient may have both conditions at the same time. When a type 2 excludes note appears under a code it is acceptable to use both the code (D61.81) and the excluded code together.
The following code(s) above
D61.81 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
- Applicable To annotations, or
- Code Also annotations, or
- Code First annotations, or
- Excludes1 annotations, or
- Excludes2 annotations, or
- Includes annotations, or
- Note annotations, or
- Use Additional annotations
that may be applicable to
D61.81:
Approximate Synonyms
- Acquired pancytopenia
- Pancytopenia (reduction all blood elements) acquir
- Pancytopenia (reduction of all blood elements)
Clinical Information
- Deficiency of all three cell elements of the blood, erythrocytes, leukocytes and platelets.
- The inability of the bone marrow to produce hematopoietic elements.
Code History
- 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
- 2017 (effective 10/1/2016): No change
- 2018 (effective 10/1/2017): No change
- 2019 (effective 10/1/2018): No change
- 2020 (effective 10/1/2019): No change
- 2021 (effective 10/1/2020): No change
- 2022 (effective 10/1/2021): No change
ICD-10-CM Codes Adjacent To D61.81
D60.8 Other acquired pure red cell aplasias
D60.9 Acquired pure red cell aplasia, unspecified
D61 Other aplastic anemias and other bone marrow failure syndromes
D61.0 Constitutional aplastic anemia
D61.01 Constitutional (pure) red blood cell aplasia
D61.09 Other constitutional aplastic anemia
D61.1 Drug-induced aplastic anemia
D61.2 Aplastic anemia due to other external agents
D61.3 Idiopathic aplastic anemia
D61.8 Other specified aplastic anemias and other bone marrow failure syndromes
D61.81
Pancytopenia
D61.810 Antineoplastic chemotherapy induced pancytopenia
D61.811 Other drug-induced pancytopenia
D61.89 Other specified aplastic anemias and other bone marrow failure syndromes
D61.9 Aplastic anemia, unspecified
D62 Acute posthemorrhagic anemia
D63 Anemia in chronic diseases classified elsewhere
D63.0 Anemia in neoplastic disease
D63.1 Anemia in chronic kidney disease
Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.