2022

  1. ICD-10-CM Codes
    2. ›
  2. D50-D89 Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
    3. ›
  3. D60-D64 Aplastic and other anemias and other bone marrow failure syndromes
    4. ›
  4. D61- Other aplastic anemias and other bone marrow failure syndromes
    5. ›
  5. 2022 ICD-10-CM Diagnosis Code D61.81

2022 ICD-10-CM Diagnosis Code D61.81

Pancytopenia

    2016 2017 2018 2019 2020 2021 2022 Non-Billable/Non-Specific Code
  • D61.81 should not be used for reimbursement purposes as there are multiple codes below it that contain a greater level of detail.
  • The 2022 edition of ICD-10-CM D61.81 became effective on October 1, 2021.
  • This is the American ICD-10-CM version of D61.81 - other international versions of ICD-10 D61.81 may differ.
Type 1 Excludes
Type 1 Excludes Help
A type 1 excludes note is a pure excludes. It means "not coded here". A type 1 excludes note indicates that the code excluded should never be used at the same time as D61.81. A type 1 excludes note is for used for when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • pancytopenia (due to) (with) aplastic anemia (
    ICD-10-CM Diagnosis Code D61.9

    Aplastic anemia, unspecified

      2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
    Applicable To
    • Hypoplastic anemia NOS
    • Medullary hypoplasia
    D61.9
    )
  • pancytopenia (due to) (with) bone marrow infiltration (
    ICD-10-CM Diagnosis Code D61.82

    Myelophthisis

      2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
    Applicable To
    • Leukoerythroblastic anemia
    • Myelophthisic anemia
    • Panmyelophthisis
    Code Also
    • the underlying disorder, such as:
    • malignant neoplasm of breast (C50.-)
    • tuberculosis (A15.-)
    Type 1 Excludes
    • idiopathic myelofibrosis (D47.1)
    • myelofibrosis NOS (D75.81)
    • myelofibrosis with myeloid metaplasia (D47.4)
    • primary myelofibrosis (D47.1)
    • secondary myelofibrosis (D75.81)
    D61.82
    )
  • pancytopenia (due to) (with) congenital (pure) red cell aplasia (
    ICD-10-CM Diagnosis Code D61.01

    Constitutional (pure) red blood cell aplasia

      2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
    Applicable To
    • Blackfan-Diamond syndrome
    • Congenital (pure) red cell aplasia
    • Familial hypoplastic anemia
    • Primary (pure) red cell aplasia
    • Red cell (pure) aplasia of infants
    Type 1 Excludes
    • acquired red cell aplasia (D60.9)
    D61.01
    )
  • pancytopenia (due to) (with) hairy cell leukemia (
    ICD-10-CM Diagnosis Code C91.4

    Hairy cell leukemia

      2016 2017 2018 2019 2020 2021 2022 Non-Billable/Non-Specific Code
    Applicable To
    • Leukemic reticuloendotheliosis
    C91.4-
    )
  • pancytopenia (due to) (with) human immunodeficiency virus disease (
    ICD-10-CM Diagnosis Code B20
    • B20 Human immunodeficiency virus [HIV] disease
    B20.-
    )
  • pancytopenia (due to) (with) leukoerythroblastic anemia (
    ICD-10-CM Diagnosis Code D61.82

    Myelophthisis

      2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
    Applicable To
    • Leukoerythroblastic anemia
    • Myelophthisic anemia
    • Panmyelophthisis
    Code Also
    • the underlying disorder, such as:
    • malignant neoplasm of breast (C50.-)
    • tuberculosis (A15.-)
    Type 1 Excludes
    • idiopathic myelofibrosis (D47.1)
    • myelofibrosis NOS (D75.81)
    • myelofibrosis with myeloid metaplasia (D47.4)
    • primary myelofibrosis (D47.1)
    • secondary myelofibrosis (D75.81)
    D61.82
    )
  • pancytopenia (due to) (with) myeloproliferative disease (
    ICD-10-CM Diagnosis Code D47.1

    Chronic myeloproliferative disease

      2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
    Applicable To
    • Chronic neutrophilic leukemia
    • Myeloproliferative disease, unspecified
    Type 1 Excludes
    • atypical chronic myeloid leukemia BCR/ABL-negative (C92.2-)
    • chronic myeloid leukemia BCR/ABL-positive (C92.1-)
    • myelofibrosis NOS (D75.81)
    • myelophthisic anemia (D61.82)
    • myelophthisis (D61.82)
    • secondary myelofibrosis NOS (D75.81)
    D47.1
    )
Type 2 Excludes
Type 2 Excludes Help
A type 2 excludes note represents "not included here". A type 2 excludes note indicates that the condition excluded is not part of the condition it is excluded from but a patient may have both conditions at the same time. When a type 2 excludes note appears under a code it is acceptable to use both the code (D61.81) and the excluded code together.
  • pancytopenia (due to) (with) myelodysplastic syndromes (
    ICD-10-CM Diagnosis Code D46
    • D46 Myelodysplastic syndromes
      • D46.0 Refractory anemia without ring sideroblasts, ...
      • D46.1 Refractory anemia with ring sideroblasts
      • D46.2 Refractory anemia with excess of blasts [RAEB...
        • D46.20 Refractory anemia with excess of blasts, unsp...
        • D46.21 Refractory anemia with excess of blasts 1
        • D46.22 Refractory anemia with excess of blasts 2
      • D46.A Refractory cytopenia with multilineage dyspla...
      • D46.B Refractory cytopenia with multilineage dyspla...
      • D46.C Myelodysplastic syndrome with isolated del(5q...
      • D46.4 Refractory anemia, unspecified
      • D46.Z Other myelodysplastic syndromes
      • D46.9 Myelodysplastic syndrome, unspecified
    D46.-
    )
The following code(s) above D61.81 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to D61.81:
  • D50-D89
    2022 ICD-10-CM Range D50-D89

    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

    Type 2 Excludes
    • autoimmune disease (systemic) NOS (M35.9)
    • certain conditions originating in the perinatal period (P00-P96)
    • complications of pregnancy, childbirth and the puerperium (O00-O9A)
    • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
    • endocrine, nutritional and metabolic diseases (E00-E88)
    • human immunodeficiency virus [HIV] disease (B20)
    • injury, poisoning and certain other consequences of external causes (S00-T88)
    • neoplasms (C00-D49)
    • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
  • D61
    ICD-10-CM Diagnosis Code D61

    Other aplastic anemias and other bone marrow failure syndromes

      2016 2017 2018 2019 2020 2021 2022 Non-Billable/Non-Specific Code
    Type 2 Excludes
    Other aplastic anemias and other bone marrow failure syndromes
Approximate Synonyms
  • Acquired pancytopenia
  • Pancytopenia (reduction all blood elements) acquir
  • Pancytopenia (reduction of all blood elements)
Clinical Information
  • Deficiency of all three cell elements of the blood, erythrocytes, leukocytes and platelets.
  • The inability of the bone marrow to produce hematopoietic elements.
Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change
  • 2022 (effective 10/1/2021): No change
ICD-10-CM Codes Adjacent To D61.81
D60.8 Other acquired pure red cell aplasias
D60.9 Acquired pure red cell aplasia, unspecified
D61 Other aplastic anemias and other bone marrow failure syndromes
D61.0 Constitutional aplastic anemia
D61.01 Constitutional (pure) red blood cell aplasia
D61.09 Other constitutional aplastic anemia
D61.1 Drug-induced aplastic anemia
D61.2 Aplastic anemia due to other external agents
D61.3 Idiopathic aplastic anemia
D61.8 Other specified aplastic anemias and other bone marrow failure syndromes
D61.81 Pancytopenia
D61.810 Antineoplastic chemotherapy induced pancytopenia
D61.811 Other drug-induced pancytopenia
D61.818 Other pancytopenia
D61.82 Myelophthisis
D61.89 Other specified aplastic anemias and other bone marrow failure syndromes
D61.9 Aplastic anemia, unspecified
D62 Acute posthemorrhagic anemia
D63 Anemia in chronic diseases classified elsewhere
D63.0 Anemia in neoplastic disease
D63.1 Anemia in chronic kidney disease

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.

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