ICD-10-CM Codes
D50-D89 Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
D65-D69 Coagulation defects, purpura and other hemorrhagic conditions
D68- Other coagulation defects
2022 ICD-10-CM Diagnosis Code D68.4

2022 ICD-10-CM Diagnosis Code D68.4

Acquired coagulation factor deficiency

2016

2017

2018

2019

2020

2021

2022

Billable/Specific Code

D68.4 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
The 2022 edition of ICD-10-CM D68.4 became effective on October 1, 2021.
This is the American ICD-10-CM version of D68.4 - other international versions of ICD-10 D68.4 may differ.

Applicable To

Deficiency of coagulation factor due to liver disease
Deficiency of coagulation factor due to vitamin K deficiency

Type 1 Excludes

Type 1 Excludes Help

A type 1 excludes note is a pure excludes. It means "not coded here". A type 1 excludes note indicates that the code excluded should never be used at the same time as D68.4. A type 1 excludes note is for used for when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.

vitamin K deficiency of newborn (
ICD-10-CM Diagnosis Code P53
Hemorrhagic disease of newborn
Applicable To
- Vitamin K deficiency of newborn
P53
)

The following code(s) above D68.4 contain annotation back-references

Annotation Back-References

In this context, annotation back-references refer to codes that contain:

Applicable To annotations, or
Code Also annotations, or
Code First annotations, or
Excludes1 annotations, or
Excludes2 annotations, or
Includes annotations, or
Note annotations, or
Use Additional annotations

that may be applicable to D68.4:

D50-D89
2022 ICD-10-CM Range D50-D89
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
Type 2 Excludes
- autoimmune disease (systemic) NOS (M35.9)
- certain conditions originating in the perinatal period (P00-P96)
- complications of pregnancy, childbirth and the puerperium (O00-O9A)
- congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
- endocrine, nutritional and metabolic diseases (E00-E88)
- human immunodeficiency virus [HIV] disease (B20)
- injury, poisoning and certain other consequences of external causes (S00-T88)
- neoplasms (C00-D49)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
D68
ICD-10-CM Diagnosis Code D68
Other coagulation defects
Type 1 Excludes
- abnormal coagulation profile (R79.1)
- coagulation defects complicating abortion or ectopic or molar pregnancy (O00-O07, O08.1)
- coagulation defects complicating pregnancy, childbirth and the puerperium (O45.0, O46.0, O67.0, O72.3)
Other coagulation defects

Approximate Synonyms

Acquired factor viii deficiency disease
Acquired factor x deficiency disease
Acquired factor xii deficiency disease
Clotting factor deficiency due to liver disease
Clotting factor deficiency from vitamin k deficien
Clotting factor deficiency, acquired
Deficiency of coagulation factor due to liver disease
Deficiency of coagulation factor due to vitamin k deficiency
Factor 10 deficiency, acquired
Factor 12 deficiency, acquired
Factor 8 deficiency, acquired

Clinical Information

Deficiency of a coagulation factor that is not caused by genetic alterations. Causes include vitamin k deficiency, amyloidosis, and severe liver disease.

ICD-10-CM D68.4 is grouped within Diagnostic Related Group(s) (MS-DRG v39.0):

813 Coagulation disorders

Convert D68.4 to ICD-9-CM

Code History

2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
2017 (effective 10/1/2016): No change
2018 (effective 10/1/2017): No change
2019 (effective 10/1/2018): No change
2020 (effective 10/1/2019): No change
2021 (effective 10/1/2020): No change
2022 (effective 10/1/2021): No change

Code annotations containing back-references to D68.4:

Type 1 Excludes: E56.1

ICD-10-CM Diagnosis Code E56.1
Deficiency of vitamin K
Type 1 Excludes
- deficiency of coagulation factor due to vitamin K deficiency (D68.4)
- vitamin K deficiency of newborn (P53)

Diagnosis Index entries containing back-references to D68.4:

Defect, defective Q89.9
ICD-10-CM Diagnosis Code Q89.9
Congenital malformation, unspecified
Applicable To
Congenital anomaly NOS
Congenital deformity NOS
- coagulation (factor) D68.9
  - see also Deficiency, factor
  ICD-10-CM Diagnosis Code D68.9
  Coagulation defect, unspecified
  2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
  - due to
    - liver disease D68.4
    - vitamin K deficiency D68.4
  - acquired D68.4
Deficiency, deficient
- AC globulin (congenital) (hereditary) D68.2
  ICD-10-CM Diagnosis Code D68.2
  Hereditary deficiency of other clotting factors
  2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
  Applicable To
  AC globulin deficiency
  Congenital afibrinogenemia
  Deficiency of factor I [fibrinogen]
  Deficiency of factor II [prothrombin]
  Deficiency of factor V [labile]
  Deficiency of factor VII [stable]
  Deficiency of factor X [Stuart-Prower]
  Deficiency of factor XII [Hageman]
  Deficiency of factor XIII [fibrin stabilizing]
  Dysfibrinogenemia (congenital)
  Hypoproconvertinemia
  Owren's disease
  Proaccelerin deficiency
  - acquired D68.4
- coagulation NOS D68.9
  ICD-10-CM Diagnosis Code D68.9
  Coagulation defect, unspecified
  2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
  - due to
    - hyperprothrombinemia D68.4
    - liver disease D68.4
    - vitamin K deficiency D68.4
  - acquired D68.4 (any)
- factor - see also Deficiency, coagulation
  - multiple (congenital) D68.8
    ICD-10-CM Diagnosis Code D68.8
    Other specified coagulation defects
    2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
    Type 1 Excludes
    hemorrhagic disease of newborn (P53)
    - acquired D68.4
- fibrin-stabilizing factor (congenital) (hereditary) D68.2
  ICD-10-CM Diagnosis Code D68.2
  Hereditary deficiency of other clotting factors
  2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
  Applicable To
  AC globulin deficiency
  Congenital afibrinogenemia
  Deficiency of factor I [fibrinogen]
  Deficiency of factor II [prothrombin]
  Deficiency of factor V [labile]
  Deficiency of factor VII [stable]
  Deficiency of factor X [Stuart-Prower]
  Deficiency of factor XII [Hageman]
  Deficiency of factor XIII [fibrin stabilizing]
  Dysfibrinogenemia (congenital)
  Hypoproconvertinemia
  Owren's disease
  Proaccelerin deficiency
  - acquired D68.4
- labile factor (congenital) (hereditary) D68.2
  ICD-10-CM Diagnosis Code D68.2
  Hereditary deficiency of other clotting factors
  2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
  Applicable To
  AC globulin deficiency
  Congenital afibrinogenemia
  Deficiency of factor I [fibrinogen]
  Deficiency of factor II [prothrombin]
  Deficiency of factor V [labile]
  Deficiency of factor VII [stable]
  Deficiency of factor X [Stuart-Prower]
  Deficiency of factor XII [Hageman]
  Deficiency of factor XIII [fibrin stabilizing]
  Dysfibrinogenemia (congenital)
  Hypoproconvertinemia
  Owren's disease
  Proaccelerin deficiency
  - acquired D68.4
- proaccelerin (congenital) (hereditary) D68.2
  ICD-10-CM Diagnosis Code D68.2
  Hereditary deficiency of other clotting factors
  2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
  Applicable To
  AC globulin deficiency
  Congenital afibrinogenemia
  Deficiency of factor I [fibrinogen]
  Deficiency of factor II [prothrombin]
  Deficiency of factor V [labile]
  Deficiency of factor VII [stable]
  Deficiency of factor X [Stuart-Prower]
  Deficiency of factor XII [Hageman]
  Deficiency of factor XIII [fibrin stabilizing]
  Dysfibrinogenemia (congenital)
  Hypoproconvertinemia
  Owren's disease
  Proaccelerin deficiency
  - acquired D68.4
- proconvertin factor (congenital) (hereditary) D68.2
  ICD-10-CM Diagnosis Code D68.2
  Hereditary deficiency of other clotting factors
  2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
  Applicable To
  AC globulin deficiency
  Congenital afibrinogenemia
  Deficiency of factor I [fibrinogen]
  Deficiency of factor II [prothrombin]
  Deficiency of factor V [labile]
  Deficiency of factor VII [stable]
  Deficiency of factor X [Stuart-Prower]
  Deficiency of factor XII [Hageman]
  Deficiency of factor XIII [fibrin stabilizing]
  Dysfibrinogenemia (congenital)
  Hypoproconvertinemia
  Owren's disease
  Proaccelerin deficiency
  - acquired D68.4
- prothrombin (congenital) (heredItary) D68.2
  ICD-10-CM Diagnosis Code D68.2
  Hereditary deficiency of other clotting factors
  2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
  Applicable To
  AC globulin deficiency
  Congenital afibrinogenemia
  Deficiency of factor I [fibrinogen]
  Deficiency of factor II [prothrombin]
  Deficiency of factor V [labile]
  Deficiency of factor VII [stable]
  Deficiency of factor X [Stuart-Prower]
  Deficiency of factor XII [Hageman]
  Deficiency of factor XIII [fibrin stabilizing]
  Dysfibrinogenemia (congenital)
  Hypoproconvertinemia
  Owren's disease
  Proaccelerin deficiency
  - acquired D68.4
- stable factor (congenital) (hereditary) D68.2
  ICD-10-CM Diagnosis Code D68.2
  Hereditary deficiency of other clotting factors
  2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
  Applicable To
  AC globulin deficiency
  Congenital afibrinogenemia
  Deficiency of factor I [fibrinogen]
  Deficiency of factor II [prothrombin]
  Deficiency of factor V [labile]
  Deficiency of factor VII [stable]
  Deficiency of factor X [Stuart-Prower]
  Deficiency of factor XII [Hageman]
  Deficiency of factor XIII [fibrin stabilizing]
  Dysfibrinogenemia (congenital)
  Hypoproconvertinemia
  Owren's disease
  Proaccelerin deficiency
  - acquired D68.4
Fibrinopenia (hereditary) D68.2
ICD-10-CM Diagnosis Code D68.2
Hereditary deficiency of other clotting factors
Applicable To
AC globulin deficiency
Congenital afibrinogenemia
Deficiency of factor I [fibrinogen]
Deficiency of factor II [prothrombin]
Deficiency of factor V [labile]
Deficiency of factor VII [stable]
Deficiency of factor X [Stuart-Prower]
Deficiency of factor XII [Hageman]
Deficiency of factor XIII [fibrin stabilizing]
Dysfibrinogenemia (congenital)
Hypoproconvertinemia
Owren's disease
Proaccelerin deficiency
- acquired D68.4
Hemophilia (classical) (familial) (hereditary) D66
ICD-10-CM Diagnosis Code D66
Hereditary factor VIII deficiency
Applicable To
Classical hemophilia
Deficiency factor VIII (with functional defect)
Hemophilia NOS
Hemophilia A
Type 1 Excludes
factor VIII deficiency with vascular defect (D68.0)
- calcipriva D68.4 - see also Defect, coagulation
- nonfamilial D68.4 - see also Defect, coagulation
Hyperprothrombinemia, causing coagulation factor deficiency D68.4
Hypoprothrombinemia (congenital) (hereditary) (idiopathic) D68.2
ICD-10-CM Diagnosis Code D68.2
Hereditary deficiency of other clotting factors
Applicable To
AC globulin deficiency
Congenital afibrinogenemia
Deficiency of factor I [fibrinogen]
Deficiency of factor II [prothrombin]
Deficiency of factor V [labile]
Deficiency of factor VII [stable]
Deficiency of factor X [Stuart-Prower]
Deficiency of factor XII [Hageman]
Deficiency of factor XIII [fibrin stabilizing]
Dysfibrinogenemia (congenital)
Hypoproconvertinemia
Owren's disease
Proaccelerin deficiency
- acquired D68.4

ICD-10-CM Codes Adjacent To D68.4

D68 Other coagulation defects

D68.0 Von Willebrand's disease

D68.1 Hereditary factor XI deficiency

D68.2 Hereditary deficiency of other clotting factors

D68.3 Hemorrhagic disorder due to circulating anticoagulants

D68.31 Hemorrhagic disorder due to intrinsic circulating anticoagulants, antibodies, or inhibitors

D68.311 Acquired hemophilia

D68.312 Antiphospholipid antibody with hemorrhagic disorder

D68.318 Other hemorrhagic disorder due to intrinsic circulating anticoagulants, antibodies, or inhibitors

D68.32 Hemorrhagic disorder due to extrinsic circulating anticoagulants

D68.4 Acquired coagulation factor deficiency

D68.5 Primary thrombophilia

D68.51 Activated protein C resistance

D68.52 Prothrombin gene mutation

D68.59 Other primary thrombophilia

D68.6 Other thrombophilia

D68.61 Antiphospholipid syndrome

D68.62 Lupus anticoagulant syndrome

D68.69 Other thrombophilia

D68.8 Other specified coagulation defects

D68.9 Coagulation defect, unspecified

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.

2022 ICD-10-CM Diagnosis Code D68.4

Acquired coagulation factor deficiency

Hemorrhagic disease of newborn

Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

Other coagulation defects

Deficiency of vitamin K

Congenital malformation, unspecified

Coagulation defect, unspecified

Hereditary deficiency of other clotting factors

Coagulation defect, unspecified

Other specified coagulation defects

Hereditary deficiency of other clotting factors

Hereditary deficiency of other clotting factors

Hereditary deficiency of other clotting factors

Hereditary deficiency of other clotting factors

Hereditary deficiency of other clotting factors

Hereditary deficiency of other clotting factors

Hereditary deficiency of other clotting factors

Hereditary factor VIII deficiency

Hereditary deficiency of other clotting factors