2021 ICD-10-CM Diagnosis Code D68.4

Acquired coagulation factor deficiency

    2016 2017 2018 2019 2020 2021 Billable/Specific Code
  • D68.4 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2021 edition of ICD-10-CM D68.4 became effective on October 1, 2020.
  • This is the American ICD-10-CM version of D68.4 - other international versions of ICD-10 D68.4 may differ.
Applicable To
  • Deficiency of coagulation factor due to liver disease
  • Deficiency of coagulation factor due to vitamin K deficiency
Type 1 Excludes
Type 1 Excludes Help
A type 1 excludes note is a pure excludes. It means "not coded here". A type 1 excludes note indicates that the code excluded should never be used at the same time as D68.4. A type 1 excludes note is for used for when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • vitamin K deficiency of newborn (
    ICD-10-CM Diagnosis Code P53

    Hemorrhagic disease of newborn

      2016 2017 2018 2019 2020 2021 Billable/Specific Code Code on Newborn Record
    Applicable To
    • Vitamin K deficiency of newborn
    P53
    )
The following code(s) above D68.4 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to D68.4:
  • D50-D89
    2021 ICD-10-CM Range D50-D89

    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

    Type 2 Excludes
    • autoimmune disease (systemic) NOS (M35.9)
    • certain conditions originating in the perinatal period (P00-P96)
    • complications of pregnancy, childbirth and the puerperium (O00-O9A)
    • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
    • endocrine, nutritional and metabolic diseases (E00-E88)
    • human immunodeficiency virus [HIV] disease (B20)
    • injury, poisoning and certain other consequences of external causes (S00-T88)
    • neoplasms (C00-D49)
    • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
  • D68
    ICD-10-CM Diagnosis Code D68

    Other coagulation defects

      2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • abnormal coagulation profile (R79.1)
    • coagulation defects complicating abortion or ectopic or molar pregnancy (O00-O07, O08.1)
    • coagulation defects complicating pregnancy, childbirth and the puerperium (O45.0, O46.0, O67.0, O72.3)
    Other coagulation defects
Approximate Synonyms
  • Acquired factor viii deficiency disease
  • Acquired factor x deficiency disease
  • Acquired factor xii deficiency disease
  • Clotting factor deficiency due to liver disease
  • Clotting factor deficiency from vitamin k deficien
  • Clotting factor deficiency, acquired
  • Deficiency of coagulation factor due to liver disease
  • Deficiency of coagulation factor due to vitamin k deficiency
  • Factor 10 deficiency, acquired
  • Factor 12 deficiency, acquired
  • Factor 8 deficiency, acquired
Clinical Information
  • Deficiency of a coagulation factor that is not caused by genetic alterations. Causes include vitamin k deficiency, amyloidosis, and severe liver disease.
ICD-10-CM D68.4 is grouped within Diagnostic Related Group(s) (MS-DRG v38.0):
  • 813 Coagulation disorders

Convert D68.4 to ICD-9-CM

Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change
Code annotations containing back-references to D68.4:
  • Type 1 Excludes: E56.1
    ICD-10-CM Diagnosis Code E56.1

    Deficiency of vitamin K

      2016 2017 2018 2019 2020 2021 Billable/Specific Code
    Type 1 Excludes
    • deficiency of coagulation factor due to vitamin K deficiency (D68.4)
    • vitamin K deficiency of newborn (P53)

Diagnosis Index entries containing back-references to D68.4:
  • Defect, defective Q89.9
    ICD-10-CM Diagnosis Code Q89.9

    Congenital malformation, unspecified

      2016 2017 2018 2019 2020 2021 Billable/Specific Code POA Exempt
    Applicable To
    • Congenital anomaly NOS
    • Congenital deformity NOS
    • coagulation (factor) D68.9
      - see also Deficiency, factor
      ICD-10-CM Diagnosis Code D68.9

      Coagulation defect, unspecified

        2016 2017 2018 2019 2020 2021 Billable/Specific Code
      • due to
        • liver disease D68.4
        • vitamin K deficiency D68.4
      • acquired D68.4
  • Deficiency, deficient
    • AC globulin (congenital) (hereditary) D68.2
      ICD-10-CM Diagnosis Code D68.2

      Hereditary deficiency of other clotting factors

        2016 2017 2018 2019 2020 2021 Billable/Specific Code
      Applicable To
      • AC globulin deficiency
      • Congenital afibrinogenemia
      • Deficiency of factor I [fibrinogen]
      • Deficiency of factor II [prothrombin]
      • Deficiency of factor V [labile]
      • Deficiency of factor VII [stable]
      • Deficiency of factor X [Stuart-Prower]
      • Deficiency of factor XII [Hageman]
      • Deficiency of factor XIII [fibrin stabilizing]
      • Dysfibrinogenemia (congenital)
      • Hypoproconvertinemia
      • Owren's disease
      • Proaccelerin deficiency
      • acquired D68.4
    • coagulation NOS D68.9
      ICD-10-CM Diagnosis Code D68.9

      Coagulation defect, unspecified

        2016 2017 2018 2019 2020 2021 Billable/Specific Code
      • due to
        • hyperprothrombinemia D68.4
        • liver disease D68.4
        • vitamin K deficiency D68.4
      • acquired D68.4 (any)
    • factor - see also Deficiency, coagulation
      • multiple (congenital) D68.8
        ICD-10-CM Diagnosis Code D68.8

        Other specified coagulation defects

          2016 2017 2018 2019 2020 2021 Billable/Specific Code
        Type 1 Excludes
        • hemorrhagic disease of newborn (P53)
        • acquired D68.4
    • fibrin-stabilizing factor (congenital) (hereditary) D68.2
      ICD-10-CM Diagnosis Code D68.2

      Hereditary deficiency of other clotting factors

        2016 2017 2018 2019 2020 2021 Billable/Specific Code
      Applicable To
      • AC globulin deficiency
      • Congenital afibrinogenemia
      • Deficiency of factor I [fibrinogen]
      • Deficiency of factor II [prothrombin]
      • Deficiency of factor V [labile]
      • Deficiency of factor VII [stable]
      • Deficiency of factor X [Stuart-Prower]
      • Deficiency of factor XII [Hageman]
      • Deficiency of factor XIII [fibrin stabilizing]
      • Dysfibrinogenemia (congenital)
      • Hypoproconvertinemia
      • Owren's disease
      • Proaccelerin deficiency
      • acquired D68.4
    • labile factor (congenital) (hereditary) D68.2
      ICD-10-CM Diagnosis Code D68.2

      Hereditary deficiency of other clotting factors

        2016 2017 2018 2019 2020 2021 Billable/Specific Code
      Applicable To
      • AC globulin deficiency
      • Congenital afibrinogenemia
      • Deficiency of factor I [fibrinogen]
      • Deficiency of factor II [prothrombin]
      • Deficiency of factor V [labile]
      • Deficiency of factor VII [stable]
      • Deficiency of factor X [Stuart-Prower]
      • Deficiency of factor XII [Hageman]
      • Deficiency of factor XIII [fibrin stabilizing]
      • Dysfibrinogenemia (congenital)
      • Hypoproconvertinemia
      • Owren's disease
      • Proaccelerin deficiency
      • acquired D68.4
    • proaccelerin (congenital) (hereditary) D68.2
      ICD-10-CM Diagnosis Code D68.2

      Hereditary deficiency of other clotting factors

        2016 2017 2018 2019 2020 2021 Billable/Specific Code
      Applicable To
      • AC globulin deficiency
      • Congenital afibrinogenemia
      • Deficiency of factor I [fibrinogen]
      • Deficiency of factor II [prothrombin]
      • Deficiency of factor V [labile]
      • Deficiency of factor VII [stable]
      • Deficiency of factor X [Stuart-Prower]
      • Deficiency of factor XII [Hageman]
      • Deficiency of factor XIII [fibrin stabilizing]
      • Dysfibrinogenemia (congenital)
      • Hypoproconvertinemia
      • Owren's disease
      • Proaccelerin deficiency
      • acquired D68.4
    • proconvertin factor (congenital) (hereditary) D68.2
      ICD-10-CM Diagnosis Code D68.2

      Hereditary deficiency of other clotting factors

        2016 2017 2018 2019 2020 2021 Billable/Specific Code
      Applicable To
      • AC globulin deficiency
      • Congenital afibrinogenemia
      • Deficiency of factor I [fibrinogen]
      • Deficiency of factor II [prothrombin]
      • Deficiency of factor V [labile]
      • Deficiency of factor VII [stable]
      • Deficiency of factor X [Stuart-Prower]
      • Deficiency of factor XII [Hageman]
      • Deficiency of factor XIII [fibrin stabilizing]
      • Dysfibrinogenemia (congenital)
      • Hypoproconvertinemia
      • Owren's disease
      • Proaccelerin deficiency
      • acquired D68.4
    • prothrombin (congenital) (heredItary) D68.2
      ICD-10-CM Diagnosis Code D68.2

      Hereditary deficiency of other clotting factors

        2016 2017 2018 2019 2020 2021 Billable/Specific Code
      Applicable To
      • AC globulin deficiency
      • Congenital afibrinogenemia
      • Deficiency of factor I [fibrinogen]
      • Deficiency of factor II [prothrombin]
      • Deficiency of factor V [labile]
      • Deficiency of factor VII [stable]
      • Deficiency of factor X [Stuart-Prower]
      • Deficiency of factor XII [Hageman]
      • Deficiency of factor XIII [fibrin stabilizing]
      • Dysfibrinogenemia (congenital)
      • Hypoproconvertinemia
      • Owren's disease
      • Proaccelerin deficiency
      • acquired D68.4
    • stable factor (congenital) (hereditary) D68.2
      ICD-10-CM Diagnosis Code D68.2

      Hereditary deficiency of other clotting factors

        2016 2017 2018 2019 2020 2021 Billable/Specific Code
      Applicable To
      • AC globulin deficiency
      • Congenital afibrinogenemia
      • Deficiency of factor I [fibrinogen]
      • Deficiency of factor II [prothrombin]
      • Deficiency of factor V [labile]
      • Deficiency of factor VII [stable]
      • Deficiency of factor X [Stuart-Prower]
      • Deficiency of factor XII [Hageman]
      • Deficiency of factor XIII [fibrin stabilizing]
      • Dysfibrinogenemia (congenital)
      • Hypoproconvertinemia
      • Owren's disease
      • Proaccelerin deficiency
      • acquired D68.4
  • Fibrinopenia (hereditary) D68.2
    ICD-10-CM Diagnosis Code D68.2

    Hereditary deficiency of other clotting factors

      2016 2017 2018 2019 2020 2021 Billable/Specific Code
    Applicable To
    • AC globulin deficiency
    • Congenital afibrinogenemia
    • Deficiency of factor I [fibrinogen]
    • Deficiency of factor II [prothrombin]
    • Deficiency of factor V [labile]
    • Deficiency of factor VII [stable]
    • Deficiency of factor X [Stuart-Prower]
    • Deficiency of factor XII [Hageman]
    • Deficiency of factor XIII [fibrin stabilizing]
    • Dysfibrinogenemia (congenital)
    • Hypoproconvertinemia
    • Owren's disease
    • Proaccelerin deficiency
    • acquired D68.4
  • Hemophilia (classical) (familial) (hereditary) D66
    ICD-10-CM Diagnosis Code D66

    Hereditary factor VIII deficiency

      2016 2017 2018 2019 2020 2021 Billable/Specific Code
    Applicable To
    • Classical hemophilia
    • Deficiency factor VIII (with functional defect)
    • Hemophilia NOS
    • Hemophilia A
    Type 1 Excludes
    • factor VIII deficiency with vascular defect (D68.0)
  • Hyperprothrombinemia, causing coagulation factor deficiency D68.4
  • Hypoprothrombinemia (congenital) (hereditary) (idiopathic) D68.2
    ICD-10-CM Diagnosis Code D68.2

    Hereditary deficiency of other clotting factors

      2016 2017 2018 2019 2020 2021 Billable/Specific Code
    Applicable To
    • AC globulin deficiency
    • Congenital afibrinogenemia
    • Deficiency of factor I [fibrinogen]
    • Deficiency of factor II [prothrombin]
    • Deficiency of factor V [labile]
    • Deficiency of factor VII [stable]
    • Deficiency of factor X [Stuart-Prower]
    • Deficiency of factor XII [Hageman]
    • Deficiency of factor XIII [fibrin stabilizing]
    • Dysfibrinogenemia (congenital)
    • Hypoproconvertinemia
    • Owren's disease
    • Proaccelerin deficiency
    • acquired D68.4

ICD-10-CM Codes Adjacent To D68.4
D68 Other coagulation defects
D68.0 Von Willebrand's disease
D68.1 Hereditary factor XI deficiency
D68.2 Hereditary deficiency of other clotting factors
D68.3 Hemorrhagic disorder due to circulating anticoagulants
D68.31 Hemorrhagic disorder due to intrinsic circulating anticoagulants, antibodies, or inhibitors
D68.311 Acquired hemophilia
D68.312 Antiphospholipid antibody with hemorrhagic disorder
D68.318 Other hemorrhagic disorder due to intrinsic circulating anticoagulants, antibodies, or inhibitors
D68.32 Hemorrhagic disorder due to extrinsic circulating anticoagulants
D68.4 Acquired coagulation factor deficiency
D68.5 Primary thrombophilia
D68.51 Activated protein C resistance
D68.52 Prothrombin gene mutation
D68.59 Other primary thrombophilia
D68.6 Other thrombophilia
D68.61 Antiphospholipid syndrome
D68.62 Lupus anticoagulant syndrome
D68.69 Other thrombophilia
D68.8 Other specified coagulation defects
D68.9 Coagulation defect, unspecified

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.