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ICD-10-CM Codes
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D50-D89
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
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D65-D69
Coagulation defects, purpura and other hemorrhagic conditions
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D68-
Other coagulation defects
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2022 ICD-10-CM Diagnosis Code D68.51
2022 ICD-10-CM Diagnosis Code D68.51
Activated protein C resistance
2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
- D68.51 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
- The 2022 edition of ICD-10-CM D68.51 became effective on October 1, 2021.
- This is the American ICD-10-CM version of D68.51 - other international versions of ICD-10 D68.51 may differ.
The following code(s) above
D68.51 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
- Applicable To annotations, or
- Code Also annotations, or
- Code First annotations, or
- Excludes1 annotations, or
- Excludes2 annotations, or
- Includes annotations, or
- Note annotations, or
- Use Additional annotations
that may be applicable to
D68.51:
- D50-D89
2022 ICD-10-CM Range D50-D89
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanismType 2 Excludes- autoimmune disease (systemic) NOS (M35.9)
- certain conditions originating in the perinatal period (P00-P96)
- complications of pregnancy, childbirth and the puerperium (O00-O9A)
- congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
- endocrine, nutritional and metabolic diseases (E00-E88)
- human immunodeficiency virus [HIV] disease (B20)
- injury, poisoning and certain other consequences of external causes (S00-T88)
- neoplasms (C00-D49)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
- D68
ICD-10-CM Diagnosis Code D68
Other coagulation defects
2016 2017 2018 2019 2020 2021 2022 Non-Billable/Non-Specific Code
Type 1 Excludes- abnormal coagulation profile (R79.1)
- coagulation defects complicating abortion or ectopic or molar pregnancy (O00-O07, O08.1)
- coagulation defects complicating pregnancy, childbirth and the puerperium (O45.0, O46.0, O67.0, O72.3)
- D68.5
ICD-10-CM Diagnosis Code D68.5
Primary thrombophilia
2016 2017 2018 2019 2020 2021 2022 Non-Billable/Non-Specific Code
Applicable To- Primary hypercoagulable states
Type 1 Excludes- antiphospholipid syndrome (D68.61)
- lupus anticoagulant (D68.62)
- secondary activated protein C resistance (D68.69)
- secondary antiphospholipid antibody syndrome (D68.69)
- secondary lupus anticoagulant with hypercoagulable state (D68.69)
- secondary systemic lupus erythematosus [SLE] inhibitor with hypercoagulable state (D68.69)
- systemic lupus erythematosus [SLE] inhibitor finding without diagnosis (R76.0)
- systemic lupus erythematosus [SLE] inhibitor with hemorrhagic disorder (D68.312)
- thrombotic thrombocytopenic purpura (M31.19)
- Factor 5 leiden mutation
- Factor 5 leiden mutation, heterozygous
- Factor 5 leiden mutation, homozygous
- Factor v leiden mutation
- Heterozygous factor v leiden mutation
- Homozygous factor v leiden mutation
- Protein c resistance
- Resistance to activated protein c due to factor v leiden
Clinical Information
- A hemostatic disorder characterized by a poor anticoagulant response to activated protein c (apc). The activated form of factor v (factor va) is more slowly degraded by activated protein c. Factor v leiden mutation (r506q) is the most common cause of apc resistance.
- An abnormality that refers to mutation of factor v leiden, which is a variant of human factor v. It results in thrombophilia, deep vein thrombosis, and a slightly increased risk of miscarriage.
ICD-10-CM D68.51 is grouped within Diagnostic Related Group(s) (MS-DRG v39.0):
- 814 Reticuloendothelial and immunity disorders with mcc
- 815 Reticuloendothelial and immunity disorders with cc
- 816 Reticuloendothelial and immunity disorders without cc/mcc
Convert D68.51 to ICD-9-CM
Code History
- 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
- 2017 (effective 10/1/2016): No change
- 2018 (effective 10/1/2017): No change
- 2019 (effective 10/1/2018): No change
- 2020 (effective 10/1/2019): No change
- 2021 (effective 10/1/2020): No change
- 2022 (effective 10/1/2021): No change
- Activated protein C resistance D68.51
- Hypercoagulable (state) D68.59
ICD-10-CM Diagnosis Code D68.59
Other primary thrombophilia
2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
Applicable To- Antithrombin III deficiency
- Hypercoagulable state NOS
- Primary hypercoagulable state NEC
- Primary thrombophilia NEC
- Protein C deficiency
- Protein S deficiency
- Thrombophilia NOS
- activated protein C resistance D68.51
- factor V Leiden mutation D68.51
- Mutation(s)
- Resistance, resistant (to)
- activated protein C D68.51
ICD-10-CM Codes Adjacent To D68.51
D68.1 Hereditary factor XI deficiency
D68.2 Hereditary deficiency of other clotting factors
D68.3 Hemorrhagic disorder due to circulating anticoagulants
D68.31 Hemorrhagic disorder due to intrinsic circulating anticoagulants, antibodies, or inhibitors
D68.312 Antiphospholipid antibody with hemorrhagic disorder
D68.318 Other hemorrhagic disorder due to intrinsic circulating anticoagulants, antibodies, or inhibitors
D68.32 Hemorrhagic disorder due to extrinsic circulating anticoagulants
D68.4 Acquired coagulation factor deficiency
D68.5 Primary thrombophilia
D68.51
Activated protein C resistance
D68.52 Prothrombin gene mutation
D68.59 Other primary thrombophilia
D68.6 Other thrombophilia
D68.61 Antiphospholipid syndrome
D68.62 Lupus anticoagulant syndrome
D68.8 Other specified coagulation defects
D68.9 Coagulation defect, unspecified
D69 Purpura and other hemorrhagic conditions
Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.
