2020 ICD-10-CM Diagnosis Code D68.52

Prothrombin gene mutation

    2016 2017 2018 2019 2020 Billable/Specific Code
  • D68.52 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2020 edition of ICD-10-CM D68.52 became effective on October 1, 2019.
  • This is the American ICD-10-CM version of D68.52 - other international versions of ICD-10 D68.52 may differ.
The following code(s) above D68.52 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to D68.52:
  • D50-D89
    2020 ICD-10-CM Range D50-D89

    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

    Type 2 Excludes
    • autoimmune disease (systemic) NOS (M35.9)
    • certain conditions originating in the perinatal period (P00-P96)
    • complications of pregnancy, childbirth and the puerperium (O00-O9A)
    • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
    • endocrine, nutritional and metabolic diseases (E00-E88)
    • human immunodeficiency virus [HIV] disease (B20)
    • injury, poisoning and certain other consequences of external causes (S00-T88)
    • neoplasms (C00-D49)
    • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
  • D68
    ICD-10-CM Diagnosis Code D68

    Other coagulation defects

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • abnormal coagulation profile (R79.1)
    • coagulation defects complicating abortion or ectopic or molar pregnancy (O00-O07, O08.1)
    • coagulation defects complicating pregnancy, childbirth and the puerperium (O45.0, O46.0, O67.0, O72.3)
    Other coagulation defects
  • D68.5
    ICD-10-CM Diagnosis Code D68.5

    Primary thrombophilia

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Applicable To
    • Primary hypercoagulable states
    Type 1 Excludes
    • antiphospholipid syndrome (D68.61)
    • lupus anticoagulant (D68.62)
    • secondary activated protein C resistance (D68.69)
    • secondary antiphospholipid antibody syndrome (D68.69)
    • secondary lupus anticoagulant with hypercoagulable state (D68.69)
    • secondary systemic lupus erythematosus [SLE] inhibitor with hypercoagulable state (D68.69)
    • systemic lupus erythematosus [SLE] inhibitor finding without diagnosis (R76.0)
    • systemic lupus erythematosus [SLE] inhibitor with hemorrhagic disorder (D68.312)
    • thrombotic thrombocytopenic purpura (M31.1)
    Primary thrombophilia
Approximate Synonyms
  • Prothrombin g20210a mutation
ICD-10-CM D68.52 is grouped within Diagnostic Related Group(s) (MS-DRG v37.0):
  • 814 Reticuloendothelial and immunity disorders with mcc
  • 815 Reticuloendothelial and immunity disorders with cc
  • 816 Reticuloendothelial and immunity disorders without cc/mcc

Convert D68.52 to ICD-9-CM

Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change

Diagnosis Index entries containing back-references to D68.52:
  • Hypercoagulable (state) D68.59
    ICD-10-CM Diagnosis Code D68.59

    Other primary thrombophilia

      2016 2017 2018 2019 2020 Billable/Specific Code
    Applicable To
    • Antithrombin III deficiency
    • Hypercoagulable state NOS
    • Primary hypercoagulable state NEC
    • Primary thrombophilia NEC
    • Protein C deficiency
    • Protein S deficiency
    • Thrombophilia NOS
    • prothrombin gene mutation D68.52
  • Mutation(s)
    • prothrombin gene D68.52
  • Prothrombin gene mutation D68.52

ICD-10-CM Codes Adjacent To D68.52
D68.2 Hereditary deficiency of other clotting factors
D68.3 Hemorrhagic disorder due to circulating anticoagulants
D68.31 Hemorrhagic disorder due to intrinsic circulating anticoagulants, antibodies, or inhibitors
D68.311 Acquired hemophilia
D68.312 Antiphospholipid antibody with hemorrhagic disorder
D68.318 Other hemorrhagic disorder due to intrinsic circulating anticoagulants, antibodies, or inhibitors
D68.32 Hemorrhagic disorder due to extrinsic circulating anticoagulants
D68.4 Acquired coagulation factor deficiency
D68.5 Primary thrombophilia
D68.51 Activated protein C resistance
D68.52 Prothrombin gene mutation
D68.59 Other primary thrombophilia
D68.6 Other thrombophilia
D68.61 Antiphospholipid syndrome
D68.62 Lupus anticoagulant syndrome
D68.69 Other thrombophilia
D68.8 Other specified coagulation defects
D68.9 Coagulation defect, unspecified
D69 Purpura and other hemorrhagic conditions
D69.0 Allergic purpura
D69.1 Qualitative platelet defects

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.