2020 ICD-10-CM Diagnosis Code D68.61

Antiphospholipid syndrome

    2016 2017 2018 2019 2020 Billable/Specific Code
  • D68.61 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2020 edition of ICD-10-CM D68.61 became effective on October 1, 2019.
  • This is the American ICD-10-CM version of D68.61 - other international versions of ICD-10 D68.61 may differ.
Applicable To
  • Anticardiolipin syndrome
  • Antiphospholipid antibody syndrome
Type 1 Excludes
Type 1 Excludes Help
A type 1 excludes note is a pure excludes. It means "not coded here". A type 1 excludes note indicates that the code excluded should never be used at the same time as D68.61. A type 1 excludes note is for used for when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • anti-phospholipid antibody, finding without diagnosis (
    ICD-10-CM Diagnosis Code R76.0

    Raised antibody titer

      2016 2017 2018 2019 2020 Billable/Specific Code
    Type 1 Excludes
    • isoimmunization in pregnancy (O36.0-O36.1)
    • isoimmunization affecting newborn (P55.-)
    R76.0
    )
  • anti-phospholipid antibody with hemorrhagic disorder (
    ICD-10-CM Diagnosis Code D68.312

    Antiphospholipid antibody with hemorrhagic disorder

      2016 2017 2018 2019 2020 Billable/Specific Code
    Applicable To
    • Lupus anticoagulant (LAC) with hemorrhagic disorder
    • Systemic lupus erythematosus [SLE] inhibitor with hemorrhagic disorder
    Type 1 Excludes
    • antiphospholipid antibody, finding without diagnosis (R76.0)
    • antiphospholipid antibody syndrome (D68.61)
    • antiphospholipid antibody with hypercoagulable state (D68.61)
    • lupus anticoagulant (LAC) finding without diagnosis (R76.0)
    • lupus anticoagulant (LAC) with hypercoagulable state (D68.62)
    • systemic lupus erythematosus [SLE] inhibitor finding without diagnosis (R76.0)
    • systemic lupus erythematosus [SLE] inhibitor with hypercoagulable state (D68.62)
    D68.312
    )
  • lupus anticoagulant syndrome (
    ICD-10-CM Diagnosis Code D68.62

    Lupus anticoagulant syndrome

      2016 2017 2018 2019 2020 Billable/Specific Code
    Applicable To
    • Lupus anticoagulant
    • Presence of systemic lupus erythematosus [SLE] inhibitor
    Type 1 Excludes
    • anticardiolipin syndrome (D68.61)
    • antiphospholipid syndrome (D68.61)
    • lupus anticoagulant (LAC) finding without diagnosis (R76.0)
    • lupus anticoagulant (LAC) with hemorrhagic disorder (D68.312)
    D68.62
    )
The following code(s) above D68.61 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to D68.61:
  • D50-D89
    2020 ICD-10-CM Range D50-D89

    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

    Type 2 Excludes
    • autoimmune disease (systemic) NOS (M35.9)
    • certain conditions originating in the perinatal period (P00-P96)
    • complications of pregnancy, childbirth and the puerperium (O00-O9A)
    • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
    • endocrine, nutritional and metabolic diseases (E00-E88)
    • human immunodeficiency virus [HIV] disease (B20)
    • injury, poisoning and certain other consequences of external causes (S00-T88)
    • neoplasms (C00-D49)
    • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
  • D68
    ICD-10-CM Diagnosis Code D68

    Other coagulation defects

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • abnormal coagulation profile (R79.1)
    • coagulation defects complicating abortion or ectopic or molar pregnancy (O00-O07, O08.1)
    • coagulation defects complicating pregnancy, childbirth and the puerperium (O45.0, O46.0, O67.0, O72.3)
    Other coagulation defects
  • D68.6
    ICD-10-CM Diagnosis Code D68.6

    Other thrombophilia

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Applicable To
    • Other hypercoagulable states
    Type 1 Excludes
    • diffuse or disseminated intravascular coagulation [DIC] (D65)
    • heparin induced thrombocytopenia (HIT) (D75.82)
    • hyperhomocysteinemia (E72.11)
    Other thrombophilia
Approximate Synonyms
  • Anticardiolipin syndrome
  • Antiphospholipid syndrome complication in pregnancy
  • Antiphospholipid syndrome in childbirth
  • Antiphospholipid syndrome in pregnancy
  • Antiphospholipid syndrome postpartum
  • Postpartum (after childbirth) antiphospholipid syndrome
  • Primary antiphospholipid syndrome
  • Secondary antiphospholipid syndrome
Clinical Information
  • A syndrome associated with a variety of diseases, notably systemic lupus erythematosus and other connective tissue diseases, thrombopenia, and arterial or venous thromboses, marked by the presence of antibodies directed against phospholipids.
  • Associated with a variety of diseases, notably systemic lupus erythematosus and other connective tissue diseases, thrombopenia, and arterial or venous thromboses; involves the presence of antibodies directed against phospholipids; cardiolipins show markedly elevated levels of anticardiolipin antibodies; present also are high levels of lupus anticoagulant; in pregnancy it can cause abortion.
  • The presence of antibodies directed against phospholipids (antibodies, antiphospholipid). The condition is associated with a variety of diseases, notably systemic lupus erythematosus and other connective tissue diseases, thrombopenia, and arterial or venous thromboses. In pregnancy it can cause abortion. Of the phospholipids, the cardiolipins show markedly elevated levels of anticardiolipin antibodies (antibodies, anticardiolipin). Present also are high levels of lupus anticoagulant (lupus coagulation inhibitor).
ICD-10-CM D68.61 is grouped within Diagnostic Related Group(s) (MS-DRG v37.0):
  • 814 Reticuloendothelial and immunity disorders with mcc
  • 815 Reticuloendothelial and immunity disorders with cc
  • 816 Reticuloendothelial and immunity disorders without cc/mcc

Convert D68.61 to ICD-9-CM

Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
Code annotations containing back-references to D68.61:
  • Type 1 Excludes: D68.62
    , D68.62
    , D68.312
    , D68.312
    , D68.5
    ICD-10-CM Diagnosis Code D68.62

    Lupus anticoagulant syndrome

      2016 2017 2018 2019 2020 Billable/Specific Code
    Applicable To
    • Lupus anticoagulant
    • Presence of systemic lupus erythematosus [SLE] inhibitor
    Type 1 Excludes
    • anticardiolipin syndrome (D68.61)
    • antiphospholipid syndrome (D68.61)
    • lupus anticoagulant (LAC) finding without diagnosis (R76.0)
    • lupus anticoagulant (LAC) with hemorrhagic disorder (D68.312)
    ICD-10-CM Diagnosis Code D68.62

    Lupus anticoagulant syndrome

      2016 2017 2018 2019 2020 Billable/Specific Code
    Applicable To
    • Lupus anticoagulant
    • Presence of systemic lupus erythematosus [SLE] inhibitor
    Type 1 Excludes
    • anticardiolipin syndrome (D68.61)
    • antiphospholipid syndrome (D68.61)
    • lupus anticoagulant (LAC) finding without diagnosis (R76.0)
    • lupus anticoagulant (LAC) with hemorrhagic disorder (D68.312)
    ICD-10-CM Diagnosis Code D68.312

    Antiphospholipid antibody with hemorrhagic disorder

      2016 2017 2018 2019 2020 Billable/Specific Code
    Applicable To
    • Lupus anticoagulant (LAC) with hemorrhagic disorder
    • Systemic lupus erythematosus [SLE] inhibitor with hemorrhagic disorder
    Type 1 Excludes
    • antiphospholipid antibody, finding without diagnosis (R76.0)
    • antiphospholipid antibody syndrome (D68.61)
    • antiphospholipid antibody with hypercoagulable state (D68.61)
    • lupus anticoagulant (LAC) finding without diagnosis (R76.0)
    • lupus anticoagulant (LAC) with hypercoagulable state (D68.62)
    • systemic lupus erythematosus [SLE] inhibitor finding without diagnosis (R76.0)
    • systemic lupus erythematosus [SLE] inhibitor with hypercoagulable state (D68.62)
    ICD-10-CM Diagnosis Code D68.312

    Antiphospholipid antibody with hemorrhagic disorder

      2016 2017 2018 2019 2020 Billable/Specific Code
    Applicable To
    • Lupus anticoagulant (LAC) with hemorrhagic disorder
    • Systemic lupus erythematosus [SLE] inhibitor with hemorrhagic disorder
    Type 1 Excludes
    • antiphospholipid antibody, finding without diagnosis (R76.0)
    • antiphospholipid antibody syndrome (D68.61)
    • antiphospholipid antibody with hypercoagulable state (D68.61)
    • lupus anticoagulant (LAC) finding without diagnosis (R76.0)
    • lupus anticoagulant (LAC) with hypercoagulable state (D68.62)
    • systemic lupus erythematosus [SLE] inhibitor finding without diagnosis (R76.0)
    • systemic lupus erythematosus [SLE] inhibitor with hypercoagulable state (D68.62)
    ICD-10-CM Diagnosis Code D68.5

    Primary thrombophilia

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Applicable To
    • Primary hypercoagulable states
    Type 1 Excludes
    • antiphospholipid syndrome (D68.61)
    • lupus anticoagulant (D68.62)
    • secondary activated protein C resistance (D68.69)
    • secondary antiphospholipid antibody syndrome (D68.69)
    • secondary lupus anticoagulant with hypercoagulable state (D68.69)
    • secondary systemic lupus erythematosus [SLE] inhibitor with hypercoagulable state (D68.69)
    • systemic lupus erythematosus [SLE] inhibitor finding without diagnosis (R76.0)
    • systemic lupus erythematosus [SLE] inhibitor with hemorrhagic disorder (D68.312)
    • thrombotic thrombocytopenic purpura (M31.1)

Diagnosis Index entries containing back-references to D68.61:
  • Antibody
    • anticardiolipin R76.0
      ICD-10-CM Diagnosis Code R76.0

      Raised antibody titer

        2016 2017 2018 2019 2020 Billable/Specific Code
      Type 1 Excludes
      • isoimmunization in pregnancy (O36.0-O36.1)
      • isoimmunization affecting newborn (P55.-)
      • with
        • hypercoagulable state D68.61
    • antiphosphatidylglycerol R76.0
      ICD-10-CM Diagnosis Code R76.0

      Raised antibody titer

        2016 2017 2018 2019 2020 Billable/Specific Code
      Type 1 Excludes
      • isoimmunization in pregnancy (O36.0-O36.1)
      • isoimmunization affecting newborn (P55.-)
      • with
        • hypercoagulable state D68.61
    • antiphosphatidylinositol R76.0
      ICD-10-CM Diagnosis Code R76.0

      Raised antibody titer

        2016 2017 2018 2019 2020 Billable/Specific Code
      Type 1 Excludes
      • isoimmunization in pregnancy (O36.0-O36.1)
      • isoimmunization affecting newborn (P55.-)
      • with
        • hypercoagulable state D68.61
    • antiphosphatidylserine R76.0
      ICD-10-CM Diagnosis Code R76.0

      Raised antibody titer

        2016 2017 2018 2019 2020 Billable/Specific Code
      Type 1 Excludes
      • isoimmunization in pregnancy (O36.0-O36.1)
      • isoimmunization affecting newborn (P55.-)
      • with
        • hypercoagulable state D68.61
    • antiphospholipid R76.0
      ICD-10-CM Diagnosis Code R76.0

      Raised antibody titer

        2016 2017 2018 2019 2020 Billable/Specific Code
      Type 1 Excludes
      • isoimmunization in pregnancy (O36.0-O36.1)
      • isoimmunization affecting newborn (P55.-)
      • with
        • hypercoagulable state D68.61
  • Anticardiolipin syndrome D68.61
  • Antiphospholipid
  • Syndrome - see also Disease
    • anticardiolipin D68.61 (-antibody)
    • antiphospholipid D68.61 (-antibody)

ICD-10-CM Codes Adjacent To D68.61
D68.311 Acquired hemophilia
D68.312 Antiphospholipid antibody with hemorrhagic disorder
D68.318 Other hemorrhagic disorder due to intrinsic circulating anticoagulants, antibodies, or inhibitors
D68.32 Hemorrhagic disorder due to extrinsic circulating anticoagulants
D68.4 Acquired coagulation factor deficiency
D68.5 Primary thrombophilia
D68.51 Activated protein C resistance
D68.52 Prothrombin gene mutation
D68.59 Other primary thrombophilia
D68.6 Other thrombophilia
D68.61 Antiphospholipid syndrome
D68.62 Lupus anticoagulant syndrome
D68.69 Other thrombophilia
D68.8 Other specified coagulation defects
D68.9 Coagulation defect, unspecified
D69 Purpura and other hemorrhagic conditions
D69.0 Allergic purpura
D69.1 Qualitative platelet defects
D69.2 Other nonthrombocytopenic purpura
D69.3 Immune thrombocytopenic purpura
D69.4 Other primary thrombocytopenia

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.