ICD-10-CM Codes
D50-D89 Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
D70-D77 Other disorders of blood and blood-forming organs
D70- Neutropenia
2022 ICD-10-CM Diagnosis Code D70.1

2022 ICD-10-CM Diagnosis Code D70.1

Agranulocytosis secondary to cancer chemotherapy

2016

2017

2018

2019

2020

2021

2022

Billable/Specific Code

D70.1 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
The 2022 edition of ICD-10-CM D70.1 became effective on October 1, 2021.
This is the American ICD-10-CM version of D70.1 - other international versions of ICD-10 D70.1 may differ.

Use Additional

Use Additional Help

Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. For such conditions the ICD-10-CM has a coding convention that requires the underlying condition be sequenced first followed by the manifestation. Wherever such a combination exists there is a "use additional code" note at the etiology code, and a "code first" note at the manifestation code. These instructional notes indicate the proper sequencing order of the codes, etiology followed by manifestation. In most cases the manifestation codes will have in the code title, "in diseases classified elsewhere." Codes with this title are a component of the etiology/manifestation convention. The code title indicates that it is a manifestation code. "In diseases classified elsewhere" codes are never permitted to be used as first listed or principle diagnosis codes. They must be used in conjunction with an underlying condition code and they must be listed following the underlying condition.

code for adverse effect, if applicable, to identify drug (
ICD-10-CM Diagnosis Code T45.1X5
Adverse effect of antineoplastic and immunosuppressive drugs
T45.1X5
)

Code Also

Code Also Help

A code also note instructs that 2 codes may be required to fully describe a condition but the sequencing of the two codes is discretionary, depending on the severity of the conditions and the reason for the encounter.

underlying neoplasm

The following code(s) above D70.1 contain annotation back-references

Annotation Back-References

In this context, annotation back-references refer to codes that contain:

Applicable To annotations, or
Code Also annotations, or
Code First annotations, or
Excludes1 annotations, or
Excludes2 annotations, or
Includes annotations, or
Note annotations, or
Use Additional annotations

that may be applicable to D70.1:

D50-D89
2022 ICD-10-CM Range D50-D89
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
Type 2 Excludes
- autoimmune disease (systemic) NOS (M35.9)
- certain conditions originating in the perinatal period (P00-P96)
- complications of pregnancy, childbirth and the puerperium (O00-O9A)
- congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
- endocrine, nutritional and metabolic diseases (E00-E88)
- human immunodeficiency virus [HIV] disease (B20)
- injury, poisoning and certain other consequences of external causes (S00-T88)
- neoplasms (C00-D49)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
D70
ICD-10-CM Diagnosis Code D70
Neutropenia
Includes
- agranulocytosis
- decreased absolute neurophile count (ANC)
Type 1 Excludes
- neutropenic splenomegaly (D73.81)
- transient neonatal neutropenia (P61.5)
Use Additional
- code for any associated:
- fever (R50.81)
- mucositis (J34.81, K12.3-, K92.81, N76.81)
Neutropenia

Approximate Synonyms

Agranulocytosis due to cancer chemotherapy
Chemotherapy-induced neutropenia
Neutropenia due to chemotherapy

ICD-10-CM D70.1 is grouped within Diagnostic Related Group(s) (MS-DRG v39.0):

808 Major hematological and immunological diagnoses except sickle cell crisis and coagulation disorders with mcc
809 Major hematological and immunological diagnoses except sickle cell crisis and coagulation disorders with cc
810 Major hematological and immunological diagnoses except sickle cell crisis and coagulation disorders without cc/mcc

Convert D70.1 to ICD-9-CM

Code History

2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
2017 (effective 10/1/2016): No change
2018 (effective 10/1/2017): No change
2019 (effective 10/1/2018): No change
2020 (effective 10/1/2019): No change
2021 (effective 10/1/2020): No change
2022 (effective 10/1/2021): No change

Diagnosis Index entries containing back-references to D70.1:

Agranulocytosis (chronic) (cyclical) (genetic) (infantile) (periodic) (pernicious) D70.9
- see also Neutropenia
ICD-10-CM Diagnosis Code D70.9
Neutropenia, unspecified
- drug-induced D70.2
  ICD-10-CM Diagnosis Code D70.2
  Other drug-induced agranulocytosis
  2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
  Use Additional
  code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)
  - due to cytoreductive cancer chemotherapy D70.1
- secondary D70.4
  ICD-10-CM Diagnosis Code D70.4
  Cyclic neutropenia
  2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
  Applicable To
  Cyclic hematopoiesis
  Periodic neutropenia
  - drug-induced D70.2
    ICD-10-CM Diagnosis Code D70.2
    Other drug-induced agranulocytosis
    2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
    Use Additional
    code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)
    - due to cytoreductive cancer chemotherapy D70.1
- cytoreductive cancer chemotherapy sequela D70.1
Leukopenia D72.819
ICD-10-CM Diagnosis Code D72.819
Decreased white blood cell count, unspecified
Applicable To
Decreased leukocytes, unspecified
Leukocytopenia, unspecified
Leukopenia
Type 1 Excludes
malignant leukopenia (D70.9)
- drug induced NEC D70.2
  ICD-10-CM Diagnosis Code D70.2
  Other drug-induced agranulocytosis
  2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
  Use Additional
  code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)
  - due to cytoreductive cancer chemotherapy D70.1
- chemotherapy D70.1 (cancer)
Neutropenia, neutropenic (chronic) (genetic) (idiopathic) (immune) (infantile) (malignant) (pernicious) (splenic) D70.9
ICD-10-CM Diagnosis Code D70.9
Neutropenia, unspecified
- drug-induced D70.2
  ICD-10-CM Diagnosis Code D70.2
  Other drug-induced agranulocytosis
  2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
  Use Additional
  code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)
  - due to cytoreductive cancer chemotherapy D70.1
- secondary (cyclic) (periodic) (splenic) D70.4
  ICD-10-CM Diagnosis Code D70.4
  Cyclic neutropenia
  2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
  Applicable To
  Cyclic hematopoiesis
  Periodic neutropenia
  - drug-induced D70.2
    ICD-10-CM Diagnosis Code D70.2
    Other drug-induced agranulocytosis
    2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
    Use Additional
    code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)
    - due to cytoreductive cancer chemotherapy D70.1
- cytoreductive cancer chemotherapy sequela D70.1

ICD-10-CM Codes Adjacent To D70.1

D69.42 Congenital and hereditary thrombocytopenia purpura

D69.49 Other primary thrombocytopenia

D69.5 Secondary thrombocytopenia

D69.51 Posttransfusion purpura

D69.59 Other secondary thrombocytopenia

D69.6 Thrombocytopenia, unspecified

D69.8 Other specified hemorrhagic conditions

D69.9 Hemorrhagic condition, unspecified

D70 Neutropenia

D70.0 Congenital agranulocytosis

D70.1 Agranulocytosis secondary to cancer chemotherapy

D70.2 Other drug-induced agranulocytosis

D70.3 Neutropenia due to infection

D70.4 Cyclic neutropenia

D70.8 Other neutropenia

D70.9 Neutropenia, unspecified

D71 Functional disorders of polymorphonuclear neutrophils

D72 Other disorders of white blood cells

D72.0 Genetic anomalies of leukocytes

D72.1 Eosinophilia

D72.10 …… unspecified

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.

2022 ICD-10-CM Diagnosis Code D70.1

Agranulocytosis secondary to cancer chemotherapy

Adverse effect of antineoplastic and immunosuppressive drugs

Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

Neutropenia

Neutropenia, unspecified

Other drug-induced agranulocytosis

Cyclic neutropenia

Other drug-induced agranulocytosis

Decreased white blood cell count, unspecified

Other drug-induced agranulocytosis

Neutropenia, unspecified

Other drug-induced agranulocytosis

Cyclic neutropenia

Other drug-induced agranulocytosis