2019 ICD-10-CM Diagnosis Code D72.0

Genetic anomalies of leukocytes

    2016 2017 2018 2019 Billable/Specific Code
  • D72.0 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2019 edition of ICD-10-CM D72.0 became effective on October 1, 2018.
  • This is the American ICD-10-CM version of D72.0 - other international versions of ICD-10 D72.0 may differ.
Applicable To
  • Alder (granulation) (granulocyte) anomaly
  • Alder syndrome
  • Hereditary leukocytic hypersegmentation
  • Hereditary leukocytic hyposegmentation
  • Hereditary leukomelanopathy
  • May-Hegglin (granulation) (granulocyte) anomaly
  • May-Hegglin syndrome
  • Pelger-Huët (granulation) (granulocyte) anomaly
  • Pelger-Huët syndrome
Type 1 Excludes
Type 1 Excludes Help
A type 1 excludes note is a pure excludes. It means "not coded here". A type 1 excludes note indicates that the code excluded should never be used at the same time as D72.0. A type 1 excludes note is for used for when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • Chédiak (-Steinbrinck)-Higashi syndrome (
    ICD-10-CM Diagnosis Code E70.330

    Chediak-Higashi syndrome

      2016 2017 2018 2019 Billable/Specific Code
    E70.330
    )
The following code(s) above D72.0 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to D72.0:
  • D50-D89
    2019 ICD-10-CM Range D50-D89

    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

    Type 2 Excludes
    • autoimmune disease (systemic) NOS (M35.9)
    • certain conditions originating in the perinatal period (P00-P96)
    • complications of pregnancy, childbirth and the puerperium (O00-O9A)
    • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
    • endocrine, nutritional and metabolic diseases (E00-E88)
    • human immunodeficiency virus [HIV] disease (B20)
    • injury, poisoning and certain other consequences of external causes (S00-T88)
    • neoplasms (C00-D49)
    • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
  • D72
    ICD-10-CM Diagnosis Code D72

    Other disorders of white blood cells

      2016 2017 2018 2019 Non-Billable/Non-Specific Code
    Type 1 Excludes
    Other disorders of white blood cells
Approximate Synonyms
  • Alder syndrome
  • Alders syndrome
  • Chediak higashi syndrome
  • Chédiak-higashi syndrome
  • Genetic anomaly of leukocyte
  • Hereditary giant neutrophilia
  • Hereditary hypersegmentation
  • Hypersegmentation
  • Hypersegmentation, hereditary
  • Leukocyte adhesion deficiency - type 1
  • Leukocyte adhesion deficiency - type 2
  • Leukocyte adhesion deficiency type 1
  • Leukocyte adhesion deficiency type 2
  • Leukocyte disorder, genetic
  • May hegglin anomaly
  • Pelger-huet anomaly
  • Pelger-huët anomaly
  • Pelger-huît anomaly
Clinical Information
  • A form of phagocyte bactericidal dysfunction characterized by unusual oculocutaneous albinism, high incidence of lymphoreticular neoplasms, and recurrent pyogenic infections. In many cell types, abnormal lysosomes are present leading to defective pigment distribution and abnormal neutrophil functions. The disease is transmitted by autosomal recessive inheritance and a similar disorder occurs in the beige mouse, the aleutian mink, and albino hereford cattle.
  • A rare autosomal recessive immunodeficiency disorder characterized by abnormal intracellular protein transport. Chediak-higashi syndrome (chs) is characterized by immune deficiency; partial oculocutaneous albinism; a bleeding disorder due to deficient platelet dense bodies; neutropenia; neutrophils with impaired chemotaxis and bactericidal activity; recurrent infection; and abnormal natural killer (nk) cell function. Chs may be associated with hepatosplenomegaly, lymphadenopathy, anemia, thrombocytopenia, roentgenologic changes in bones, lungs and heart, and skin and psychomotor abnormalities; it is often fatal in childhood as a result of infection or an accelerated lymphoma-like phase. Chs occurs in mink, cattle, and mice, as well as man.
  • Form of phagocyte bactericidal dysfunction characterized by unusual oculocutaneous albinism, high incidence of lymphoreticular neoplasms, and recurrent pyogenic infections; in many cell types, abnormal lysosomes are present leading to defective pigment distribution and abnormal neutrophil functions; transmitted by autosomal recessive inheritance and a similar disorder occurs in the beige mouse, the aleutian mink, and albino hereford cattle.
ICD-10-CM D72.0 is grouped within Diagnostic Related Group(s) (MS-DRG v36.0):
  • 808 Major hematological and immunological diagnoses except sickle cell crisis and coagulation disorders with mcc
  • 809 Major hematological and immunological diagnoses except sickle cell crisis and coagulation disorders with cc
  • 810 Major hematological and immunological diagnoses except sickle cell crisis and coagulation disorders without cc/mcc

Convert D72.0 to ICD-9-CM

Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change

Diagnosis Index entries containing back-references to D72.0:
  • Alder D72.0 (-Reilly) anomaly or syndrome (leukocyte granulation)
  • Anomaly, anomalous (congenital) (unspecified type) Q89.9
    ICD-10-CM Diagnosis Code Q89.9

    Congenital malformation, unspecified

      2016 2017 2018 2019 Billable/Specific Code POA Exempt
    Applicable To
    • Congenital anomaly NOS
    • Congenital deformity NOS
    • leukocytes, genetic D72.0
      • granulation D72.0 (constitutional)
    • Alder D72.0 (-Reilly) (leukocyte granulation)
    • granulation or granulocyte, genetic D72.0 (constitutional) (leukocyte)
    • Hegglin's D72.0
    • hypersegmentation of neutrophils, hereditary D72.0
    • Jordan's D72.0
    • May D72.0 (-Hegglin)
    • Pelger-Huët D72.0 (hereditary hyposegmentation)
  • Dohle body panmyelopathic syndrome D72.0
  • Dysgenesis
    • reticular D72.0
  • Hegglin's anomaly or syndrome D72.0
  • Hypersegmentation, leukocytic, hereditary D72.0
  • Hyposegmentation, leukocytic, hereditary D72.0
  • Inclusion
    • azurophilic leukocytic D72.0
  • Jordan's anomaly or syndrome D72.0
  • Leukomelanopathy, hereditary D72.0
  • May D72.0 (-Hegglin)
  • Neutrophilia, hereditary giant D72.0
  • Pelger-Huët anomaly or syndrome D72.0
  • Syndrome - see also Disease
    • Alder's D72.0
    • Döhle body-panmyelopathic D72.0
    • Hegglin's D72.0
    • May D72.0 (-Hegglin)
    • Pelger-Huet D72.0

ICD-10-CM Codes Adjacent To D72.0
D70 Neutropenia
D70.0 Congenital agranulocytosis
D70.1 Agranulocytosis secondary to cancer chemotherapy
D70.2 Other drug-induced agranulocytosis
D70.3 Neutropenia due to infection
D70.4 Cyclic neutropenia
D70.8 Other neutropenia
D70.9 Neutropenia, unspecified
D71 Functional disorders of polymorphonuclear neutrophils
D72 Other disorders of white blood cells
D72.0 Genetic anomalies of leukocytes
D72.1 Eosinophilia
D72.8 Other specified disorders of white blood cells
D72.81 Decreased white blood cell count
D72.810 Lymphocytopenia
D72.818 Other decreased white blood cell count
D72.819 …… unspecified
D72.82 Elevated white blood cell count
D72.820 Lymphocytosis (symptomatic)
D72.821 Monocytosis (symptomatic)
D72.822 Plasmacytosis

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.