2022 ICD-10-CM Diagnosis Code D75.81

Myelofibrosis

    2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code Manifestation Code
  • D75.81 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2022 edition of ICD-10-CM D75.81 became effective on October 1, 2021.
  • This is the American ICD-10-CM version of D75.81 - other international versions of ICD-10 D75.81 may differ.
ICD-10-CM Coding Rules
  • D75.81 describes the manifestation of an underlying disease, not the disease itself.
Applicable To
  • Myelofibrosis NOS
  • Secondary myelofibrosis NOS
Use Additional
Use Additional Help
Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. For such conditions the ICD-10-CM has a coding convention that requires the underlying condition be sequenced first followed by the manifestation. Wherever such a combination exists there is a "use additional code" note at the etiology code, and a "code first" note at the manifestation code. These instructional notes indicate the proper sequencing order of the codes, etiology followed by manifestation. In most cases the manifestation codes will have in the code title, "in diseases classified elsewhere." Codes with this title are a component of the etiology/manifestation convention. The code title indicates that it is a manifestation code. "In diseases classified elsewhere" codes are never permitted to be used as first listed or principle diagnosis codes. They must be used in conjunction with an underlying condition code and they must be listed following the underlying condition.
  • code, if applicable, for associated therapy-related myelodysplastic syndrome (
    ICD-10-CM Diagnosis Code D46
    • D46 Myelodysplastic syndromes
      • D46.0 Refractory anemia without ring sideroblasts, ...
      • D46.1 Refractory anemia with ring sideroblasts
      • D46.2 Refractory anemia with excess of blasts [RAEB...
        • D46.20 Refractory anemia with excess of blasts, unsp...
        • D46.21 Refractory anemia with excess of blasts 1
        • D46.22 Refractory anemia with excess of blasts 2
      • D46.A Refractory cytopenia with multilineage dyspla...
      • D46.B Refractory cytopenia with multilineage dyspla...
      • D46.C Myelodysplastic syndrome with isolated del(5q...
      • D46.4 Refractory anemia, unspecified
      • D46.Z Other myelodysplastic syndromes
      • D46.9 Myelodysplastic syndrome, unspecified
    D46.-
    )
Code First
Code First Help
Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. For such conditions, ICD-10-CM has a coding convention that requires the underlying condition be sequenced first followed by the manifestation. Wherever such a combination exists there is a "use additional code" note at the etiology code, and a "code first" note at the manifestation code. These instructional notes indicate the proper sequencing order of the codes, etiology followed by manifestation. In most cases the manifestation codes will have in the code title, "in diseases classified elsewhere." Codes with this title are a component of the etiology/manifestation convention. The code title indicates that it is a manifestation code. "In diseases classified elsewhere" codes are never permitted to be used as first listed or principle diagnosis codes. They must be used in conjunction with an underlying condition code and they must be listed following the underlying condition.
  • the underlying disorder, such as:
  • malignant neoplasm of breast (
    ICD-10-CM Diagnosis Code C50
    • C50 Malignant neoplasm of breast
      • C50.0 Malignant neoplasm of nipple and areola
        • C50.01 Malignant neoplasm of nipple and areola, fema...
          • C50.011 Malignant neoplasm of nipple and areola, righ...
          • C50.012 Malignant neoplasm of nipple and areola, left...
          • C50.019 Malignant neoplasm of nipple and areola, unsp...
        • C50.02 Malignant neoplasm of nipple and areola, male...
          • C50.021 Malignant neoplasm of nipple and areola, righ...
          • C50.022 Malignant neoplasm of nipple and areola, left...
          • C50.029 Malignant neoplasm of nipple and areola, unsp...
      • C50.1 Malignant neoplasm of central portion of brea...
        • C50.11 Malignant neoplasm of central portion of brea...
          • C50.111 Malignant neoplasm of central portion of righ...
          • C50.112 Malignant neoplasm of central portion of left...
          • C50.119 Malignant neoplasm of central portion of unsp...
        • C50.12 Malignant neoplasm of central portion of brea...
          • C50.121 Malignant neoplasm of central portion of righ...
          • C50.122 Malignant neoplasm of central portion of left...
          • C50.129 Malignant neoplasm of central portion of unsp...
      • C50.2 Malignant neoplasm of upper-inner quadrant of...
        • C50.21 Malignant neoplasm of upper-inner quadrant of...
          • C50.211 Malignant neoplasm of upper-inner quadrant of...
          • C50.212 Malignant neoplasm of upper-inner quadrant of...
          • C50.219 Malignant neoplasm of upper-inner quadrant of...
        • C50.22 Malignant neoplasm of upper-inner quadrant of...
          • C50.221 Malignant neoplasm of upper-inner quadrant of...
          • C50.222 Malignant neoplasm of upper-inner quadrant of...
          • C50.229 Malignant neoplasm of upper-inner quadrant of...
      • C50.3 Malignant neoplasm of lower-inner quadrant of...
        • C50.31 Malignant neoplasm of lower-inner quadrant of...
          • C50.311 Malignant neoplasm of lower-inner quadrant of...
          • C50.312 Malignant neoplasm of lower-inner quadrant of...
          • C50.319 Malignant neoplasm of lower-inner quadrant of...
        • C50.32 Malignant neoplasm of lower-inner quadrant of...
          • C50.321 Malignant neoplasm of lower-inner quadrant of...
          • C50.322 Malignant neoplasm of lower-inner quadrant of...
          • C50.329 Malignant neoplasm of lower-inner quadrant of...
      • C50.4 Malignant neoplasm of upper-outer quadrant of...
        • C50.41 Malignant neoplasm of upper-outer quadrant of...
          • C50.411 Malignant neoplasm of upper-outer quadrant of...
          • C50.412 Malignant neoplasm of upper-outer quadrant of...
          • C50.419 Malignant neoplasm of upper-outer quadrant of...
        • C50.42 Malignant neoplasm of upper-outer quadrant of...
          • C50.421 Malignant neoplasm of upper-outer quadrant of...
          • C50.422 Malignant neoplasm of upper-outer quadrant of...
          • C50.429 Malignant neoplasm of upper-outer quadrant of...
      • C50.5 Malignant neoplasm of lower-outer quadrant of...
        • C50.51 Malignant neoplasm of lower-outer quadrant of...
          • C50.511 Malignant neoplasm of lower-outer quadrant of...
          • C50.512 Malignant neoplasm of lower-outer quadrant of...
          • C50.519 Malignant neoplasm of lower-outer quadrant of...
        • C50.52 Malignant neoplasm of lower-outer quadrant of...
          • C50.521 Malignant neoplasm of lower-outer quadrant of...
          • C50.522 Malignant neoplasm of lower-outer quadrant of...
          • C50.529 Malignant neoplasm of lower-outer quadrant of...
      • C50.6 Malignant neoplasm of axillary tail of breast...
        • C50.61 Malignant neoplasm of axillary tail of breast...
          • C50.611 Malignant neoplasm of axillary tail of right ...
          • C50.612 Malignant neoplasm of axillary tail of left f...
          • C50.619 Malignant neoplasm of axillary tail of unspec...
        • C50.62 Malignant neoplasm of axillary tail of breast...
          • C50.621 Malignant neoplasm of axillary tail of right ...
          • C50.622 Malignant neoplasm of axillary tail of left m...
          • C50.629 Malignant neoplasm of axillary tail of unspec...
      • C50.8 Malignant neoplasm of overlapping sites of br...
        • C50.81 Malignant neoplasm of overlapping sites of br...
          • C50.811 Malignant neoplasm of overlapping sites of ri...
          • C50.812 Malignant neoplasm of overlapping sites of le...
          • C50.819 Malignant neoplasm of overlapping sites of un...
        • C50.82 Malignant neoplasm of overlapping sites of br...
          • C50.821 Malignant neoplasm of overlapping sites of ri...
          • C50.822 Malignant neoplasm of overlapping sites of le...
          • C50.829 Malignant neoplasm of overlapping sites of un...
      • C50.9 Malignant neoplasm of breast of unspecified s...
        • C50.91 Malignant neoplasm of breast of unspecified s...
          • C50.911 Malignant neoplasm of unspecified site of rig...
          • C50.912 Malignant neoplasm of unspecified site of lef...
          • C50.919 Malignant neoplasm of unspecified site of uns...
        • C50.92 Malignant neoplasm of breast of unspecified s...
          • C50.921 Malignant neoplasm of unspecified site of rig...
          • C50.922 Malignant neoplasm of unspecified site of lef...
          • C50.929 Malignant neoplasm of unspecified site of uns...
    C50.-
    )
Type 1 Excludes
Type 1 Excludes Help
A type 1 excludes note is a pure excludes. It means "not coded here". A type 1 excludes note indicates that the code excluded should never be used at the same time as D75.81. A type 1 excludes note is for used for when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • acute myelofibrosis (
    ICD-10-CM Diagnosis Code C94.4

    Acute panmyelosis with myelofibrosis

      2016 2017 2018 2019 2020 2021 2022 Non-Billable/Non-Specific Code
    Applicable To
    • Acute myelofibrosis
    Type 1 Excludes
    • myelofibrosis NOS (D75.81)
    • secondary myelofibrosis NOS (D75.81)
    C94.4-
    )
  • idiopathic myelofibrosis (
    ICD-10-CM Diagnosis Code D47.1

    Chronic myeloproliferative disease

      2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
    Applicable To
    • Chronic neutrophilic leukemia
    • Myeloproliferative disease, unspecified
    Type 1 Excludes
    • atypical chronic myeloid leukemia BCR/ABL-negative (C92.2-)
    • chronic myeloid leukemia BCR/ABL-positive (C92.1-)
    • myelofibrosis NOS (D75.81)
    • myelophthisic anemia (D61.82)
    • myelophthisis (D61.82)
    • secondary myelofibrosis NOS (D75.81)
    D47.1
    )
  • leukoerythroblastic anemia (
    ICD-10-CM Diagnosis Code D61.82

    Myelophthisis

      2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
    Applicable To
    • Leukoerythroblastic anemia
    • Myelophthisic anemia
    • Panmyelophthisis
    Code Also
    • the underlying disorder, such as:
    • malignant neoplasm of breast (C50.-)
    • tuberculosis (A15.-)
    Type 1 Excludes
    • idiopathic myelofibrosis (D47.1)
    • myelofibrosis NOS (D75.81)
    • myelofibrosis with myeloid metaplasia (D47.4)
    • primary myelofibrosis (D47.1)
    • secondary myelofibrosis (D75.81)
    D61.82
    )
  • myelofibrosis with myeloid metaplasia (
    ICD-10-CM Diagnosis Code D47.4

    Osteomyelofibrosis

      2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
    Applicable To
    • Chronic idiopathic myelofibrosis
    • Myelofibrosis (idiopathic) (with myeloid metaplasia)
    • Myelosclerosis (megakaryocytic) with myeloid metaplasia
    • Secondary myelofibrosis in myeloproliferative disease
    Type 1 Excludes
    D47.4
    )
  • myelophthisic anemia (
    ICD-10-CM Diagnosis Code D61.82

    Myelophthisis

      2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
    Applicable To
    • Leukoerythroblastic anemia
    • Myelophthisic anemia
    • Panmyelophthisis
    Code Also
    • the underlying disorder, such as:
    • malignant neoplasm of breast (C50.-)
    • tuberculosis (A15.-)
    Type 1 Excludes
    • idiopathic myelofibrosis (D47.1)
    • myelofibrosis NOS (D75.81)
    • myelofibrosis with myeloid metaplasia (D47.4)
    • primary myelofibrosis (D47.1)
    • secondary myelofibrosis (D75.81)
    D61.82
    )
  • myelophthisis (
    ICD-10-CM Diagnosis Code D61.82

    Myelophthisis

      2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
    Applicable To
    • Leukoerythroblastic anemia
    • Myelophthisic anemia
    • Panmyelophthisis
    Code Also
    • the underlying disorder, such as:
    • malignant neoplasm of breast (C50.-)
    • tuberculosis (A15.-)
    Type 1 Excludes
    • idiopathic myelofibrosis (D47.1)
    • myelofibrosis NOS (D75.81)
    • myelofibrosis with myeloid metaplasia (D47.4)
    • primary myelofibrosis (D47.1)
    • secondary myelofibrosis (D75.81)
    D61.82
    )
  • primary myelofibrosis (
    ICD-10-CM Diagnosis Code D47.1

    Chronic myeloproliferative disease

      2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
    Applicable To
    • Chronic neutrophilic leukemia
    • Myeloproliferative disease, unspecified
    Type 1 Excludes
    • atypical chronic myeloid leukemia BCR/ABL-negative (C92.2-)
    • chronic myeloid leukemia BCR/ABL-positive (C92.1-)
    • myelofibrosis NOS (D75.81)
    • myelophthisic anemia (D61.82)
    • myelophthisis (D61.82)
    • secondary myelofibrosis NOS (D75.81)
    D47.1
    )
The following code(s) above D75.81 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to D75.81:
  • D50-D89
    2022 ICD-10-CM Range D50-D89

    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

    Type 2 Excludes
    • autoimmune disease (systemic) NOS (M35.9)
    • certain conditions originating in the perinatal period (P00-P96)
    • complications of pregnancy, childbirth and the puerperium (O00-O9A)
    • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
    • endocrine, nutritional and metabolic diseases (E00-E88)
    • human immunodeficiency virus [HIV] disease (B20)
    • injury, poisoning and certain other consequences of external causes (S00-T88)
    • neoplasms (C00-D49)
    • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
  • D75
    ICD-10-CM Diagnosis Code D75

    Other and unspecified diseases of blood and blood-forming organs

      2016 2017 2018 2019 2020 2021 2022 Non-Billable/Non-Specific Code
    Type 2 Excludes
    • acute lymphadenitis (L04.-)
    • chronic lymphadenitis (I88.1)
    • enlarged lymph nodes (R59.-)
    • hypergammaglobulinemia NOS (D89.2)
    • lymphadenitis NOS (I88.9)
    • mesenteric lymphadenitis (acute) (chronic) (I88.0)
    Other and unspecified diseases of blood and blood-forming organs
Approximate Synonyms
  • Secondary myelofibrosis
Clinical Information
  • A chronic myeloproliferative neoplasm characterized by bone marrow fibrosis, proliferation of atypical megakaryocytes and granulocytes in the bone marrow, anemia, splenomegaly, and extramedullary hematopoiesis. The cause is unknown. The median survival time is 3-5 years from diagnosis. (who, 2001)
  • A de novo myeloproliferation arising from an abnormal stem cell. It is characterized by the replacement of bone marrow by fibrous tissue, a process that is mediated by cytokines arising from the abnormal clone.
  • A disorder in which the bone marrow is replaced by fibrous tissue.
  • A partial or complete replacement of the bone marrow stroma by fibrous tissue. It can be a primary bone marrow lesion as part of the chronic myeloproliferative disorders (chronic idiopathic myelofibrosis), a manifestation of acute myeloid leukemia (acute panmyelosis with myelofibrosis), or a secondary phenomenon due to bone marrow involvement by a metastatic tumor (e.g., metastatic breast carcinoma).
  • A progressive, chronic disease in which the bone marrow is replaced by fibrous tissue and blood is made in organs such as the liver and the spleen, instead of in the bone marrow. This disease is marked by an enlarged spleen and progressive anemia.
  • Replacement of the bone marrow by fibrous tissue, occurring in association with a myeloproliferative disorder or secondary to another unrelated condition.
ICD-10-CM D75.81 is grouped within Diagnostic Related Group(s) (MS-DRG v39.0):
  • 820 Lymphoma and leukemia with major o.r. Procedures with mcc
  • 821 Lymphoma and leukemia with major o.r. Procedures with cc
  • 822 Lymphoma and leukemia with major o.r. Procedures without cc/mcc
  • 823 Lymphoma and non-acute leukemia with other procedures with mcc
  • 824 Lymphoma and non-acute leukemia with other procedures with cc
  • 825 Lymphoma and non-acute leukemia with other procedures without cc/mcc
  • 840 Lymphoma and non-acute leukemia with mcc
  • 841 Lymphoma and non-acute leukemia with cc
  • 842 Lymphoma and non-acute leukemia without cc/mcc

Convert D75.81 to ICD-9-CM

Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change
  • 2022 (effective 10/1/2021): No change
Code annotations containing back-references to D75.81:
  • Type 1 Excludes: C94.4
    , C94.4
    , M85.8
    , D47.1
    , D47.1
    , D61.82
    , D61.82
    ICD-10-CM Diagnosis Code C94.4

    Acute panmyelosis with myelofibrosis

      2016 2017 2018 2019 2020 2021 2022 Non-Billable/Non-Specific Code
    Applicable To
    • Acute myelofibrosis
    Type 1 Excludes
    • myelofibrosis NOS (D75.81)
    • secondary myelofibrosis NOS (D75.81)
    ICD-10-CM Diagnosis Code C94.4

    Acute panmyelosis with myelofibrosis

      2016 2017 2018 2019 2020 2021 2022 Non-Billable/Non-Specific Code
    Applicable To
    • Acute myelofibrosis
    Type 1 Excludes
    • myelofibrosis NOS (D75.81)
    • secondary myelofibrosis NOS (D75.81)
    ICD-10-CM Diagnosis Code M85.8

    Other specified disorders of bone density and structure

      2016 2017 2018 2019 2020 2021 2022 Non-Billable/Non-Specific Code
    Applicable To
    • Hyperostosis of bones, except skull
    • Osteosclerosis, acquired
    Type 1 Excludes
    • diffuse idiopathic skeletal hyperostosis [DISH] (M48.1)
    • osteosclerosis congenita (Q77.4)
    • osteosclerosis fragilitas (generalista) (Q78.2)
    • osteosclerosis myelofibrosis (D75.81)
    ICD-10-CM Diagnosis Code D47.1

    Chronic myeloproliferative disease

      2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
    Applicable To
    • Chronic neutrophilic leukemia
    • Myeloproliferative disease, unspecified
    Type 1 Excludes
    • atypical chronic myeloid leukemia BCR/ABL-negative (C92.2-)
    • chronic myeloid leukemia BCR/ABL-positive (C92.1-)
    • myelofibrosis NOS (D75.81)
    • myelophthisic anemia (D61.82)
    • myelophthisis (D61.82)
    • secondary myelofibrosis NOS (D75.81)
    ICD-10-CM Diagnosis Code D47.1

    Chronic myeloproliferative disease

      2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
    Applicable To
    • Chronic neutrophilic leukemia
    • Myeloproliferative disease, unspecified
    Type 1 Excludes
    • atypical chronic myeloid leukemia BCR/ABL-negative (C92.2-)
    • chronic myeloid leukemia BCR/ABL-positive (C92.1-)
    • myelofibrosis NOS (D75.81)
    • myelophthisic anemia (D61.82)
    • myelophthisis (D61.82)
    • secondary myelofibrosis NOS (D75.81)
    ICD-10-CM Diagnosis Code D61.82

    Myelophthisis

      2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
    Applicable To
    • Leukoerythroblastic anemia
    • Myelophthisic anemia
    • Panmyelophthisis
    Code Also
    • the underlying disorder, such as:
    • malignant neoplasm of breast (C50.-)
    • tuberculosis (A15.-)
    Type 1 Excludes
    • idiopathic myelofibrosis (D47.1)
    • myelofibrosis NOS (D75.81)
    • myelofibrosis with myeloid metaplasia (D47.4)
    • primary myelofibrosis (D47.1)
    • secondary myelofibrosis (D75.81)
    ICD-10-CM Diagnosis Code D61.82

    Myelophthisis

      2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
    Applicable To
    • Leukoerythroblastic anemia
    • Myelophthisic anemia
    • Panmyelophthisis
    Code Also
    • the underlying disorder, such as:
    • malignant neoplasm of breast (C50.-)
    • tuberculosis (A15.-)
    Type 1 Excludes
    • idiopathic myelofibrosis (D47.1)
    • myelofibrosis NOS (D75.81)
    • myelofibrosis with myeloid metaplasia (D47.4)
    • primary myelofibrosis (D47.1)
    • secondary myelofibrosis (D75.81)

Diagnosis Index entries containing back-references to D75.81:
  • Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) D64.9
    ICD-10-CM Diagnosis Code D64.9

    Anemia, unspecified

      2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
    • myelofibrosis D75.81
  • Myelofibrosis D75.81
  • Osteosclerosis Q78.2
    ICD-10-CM Diagnosis Code Q78.2

    Osteopetrosis

      2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code POA Exempt
    Applicable To
    • Albers-Schönberg syndrome
    • Osteosclerosis NOS
    • myelofibrosis D75.81

ICD-10-CM Codes Adjacent To D75.81
D73.89 Other diseases of spleen
D73.9 Disease of spleen, unspecified
D74 Methemoglobinemia
D74.0 Congenital methemoglobinemia
D74.8 Other methemoglobinemias
D74.9 Methemoglobinemia, unspecified
D75 Other and unspecified diseases of blood and blood-forming organs
D75.0 Familial erythrocytosis
D75.1 Secondary polycythemia
D75.8 Other specified diseases of blood and blood-forming organs
D75.81 Myelofibrosis
D75.82 Heparin induced thrombocytopenia (HIT)
D75.83 Thrombocytosis
D75.838 Other thrombocytosis
D75.839 …… unspecified
D75.89 Other specified diseases of blood and blood-forming organs
D75.9 Disease of blood and blood-forming organs, unspecified
D75.A Glucose-6-phosphate dehydrogenase (G6PD) deficiency without anemia
D76 Other specified diseases with participation of lymphoreticular and reticulohistiocytic tissue
D76.1 Hemophagocytic lymphohistiocytosis
D76.2 Hemophagocytic syndrome, infection-associated

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.