2020 ICD-10-CM Diagnosis Code D80

Immunodeficiency with predominantly antibody defects

    2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
  • D80 should not be used for reimbursement purposes as there are multiple codes below it that contain a greater level of detail.
  • The 2020 edition of ICD-10-CM D80 became effective on October 1, 2019.
  • This is the American ICD-10-CM version of D80 - other international versions of ICD-10 D80 may differ.
The following code(s) above D80 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to D80:
  • D50-D89
    2020 ICD-10-CM Range D50-D89

    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

    Type 2 Excludes
    • autoimmune disease (systemic) NOS (M35.9)
    • certain conditions originating in the perinatal period (P00-P96)
    • complications of pregnancy, childbirth and the puerperium (O00-O9A)
    • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
    • endocrine, nutritional and metabolic diseases (E00-E88)
    • human immunodeficiency virus [HIV] disease (B20)
    • injury, poisoning and certain other consequences of external causes (S00-T88)
    • neoplasms (C00-D49)
    • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
  • D80-D89
    2020 ICD-10-CM Range D80-D89

    Certain disorders involving the immune mechanism

    Includes
    • defects in the complement system
    • immunodeficiency disorders, except human immunodeficiency virus [HIV] disease
    • sarcoidosis
    Type 1 Excludes
    • autoimmune disease (systemic) NOS (M35.9)
    • functional disorders of polymorphonuclear neutrophils (D71)
    • human immunodeficiency virus [HIV] disease (B20)
    Certain disorders involving the immune mechanism
Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
Code annotations containing back-references to D80:
  • Code First: M36.8
    ICD-10-CM Diagnosis Code M36.8

    Systemic disorders of connective tissue in other diseases classified elsewhere

      2016 2017 2018 2019 2020 Billable/Specific Code Manifestation Code
    Code First
    • underlying disease, such as:
    • alkaptonuria (E70.2)
    • hypogammaglobulinemia (D80.-)
    • ochronosis (E70.2)
ICD-10-CM Codes Adjacent To D80
D78.21 …… on the spleen
D78.22 Postprocedural hemorrhage of the spleen following other procedure
D78.3 Postprocedural hematoma and seroma of the spleen following a procedure
D78.31 Postprocedural hematoma of the spleen following a procedure on the spleen
D78.32 Postprocedural hematoma of the spleen following other procedure
D78.33 Postprocedural seroma of the spleen following a procedure on the spleen
D78.34 Postprocedural seroma of the spleen following other procedure
D78.8 Other intraoperative and postprocedural complications of the spleen
D78.81 Other intraoperative complications of the spleen
D78.89 Other postprocedural complications of the spleen
D80 Immunodeficiency with predominantly antibody defects
D80.0 Hereditary hypogammaglobulinemia
D80.1 Nonfamilial hypogammaglobulinemia
D80.2 Selective deficiency of immunoglobulin A [IgA]
D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses
D80.4 Selective deficiency of immunoglobulin M [IgM]
D80.5 Immunodeficiency with increased immunoglobulin M [IgM]
D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinemia
D80.7 Transient hypogammaglobulinemia of infancy
D80.8 Other immunodeficiencies with predominantly antibody defects
D80.9 Immunodeficiency with predominantly antibody defects, unspecified

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.