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ICD-10-CM Codes
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D50-D89
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
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D80-D89
Certain disorders involving the immune mechanism
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D81-
Combined immunodeficiencies
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2022 ICD-10-CM Diagnosis Code D81.1
2022 ICD-10-CM Diagnosis Code D81.1
Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
- D81.1 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
- Short description: Severe combined immunodeficiency w low T- and B-cell numbers
- The 2022 edition of ICD-10-CM D81.1 became effective on October 1, 2021.
- This is the American ICD-10-CM version of D81.1 - other international versions of ICD-10 D81.1 may differ.
The following code(s) above
D81.1 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
- Applicable To annotations, or
- Code Also annotations, or
- Code First annotations, or
- Excludes1 annotations, or
- Excludes2 annotations, or
- Includes annotations, or
- Note annotations, or
- Use Additional annotations
that may be applicable to
D81.1:
- D50-D89
2022 ICD-10-CM Range D50-D89
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanismType 2 Excludes- autoimmune disease (systemic) NOS (M35.9)
- certain conditions originating in the perinatal period (P00-P96)
- complications of pregnancy, childbirth and the puerperium (O00-O9A)
- congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
- endocrine, nutritional and metabolic diseases (E00-E88)
- human immunodeficiency virus [HIV] disease (B20)
- injury, poisoning and certain other consequences of external causes (S00-T88)
- neoplasms (C00-D49)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
- D80-D89
2022 ICD-10-CM Range D80-D89
Certain disorders involving the immune mechanismIncludes- defects in the complement system
- immunodeficiency disorders, except human immunodeficiency virus [HIV] disease
- sarcoidosis
Type 1 Excludes- autoimmune disease (systemic) NOS (M35.9)
- functional disorders of polymorphonuclear neutrophils (D71)
- human immunodeficiency virus [HIV] disease (B20)
- D81
ICD-10-CM Diagnosis Code D81
Combined immunodeficiencies
2016 2017 2018 2019 2020 2021 2022 Non-Billable/Non-Specific Code
Type 1 Excludes- autosomal recessive agammaglobulinemia (Swiss type) (D80.0)
- Immunodeficiency, severe comb low t- and b-cells
- Severe combined immunodeficiency with low t- and b-cell numbers
ICD-10-CM D81.1 is grouped within Diagnostic Related Group(s) (MS-DRG v39.0):
- 808 Major hematological and immunological diagnoses except sickle cell crisis and coagulation disorders with mcc
- 809 Major hematological and immunological diagnoses except sickle cell crisis and coagulation disorders with cc
- 810 Major hematological and immunological diagnoses except sickle cell crisis and coagulation disorders without cc/mcc
Convert D81.1 to ICD-9-CM
Code History
- 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
- 2017 (effective 10/1/2016): No change
- 2018 (effective 10/1/2017): No change
- 2019 (effective 10/1/2018): No change
- 2020 (effective 10/1/2019): No change
- 2021 (effective 10/1/2020): No change
- 2022 (effective 10/1/2021): No change
- Immunodeficiency D84.9
ICD-10-CM Diagnosis Code D84.9
Immunodeficiency, unspecified
2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
Applicable To- Immunocompromised NOS
- Immunodeficient NOS
- Immunosuppressed NOS
- combined D81.9
ICD-10-CM Diagnosis Code D81.9
Combined immunodeficiency, unspecified
2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
Applicable To- Severe combined immunodeficiency disorder [SCID] NOS
- severe (SCID) D81.9
ICD-10-CM Diagnosis Code D81.9
Combined immunodeficiency, unspecified
2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
Applicable To- Severe combined immunodeficiency disorder [SCID] NOS
- with
- low T- and B-cell numbers D81.1
ICD-10-CM Codes Adjacent To D81.1
D80.2 Selective deficiency of immunoglobulin A [IgA]
D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses
D80.4 Selective deficiency of immunoglobulin M [IgM]
D80.5 Immunodeficiency with increased immunoglobulin M [IgM]
D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinemia
D80.7 Transient hypogammaglobulinemia of infancy
D80.8 Other immunodeficiencies with predominantly antibody defects
D80.9 Immunodeficiency with predominantly antibody defects, unspecified
D81 Combined immunodeficiencies
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis
D81.1
Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers
D81.3 Adenosine deaminase [ADA] deficiency
D81.30 Adenosine deaminase deficiency, unspecified
D81.31 Severe combined immunodeficiency due to adenosine deaminase deficiency
D81.32 Adenosine deaminase 2 deficiency
D81.39 Other adenosine deaminase deficiency
D81.5 Purine nucleoside phosphorylase [PNP] deficiency
D81.6 Major histocompatibility complex class I deficiency
D81.7 Major histocompatibility complex class II deficiency
Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.
