ICD-10-CM Codes
D50-D89
D80-D89
D81-
2023 ICD-10-CM Diagnosis Code D81.82

2023 ICD-10-CM Diagnosis Code D81.82

Activated Phosphoinositide 3-kinase Delta Syndrome [APDS]

2023 - New Code

Billable/Specific Code

D81.82 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
ICD-10-CM D81.82 is a new 2023 ICD-10-CM code that became effective on October 1, 2022.
This is the American ICD-10-CM version of D81.82 - other international versions of ICD-10 D81.82 may differ.

Applicable To

p110d-activating mutation causing senescent T cells, lymphadenopathy, and immunodeficiency [PASLI] disease

Code Also

Code Also Help

A code also note instructs that 2 codes may be required to fully describe a condition but the sequencing of the two codes is discretionary, depending on the severity of the conditions and the reason for the encounter.

, if applicable, any associated manifestations, such as:
bronchiectasis (
ICD-10-CM Diagnosis Code J47
- J47 Bronchiectasis
  - J47.0 Bronchiectasis with acute lower respiratory i...
  - J47.1 Bronchiectasis with (acute) exacerbation
  - J47.9 Bronchiectasis, uncomplicated
J47.-
)
herpes virus infections (
ICD-10-CM Diagnosis Code B00
- B00 Herpesviral [herpes simplex] infections
  - B00.0 Eczema herpeticum
  - B00.1 Herpesviral vesicular dermatitis
  - B00.2 Herpesviral gingivostomatitis and pharyngoton...
  - B00.3 Herpesviral meningitis
  - B00.4 Herpesviral encephalitis
  - B00.5 Herpesviral ocular disease
    - B00.50 …… unspecified
    - B00.51 Herpesviral iridocyclitis
    - B00.52 Herpesviral keratitis
    - B00.53 Herpesviral conjunctivitis
    - B00.59 Other herpesviral disease of eye
  - B00.7 Disseminated herpesviral disease
  - B00.8 Other forms of herpesviral infections
    - B00.81 Herpesviral hepatitis
    - B00.82 Herpes simplex myelitis
    - B00.89 Other herpesviral infection
  - B00.9 Herpesviral infection, unspecified
B00.-
)
other acute respiratory tract infections (J00-J06
ICD-10-CM Range J00-J06
Acute upper respiratory infections
Type 1 Excludes
- chronic obstructive pulmonary disease with acute lower respiratory infection (J44.0)
- J00 Acute nasopharyngitis [common cold]
- J01 Acute sinusitis
- J02 Acute pharyngitis
- J03 Acute tonsillitis
- J04 Acute laryngitis and tracheitis
- J05 Acute obstructive laryngitis [croup] and...
- J06 Acute upper respiratory infections of mu...
; J20-J22
ICD-10-CM Range J20-J22
Other acute lower respiratory infections
Type 2 Excludes
- chronic obstructive pulmonary disease with acute lower respiratory infection (J44.0)
- J20 Acute bronchitis
- J21 Acute bronchiolitis
- J22 Unspecified acute lower respiratory infe...
)
other infections (A00-B99
ICD-10-CM Range A00-B99
Certain infectious and parasitic diseases
- A00-A09 Intestinal infectious diseases
- A15-A19 Tuberculosis
- A20-A28 Certain zoonotic bacterial diseases
- A30-A49 Other bacterial diseases
- A50-A64 Infections with a predominantly sexual m...
- A65-A69 Other spirochetal diseases
- A70-A74 Other diseases caused by chlamydiae
- A75-A79 Rickettsioses
- A80-A89 Viral and prion infections of the centra...
- A90-A99 Arthropod-borne viral fevers and viral h...
- B00-B09 Viral infections characterized by skin a...
- B10-B10 Other human herpesviruses
- B15-B19 Viral hepatitis
- B20-B20 Human immunodeficiency virus [HIV] disea...
- B25-B34 Other viral diseases
- B35-B49 Mycoses
- B50-B64 Protozoal diseases
- B65-B83 Helminthiases
- B85-B89 Pediculosis, acariasis and other infesta...
- B90-B94 Sequelae of infectious and parasitic dis...
- B95-B97 Bacterial and viral infectious agents
- B99-B99 Other infectious diseases
)
pneumonia (
ICD-10-CM Diagnosis Code J12
Viral pneumonia, not elsewhere classified
Code First
- associated influenza, if applicable (J09.X1, J10.0-, J11.0-)
Code Also
- associated abscess, if applicable (J85.1)
Includes
- bronchopneumonia due to viruses other than influenza viruses
Type 1 Excludes
- aspiration pneumonia due to anesthesia during labor and delivery (O74.0)
- aspiration pneumonia due to anesthesia during pregnancy (O29)
- aspiration pneumonia due to anesthesia during puerperium (O89.0)
- aspiration pneumonia due to solids and liquids (J69.-)
- aspiration pneumonia NOS (J69.0)
- congenital pneumonia (P23.0)
- congenital rubella pneumonitis (P35.0)
- interstitial pneumonia NOS (J84.9)
- lipid pneumonia (J69.1)
- neonatal aspiration pneumonia (P24.-)
J12
-
ICD-10-CM Diagnosis Code J18
Pneumonia, unspecified organism
Code First
- associated influenza, if applicable (J09.X1, J10.0-, J11.0-)
Type 1 Excludes
- abscess of lung with pneumonia (J85.1)
- aspiration pneumonia due to anesthesia during labor and delivery (O74.0)
- aspiration pneumonia due to anesthesia during pregnancy (O29)
- aspiration pneumonia due to anesthesia during puerperium (O89.0)
- aspiration pneumonia due to solids and liquids (J69.-)
- aspiration pneumonia NOS (J69.0)
- congenital pneumonia (P23.0)
- drug-induced interstitial lung disorder (J70.2-J70.4)
- interstitial pneumonia NOS (J84.9)
- lipid pneumonia (J69.1)
- neonatal aspiration pneumonia (P24.-)
- pneumonitis due to external agents (J67-J70)
- pneumonitis due to fumes and vapors (J68.0)
- usual interstitial pneumonia (J84.178)
J18
)

The following code(s) above D81.82 contain annotation back-references

Annotation Back-References

In this context, annotation back-references refer to codes that contain:

Applicable To annotations, or
Code Also annotations, or
Code First annotations, or
Excludes1 annotations, or
Excludes2 annotations, or
Includes annotations, or
Note annotations, or
Use Additional annotations

that may be applicable to D81.82:

D50-D89
2023 ICD-10-CM Range D50-D89
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
Type 2 Excludes
- autoimmune disease (systemic) NOS (M35.9)
- certain conditions originating in the perinatal period (P00-P96)
- complications of pregnancy, childbirth and the puerperium (O00-O9A)
- congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
- endocrine, nutritional and metabolic diseases (E00-E88)
- human immunodeficiency virus [HIV] disease (B20)
- injury, poisoning and certain other consequences of external causes (S00-T88)
- neoplasms (C00-D49)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
D80-D89
2023 ICD-10-CM Range D80-D89
Certain disorders involving the immune mechanism
Includes
- defects in the complement system
- immunodeficiency disorders, except human immunodeficiency virus [HIV] disease
- sarcoidosis
Type 1 Excludes
- autoimmune disease (systemic) NOS (M35.9)
- functional disorders of polymorphonuclear neutrophils (D71)
- human immunodeficiency virus [HIV] disease (B20)
Certain disorders involving the immune mechanism
D81
ICD-10-CM Diagnosis Code D81
Combined immunodeficiencies
Type 1 Excludes
- autosomal recessive agammaglobulinemia (Swiss type) (D80.0)
Combined immunodeficiencies

ICD-10-CM D81.82 is grouped within Diagnostic Related Group(s) (MS-DRG v40.0):

808 Major hematological and immunological diagnoses except sickle cell crisis and coagulation disorders with mcc
809 Major hematological and immunological diagnoses except sickle cell crisis and coagulation disorders with cc
810 Major hematological and immunological diagnoses except sickle cell crisis and coagulation disorders without cc/mcc

Code History

2023 (effective 10/1/2022): New code

Diagnosis Index entries containing back-references to D81.82:

Disease, diseased - see also Syndrome
- p110d-activating mutation causing senescent T cells, lymphadenopathy, and immunodeficiency [PASLI] D81.82
Syndrome - see also Disease
- activated phosphoinositide 3-kinase delta syndrome [APDS] D81.82

ICD-10-CM Codes Adjacent To D81.82

D81.39 Other adenosine deaminase deficiency

D81.4 Nezelof's syndrome

D81.5 Purine nucleoside phosphorylase [PNP] deficiency

D81.6 Major histocompatibility complex class I deficiency

D81.7 Major histocompatibility complex class II deficiency

D81.8 Other combined immunodeficiencies

D81.81 Biotin-dependent carboxylase deficiency

D81.810 Biotinidase deficiency

D81.818 Other biotin-dependent carboxylase deficiency

D81.819 …… unspecified

D81.82 Activated Phosphoinositide 3-kinase Delta Syndrome [APDS]

D81.89 Other combined immunodeficiencies

D81.9 Combined immunodeficiency, unspecified

D82 Immunodeficiency associated with other major defects

D82.0 Wiskott-Aldrich syndrome

D82.1 Di George's syndrome

D82.2 Immunodeficiency with short-limbed stature

D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus

D82.4 Hyperimmunoglobulin E [IgE] syndrome

D82.8 Immunodeficiency associated with other specified major defects

D82.9 Immunodeficiency associated with major defect, unspecified

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.

2023 ICD-10-CM Diagnosis Code D81.82

Activated Phosphoinositide 3-kinase Delta Syndrome [APDS]

Acute upper respiratory infections

Other acute lower respiratory infections

Certain infectious and parasitic diseases

Viral pneumonia, not elsewhere classified

Pneumonia, unspecified organism

Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

Certain disorders involving the immune mechanism

Combined immunodeficiencies