2023 ICD-10-CM Diagnosis Code D81.82

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Activated Phosphoinositide 3-kinase Delta Syndrome [APDS]

    2023 - New Code Billable/Specific Code
  • D81.82 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • ICD-10-CM D81.82 is a new 2023 ICD-10-CM code that became effective on October 1, 2022.
  • This is the American ICD-10-CM version of D81.82 - other international versions of ICD-10 D81.82 may differ.
Applicable To
  • p110d-activating mutation causing senescent T cells, lymphadenopathy, and immunodeficiency [PASLI] disease
Code Also
Code Also Help
A code also note instructs that 2 codes may be required to fully describe a condition but the sequencing of the two codes is discretionary, depending on the severity of the conditions and the reason for the encounter.
  • , if applicable, any associated manifestations, such as:
  • bronchiectasis (
    ICD-10-CM Diagnosis Code J47
    • J47 Bronchiectasis
      • J47.0 Bronchiectasis with acute lower respiratory i...
      • J47.1 Bronchiectasis with (acute) exacerbation
      • J47.9 Bronchiectasis, uncomplicated
    J47.-
    )
  • herpes virus infections (
    ICD-10-CM Diagnosis Code B00
    • B00 Herpesviral [herpes simplex] infections
      • B00.0 Eczema herpeticum
      • B00.1 Herpesviral vesicular dermatitis
      • B00.2 Herpesviral gingivostomatitis and pharyngoton...
      • B00.3 Herpesviral meningitis
      • B00.4 Herpesviral encephalitis
      • B00.5 Herpesviral ocular disease
        • B00.50 …… unspecified
        • B00.51 Herpesviral iridocyclitis
        • B00.52 Herpesviral keratitis
        • B00.53 Herpesviral conjunctivitis
        • B00.59 Other herpesviral disease of eye
      • B00.7 Disseminated herpesviral disease
      • B00.8 Other forms of herpesviral infections
        • B00.81 Herpesviral hepatitis
        • B00.82 Herpes simplex myelitis
        • B00.89 Other herpesviral infection
      • B00.9 Herpesviral infection, unspecified
    B00.-
    )
  • other acute respiratory tract infections (J00-J06
    ICD-10-CM Range J00-J06

    Acute upper respiratory infections

    Type 1 Excludes
    • chronic obstructive pulmonary disease with acute lower respiratory infection (J44.0)
    • J00 Acute nasopharyngitis [common cold]
    • J01 Acute sinusitis
    • J02 Acute pharyngitis
    • J03 Acute tonsillitis
    • J04 Acute laryngitis and tracheitis
    • J05 Acute obstructive laryngitis [croup] and...
    • J06 Acute upper respiratory infections of mu...
    ; J20-J22
    ICD-10-CM Range J20-J22

    Other acute lower respiratory infections

    Type 2 Excludes
    • chronic obstructive pulmonary disease with acute lower respiratory infection (J44.0)
    • J20 Acute bronchitis
    • J21 Acute bronchiolitis
    • J22 Unspecified acute lower respiratory infe...
    )
  • other infections (A00-B99
    ICD-10-CM Range A00-B99

    Certain infectious and parasitic diseases

    • A00-A09 Intestinal infectious diseases
    • A15-A19 Tuberculosis
    • A20-A28 Certain zoonotic bacterial diseases
    • A30-A49 Other bacterial diseases
    • A50-A64 Infections with a predominantly sexual m...
    • A65-A69 Other spirochetal diseases
    • A70-A74 Other diseases caused by chlamydiae
    • A75-A79 Rickettsioses
    • A80-A89 Viral and prion infections of the centra...
    • A90-A99 Arthropod-borne viral fevers and viral h...
    • B00-B09 Viral infections characterized by skin a...
    • B10-B10 Other human herpesviruses
    • B15-B19 Viral hepatitis
    • B20-B20 Human immunodeficiency virus [HIV] disea...
    • B25-B34 Other viral diseases
    • B35-B49 Mycoses
    • B50-B64 Protozoal diseases
    • B65-B83 Helminthiases
    • B85-B89 Pediculosis, acariasis and other infesta...
    • B90-B94 Sequelae of infectious and parasitic dis...
    • B95-B97 Bacterial and viral infectious agents
    • B99-B99 Other infectious diseases
    )
  • pneumonia (
    ICD-10-CM Diagnosis Code J12

    Viral pneumonia, not elsewhere classified

      2016 2017 2018 2019 2020 2021 2022 2023 Non-Billable/Non-Specific Code
    Code First
    Code Also
    • associated abscess, if applicable (J85.1)
    Includes
    • bronchopneumonia due to viruses other than influenza viruses
    Type 1 Excludes
    • aspiration pneumonia due to anesthesia during labor and delivery (O74.0)
    • aspiration pneumonia due to anesthesia during pregnancy (O29)
    • aspiration pneumonia due to anesthesia during puerperium (O89.0)
    • aspiration pneumonia due to solids and liquids (J69.-)
    • aspiration pneumonia NOS (J69.0)
    • congenital pneumonia (P23.0)
    • congenital rubella pneumonitis (P35.0)
    • interstitial pneumonia NOS (J84.9)
    • lipid pneumonia (J69.1)
    • neonatal aspiration pneumonia (P24.-)
    J12
    -
    ICD-10-CM Diagnosis Code J18

    Pneumonia, unspecified organism

      2016 2017 2018 2019 2020 2021 2022 2023 Non-Billable/Non-Specific Code
    Code First
    Type 1 Excludes
    • abscess of lung with pneumonia (J85.1)
    • aspiration pneumonia due to anesthesia during labor and delivery (O74.0)
    • aspiration pneumonia due to anesthesia during pregnancy (O29)
    • aspiration pneumonia due to anesthesia during puerperium (O89.0)
    • aspiration pneumonia due to solids and liquids (J69.-)
    • aspiration pneumonia NOS (J69.0)
    • congenital pneumonia (P23.0)
    • drug-induced interstitial lung disorder (J70.2-J70.4)
    • interstitial pneumonia NOS (J84.9)
    • lipid pneumonia (J69.1)
    • neonatal aspiration pneumonia (P24.-)
    • pneumonitis due to external agents (J67-J70)
    • pneumonitis due to fumes and vapors (J68.0)
    • usual interstitial pneumonia (J84.178)
    J18
    )
The following code(s) above D81.82 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to D81.82:
  • D50-D89
    2023 ICD-10-CM Range D50-D89

    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

    Type 2 Excludes
    • autoimmune disease (systemic) NOS (M35.9)
    • certain conditions originating in the perinatal period (P00-P96)
    • complications of pregnancy, childbirth and the puerperium (O00-O9A)
    • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
    • endocrine, nutritional and metabolic diseases (E00-E88)
    • human immunodeficiency virus [HIV] disease (B20)
    • injury, poisoning and certain other consequences of external causes (S00-T88)
    • neoplasms (C00-D49)
    • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
  • D80-D89
    2023 ICD-10-CM Range D80-D89

    Certain disorders involving the immune mechanism

    Includes
    • defects in the complement system
    • immunodeficiency disorders, except human immunodeficiency virus [HIV] disease
    • sarcoidosis
    Type 1 Excludes
    • autoimmune disease (systemic) NOS (M35.9)
    • functional disorders of polymorphonuclear neutrophils (D71)
    • human immunodeficiency virus [HIV] disease (B20)
    Certain disorders involving the immune mechanism
  • D81
    ICD-10-CM Diagnosis Code D81

    Combined immunodeficiencies

      2016 2017 2018 2019 2020 2021 2022 2023 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • autosomal recessive agammaglobulinemia (Swiss type) (D80.0)
    Combined immunodeficiencies
ICD-10-CM D81.82 is grouped within Diagnostic Related Group(s) (MS-DRG v40.0):
  • 808 Major hematological and immunological diagnoses except sickle cell crisis and coagulation disorders with mcc
  • 809 Major hematological and immunological diagnoses except sickle cell crisis and coagulation disorders with cc
  • 810 Major hematological and immunological diagnoses except sickle cell crisis and coagulation disorders without cc/mcc
Code History
  • 2023 (effective 10/1/2022): New code

Diagnosis Index entries containing back-references to D81.82:
  • Disease, diseased - see also Syndrome
    • p110d-activating mutation causing senescent T cells, lymphadenopathy, and immunodeficiency [PASLI] D81.82
  • Syndrome - see also Disease
    • activated phosphoinositide 3-kinase delta syndrome [APDS] D81.82

ICD-10-CM Codes Adjacent To D81.82
D81.39 Other adenosine deaminase deficiency
D81.4 Nezelof's syndrome
D81.5 Purine nucleoside phosphorylase [PNP] deficiency
D81.6 Major histocompatibility complex class I deficiency
D81.7 Major histocompatibility complex class II deficiency
D81.8 Other combined immunodeficiencies
D81.81 Biotin-dependent carboxylase deficiency
D81.810 Biotinidase deficiency
D81.818 Other biotin-dependent carboxylase deficiency
D81.819 …… unspecified
D81.82 Activated Phosphoinositide 3-kinase Delta Syndrome [APDS]
D81.89 Other combined immunodeficiencies
D81.9 Combined immunodeficiency, unspecified
D82 Immunodeficiency associated with other major defects
D82.0 Wiskott-Aldrich syndrome
D82.1 Di George's syndrome
D82.2 Immunodeficiency with short-limbed stature
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus
D82.4 Hyperimmunoglobulin E [IgE] syndrome
D82.8 Immunodeficiency associated with other specified major defects
D82.9 Immunodeficiency associated with major defect, unspecified

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.