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ICD-10-CM Codes
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D50-D89
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D80-D89
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D84-
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2023 ICD-10-CM Diagnosis Code D84.1
2023 ICD-10-CM Diagnosis Code D84.1
Defects in the complement system
2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
- D84.1 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
- The 2023 edition of ICD-10-CM D84.1 became effective on October 1, 2022.
- This is the American ICD-10-CM version of D84.1 - other international versions of ICD-10 D84.1 may differ.
Applicable To- C1 esterase inhibitor [C1-INH] deficiency
The following code(s) above
D84.1 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
- Applicable To annotations, or
- Code Also annotations, or
- Code First annotations, or
- Excludes1 annotations, or
- Excludes2 annotations, or
- Includes annotations, or
- Note annotations, or
- Use Additional annotations
that may be applicable to
D84.1:
Approximate Synonyms
- Angioedema, hereditary
- Circulating enzyme deficiency
- Complement 4 deficiency
- Complement deficiency c4
- Complement deficiency disease
- Deficiency of circulating enzyme
- Hereditary angioneurotic edema
- Hypocomplementemia
Clinical Information
- Rare disease where complement protein(s) are absent or in diminished amount relative to the normal requirement of an organism; associated with autoimmune disease or increased susceptibility to infections, problems encountered depend on which pathway is affected.
ICD-10-CM D84.1 is grouped within Diagnostic Related Group(s) (MS-DRG v40.0):
- 642 Inborn and other disorders of metabolism
Convert D84.1 to ICD-9-CM
Code History
- 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
- 2017 (effective 10/1/2016): No change
- 2018 (effective 10/1/2017): No change
- 2019 (effective 10/1/2018): No change
- 2020 (effective 10/1/2019): No change
- 2021 (effective 10/1/2020): No change
- 2022 (effective 10/1/2021): No change
- 2023 (effective 10/1/2022): No change
Code annotations containing back-references to D84.1:
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Code Also: D59.32
ICD-10-CM Diagnosis Code D59.32
Hereditary hemolytic-uremic syndrome
2023 - New Code Billable/Specific Code
Applicable To- Atypical hemolytic uremic syndrome with an identified genetic cause
Code Also- , if applicable:
- defects in the complement system (D84.1)
- methylmalonic acidemia (E71.120)
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Type 1 Excludes: D84.81, L50
ICD-10-CM Diagnosis Code D84.81
Immunodeficiency due to conditions classified elsewhere
2021 - New Code 2022 2023 Billable/Specific Code Manifestation Code
Code First- underlying condition, such as:
- chromosomal abnormalities (Q90-Q99)
- diabetes mellitus (E08-E13)
- malignant neoplasms (C00-C96)
Type 1 Excludes- certain disorders involving the immune mechanism (D80-D83, D84.0, D84.1, D84.9)
- human immunodeficiency virus [HIV] disease (B20)
ICD-10-CM Diagnosis Code L50
Urticaria
2016 2017 2018 2019 2020 2021 2022 2023 Non-Billable/Non-Specific Code
Type 1 Excludes- allergic contact dermatitis (L23.-)
- angioneurotic edema (T78.3)
- giant urticaria (T78.3)
- hereditary angio-edema (D84.1)
- Quincke's edema (T78.3)
- serum urticaria (T80.6-)
- solar urticaria (L56.3)
- urticaria neonatorum (P83.8)
- urticaria papulosa (L28.2)
- urticaria pigmentosa (D47.01)
- Angioedema (allergic) (any site) (with urticaria) T78.3
ICD-10-CM Diagnosis Code T78.3
Angioneurotic edema
2016 2017 2018 2019 2020 2021 2022 2023 Non-Billable/Non-Specific Code
Applicable To- Allergic angioedema
- Giant urticaria
- Quincke's edema
- Angioneurotic edema (allergic) (any site) (with urticaria) T78.3
ICD-10-CM Diagnosis Code T78.3
Angioneurotic edema
2016 2017 2018 2019 2020 2021 2022 2023 Non-Billable/Non-Specific Code
Applicable To- Allergic angioedema
- Giant urticaria
- Quincke's edema
- Bannister's disease T78.3
ICD-10-CM Diagnosis Code T78.3
Angioneurotic edema
2016 2017 2018 2019 2020 2021 2022 2023 Non-Billable/Non-Specific Code
Applicable To- Allergic angioedema
- Giant urticaria
- Quincke's edema
- Defect, defective Q89.9
ICD-10-CM Diagnosis Code Q89.9
Congenital malformation, unspecified
2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code POA Exempt
Applicable To- Congenital anomaly NOS
- Congenital deformity NOS
- Deficiency, deficient
- C1 esterase inhibitor D84.1 (C1-INH)
- Edema, edematous (infectious) (pitting) (toxic) R60.9
ICD-10-CM Diagnosis Code R60.9
Edema, unspecified
2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
- angioneurotic (allergic) (any site) (with urticaria) T78.3
ICD-10-CM Diagnosis Code T78.3
Angioneurotic edema
2016 2017 2018 2019 2020 2021 2022 2023 Non-Billable/Non-Specific Code
Applicable To- Allergic angioedema
- Giant urticaria
- Quincke's edema
- circumscribed, acute T78.3
ICD-10-CM Diagnosis Code T78.3
Angioneurotic edema
2016 2017 2018 2019 2020 2021 2022 2023 Non-Billable/Non-Specific Code
Applicable To- Allergic angioedema
- Giant urticaria
- Quincke's edema
- essential, acute T78.3
ICD-10-CM Diagnosis Code T78.3
Angioneurotic edema
2016 2017 2018 2019 2020 2021 2022 2023 Non-Billable/Non-Specific Code
Applicable To- Allergic angioedema
- Giant urticaria
- Quincke's edema
- glottis, glottic, glottidis (obstructive) (passive) J38.4
ICD-10-CM Diagnosis Code J38.4
Edema of larynx
2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
Applicable To- Edema (of) glottis
- Subglottic edema
- Supraglottic edema
Type 1 Excludes- acute obstructive laryngitis [croup] (J05.0)
- edematous laryngitis (J04.0)
- allergic T78.3
ICD-10-CM Diagnosis Code T78.3
Angioneurotic edema
2016 2017 2018 2019 2020 2021 2022 2023 Non-Billable/Non-Specific Code
Applicable To- Allergic angioedema
- Giant urticaria
- Quincke's edema
- periodic T78.3
ICD-10-CM Diagnosis Code T78.3
Angioneurotic edema
2016 2017 2018 2019 2020 2021 2022 2023 Non-Billable/Non-Specific Code
Applicable To- Allergic angioedema
- Giant urticaria
- Quincke's edema
- Quincke's T78.3
ICD-10-CM Diagnosis Code T78.3
Angioneurotic edema
2016 2017 2018 2019 2020 2021 2022 2023 Non-Billable/Non-Specific Code
Applicable To- Allergic angioedema
- Giant urticaria
- Quincke's edema
- Giant
- urticaria T78.3
ICD-10-CM Diagnosis Code T78.3
Angioneurotic edema
2016 2017 2018 2019 2020 2021 2022 2023 Non-Billable/Non-Specific Code
Applicable To- Allergic angioedema
- Giant urticaria
- Quincke's edema
- Quincke's disease or edema T78.3
ICD-10-CM Diagnosis Code T78.3
Angioneurotic edema
2016 2017 2018 2019 2020 2021 2022 2023 Non-Billable/Non-Specific Code
Applicable To- Allergic angioedema
- Giant urticaria
- Quincke's edema
- Urticaria L50.9
ICD-10-CM Diagnosis Code L50.9
Urticaria, unspecified
2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
- with angioneurotic edema T78.3
ICD-10-CM Diagnosis Code T78.3
Angioneurotic edema
2016 2017 2018 2019 2020 2021 2022 2023 Non-Billable/Non-Specific Code
Applicable To- Allergic angioedema
- Giant urticaria
- Quincke's edema
- giant T78.3
ICD-10-CM Diagnosis Code T78.3
Angioneurotic edema
2016 2017 2018 2019 2020 2021 2022 2023 Non-Billable/Non-Specific Code
Applicable To- Allergic angioedema
- Giant urticaria
- Quincke's edema
- larynx T78.3
ICD-10-CM Diagnosis Code T78.3
Angioneurotic edema
2016 2017 2018 2019 2020 2021 2022 2023 Non-Billable/Non-Specific Code
Applicable To- Allergic angioedema
- Giant urticaria
- Quincke's edema
ICD-10-CM Codes Adjacent To D84.1
D82.8 Immunodeficiency associated with other specified major defects
D82.9 Immunodeficiency associated with major defect, unspecified
D83 Common variable immunodeficiency
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells
D83.8 Other common variable immunodeficiencies
D83.9 Common variable immunodeficiency, unspecified
D84 Other immunodeficiencies
D84.0 Lymphocyte function antigen-1 [LFA-1] defect
D84.1
Defects in the complement system
D84.8 Other specified immunodeficiencies
D84.81 Immunodeficiency due to conditions classified elsewhere
D84.82 Immunodeficiency due to drugs and external causes
D84.821 Immunodeficiency due to drugs
D84.822 Immunodeficiency due to external causes
D84.89 Other immunodeficiencies
D84.9 Immunodeficiency, unspecified
D86.0 Sarcoidosis of lung
D86.1 Sarcoidosis of lymph nodes
Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.