2021 ICD-10-CM Diagnosis Code D84.81

Immunodeficiency due to conditions classified elsewhere

    2021 - New Code Billable/Specific Code
  • D84.81 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • ICD-10-CM D84.81 is a new 2021 ICD-10-CM code that became effective on October 1, 2020.
  • This is the American ICD-10-CM version of D84.81 - other international versions of ICD-10 D84.81 may differ.
Code First
Code First Help
Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. For such conditions, ICD-10-CM has a coding convention that requires the underlying condition be sequenced first followed by the manifestation. Wherever such a combination exists there is a "use additional code" note at the etiology code, and a "code first" note at the manifestation code. These instructional notes indicate the proper sequencing order of the codes, etiology followed by manifestation. In most cases the manifestation codes will have in the code title, "in diseases classified elsewhere." Codes with this title are a component of the etiology/manifestation convention. The code title indicates that it is a manifestation code. "In diseases classified elsewhere" codes are never permitted to be used as first listed or principle diagnosis codes. They must be used in conjunction with an underlying condition code and they must be listed following the underlying condition.
  • underlying condition, such as:
  • chromosomal abnormalities (Q90-Q99
    ICD-10-CM Range Q90-Q99

    Chromosomal abnormalities, not elsewhere classified

    Type 2 Excludes
    • mitochondrial metabolic disorders (E88.4-)
    • Q90 Down syndrome
    • Q91 Trisomy 18 and Trisomy 13
    • Q92 Other trisomies and partial trisomies of...
    • Q93 Monosomies and deletions from the autoso...
    • Q95 Balanced rearrangements and structural m...
    • Q96 Turner's syndrome
    • Q97 Other sex chromosome abnormalities, fema...
    • Q98 Other sex chromosome abnormalities, male...
    • Q99 Other chromosome abnormalities, not else...
    )
  • diabetes mellitus (E08-E13
    ICD-10-CM Range E08-E13

    Diabetes mellitus

    • E08 Diabetes mellitus due to underlying cond...
    • E09 Drug or chemical induced diabetes mellit...
    • E10 Type 1 diabetes mellitus
    • E11 Type 2 diabetes mellitus
    • E13 Other specified diabetes mellitus
    )
  • malignant neoplasms (
    ICD-10-CM Diagnosis Code C00

    Malignant neoplasm of lip

      2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • malignant melanoma of lip (C43.0)
    • Merkel cell carcinoma of lip (C4A.0)
    • other and unspecified malignant neoplasm of skin of lip (C44.0-)
    Use Additional
    • code to identify:
    • alcohol abuse and dependence (F10.-)
    • history of tobacco dependence (Z87.891)
    • tobacco dependence (F17.-)
    • tobacco use (Z72.0)
    C00
    -
    ICD-10-CM Diagnosis Code C96

    Other and unspecified malignant neoplasms of lymphoid, hematopoietic and related tissue

      2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • personal history of other malignant neoplasms of lymphoid, hematopoietic and related tissues (Z85.79)
    C96
    )
Type 1 Excludes
Type 1 Excludes Help
A type 1 excludes note is a pure excludes. It means "not coded here". A type 1 excludes note indicates that the code excluded should never be used at the same time as D84.81. A type 1 excludes note is for used for when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • certain disorders involving the immune mechanism (
    ICD-10-CM Diagnosis Code D80

    Immunodeficiency with predominantly antibody defects

      2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
    D80
    -
    ICD-10-CM Diagnosis Code D83

    Common variable immunodeficiency

      2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
    D83
    ,
    ICD-10-CM Diagnosis Code D84.0

    Lymphocyte function antigen-1 [LFA-1] defect

      2016 2017 2018 2019 2020 2021 Billable/Specific Code
    D84.0
    ,
    ICD-10-CM Diagnosis Code D84.1

    Defects in the complement system

      2016 2017 2018 2019 2020 2021 Billable/Specific Code
    Applicable To
    • C1 esterase inhibitor [C1-INH] deficiency
    D84.1
    ,
    ICD-10-CM Diagnosis Code D84.9

    Immunodeficiency, unspecified

      2016 2017 2018 2019 2020 2021 Billable/Specific Code
    Applicable To
    • Immunocompromised NOS
    • Immunodeficient NOS
    • Immunosuppressed NOS
    D84.9
    )
  • human immunodeficiency virus [HIV] disease (
    ICD-10-CM Diagnosis Code B20

    Human immunodeficiency virus [HIV] disease

      2016 2017 2018 2019 2020 2021 Billable/Specific Code
    Code First
    • Human immunodeficiency virus [HIV] disease complicating pregnancy, childbirth and the puerperium, if applicable (O98.7-)
    Includes
    • acquired immune deficiency syndrome [AIDS]
    • AIDS-related complex [ARC]
    • HIV infection, symptomatic
    Type 1 Excludes
    • asymptomatic human immunodeficiency virus [HIV] infection status (Z21)
    • exposure to HIV virus (Z20.6)
    • inconclusive serologic evidence of HIV (R75)
    Use Additional
    • code(s) to identify all manifestations of HIV infection
    B20
    )
The following code(s) above D84.81 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to D84.81:
  • D50-D89
    2021 ICD-10-CM Range D50-D89

    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

    Type 2 Excludes
    • autoimmune disease (systemic) NOS (M35.9)
    • certain conditions originating in the perinatal period (P00-P96)
    • complications of pregnancy, childbirth and the puerperium (O00-O9A)
    • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
    • endocrine, nutritional and metabolic diseases (E00-E88)
    • human immunodeficiency virus [HIV] disease (B20)
    • injury, poisoning and certain other consequences of external causes (S00-T88)
    • neoplasms (C00-D49)
    • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
  • D80-D89
    2021 ICD-10-CM Range D80-D89

    Certain disorders involving the immune mechanism

    Includes
    • defects in the complement system
    • immunodeficiency disorders, except human immunodeficiency virus [HIV] disease
    • sarcoidosis
    Type 1 Excludes
    • autoimmune disease (systemic) NOS (M35.9)
    • functional disorders of polymorphonuclear neutrophils (D71)
    • human immunodeficiency virus [HIV] disease (B20)
    Certain disorders involving the immune mechanism
ICD-10-CM D84.81 is grouped within Diagnostic Related Group(s) (MS-DRG v38.0):
  • 814 Reticuloendothelial and immunity disorders with mcc
  • 815 Reticuloendothelial and immunity disorders with cc
  • 816 Reticuloendothelial and immunity disorders without cc/mcc
Code History
  • 2021 (effective 10/1/2020): New code

Diagnosis Index entries containing back-references to D84.81:
  • Immunodeficiency D84.9
    ICD-10-CM Diagnosis Code D84.9

    Immunodeficiency, unspecified

      2016 2017 2018 2019 2020 2021 Billable/Specific Code
    Applicable To
    • Immunocompromised NOS
    • Immunodeficient NOS
    • Immunosuppressed NOS
    • due to
      • conditions classified elsewhere D84.81

ICD-10-CM Codes Adjacent To D84.81
D83 Common variable immunodeficiency
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells
D83.8 Other common variable immunodeficiencies
D83.9 Common variable immunodeficiency, unspecified
D84 Other immunodeficiencies
D84.0 Lymphocyte function antigen-1 [LFA-1] defect
D84.1 Defects in the complement system
D84.8 Other specified immunodeficiencies
D84.81 Immunodeficiency due to conditions classified elsewhere
D84.82 Immunodeficiency due to drugs and external causes
D84.821 Immunodeficiency due to drugs
D84.822 Immunodeficiency due to external causes
D84.89 Other immunodeficiencies
D84.9 Immunodeficiency, unspecified
D86 Sarcoidosis
D86.0 Sarcoidosis of lung
D86.1 Sarcoidosis of lymph nodes
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes
D86.3 Sarcoidosis of skin

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.