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ICD-10-CM Codes
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D50-D89
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
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D80-D89
Certain disorders involving the immune mechanism
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D89-
Other disorders involving the immune mechanism, not elsewhere classified
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2019 ICD-10-CM Diagnosis Code D89.1
Cryoglobulinemia
2016 2017 2018 2019 Billable/Specific Code
- D89.1 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
- The 2019 edition of ICD-10-CM D89.1 became effective on October 1, 2018.
- This is the American ICD-10-CM version of D89.1 - other international versions of ICD-10 D89.1 may differ.
Applicable To- Cryoglobulinemic purpura
- Cryoglobulinemic vasculitis
- Essential cryoglobulinemia
- Idiopathic cryoglobulinemia
- Mixed cryoglobulinemia
- Primary cryoglobulinemia
- Secondary cryoglobulinemia
The following code(s) above
D89.1 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
- Applicable To annotations, or
- Code Also annotations, or
- Code First annotations, or
- Excludes1 annotations, or
- Excludes2 annotations, or
- Includes annotations, or
- Note annotations, or
- Use Additional annotations
that may be applicable to
D89.1:
- D50-D89
2019 ICD-10-CM Range D50-D89
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanismType 2 Excludes- autoimmune disease (systemic) NOS (M35.9)
- certain conditions originating in the perinatal period (P00-P96)
- complications of pregnancy, childbirth and the puerperium (O00-O9A)
- congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
- endocrine, nutritional and metabolic diseases (E00-E88)
- human immunodeficiency virus [HIV] disease (B20)
- injury, poisoning and certain other consequences of external causes (S00-T88)
- neoplasms (C00-D49)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
- D80-D89
2019 ICD-10-CM Range D80-D89
Certain disorders involving the immune mechanismIncludes- defects in the complement system
- immunodeficiency disorders, except human immunodeficiency virus [HIV] disease
- sarcoidosis
Type 1 Excludes- autoimmune disease (systemic) NOS (M35.9)
- functional disorders of polymorphonuclear neutrophils (D71)
- human immunodeficiency virus [HIV] disease (B20)
- D89
ICD-10-CM Diagnosis Code D89
Other disorders involving the immune mechanism, not elsewhere classified
2016 2017 2018 2019 Non-Billable/Non-Specific Code
Type 1 Excludes- hyperglobulinemia NOS (R77.1)
- monoclonal gammopathy (of undetermined significance) (D47.2)
Type 2 Excludes- transplant failure and rejection (T86.-)
- Cryoglobulinemia due to chronic hepatitis c
Clinical Information
- A condition characterized by the presence of abnormal quantities of cryoglobulins in the blood. Upon cold exposure, these abnormal proteins precipitate into the microvasculature leading to restricted blood flow in the exposed areas.
- A condition characterized by the presence of cryoglobulins in the blood. Cryoglobulins are abnormal proteins that precipitate within the microvasculature on exposure to cold; microvasculature effects of cryoglobulinemia may result in restricted tissue blood flow, tissue hypoxia, and tissue necrosis.
ICD-10-CM D89.1 is grouped within Diagnostic Related Group(s) (MS-DRG v36.0):
- 820 Lymphoma and leukemia with major o.r. Procedure with mcc
- 821 Lymphoma and leukemia with major o.r. Procedure with cc
- 822 Lymphoma and leukemia with major o.r. Procedure without cc/mcc
- 823 Lymphoma and non-acute leukemia with other procedure with mcc
- 824 Lymphoma and non-acute leukemia with other procedure with cc
- 825 Lymphoma and non-acute leukemia with other procedure without cc/mcc
- 840 Lymphoma and non-acute leukemia with mcc
- 841 Lymphoma and non-acute leukemia with cc
- 842 Lymphoma and non-acute leukemia without cc/mcc
Convert D89.1 to ICD-9-CM
Code History
- 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
- 2017 (effective 10/1/2016): No change
- 2018 (effective 10/1/2017): No change
- 2019 (effective 10/1/2018): No change
Code annotations containing back-references to D89.1:
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Code First: N08, N16, J99
ICD-10-CM Diagnosis Code N08
Glomerular disorders in diseases classified elsewhere
2016 2017 2018 2019 Billable/Specific Code Manifestation Code
Applicable To- Glomerulonephritis
- Nephritis
- Nephropathy
Type 1 Excludes- glomerulonephritis, nephritis and nephropathy (in):
- antiglomerular basement membrane disease (M31.0)
- diabetes (E08-E13 with .21)
- gonococcal (A54.21)
- Goodpasture's syndrome (M31.0)
- hemolytic-uremic syndrome (D59.3)
- lupus (M32.14)
- mumps (B26.83)
- syphilis (A52.75)
- systemic lupus erythematosus (M32.14)
- Wegener's granulomatosis (M31.31)
- pyelonephritis in diseases classified elsewhere (N16)
- renal tubulo-interstitial disorders classified elsewhere (N16)
ICD-10-CM Diagnosis Code N16
Renal tubulo-interstitial disorders in diseases classified elsewhere
2016 2017 2018 2019 Billable/Specific Code Manifestation Code
Applicable To- Pyelonephritis
- Tubulo-interstitial nephritis
Type 1 Excludes- diphtheritic pyelonephritis and tubulo-interstitial nephritis (A36.84)
- pyelonephritis and tubulo-interstitial nephritis in candidiasis (B37.49)
- pyelonephritis and tubulo-interstitial nephritis in cystinosis (E72.04)
- pyelonephritis and tubulo-interstitial nephritis in salmonella infection (A02.25)
- pyelonephritis and tubulo-interstitial nephritis in sarcoidosis (D86.84)
- pyelonephritis and tubulo-interstitial nephritis in sicca syndrome [Sjogren's] (M35.04)
- pyelonephritis and tubulo-interstitial nephritis in systemic lupus erythematosus (M32.15)
- pyelonephritis and tubulo-interstitial nephritis in toxoplasmosis (B58.83)
- renal tubular degeneration in diabetes (E08-E13 with .29)
- syphilitic pyelonephritis and tubulo-interstitial nephritis (A52.75)
ICD-10-CM Diagnosis Code J99
Respiratory disorders in diseases classified elsewhere
2016 2017 2018 2019 Billable/Specific Code Manifestation Code
Code First- underlying disease, such as:
- amyloidosis (E85.-)
- ankylosing spondylitis (M45)
- congenital syphilis (A50.5)
- cryoglobulinemia (D89.1)
- early congenital syphilis (A50.0)
- plasminogen deficiency (E88.02)
- schistosomiasis (B65.0-B65.9)
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Type 1 Excludes: D69
ICD-10-CM Diagnosis Code D69
Purpura and other hemorrhagic conditions
2016 2017 2018 2019 Non-Billable/Non-Specific Code
Type 1 Excludes- benign hypergammaglobulinemic purpura (D89.0)
- cryoglobulinemic purpura (D89.1)
- essential (hemorrhagic) thrombocythemia (D47.3)
- hemorrhagic thrombocythemia (D47.3)
- purpura fulminans (D65)
- thrombotic thrombocytopenic purpura (M31.1)
- Waldenström hypergammaglobulinemic purpura (D89.0)
- Cryoglobulinemia (essential) (idiopathic) (mixed) (primary) (purpura) (secondary) (vasculitis) D89.1
- with lung involvement D89.1
- Disorder (of) - see also Disease
- glomerular (in) N05.9
ICD-10-CM Diagnosis Code N05.9
Unspecified nephritic syndrome with unspecified morphologic changes
2016 2017 2018 2019 Billable/Specific Code
- tubulo-interstitial (in)
- mixed cryoglobulinemia D89.1
- Glomerulonephritis N05.9 - see also Nephritis
ICD-10-CM Diagnosis Code N05.9
Unspecified nephritic syndrome with unspecified morphologic changes
2016 2017 2018 2019 Billable/Specific Code
- Nephritis, nephritic (albuminuric) (azotemic) (congenital) (disseminated) (epithelial) (familial) (focal) (granulomatous) (hemorrhagic) (infantile) (nonsuppurative, excretory) (uremic) N05.9
ICD-10-CM Diagnosis Code N05.9
Unspecified nephritic syndrome with unspecified morphologic changes
2016 2017 2018 2019 Billable/Specific Code
- tubulo-interstitial (in) N12
ICD-10-CM Diagnosis Code N12
Tubulo-interstitial nephritis, not specified as acute or chronic
2016 2017 2018 2019 Billable/Specific Code
Applicable To- Interstitial nephritis NOS
- Pyelitis NOS
- Pyelonephritis NOS
Type 1 Excludes- calculous pyelonephritis (N20.9)
- Purpura D69.2
ICD-10-CM Diagnosis Code D69.2
Other nonthrombocytopenic purpura
2016 2017 2018 2019 Billable/Specific Code
Applicable To- Purpura NOS
- Purpura simplex
- Senile purpura
- Pyelonephritis - see also Nephritis, tubulo-interstitial
- in (due to)
- cryoglobulinemia D89.1 (mixed)
- Vasculitis I77.6
ICD-10-CM Diagnosis Code I77.6
Arteritis, unspecified
2016 2017 2018 2019 Billable/Specific Code
Applicable To- Aortitis NOS
- Endarteritis NOS
ICD-10-CM Codes Adjacent To D89.1
D86.82 Multiple cranial nerve palsies in sarcoidosis
D86.89 Sarcoidosis of other sites
D86.9 Sarcoidosis, unspecified
D89 Other disorders involving the immune mechanism, not elsewhere classified
D89.0 Polyclonal hypergammaglobulinemia
D89.1
Cryoglobulinemia
D89.2 Hypergammaglobulinemia, unspecified
D89.3 Immune reconstitution syndrome
D89.4 Mast cell activation syndrome and related disorders
D89.40 Mast cell activation, unspecified
D89.41 Monoclonal mast cell activation syndrome
D89.42 Idiopathic mast cell activation syndrome
D89.43 Secondary mast cell activation
D89.49 Other mast cell activation disorder
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified
D89.81 Graft-versus-host disease
Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.
