ICD-10-CM Codes
D50-D89
D80-D89
D89-
2023 ICD-10-CM Diagnosis Code D89.1

2023 ICD-10-CM Diagnosis Code D89.1

Cryoglobulinemia

2016

2017

2018

2019

2020

2021

2022

2023

Billable/Specific Code

D89.1 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
The 2023 edition of ICD-10-CM D89.1 became effective on October 1, 2022.
This is the American ICD-10-CM version of D89.1 - other international versions of ICD-10 D89.1 may differ.

Applicable To

Cryoglobulinemic purpura
Cryoglobulinemic vasculitis
Essential cryoglobulinemia
Idiopathic cryoglobulinemia
Mixed cryoglobulinemia
Primary cryoglobulinemia
Secondary cryoglobulinemia

The following code(s) above D89.1 contain annotation back-references

Annotation Back-References

In this context, annotation back-references refer to codes that contain:

Applicable To annotations, or
Code Also annotations, or
Code First annotations, or
Excludes1 annotations, or
Excludes2 annotations, or
Includes annotations, or
Note annotations, or
Use Additional annotations

that may be applicable to D89.1:

D50-D89
2023 ICD-10-CM Range D50-D89
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
Type 2 Excludes
- autoimmune disease (systemic) NOS (M35.9)
- certain conditions originating in the perinatal period (P00-P96)
- complications of pregnancy, childbirth and the puerperium (O00-O9A)
- congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
- endocrine, nutritional and metabolic diseases (E00-E88)
- human immunodeficiency virus [HIV] disease (B20)
- injury, poisoning and certain other consequences of external causes (S00-T88)
- neoplasms (C00-D49)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
D80-D89
2023 ICD-10-CM Range D80-D89
Certain disorders involving the immune mechanism
Includes
- defects in the complement system
- immunodeficiency disorders, except human immunodeficiency virus [HIV] disease
- sarcoidosis
Type 1 Excludes
- autoimmune disease (systemic) NOS (M35.9)
- functional disorders of polymorphonuclear neutrophils (D71)
- human immunodeficiency virus [HIV] disease (B20)
Certain disorders involving the immune mechanism
D89
ICD-10-CM Diagnosis Code D89
Other disorders involving the immune mechanism, not elsewhere classified
Type 1 Excludes
- hyperglobulinemia NOS (R77.1)
- monoclonal gammopathy (of undetermined significance) (D47.2)
Type 2 Excludes
- transplant failure and rejection (T86.-)
Other disorders involving the immune mechanism, not elsewhere classified

Approximate Synonyms

Cryoglobulinemia due to chronic hepatitis c

Clinical Information

A condition characterized by the presence of abnormal quantities of cryoglobulins in the blood. Upon cold exposure, these abnormal proteins precipitate into the microvasculature leading to restricted blood flow in the exposed areas.
A condition characterized by the presence of cryoglobulins in the blood. Cryoglobulins are abnormal proteins that precipitate within the microvasculature on exposure to cold; microvasculature effects of cryoglobulinemia may result in restricted tissue blood flow, tissue hypoxia, and tissue necrosis.

ICD-10-CM D89.1 is grouped within Diagnostic Related Group(s) (MS-DRG v40.0):

820 Lymphoma and leukemia with major o.r. Procedures with mcc
821 Lymphoma and leukemia with major o.r. Procedures with cc
822 Lymphoma and leukemia with major o.r. Procedures without cc/mcc
823 Lymphoma and non-acute leukemia with other procedures with mcc
824 Lymphoma and non-acute leukemia with other procedures with cc
825 Lymphoma and non-acute leukemia with other procedures without cc/mcc
840 Lymphoma and non-acute leukemia with mcc
841 Lymphoma and non-acute leukemia with cc
842 Lymphoma and non-acute leukemia without cc/mcc

Convert D89.1 to ICD-9-CM

Code History

2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
2017 (effective 10/1/2016): No change
2018 (effective 10/1/2017): No change
2019 (effective 10/1/2018): No change
2020 (effective 10/1/2019): No change
2021 (effective 10/1/2020): No change
2022 (effective 10/1/2021): No change
2023 (effective 10/1/2022): No change

Code annotations containing back-references to D89.1:

Code First: N08
, N16
, J99

ICD-10-CM Diagnosis Code N08
Glomerular disorders in diseases classified elsewhere
Applicable To
- Glomerulonephritis
- Nephritis
- Nephropathy
Code First
- underlying disease, such as:
- amyloidosis (E85.-)
- congenital syphilis (A50.5)
- cryoglobulinemia (D89.1)
- disseminated intravascular coagulation (D65)
- gout (M1A.-, M10.-)
- microscopic polyangiitis (M31.7)
- multiple myeloma (C90.0-)
- sepsis (A40.0-A41.9)
- sickle-cell disease (D57.0-D57.8)
Type 1 Excludes
- glomerulonephritis, nephritis and nephropathy (in):
- antiglomerular basement membrane disease (M31.0)
- diabetes (E08-E13 with .21)
- gonococcal (A54.21)
- Goodpasture's syndrome (M31.0)
- hemolytic-uremic syndrome (D59.3-)
- lupus (M32.14)
- mumps (B26.83)
- syphilis (A52.75)
- systemic lupus erythematosus (M32.14)
- Wegener's granulomatosis (M31.31)
- pyelonephritis in diseases classified elsewhere (N16)
- renal tubulo-interstitial disorders classified elsewhere (N16)
ICD-10-CM Diagnosis Code N16
Renal tubulo-interstitial disorders in diseases classified elsewhere
Applicable To
- Pyelonephritis
- Tubulo-interstitial nephritis
Code First
- underlying disease, such as:
- brucellosis (A23.0-A23.9)
- cryoglobulinemia (D89.1)
- glycogen storage disease (E74.0)
- leukemia (C91-C95)
- lymphoma (C81.0-C85.9, C96.0-C96.9)
- multiple myeloma (C90.0-)
- sepsis (A40.0-A41.9)
- Wilson's disease (E83.0)
Type 1 Excludes
- diphtheritic pyelonephritis and tubulo-interstitial nephritis (A36.84)
- pyelonephritis and tubulo-interstitial nephritis in candidiasis (B37.49)
- pyelonephritis and tubulo-interstitial nephritis in cystinosis (E72.04)
- pyelonephritis and tubulo-interstitial nephritis in salmonella infection (A02.25)
- pyelonephritis and tubulo-interstitial nephritis in sarcoidosis (D86.84)
- pyelonephritis and tubulo-interstitial nephritis in Sjogren syndrome (M35.04)
- pyelonephritis and tubulo-interstitial nephritis in systemic lupus erythematosus (M32.15)
- pyelonephritis and tubulo-interstitial nephritis in toxoplasmosis (B58.83)
- renal tubular degeneration in diabetes (E08-E13 with .29)
- syphilitic pyelonephritis and tubulo-interstitial nephritis (A52.75)
ICD-10-CM Diagnosis Code J99
Respiratory disorders in diseases classified elsewhere
Code First
- underlying disease, such as:
- amyloidosis (E85.-)
- ankylosing spondylitis (M45)
- congenital syphilis (A50.5)
- cryoglobulinemia (D89.1)
- early congenital syphilis (A50.0)
- plasminogen deficiency (E88.02)
- schistosomiasis (B65.0-B65.9)
Type 1 Excludes
- respiratory disorders in:
- amebiasis (A06.5)
- blastomycosis (B40.0-B40.2)
- candidiasis (B37.1)
- coccidioidomycosis (B38.0-B38.2)
- cystic fibrosis with pulmonary manifestations (E84.0)
- dermatomyositis (M33.01, M33.11)
- histoplasmosis (B39.0-B39.2)
- late syphilis (A52.72, A52.73)
- polymyositis (M33.21)
- Sjögren syndrome (M35.02)
- systemic lupus erythematosus (M32.13)
- systemic sclerosis (M34.81)
- Wegener's granulomatosis (M31.30-M31.31)
Type 1 Excludes: D69

ICD-10-CM Diagnosis Code D69
Purpura and other hemorrhagic conditions
Type 1 Excludes
- benign hypergammaglobulinemic purpura (D89.0)
- cryoglobulinemic purpura (D89.1)
- essential (hemorrhagic) thrombocythemia (D47.3)
- hemorrhagic thrombocythemia (D47.3)
- purpura fulminans (D65)
- thrombotic thrombocytopenic purpura (M31.19)
- Waldenström hypergammaglobulinemic purpura (D89.0)

Diagnosis Index entries containing back-references to D89.1:

Cryoglobulinemia (essential) (idiopathic) (mixed) (primary) (purpura) (secondary) (vasculitis) D89.1
- with lung involvement D89.1
Disorder (of) - see also Disease
- glomerular (in) N05.9
  ICD-10-CM Diagnosis Code N05.9
  Unspecified nephritic syndrome with unspecified morphologic changes
  2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
  - cryoglobulinemia D89.1
- tubulo-interstitial (in)
  - mixed cryoglobulinemia D89.1
Glomerulonephritis N05.9
- see also Nephritis
ICD-10-CM Diagnosis Code N05.9
Unspecified nephritic syndrome with unspecified morphologic changes
- in (due to)
  - cryoglobulinemia D89.1
Nephritis, nephritic (albuminuric) (azotemic) (congenital) (disseminated) (epithelial) (familial) (focal) (granulomatous) (hemorrhagic) (infantile) (nonsuppurative, excretory) (uremic) N05.9
ICD-10-CM Diagnosis Code N05.9
Unspecified nephritic syndrome with unspecified morphologic changes
- tubulo-interstitial (in) N12
  ICD-10-CM Diagnosis Code N12
  Tubulo-interstitial nephritis, not specified as acute or chronic
  2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
  Applicable To
  Interstitial nephritis NOS
  Pyelitis NOS
  Pyelonephritis NOS
  Type 1 Excludes
  calculous pyelonephritis (N20.9)
  - due to
    - cryoglobulinemia D89.1
Purpura D69.2
ICD-10-CM Diagnosis Code D69.2
Other nonthrombocytopenic purpura
Applicable To
Purpura NOS
Purpura simplex
Senile purpura
- cryoglobulinemic D89.1
Pyelonephritis - see also Nephritis, tubulo-interstitial
- in (due to)
  - cryoglobulinemia D89.1 (mixed)
Vasculitis I77.6
ICD-10-CM Diagnosis Code I77.6
Arteritis, unspecified
Applicable To
Aortitis NOS
Endarteritis NOS
Type 1 Excludes
arteritis or endarteritis:
aortic arch (M31.4)
cerebral NEC (I67.7)
coronary (I25.89)
deformans (I70.-)
giant cell (M31.5, M31.6)
obliterans (I70.-)
senile (I70.-)
- cryoglobulinemic D89.1

ICD-10-CM Codes Adjacent To D89.1

D86.82 Multiple cranial nerve palsies in sarcoidosis

D86.83 Sarcoid iridocyclitis

D86.84 Sarcoid pyelonephritis

D86.85 Sarcoid myocarditis

D86.86 Sarcoid arthropathy

D86.87 Sarcoid myositis

D86.89 Sarcoidosis of other sites

D86.9 Sarcoidosis, unspecified

D89 Other disorders involving the immune mechanism, not elsewhere classified

D89.0 Polyclonal hypergammaglobulinemia

D89.1 Cryoglobulinemia

D89.2 Hypergammaglobulinemia, unspecified

D89.3 Immune reconstitution syndrome

D89.4 Mast cell activation syndrome and related disorders

D89.40 Mast cell activation, unspecified

D89.41 Monoclonal mast cell activation syndrome

D89.42 Idiopathic mast cell activation syndrome

D89.43 Secondary mast cell activation

D89.44 Hereditary alpha tryptasemia

D89.49 Other mast cell activation disorder

D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.

2023 ICD-10-CM Diagnosis Code D89.1

Cryoglobulinemia

Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

Certain disorders involving the immune mechanism

Other disorders involving the immune mechanism, not elsewhere classified

Glomerular disorders in diseases classified elsewhere

Renal tubulo-interstitial disorders in diseases classified elsewhere

Respiratory disorders in diseases classified elsewhere

Purpura and other hemorrhagic conditions

Unspecified nephritic syndrome with unspecified morphologic changes

Unspecified nephritic syndrome with unspecified morphologic changes

Unspecified nephritic syndrome with unspecified morphologic changes

Tubulo-interstitial nephritis, not specified as acute or chronic

Other nonthrombocytopenic purpura

Arteritis, unspecified