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ICD-10-CM Codes
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D50-D89
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D80-D89
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D89-
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2023 ICD-10-CM Diagnosis Code D89.3
2023 ICD-10-CM Diagnosis Code D89.3
Immune reconstitution syndrome
2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
- D89.3 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
- The 2023 edition of ICD-10-CM D89.3 became effective on October 1, 2022.
- This is the American ICD-10-CM version of D89.3 - other international versions of ICD-10 D89.3 may differ.
Applicable To- Immune reconstitution inflammatory syndrome [IRIS]
Use AdditionalUse Additional Help
Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. For such conditions the ICD-10-CM has a coding convention that requires the underlying condition be sequenced first followed by the manifestation. Wherever such a combination exists there is a "use additional code" note at the etiology code, and a "code first" note at the manifestation code. These instructional notes indicate the proper sequencing order of the codes, etiology followed by manifestation. In most cases the manifestation codes will have in the code title, "in diseases classified elsewhere." Codes with this title are a component of the etiology/manifestation convention. The code title indicates that it is a manifestation code. "In diseases classified elsewhere" codes are never permitted to be used as first listed or principle diagnosis codes. They must be used in conjunction with an underlying condition code and they must be listed following the underlying condition.
- code for adverse effect, if applicable, to identify drug (T36-T50
ICD-10-CM Range T36-T50
Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substancesCode First- , for adverse effects, the nature of the adverse effect, such as:
- adverse effect NOS (T88.7)
- aspirin gastritis (K29.-)
- blood disorders (D56-D76)
- contact dermatitis (L23-L25)
- dermatitis due to substances taken internally (L27.-)
- nephropathy (N14.0-N14.2)
Includes- adverse effect of correct substance properly administered
- poisoning by overdose of substance
- poisoning by wrong substance given or taken in error
- underdosing by (inadvertently) (deliberately) taking less substance than prescribed or instructed
Note- The drug giving rise to the adverse effect should be identified by use of codes from categories T36-T50 with fifth or sixth character 5.
Type 1 Excludes- toxic reaction to local anesthesia in pregnancy (O29.3-)
Type 2 Excludes- abuse and dependence of psychoactive substances (F10-F19)
- abuse of non-dependence-producing substances (F55.-)
- immunodeficiency due to drugs (D84.821)
- drug reaction and poisoning affecting newborn (P00-P96)
- pathological drug intoxication (inebriation) (F10-F19)
Use Additional- code(s) to specify:
- manifestations of poisoning
- underdosing or failure in dosage during medical and surgical care (Y63.6, Y63.8-Y63.9)
- underdosing of medication regimen (Z91.12-, Z91.13-)
- T36 Poisoning by, adverse effect of and unde...
- T37 Poisoning by, adverse effect of and unde...
- T38 Poisoning by, adverse effect of and unde...
- T39 Poisoning by, adverse effect of and unde...
- T40 Poisoning by, adverse effect of and unde...
- T41 Poisoning by, adverse effect of and unde...
- T42 Poisoning by, adverse effect of and unde...
- T43 Poisoning by, adverse effect of and unde...
- T44 Poisoning by, adverse effect of and unde...
- T45 Poisoning by, adverse effect of and unde...
- T46 Poisoning by, adverse effect of and unde...
- T47 Poisoning by, adverse effect of and unde...
- T48 Poisoning by, adverse effect of and unde...
- T49 Poisoning by, adverse effect of and unde...
- T50 Poisoning by, adverse effect of and unde...
The following code(s) above
D89.3 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
- Applicable To annotations, or
- Code Also annotations, or
- Code First annotations, or
- Excludes1 annotations, or
- Excludes2 annotations, or
- Includes annotations, or
- Note annotations, or
- Use Additional annotations
that may be applicable to
D89.3:
- D50-D89
2023 ICD-10-CM Range D50-D89
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanismType 2 Excludes- autoimmune disease (systemic) NOS (M35.9)
- certain conditions originating in the perinatal period (P00-P96)
- complications of pregnancy, childbirth and the puerperium (O00-O9A)
- congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
- endocrine, nutritional and metabolic diseases (E00-E88)
- human immunodeficiency virus [HIV] disease (B20)
- injury, poisoning and certain other consequences of external causes (S00-T88)
- neoplasms (C00-D49)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
- D80-D89
2023 ICD-10-CM Range D80-D89
Certain disorders involving the immune mechanismIncludes- defects in the complement system
- immunodeficiency disorders, except human immunodeficiency virus [HIV] disease
- sarcoidosis
Type 1 Excludes- autoimmune disease (systemic) NOS (M35.9)
- functional disorders of polymorphonuclear neutrophils (D71)
- human immunodeficiency virus [HIV] disease (B20)
- D89
ICD-10-CM Diagnosis Code D89
Other disorders involving the immune mechanism, not elsewhere classified
2016 2017 2018 2019 2020 2021 2022 2023 Non-Billable/Non-Specific Code
Type 1 Excludes- hyperglobulinemia NOS (R77.1)
- monoclonal gammopathy (of undetermined significance) (D47.2)
Type 2 Excludes- transplant failure and rejection (T86.-)
- 814 Reticuloendothelial and immunity disorders with mcc
- 815 Reticuloendothelial and immunity disorders with cc
- 816 Reticuloendothelial and immunity disorders without cc/mcc
Convert D89.3 to ICD-9-CM
Code History
- 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
- 2017 (effective 10/1/2016): No change
- 2018 (effective 10/1/2017): No change
- 2019 (effective 10/1/2018): No change
- 2020 (effective 10/1/2019): No change
- 2021 (effective 10/1/2020): No change
- 2022 (effective 10/1/2021): No change
- 2023 (effective 10/1/2022): No change
- Immune reconstitution D89.3 (inflammatory)
- Syndrome - see also Disease
- immune reconstitution D89.3
- immune reconstitution inflammatory [IRIS] D89.3
ICD-10-CM Codes Adjacent To D89.3
D86.89 Sarcoidosis of other sites
D86.9 Sarcoidosis, unspecified
D89 Other disorders involving the immune mechanism, not elsewhere classified
D89.0 Polyclonal hypergammaglobulinemia
D89.2 Hypergammaglobulinemia, unspecified
D89.3
Immune reconstitution syndrome
D89.4 Mast cell activation syndrome and related disorders
D89.40 Mast cell activation, unspecified
D89.41 Monoclonal mast cell activation syndrome
D89.42 Idiopathic mast cell activation syndrome
D89.43 Secondary mast cell activation
D89.44 Hereditary alpha tryptasemia
D89.49 Other mast cell activation disorder
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified
D89.81 Graft-versus-host disease
D89.810 Acute graft-versus-host disease
Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.
