2022 ICD-10-CM Diagnosis Code D89.44

Hereditary alpha tryptasemia

    2022 - New Code Billable/Specific Code
  • D89.44 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • ICD-10-CM D89.44 is a new 2022 ICD-10-CM code that became effective on October 1, 2021.
  • This is the American ICD-10-CM version of D89.44 - other international versions of ICD-10 D89.44 may differ.
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Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. For such conditions the ICD-10-CM has a coding convention that requires the underlying condition be sequenced first followed by the manifestation. Wherever such a combination exists there is a "use additional code" note at the etiology code, and a "code first" note at the manifestation code. These instructional notes indicate the proper sequencing order of the codes, etiology followed by manifestation. In most cases the manifestation codes will have in the code title, "in diseases classified elsewhere." Codes with this title are a component of the etiology/manifestation convention. The code title indicates that it is a manifestation code. "In diseases classified elsewhere" codes are never permitted to be used as first listed or principle diagnosis codes. They must be used in conjunction with an underlying condition code and they must be listed following the underlying condition.
  • code, if applicable, for:
  • allergy status, other than to drugs and biological substances (
    ICD-10-CM Diagnosis Code Z91.0

    Allergy status, other than to drugs and biological substances

      2016 2017 2018 2019 2020 2021 2022 Non-Billable/Non-Specific Code
    Type 2 Excludes
    • Allergy status to drugs, medicaments, and biological substances (Z88.-)
    Z91.0-
    )
  • personal history of anaphylaxis (
    ICD-10-CM Diagnosis Code Z87.892

    Personal history of anaphylaxis

      2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code POA Exempt
    Code Also
    • allergy status such as:
    • allergy status to drugs, medicaments and biological substances (Z88.-)
    • allergy status, other than to drugs and biological substances (Z91.0-)
    Z87.892
    )
The following code(s) above D89.44 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to D89.44:
  • D50-D89
    2022 ICD-10-CM Range D50-D89

    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

    Type 2 Excludes
    • autoimmune disease (systemic) NOS (M35.9)
    • certain conditions originating in the perinatal period (P00-P96)
    • complications of pregnancy, childbirth and the puerperium (O00-O9A)
    • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
    • endocrine, nutritional and metabolic diseases (E00-E88)
    • human immunodeficiency virus [HIV] disease (B20)
    • injury, poisoning and certain other consequences of external causes (S00-T88)
    • neoplasms (C00-D49)
    • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
  • D80-D89
    2022 ICD-10-CM Range D80-D89

    Certain disorders involving the immune mechanism

    Includes
    • defects in the complement system
    • immunodeficiency disorders, except human immunodeficiency virus [HIV] disease
    • sarcoidosis
    Type 1 Excludes
    • autoimmune disease (systemic) NOS (M35.9)
    • functional disorders of polymorphonuclear neutrophils (D71)
    • human immunodeficiency virus [HIV] disease (B20)
    Certain disorders involving the immune mechanism
  • D89
    ICD-10-CM Diagnosis Code D89

    Other disorders involving the immune mechanism, not elsewhere classified

      2016 2017 2018 2019 2020 2021 2022 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • hyperglobulinemia NOS (R77.1)
    • monoclonal gammopathy (of undetermined significance) (D47.2)
    Type 2 Excludes
    • transplant failure and rejection (T86.-)
    Other disorders involving the immune mechanism, not elsewhere classified
  • D89.4
    ICD-10-CM Diagnosis Code D89.4

    Mast cell activation syndrome and related disorders

      2016 2017 2018 2019 2020 2021 2022 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • aggressive systemic mastocytosis (C96.21)
    • congenital cutaneous mastocytosis (Q82.2)
    • (non-congenital) cutaneous mastocytosis (D47.01)
    • (indolent) systemic mastocytosis (D47.02)
    • malignant mast cell neoplasm (C96.2-)
    • malignant mastocytoma (C96.29)
    • mast cell leukemia (C94.3-)
    • mast cell sarcoma (C96.22)
    • mastocytoma NOS (D47.09)
    • other mast cell neoplasms of uncertain behavior (D47.09)
    • systemic mastocytosis associated with a clonal hematologic non-mast cell lineage disease (SM-AHNMD) (D47.02)
    Mast cell activation syndrome and related disorders
ICD-10-CM D89.44 is grouped within Diagnostic Related Group(s) (MS-DRG v39.0):
  • 814 Reticuloendothelial and immunity disorders with mcc
  • 815 Reticuloendothelial and immunity disorders with cc
  • 816 Reticuloendothelial and immunity disorders without cc/mcc
Code History
  • 2022 (effective 10/1/2021): New code

Diagnosis Index entries containing back-references to D89.44:
  • Hereditary alpha tryptasemia D89.44 (syndrome)
  • Syndrome - see also Disease
    • hereditary alpha tryptasemia D89.44
  • Tryptasemia, hereditary alpha D89.44

ICD-10-CM Codes Adjacent To D89.44
D89 Other disorders involving the immune mechanism, not elsewhere classified
D89.0 Polyclonal hypergammaglobulinemia
D89.1 Cryoglobulinemia
D89.2 Hypergammaglobulinemia, unspecified
D89.3 Immune reconstitution syndrome
D89.4 Mast cell activation syndrome and related disorders
D89.40 Mast cell activation, unspecified
D89.41 Monoclonal mast cell activation syndrome
D89.42 Idiopathic mast cell activation syndrome
D89.43 Secondary mast cell activation
D89.44 Hereditary alpha tryptasemia
D89.49 Other mast cell activation disorder
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified
D89.81 Graft-versus-host disease
D89.810 Acute graft-versus-host disease
D89.811 Chronic graft-versus-host disease
D89.812 Acute on chronic graft-versus-host disease
D89.813 …… unspecified
D89.82 Autoimmune lymphoproliferative syndrome [ALPS]
D89.83 Cytokine release syndrome
D89.831 …… grade 1

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.