1. ICD-10-CM Codes
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2. D50-D89 Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
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3. D80-D89 Certain disorders involving the immune mechanism
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4. D89- Other disorders involving the immune mechanism, not elsewhere classified
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5. 2022 ICD-10-CM Diagnosis Code D89.81

2022 ICD-10-CM Diagnosis Code D89.81

Graft-versus-host disease

2016 2017 2018 2019 2020 2021 2022 Non-Billable/Non-Specific Code

• D89.81 should not be used for reimbursement purposes as there are multiple codes below it that contain a greater level of detail.
• The 2022 edition of ICD-10-CM D89.81 became effective on October 1, 2021.
• This is the American ICD-10-CM version of D89.81 - other international versions of ICD-10 D89.81 may differ.

• A disease caused when cells from a donated stem cell graft attack the normal tissue of the transplant patient. Symptoms include jaundice, skin rash or blisters, a dry mouth, or dry eyes.
• An incompatibility reaction (which may be fatal) in a subject (host) of low immunological competence (deficient lymphoid tissue) who has been the recipient of immunologically competent lymphoid tissue from a donor who lacks at least one antigen possessed by the recipient host; the reaction, or disease, is the result of action of the transplanted cells against those host tissues that possess the antigen not possessed by the donor. Seen most commonly following bone marrow transplantation, acute disease is seen after 5-40 days and chronic disease weeks to months after transplantation, affecting, principally, the gastrointestinal tract, liver, and skin.
• Caused by immunologically competent t cells in the graft recognizing and attacking host tissues as foreign; clinical symptoms include skin rashes, diarrhea, and abnormal liver functions.
• The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the graft vs host reaction.

• 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
• 2017 (effective 10/1/2016): No change
• 2018 (effective 10/1/2017): No change
• 2019 (effective 10/1/2018): No change
• 2020 (effective 10/1/2019): No change
• 2021 (effective 10/1/2020): No change
• 2022 (effective 10/1/2021): No change

• Use Additional: T86
  , M31.11
  , T80.89
  ICD-10-CM Diagnosis Code T86

  Complications of transplanted organs and tissue

  2016 2017 2018 2019 2020 2021 2022 Non-Billable/Non-Specific Code

  Use Additional

  • code to identify other transplant complications, such as:
  • graft-versus-host disease (D89.81-)
  • malignancy associated with organ transplant (C80.2)
  • post-transplant lymphoproliferative disorders (PTLD) (D47.Z1)
  ICD-10-CM Diagnosis Code M31.11

  Hematopoietic stem cell transplantation-associated thrombotic microangiopathy [HSCT-TMA]

  2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code

  Applicable To

  • Transplant-associated thrombotic microangiopathy [TA-TMA]

  Code First

  • if applicable:
  • complications of bone marrow transplant (T86.0-)
  • complications of stem cell transplant (T86.5)

  Use Additional

  • code to identify specific organ dysfunction, such as:
  • acute kidney failure (N17.-)
  • acute respiratory distress syndrome (J80)
  • capillary leak syndrome (I78.8)
  • diffuse alveolar hemorrhage (R04.89)
  • encephalopathy (metabolic) (septic) (G93.41)
  • fluid overload, unspecified (E87.70)
  • graft versus host disease (D89.81-)
  • hemolytic uremic syndrome (D59.3)
  • hepatic failure (K72.-)
  • hepatic veno-occlusive disease (K76.5)
  • idiopathic interstitial pneumonia (J84.11-)
  • sinusoidal obstruction syndrome (K76.5)
  ICD-10-CM Diagnosis Code T80.89

  Other complications following infusion, transfusion and therapeutic injection

  2016 2017 2018 2019 2020 2021 2022 Non-Billable/Non-Specific Code

  Applicable To

  • Delayed serologic transfusion reaction (DSTR), unspecified incompatibility

  Use Additional

  • code to identify graft-versus-host reaction, if applicable, (D89.81-)

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.