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ICD-10-CM Codes
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D50-D89
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
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D80-D89
Certain disorders involving the immune mechanism
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D89-
Other disorders involving the immune mechanism, not elsewhere classified
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2021 ICD-10-CM Diagnosis Code D89.81
2021 ICD-10-CM Diagnosis Code D89.81
Graft-versus-host disease
2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
- D89.81 should not be used for reimbursement purposes as there are multiple codes below it that contain a greater level of detail.
- The 2021 edition of ICD-10-CM D89.81 became effective on October 1, 2020.
- This is the American ICD-10-CM version of D89.81 - other international versions of ICD-10 D89.81 may differ.
Use AdditionalUse Additional Help
Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. For such conditions the ICD-10-CM has a coding convention that requires the underlying condition be sequenced first followed by the manifestation. Wherever such a combination exists there is a "use additional code" note at the etiology code, and a "code first" note at the manifestation code. These instructional notes indicate the proper sequencing order of the codes, etiology followed by manifestation. In most cases the manifestation codes will have in the code title, "in diseases classified elsewhere." Codes with this title are a component of the etiology/manifestation convention. The code title indicates that it is a manifestation code. "In diseases classified elsewhere" codes are never permitted to be used as first listed or principle diagnosis codes. They must be used in conjunction with an underlying condition code and they must be listed following the underlying condition.
- code to identify associated manifestations, such as:
- desquamative dermatitis (
ICD-10-CM Diagnosis Code L30.8
Other specified dermatitis
2016 2017 2018 2019 2020 2021 Billable/Specific Code
- diarrhea (
ICD-10-CM Diagnosis Code R19.7
Diarrhea, unspecified
2016 2017 2018 2019 2020 2021 Billable/Specific Code
Type 1 Excludes- functional diarrhea (K59.1)
- neonatal diarrhea (P78.3)
- psychogenic diarrhea (F45.8)
- elevated bilirubin (
ICD-10-CM Diagnosis Code R17
Unspecified jaundice
2016 2017 2018 2019 2020 2021 Billable/Specific Code
- hair loss (
ICD-10-CM Diagnosis Code L65.9
Nonscarring hair loss, unspecified
2016 2017 2018 2019 2020 2021 Billable/Specific Code
Code FirstCode First Help
Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. For such conditions, ICD-10-CM has a coding convention that requires the underlying condition be sequenced first followed by the manifestation. Wherever such a combination exists there is a "use additional code" note at the etiology code, and a "code first" note at the manifestation code. These instructional notes indicate the proper sequencing order of the codes, etiology followed by manifestation. In most cases the manifestation codes will have in the code title, "in diseases classified elsewhere." Codes with this title are a component of the etiology/manifestation convention. The code title indicates that it is a manifestation code. "In diseases classified elsewhere" codes are never permitted to be used as first listed or principle diagnosis codes. They must be used in conjunction with an underlying condition code and they must be listed following the underlying condition.
The following code(s) above
D89.81 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
- Applicable To annotations, or
- Code Also annotations, or
- Code First annotations, or
- Excludes1 annotations, or
- Excludes2 annotations, or
- Includes annotations, or
- Note annotations, or
- Use Additional annotations
that may be applicable to
D89.81:
- D50-D89
2021 ICD-10-CM Range D50-D89
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanismType 2 Excludes- autoimmune disease (systemic) NOS (M35.9)
- certain conditions originating in the perinatal period (P00-P96)
- complications of pregnancy, childbirth and the puerperium (O00-O9A)
- congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
- endocrine, nutritional and metabolic diseases (E00-E88)
- human immunodeficiency virus [HIV] disease (B20)
- injury, poisoning and certain other consequences of external causes (S00-T88)
- neoplasms (C00-D49)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
- D80-D89
2021 ICD-10-CM Range D80-D89
Certain disorders involving the immune mechanismIncludes- defects in the complement system
- immunodeficiency disorders, except human immunodeficiency virus [HIV] disease
- sarcoidosis
Type 1 Excludes- autoimmune disease (systemic) NOS (M35.9)
- functional disorders of polymorphonuclear neutrophils (D71)
- human immunodeficiency virus [HIV] disease (B20)
- D89
ICD-10-CM Diagnosis Code D89
Other disorders involving the immune mechanism, not elsewhere classified
2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
Type 1 Excludes- hyperglobulinemia NOS (R77.1)
- monoclonal gammopathy (of undetermined significance) (D47.2)
Type 2 Excludes- transplant failure and rejection (T86.-)
- A disease caused when cells from a donated stem cell graft attack the normal tissue of the transplant patient. Symptoms include jaundice, skin rash or blisters, a dry mouth, or dry eyes.
- An incompatibility reaction (which may be fatal) in a subject (host) of low immunological competence (deficient lymphoid tissue) who has been the recipient of immunologically competent lymphoid tissue from a donor who lacks at least one antigen possessed by the recipient host; the reaction, or disease, is the result of action of the transplanted cells against those host tissues that possess the antigen not possessed by the donor. Seen most commonly following bone marrow transplantation, acute disease is seen after 5-40 days and chronic disease weeks to months after transplantation, affecting, principally, the gastrointestinal tract, liver, and skin.
- Caused by immunologically competent t cells in the graft recognizing and attacking host tissues as foreign; clinical symptoms include skin rashes, diarrhea, and abnormal liver functions.
- The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the graft vs host reaction.
Code History
- 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
- 2017 (effective 10/1/2016): No change
- 2018 (effective 10/1/2017): No change
- 2019 (effective 10/1/2018): No change
- 2020 (effective 10/1/2019): No change
- 2021 (effective 10/1/2020): No change
Code annotations containing back-references to D89.81:
ICD-10-CM Codes Adjacent To D89.81
D89.2 Hypergammaglobulinemia, unspecified
D89.3 Immune reconstitution syndrome
D89.4 Mast cell activation syndrome and related disorders
D89.40 Mast cell activation, unspecified
D89.41 Monoclonal mast cell activation syndrome
D89.42 Idiopathic mast cell activation syndrome
D89.43 Secondary mast cell activation
D89.49 Other mast cell activation disorder
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified
D89.81
Graft-versus-host disease
D89.810 Acute graft-versus-host disease
D89.811 Chronic graft-versus-host disease
D89.812 Acute on chronic graft-versus-host disease
D89.82 Autoimmune lymphoproliferative syndrome [ALPS]
D89.83 Cytokine release syndrome
Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.
