2020 ICD-10-CM Diagnosis Code D89.82

Autoimmune lymphoproliferative syndrome [ALPS]

    2016 2017 2018 2019 2020 Billable/Specific Code
  • D89.82 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2020 edition of ICD-10-CM D89.82 became effective on October 1, 2019.
  • This is the American ICD-10-CM version of D89.82 - other international versions of ICD-10 D89.82 may differ.
The following code(s) above D89.82 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to D89.82:
  • D50-D89
    2020 ICD-10-CM Range D50-D89

    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

    Type 2 Excludes
    • autoimmune disease (systemic) NOS (M35.9)
    • certain conditions originating in the perinatal period (P00-P96)
    • complications of pregnancy, childbirth and the puerperium (O00-O9A)
    • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
    • endocrine, nutritional and metabolic diseases (E00-E88)
    • human immunodeficiency virus [HIV] disease (B20)
    • injury, poisoning and certain other consequences of external causes (S00-T88)
    • neoplasms (C00-D49)
    • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
  • D80-D89
    2020 ICD-10-CM Range D80-D89

    Certain disorders involving the immune mechanism

    • defects in the complement system
    • immunodeficiency disorders, except human immunodeficiency virus [HIV] disease
    • sarcoidosis
    Type 1 Excludes
    • autoimmune disease (systemic) NOS (M35.9)
    • functional disorders of polymorphonuclear neutrophils (D71)
    • human immunodeficiency virus [HIV] disease (B20)
    Certain disorders involving the immune mechanism
  • D89
    ICD-10-CM Diagnosis Code D89

    Other disorders involving the immune mechanism, not elsewhere classified

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • hyperglobulinemia NOS (R77.1)
    • monoclonal gammopathy (of undetermined significance) (D47.2)
    Type 2 Excludes
    • transplant failure and rejection (T86.-)
    Other disorders involving the immune mechanism, not elsewhere classified
Approximate Synonyms
  • Autoimmune lymphoproliferative syndrome
Clinical Information
  • An autoimmune hematologic disorder characterized by autoimmune hemolytic anemia, thrombocytopenia, lymphadenopathy, hepatomegaly and splenomegaly. Patients are at an increased risk of developing hodgkin and non-hodgkin lymphomas.
  • Rare congenital lymphoid disorder due to mutations in certain fas-fas ligand pathway genes. Known causes include mutations in fas, tnfsf6, nras, casp8, and casp10 proteins. Clinical features include lymphadenopathy; splenomegaly; and autoimmunity.
ICD-10-CM D89.82 is grouped within Diagnostic Related Group(s) (MS-DRG v37.0):
  • 545 Connective tissue disorders with mcc
  • 546 Connective tissue disorders with cc
  • 547 Connective tissue disorders without cc/mcc

Convert D89.82 to ICD-9-CM

Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change

Diagnosis Index entries containing back-references to D89.82:
  • Autoimmune
    • lymphoproliferative syndrome [ALPS] D89.82
  • Syndrome - see also Disease
    • autoimmune lymphoproliferative [ALPS] D89.82

ICD-10-CM Codes Adjacent To D89.82
D89.41 Monoclonal mast cell activation syndrome
D89.42 Idiopathic mast cell activation syndrome
D89.43 Secondary mast cell activation
D89.49 Other mast cell activation disorder
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified
D89.81 Graft-versus-host disease
D89.810 Acute graft-versus-host disease
D89.811 Chronic graft-versus-host disease
D89.812 Acute on chronic graft-versus-host disease
D89.813 …… unspecified
D89.82 Autoimmune lymphoproliferative syndrome [ALPS]
D89.89 Other specified disorders involving the immune mechanism, not elsewhere classified
D89.9 Disorder involving the immune mechanism, unspecified
E00 Congenital iodine-deficiency syndrome
E00.0 Congenital iodine-deficiency syndrome, neurological type
E00.1 Congenital iodine-deficiency syndrome, myxedematous type
E00.2 Congenital iodine-deficiency syndrome, mixed type
E00.9 Congenital iodine-deficiency syndrome, unspecified
E01 Iodine-deficiency related thyroid disorders and allied conditions
E01.0 Iodine-deficiency related diffuse (endemic) goiter
E01.1 Iodine-deficiency related multinodular (endemic) goiter

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.