2021 ICD-10-CM Diagnosis Code D89.839

Cytokine release syndrome, grade unspecified

    2021 - New Code Billable/Specific Code
  • D89.839 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • ICD-10-CM D89.839 is a new 2021 ICD-10-CM code that became effective on October 1, 2020.
  • This is the American ICD-10-CM version of D89.839 - other international versions of ICD-10 D89.839 may differ.
The following code(s) above D89.839 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to D89.839:
  • D50-D89
    2021 ICD-10-CM Range D50-D89

    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

    Type 2 Excludes
    • autoimmune disease (systemic) NOS (M35.9)
    • certain conditions originating in the perinatal period (P00-P96)
    • complications of pregnancy, childbirth and the puerperium (O00-O9A)
    • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
    • endocrine, nutritional and metabolic diseases (E00-E88)
    • human immunodeficiency virus [HIV] disease (B20)
    • injury, poisoning and certain other consequences of external causes (S00-T88)
    • neoplasms (C00-D49)
    • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
    Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
  • D80-D89
    2021 ICD-10-CM Range D80-D89

    Certain disorders involving the immune mechanism

    • defects in the complement system
    • immunodeficiency disorders, except human immunodeficiency virus [HIV] disease
    • sarcoidosis
    Type 1 Excludes
    • autoimmune disease (systemic) NOS (M35.9)
    • functional disorders of polymorphonuclear neutrophils (D71)
    • human immunodeficiency virus [HIV] disease (B20)
    Certain disorders involving the immune mechanism
  • D89
    ICD-10-CM Diagnosis Code D89

    Other disorders involving the immune mechanism, not elsewhere classified

      2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • hyperglobulinemia NOS (R77.1)
    • monoclonal gammopathy (of undetermined significance) (D47.2)
    Type 2 Excludes
    • transplant failure and rejection (T86.-)
    Other disorders involving the immune mechanism, not elsewhere classified
  • D89.83
    ICD-10-CM Diagnosis Code D89.83

    Cytokine release syndrome

      2021 - New Code Non-Billable/Non-Specific Code
    Code First
    • underlying cause, such as:
    • complications following infusion, transfusion and therapeutic injection (T80.89-)
    • complications of transplanted organs and tissue (T86.-)
    Use Additional
    • code to identify associated manifestations
    Cytokine release syndrome
ICD-10-CM D89.839 is grouped within Diagnostic Related Group(s) (MS-DRG v38.0):
  • 814 Reticuloendothelial and immunity disorders with mcc
  • 815 Reticuloendothelial and immunity disorders with cc
  • 816 Reticuloendothelial and immunity disorders without cc/mcc
Code History
  • 2021 (effective 10/1/2020): New code

Diagnosis Index entries containing back-references to D89.839:

ICD-10-CM Codes Adjacent To D89.839
D89.811 Chronic graft-versus-host disease
D89.812 Acute on chronic graft-versus-host disease
D89.813 …… unspecified
D89.82 Autoimmune lymphoproliferative syndrome [ALPS]
D89.83 Cytokine release syndrome
D89.831 …… grade 1
D89.832 …… grade 2
D89.833 …… grade 3
D89.834 …… grade 4
D89.835 …… grade 5
D89.839 …… grade unspecified
D89.89 Other specified disorders involving the immune mechanism, not elsewhere classified
D89.9 Disorder involving the immune mechanism, unspecified
E00 Congenital iodine-deficiency syndrome
E00.0 Congenital iodine-deficiency syndrome, neurological type
E00.1 Congenital iodine-deficiency syndrome, myxedematous type
E00.2 Congenital iodine-deficiency syndrome, mixed type
E00.9 Congenital iodine-deficiency syndrome, unspecified
E01 Iodine-deficiency related thyroid disorders and allied conditions
E01.0 Iodine-deficiency related diffuse (endemic) goiter
E01.1 Iodine-deficiency related multinodular (endemic) goiter

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.