2021 ICD-10-CM Diagnosis Code E05.0

Thyrotoxicosis with diffuse goiter

    2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
  • E05.0 should not be used for reimbursement purposes as there are multiple codes below it that contain a greater level of detail.
  • The 2021 edition of ICD-10-CM E05.0 became effective on October 1, 2020.
  • This is the American ICD-10-CM version of E05.0 - other international versions of ICD-10 E05.0 may differ.
Applicable To
  • Exophthalmic or toxic goiter NOS
  • Graves' disease
  • Toxic diffuse goiter
The following code(s) above E05.0 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to E05.0:
  • E00-E89
    2021 ICD-10-CM Range E00-E89

    Endocrine, nutritional and metabolic diseases

    • All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
    Type 1 Excludes
    • transitory endocrine and metabolic disorders specific to newborn (P70-P74)
    Endocrine, nutritional and metabolic diseases
  • E05
    ICD-10-CM Diagnosis Code E05

    Thyrotoxicosis [hyperthyroidism]

      2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • chronic thyroiditis with transient thyrotoxicosis (E06.2)
    • neonatal thyrotoxicosis (P72.1)
    Thyrotoxicosis [hyperthyroidism]
Clinical Information
  • A common form of hyperthyroidism with a diffuse hyperplastic goiter. It is an autoimmune disorder that produces antibodies against the thyroid stimulating hormone receptor. These autoantibodies activate the tsh receptor, thereby stimulating the thyroid gland and hypersecretion of thyroid hormones. These autoantibodies can also affect the eyes (graves ophthalmopathy) and the skin (graves dermopathy).
  • A condition usually caused by excessive production of thyroid hormone and characterized by an enlarged thyroid gland
  • Exophthalmos occurring in association with goiter; hyperthyroidism with protrusion of the eyeballs.
  • Hyperthyroidism associated with diffuse hyperplasia of the thyroid gland (goiter), resulting from production of antibodies that are directed against the thyrotropin receptor complex of the follicular epithelial cells. As a result, the thyroid gland enlarges and secrets increased amounts of thyroid hormones.
Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change
Code annotations containing back-references to E05.0:
  • Code First: I43
    ICD-10-CM Diagnosis Code I43

    Cardiomyopathy in diseases classified elsewhere

      2016 2017 2018 2019 2020 2021 Billable/Specific Code Manifestation Code
    Code First
    Type 1 Excludes
ICD-10-CM Codes Adjacent To E05.0
E03.5 Myxedema coma
E03.8 Other specified hypothyroidism
E03.9 Hypothyroidism, unspecified
E04 Other nontoxic goiter
E04.0 Nontoxic diffuse goiter
E04.1 Nontoxic single thyroid nodule
E04.2 Nontoxic multinodular goiter
E04.8 Other specified nontoxic goiter
E04.9 Nontoxic goiter, unspecified
E05 Thyrotoxicosis [hyperthyroidism]
E05.0 Thyrotoxicosis with diffuse goiter
E05.00 …… without thyrotoxic crisis or storm
E05.01 …… with thyrotoxic crisis or storm
E05.1 Thyrotoxicosis with toxic single thyroid nodule
E05.10 …… without thyrotoxic crisis or storm
E05.11 …… with thyrotoxic crisis or storm
E05.2 Thyrotoxicosis with toxic multinodular goiter
E05.20 …… without thyrotoxic crisis or storm
E05.21 …… with thyrotoxic crisis or storm
E05.3 Thyrotoxicosis from ectopic thyroid tissue
E05.30 …… without thyrotoxic crisis or storm

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.