2019 ICD-10-CM Diagnosis Code E16.1

Other hypoglycemia

    2016 2017 2018 2019 Billable/Specific Code
  • E16.1 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2019 edition of ICD-10-CM E16.1 became effective on October 1, 2018.
  • This is the American ICD-10-CM version of E16.1 - other international versions of ICD-10 E16.1 may differ.
Applicable To
  • Functional hyperinsulinism
  • Functional nonhyperinsulinemic hypoglycemia
  • Hyperinsulinism NOS
  • Hyperplasia of pancreatic islet beta cells NOS
Type 1 Excludes
Type 1 Excludes Help
A type 1 excludes note is a pure excludes. It means "not coded here". A type 1 excludes note indicates that the code excluded should never be used at the same time as E16.1. A type 1 excludes note is for used for when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • diabetes with hypoglycemia (
    ICD-10-CM Diagnosis Code E08.649

    Diabetes mellitus due to underlying condition with hypoglycemia without coma

      2016 2017 2018 2019 Billable/Specific Code Manifestation Code
    E08.649
    ,
    ICD-10-CM Diagnosis Code E10.649

    Type 1 diabetes mellitus with hypoglycemia without coma

      2016 2017 2018 2019 Billable/Specific Code
    E10.649
    ,
    ICD-10-CM Diagnosis Code E11.649

    Type 2 diabetes mellitus with hypoglycemia without coma

      2016 2017 2018 2019 Billable/Specific Code
    E11.649
    ,
    ICD-10-CM Diagnosis Code E13.649

    Other specified diabetes mellitus with hypoglycemia without coma

      2016 2017 2018 2019 Billable/Specific Code
    E13.649
    )
  • hypoglycemia in infant of diabetic mother (
    ICD-10-CM Diagnosis Code P70.1

    Syndrome of infant of a diabetic mother

      2016 2017 2018 2019 Billable/Specific Code Code on Newborn Record
    Applicable To
    • Newborn (with hypoglycemia) affected by maternal (pre-existing) diabetes mellitus
    Type 1 Excludes
    • newborn (with hypoglycemia) affected by maternal gestational diabetes (P70.0)
    • syndrome of infant of mother with gestational diabetes (P70.0)
    P70.1
    )
  • neonatal hypoglycemia (
    ICD-10-CM Diagnosis Code P70.4

    Other neonatal hypoglycemia

      2016 2017 2018 2019 Billable/Specific Code Code on Newborn Record
    Applicable To
    • Transitory neonatal hypoglycemia
    P70.4
    )
The following code(s) above E16.1 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to E16.1:
  • E00-E89
    2019 ICD-10-CM Range E00-E89

    Endocrine, nutritional and metabolic diseases

    Note
    • All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
    Type 1 Excludes
    • transitory endocrine and metabolic disorders specific to newborn (P70-P74)
    Endocrine, nutritional and metabolic diseases
Approximate Synonyms
  • Hyperinsulinism
  • Hyperinsulinism, iatrogenic
  • Hyperplasia of pancreatic islet beta cell
  • Hypoglycemia (low blood sugar), reactive
  • Iatrogenic hyperinsulinism
  • Reactive hypoglycemia
Clinical Information
  • A syndrome with excessively high insulin levels in the blood. It may cause hypoglycemia. Etiology of hyperinsulinism varies, including hypersecretion of a beta cell tumor (insulinoma); autoantibodies against insulin (insulin antibodies); defective insulin receptor (insulin resistance); or overuse of exogenous insulin or hypoglycemic agents.
  • Syndrome with excessively high insulin levels in the blood; it may cause hypoglycemia; etiology of hyperinsulinism varies, including hypersecretion of a beta cell tumor, autoantibodies against insulin, defective insulin receptor, or overuse of exogeneous insulin or hypoglycemic agents.
ICD-10-CM E16.1 is grouped within Diagnostic Related Group(s) (MS-DRG v36.0):
  • 643 Endocrine disorders with mcc
  • 644 Endocrine disorders with cc
  • 645 Endocrine disorders without cc/mcc

Convert E16.1 to ICD-9-CM

Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change

Diagnosis Index entries containing back-references to E16.1:
  • Encephalopathy (acute) G93.40
    ICD-10-CM Diagnosis Code G93.40

    Encephalopathy, unspecified

      2016 2017 2018 2019 Billable/Specific Code
    • in (due to) (with)
      • hyperinsulinism E16.1
    • posthypoglycemic E16.1 (coma)
  • Hyperinsulinism (functional) E16.1
    • with
      • encephalopathy E16.1
    • ectopic E16.1
  • Hyperplasia, hyperplastic
    • pancreatic islet cells E16.9
      ICD-10-CM Diagnosis Code E16.9

      Disorder of pancreatic internal secretion, unspecified

        2016 2017 2018 2019 Billable/Specific Code
      Applicable To
      • Islet-cell hyperplasia NOS
      • Pancreatic endocrine cell hyperplasia NOS
      • beta E16.1
  • Hypoglycemia (spontaneous) E16.2
    ICD-10-CM Diagnosis Code E16.2

    Hypoglycemia, unspecified

      2016 2017 2018 2019 Billable/Specific Code
    Type 1 Excludes
    • functional, nonhyperinsulinemic E16.1
    • infantile E16.1
    • reactive E16.1 (not drug-induced)

ICD-10-CM Codes Adjacent To E16.1
E13.64 Other specified diabetes mellitus with hypoglycemia
E13.641 …… with coma
E13.649 …… without coma
E13.65 Other specified diabetes mellitus with hyperglycemia
E13.69 Other specified diabetes mellitus with other specified complication
E13.8 Other specified diabetes mellitus with unspecified complications
E13.9 Other specified diabetes mellitus without complications
E15 Nondiabetic hypoglycemic coma
E16 Other disorders of pancreatic internal secretion
E16.0 Drug-induced hypoglycemia without coma
E16.1 Other hypoglycemia
E16.2 Hypoglycemia, unspecified
E16.3 Increased secretion of glucagon
E16.4 Increased secretion of gastrin
E16.8 Other specified disorders of pancreatic internal secretion
E16.9 Disorder of pancreatic internal secretion, unspecified
E20 Hypoparathyroidism
E20.0 Idiopathic hypoparathyroidism
E20.1 Pseudohypoparathyroidism
E20.8 Other hypoparathyroidism
E20.9 Hypoparathyroidism, unspecified

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.