1. ICD-10-CM Codes
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2. E00-E89 Endocrine, nutritional and metabolic diseases
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3. E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
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4. E16- Other disorders of pancreatic internal secretion
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5. 2022 ICD-10-CM Diagnosis Code E16.4

2022 ICD-10-CM Diagnosis Code E16.4

Increased secretion of gastrin

2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code

• E16.4 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
• The 2022 edition of ICD-10-CM E16.4 became effective on October 1, 2021.
• This is the American ICD-10-CM version of E16.4 - other international versions of ICD-10 E16.4 may differ.

• Hypergastrinemia
• Increased gastrin secretion

• A disorder in which tumors of the pancreatic islet cells produce large amounts of gastrin (a hormone), leading to excess acid in the stomach and, possibly, a peptic ulcer (ulcer of the stomach or the upper part of the small intestine).
• A syndrome characterized by the presence of a gastrin-secreting tumor, usually in the pancreas or duodenum, resulting in increased gastric acidity and formation of gastric ulcers. Signs and symptoms include abdominal pain and diarrhea. It may be sporadic or a manifestation of multiple endocrine neoplasia type 1.
• A syndrome that is characterized by the triad of severe peptic ulcer, hypersecretion of gastric acid, and gastrin-producing tumors of the pancreas or other tissue (gastrinoma). This syndrome may be sporadic or be associated with multiple endocrine neoplasia type 1.
• Triad comprising intractable, sometimes fulminating atypical ulcers, extremely elevated gastic acidity, and gastrin secreting non beta islet cell tumors.

• 380 Complicated peptic ulcer with mcc
• 381 Complicated peptic ulcer with cc
• 382 Complicated peptic ulcer without cc/mcc

Convert E16.4 to ICD-9-CM

• 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
• 2017 (effective 10/1/2016): No change
• 2018 (effective 10/1/2017): No change
• 2019 (effective 10/1/2018): No change
• 2020 (effective 10/1/2019): No change
• 2021 (effective 10/1/2020): No change
• 2022 (effective 10/1/2021): No change

• Type 1 Excludes: K29
  ICD-10-CM Diagnosis Code K29

  Gastritis and duodenitis

  2016 2017 2018 2019 2020 2021 2022 Non-Billable/Non-Specific Code

  Type 1 Excludes

  • eosinophilic gastritis or gastroenteritis (K52.81)
  • Zollinger-Ellison syndrome (E16.4)

• Abnormal, abnormality, abnormalities - see also Anomaly
  • secretion
    • gastrin E16.4
  • gastrin secretion E16.4
• Ellison-Zollinger syndrome E16.4
• Hypergastrinemia E16.4
• Hyperplasia, hyperplastic
  • pancreatic islet cells E16.9
    ICD-10-CM Diagnosis Code E16.9

    Disorder of pancreatic internal secretion, unspecified

    2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code

    Applicable To

    • Islet-cell hyperplasia NOS
    • Pancreatic endocrine cell hyperplasia NOS
    • alpha E16.8
      ICD-10-CM Diagnosis Code E16.8

      Other specified disorders of pancreatic internal secretion

      2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code

      Applicable To

      • Increased secretion from endocrine pancreas of growth hormone-releasing hormone
      • Increased secretion from endocrine pancreas of pancreatic polypeptide
      • Increased secretion from endocrine pancreas of somatostatin
      • Increased secretion from endocrine pancreas of vasoactive-intestinal polypeptide
      • with excess
        • gastrin E16.4
• Hypersecretion
  • gastrin E16.4
• Increase, increased
  • secretion
    • gastrin E16.4
• Zollinger-Ellison syndrome E16.4

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.