2020 ICD-10-CM Diagnosis Code E16.4

Increased secretion of gastrin

    2016 2017 2018 2019 2020 Billable/Specific Code
  • E16.4 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2020 edition of ICD-10-CM E16.4 became effective on October 1, 2019.
  • This is the American ICD-10-CM version of E16.4 - other international versions of ICD-10 E16.4 may differ.
Applicable To
  • Hypergastrinemia
  • Hyperplasia of pancreatic endocrine cells with gastrin excess
  • Zollinger-Ellison syndrome
The following code(s) above E16.4 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to E16.4:
  • E00-E89
    2020 ICD-10-CM Range E00-E89

    Endocrine, nutritional and metabolic diseases

    Note
    • All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
    Type 1 Excludes
    • transitory endocrine and metabolic disorders specific to newborn (P70-P74)
    Endocrine, nutritional and metabolic diseases
Approximate Synonyms
  • Hypergastrinemia
  • Increased gastrin secretion
Clinical Information
  • A disorder in which tumors of the pancreatic islet cells produce large amounts of gastrin (a hormone), leading to excess acid in the stomach and, possibly, a peptic ulcer (ulcer of the stomach or the upper part of the small intestine).
  • A syndrome characterized by the presence of a gastrin-secreting tumor, usually in the pancreas or duodenum, resulting in increased gastric acidity and formation of gastric ulcers. Signs and symptoms include abdominal pain and diarrhea. It may be sporadic or a manifestation of multiple endocrine neoplasia type 1.
  • A syndrome that is characterized by the triad of severe peptic ulcer, hypersecretion of gastric acid, and gastrin-producing tumors of the pancreas or other tissue (gastrinoma). This syndrome may be sporadic or be associated with multiple endocrine neoplasia type 1.
  • Triad comprising intractable, sometimes fulminating atypical ulcers, extremely elevated gastic acidity, and gastrin secreting non beta islet cell tumors.
ICD-10-CM E16.4 is grouped within Diagnostic Related Group(s) (MS-DRG v37.0):
  • 380 Complicated peptic ulcer with mcc
  • 381 Complicated peptic ulcer with cc
  • 382 Complicated peptic ulcer without cc/mcc

Convert E16.4 to ICD-9-CM

Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
Code annotations containing back-references to E16.4:
  • Type 1 Excludes: K29
    ICD-10-CM Diagnosis Code K29

    Gastritis and duodenitis

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • eosinophilic gastritis or gastroenteritis (K52.81)
    • Zollinger-Ellison syndrome (E16.4)

Diagnosis Index entries containing back-references to E16.4:
  • Abnormal, abnormality, abnormalities - see also Anomaly
    • secretion
      • gastrin E16.4
    • gastrin secretion E16.4
  • Ellison-Zollinger syndrome E16.4
  • Hypergastrinemia E16.4
  • Hyperplasia, hyperplastic
    • pancreatic islet cells E16.9
      ICD-10-CM Diagnosis Code E16.9

      Disorder of pancreatic internal secretion, unspecified

        2016 2017 2018 2019 2020 Billable/Specific Code
      Applicable To
      • Islet-cell hyperplasia NOS
      • Pancreatic endocrine cell hyperplasia NOS
      • alpha E16.8
        ICD-10-CM Diagnosis Code E16.8

        Other specified disorders of pancreatic internal secretion

          2016 2017 2018 2019 2020 Billable/Specific Code
        Applicable To
        • Increased secretion from endocrine pancreas of growth hormone-releasing hormone
        • Increased secretion from endocrine pancreas of pancreatic polypeptide
        • Increased secretion from endocrine pancreas of somatostatin
        • Increased secretion from endocrine pancreas of vasoactive-intestinal polypeptide
  • Hypersecretion
    • gastrin E16.4
  • Increase, increased
  • Zollinger-Ellison syndrome E16.4

ICD-10-CM Codes Adjacent To E16.4
E13.65 Other specified diabetes mellitus with hyperglycemia
E13.69 Other specified diabetes mellitus with other specified complication
E13.8 Other specified diabetes mellitus with unspecified complications
E13.9 Other specified diabetes mellitus without complications
E15 Nondiabetic hypoglycemic coma
E16 Other disorders of pancreatic internal secretion
E16.0 Drug-induced hypoglycemia without coma
E16.1 Other hypoglycemia
E16.2 Hypoglycemia, unspecified
E16.3 Increased secretion of glucagon
E16.4 Increased secretion of gastrin
E16.8 Other specified disorders of pancreatic internal secretion
E16.9 Disorder of pancreatic internal secretion, unspecified
E20 Hypoparathyroidism
E20.0 Idiopathic hypoparathyroidism
E20.1 Pseudohypoparathyroidism
E20.8 Other hypoparathyroidism
E20.9 Hypoparathyroidism, unspecified
E21 Hyperparathyroidism and other disorders of parathyroid gland
E21.0 Primary hyperparathyroidism
E21.1 Secondary hyperparathyroidism, not elsewhere classified

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.