1. ICD-10-CM Codes
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2. E00-E89
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3. E20-E35
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4. E21-
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5. 2023 ICD-10-CM Diagnosis Code E21.0

2023 ICD-10-CM Diagnosis Code E21.0

Primary hyperparathyroidism

2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code

• E21.0 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
• The 2023 edition of ICD-10-CM E21.0 became effective on October 1, 2022.
• This is the American ICD-10-CM version of E21.0 - other international versions of ICD-10 E21.0 may differ.

• Hyperparathyroidism, primary
• Parathyroid hyperplasia

• A condition of abnormally elevated output of parathyroid hormone due to parathyroid hyperplasia or parathyroid neoplasms. It is characterized by the combination of hypercalcemia, phosphaturia, elevated renal 1,25-dihydroxyvitamin d3 synthesis, and increased bone resorption.
• Abnormal increase in the number of otherwise normal cells in the parathyroid gland without tumor formation that leading to enlargement of the gland; it differs from hypertrophy, which is an increase in bulk without an increase in the number of cells.
• Hyperfunction of the parathyroid glands resulting in the overproduction of parathyroid hormone. It is caused by parathyroid adenoma, parathyroid hyperplasia, parathyroid carcinoma, and multiple endocrine neoplasia. It is associated with hypercalcemia and hypophosphatemia. Signs and symptoms include weakness, fatigue, nausea, vomiting, constipation, depression, bone pain, osteoporosis, cystic bone lesions, and kidney stones.

• 643 Endocrine disorders with mcc
• 644 Endocrine disorders with cc
• 645 Endocrine disorders without cc/mcc

Convert E21.0 to ICD-9-CM

• 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
• 2017 (effective 10/1/2016): No change
• 2018 (effective 10/1/2017): No change
• 2019 (effective 10/1/2018): No change
• 2020 (effective 10/1/2019): No change
• 2021 (effective 10/1/2020): No change
• 2022 (effective 10/1/2021): No change
• 2023 (effective 10/1/2022): No change

• Code First: M49
  , G73.7
  ICD-10-CM Diagnosis Code M49

  Spondylopathies in diseases classified elsewhere

  2016 2017 2018 2019 2020 2021 2022 2023 Non-Billable/Non-Specific Code

  Code First

  • underlying disease, such as:
  • brucellosis (A23.-)
  • Charcot-Marie-Tooth disease (G60.0)
  • enterobacterial infections (A01-A04)
  • osteitis fibrosa cystica (E21.0)

  Includes

  • curvature of spine in diseases classified elsewhere
  • deformity of spine in diseases classified elsewhere
  • kyphosis in diseases classified elsewhere
  • scoliosis in diseases classified elsewhere
  • spondylopathy in diseases classified elsewhere

  Type 1 Excludes

  • curvature of spine in tuberculosis [Pott's] (A18.01)
  • enteropathic arthropathies (M07.-)
  • gonococcal spondylitis (A54.41)
  • neuropathic [tabes dorsalis] spondylitis (A52.11)
  • neuropathic spondylopathy in syringomyelia (G95.0)
  • neuropathic spondylopathy in tabes dorsalis (A52.11)
  • nonsyphilitic neuropathic spondylopathy NEC (G98.0)
  • spondylitis in syphilis (acquired) (A52.77)
  • tuberculous spondylitis (A18.01)
  • typhoid fever spondylitis (A01.05)
  ICD-10-CM Diagnosis Code G73.7

  Myopathy in diseases classified elsewhere

  2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code Manifestation Code

  Code First

  • underlying disease, such as:
  • hyperparathyroidism (E21.0, E21.3)
  • hypoparathyroidism (E20.-)
  • glycogen storage disease (E74.0)
  • lipid storage disorders (E75.-)

  Type 1 Excludes

  • myopathy in:
  • rheumatoid arthritis (M05.32)
  • sarcoidosis (D86.87)
  • scleroderma (M34.82)
  • Sjögren syndrome (M35.03)
  • systemic lupus erythematosus (M32.19)
• Type 1 Excludes: M85.6
  , E83.5
  ICD-10-CM Diagnosis Code M85.6

  Other cyst of bone

  2016 2017 2018 2019 2020 2021 2022 2023 Non-Billable/Non-Specific Code

  Type 1 Excludes

  • cyst of jaw NEC (M27.4)
  • osteitis fibrosa cystica generalisata [von Recklinghausen's disease of bone] (E21.0)
  ICD-10-CM Diagnosis Code E83.5

  Disorders of calcium metabolism

  2016 2017 2018 2019 2020 2021 2022 2023 Non-Billable/Non-Specific Code

  Type 1 Excludes

  • chondrocalcinosis (M11.1-M11.2)
  • hungry bone syndrome (E83.81)
  • hyperparathyroidism (E21.0-E21.3)

• Curvature
  • spine (acquired) (angular) (idiopathic) (incorrect) (postural) - see Dorsopathy, deforming
    • due to or associated with
      • osteitis
        • fibrosa cystica E21.0 - see also subcategory M49.8
• Disease, diseased - see also Syndrome
  • osteofibrocystic E21.0
• Enlargement, enlarged - see also Hypertrophy
  • parathyroid E21.0 (gland)
• Hyperparathyroidism E21.3
  ICD-10-CM Diagnosis Code E21.3

  Hyperparathyroidism, unspecified

  2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
  • primary E21.0
• Hyperplasia, hyperplastic
  • parathyroid E21.0 (gland)
• Hypertrophy, hypertrophic
  • parathyroid E21.0 (gland)
• Osteitis - see also Osteomyelitis
  • fibrosa NEC - see Cyst, bone, by site
    • cystica E21.0 (generalisata)
    • osteoplastica E21.0
  • parathyroid E21.0
• Recklinghausen disease Q85.01
  ICD-10-CM Diagnosis Code Q85.01

  Neurofibromatosis, type 1

  2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code POA Exempt

  Applicable To

  • Von Recklinghausen disease
  • bones E21.0
• Von Recklinghausen
  • disease (neurofibromatosis) Q85.01
    ICD-10-CM Diagnosis Code Q85.01

    Neurofibromatosis, type 1

    2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code POA Exempt

    Applicable To

    • Von Recklinghausen disease
    • bones E21.0

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.