2020 ICD-10-CM Diagnosis Code E21.3

Hyperparathyroidism, unspecified

    2016 2017 2018 2019 2020 Billable/Specific Code
  • E21.3 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2020 edition of ICD-10-CM E21.3 became effective on October 1, 2019.
  • This is the American ICD-10-CM version of E21.3 - other international versions of ICD-10 E21.3 may differ.
The following code(s) above E21.3 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to E21.3:
  • E00-E89
    2020 ICD-10-CM Range E00-E89

    Endocrine, nutritional and metabolic diseases

    Note
    • All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
    Type 1 Excludes
    • transitory endocrine and metabolic disorders specific to newborn (P70-P74)
    Endocrine, nutritional and metabolic diseases
  • E20-E35
    2020 ICD-10-CM Range E20-E35

    Disorders of other endocrine glands

    Type 1 Excludes
    Disorders of other endocrine glands
  • E21
    ICD-10-CM Diagnosis Code E21

    Hyperparathyroidism and other disorders of parathyroid gland

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • adult osteomalacia (M83.-)
    • ectopic hyperparathyroidism (E34.2)
    • familial hypocalciuric hypercalcemia (E83.52)
    • hungry bone syndrome (E83.81)
    • infantile and juvenile osteomalacia (E55.0)
    Hyperparathyroidism and other disorders of parathyroid gland
Approximate Synonyms
  • Hyperparathyroidism
  • Hyperparathyroidism (high parathyroid hormone level)
Clinical Information
  • A condition in which the parathyroid gland (one of four pea-sized organs found on the thyroid) makes too much parathyroid hormone. This causes a loss of calcium from the bones and an increased level of calcium in the blood. Symptoms include bone pain and kidney problems.
  • A condition of abnormally elevated output of parathyroid hormone (or pth) triggering responses that increase blood calcium. It is characterized by hypercalcemia and bone resorption, eventually leading to bone diseases. Primary hyperparathyroidism is caused by parathyroid hyperplasia or parathyroid neoplasms. Secondary hyperparathyroidism is increased pth secretion in response to hypocalcemia, usually caused by chronic kidney diseases.
  • A disorder characterized by an increase in production of parathyroid hormone by the parathyroid glands. This results in hypercalcemia (abnormally high levels of calcium in the blood).
  • Abnormally increased activity of the parathyroid glands, which may be primary or secondary; primary hyperparathyroidism is associated with neoplasia or hyperplasia; excess of parathyroid hormone leads to alteration in function of bone, renal tubules, and gastrointestinal mucosa.
  • Hyperfunction of the parathyroid glands resulting in the overproduction of parathyroid hormone. It may be primary or secondary; primary hyperparathyroidism is caused by parathyroid adenoma, parathyroid hyperplasia, parathyroid carcinoma, and multiple endocrine neoplasia. It is associated with hypercalcemia and hypophosphatemia. Signs and symptoms include weakness, fatigue, nausea, vomiting, constipation, depression, bone pain, osteoporosis, cystic bone lesions, and kidney stones. Secondary hyperparathyroidism is caused by the chronic stimulation of the parathyroid glands in patients with chronic renal failure, rickets, and malabsorption syndromes.
  • What: hyperparathyroidism. Hyperparathyroidism: a condition due to an increase in the secretion of the parathyroids, causing generalized osteitis fibrosa cystica, elevated serum calcium, decreased serum phosphorus, and increased excretion of both calcium and phosphorus. Why: several rheumatological disorders are associated with hyperpara- thyroidism. First, hyperuricemia and gouty arthritis (which may mimic hyperparathyroidism with renal stone formation and colic) have an increased incidence in patients with hyperparathyroidism. Second, patients with primary hyperparathyroidism show an increased incidence of chondrocalcinosis with episodes of calcium pyrophosphate crystal induced synovitis. Approximately 25% of patients with hyperparathyroidism will show radiographic evidence of calcification of articular cartilage and joint capsules. Finally, there can be a synovial and cartilaginous lesion ("osteogenic synovitis") in patients with hyperparathyroidism which may mimic other primary rheumatic diseases such as rheumatoid arthritis. In osteogenic synovitis there is softening and collapse of subchondral bone. Eventually the cartilage overlying this area erodes and is replaced by an irregular fibrocartilage. Eventually the articular surface of the joint is destroyed and secondary degenerative arthritis may develop. Refs: 1) zvaifler, nj; reefe, we and black, rl: articular manifestations in primary hyperparathyroidism. Arthritis rheum 5:237, 1962. 2) scott, jt; dixon, asj and bywaters, egl: association of hyperuricemia and gout with hyperparathyroidism. Br med j 1:1070, 1964. 3) bywaters, egl and scott, jt : joint lesions of hyperparathyroidism. Ann rheum dis 22:171-87, 1963.
ICD-10-CM E21.3 is grouped within Diagnostic Related Group(s) (MS-DRG v37.0):
  • 643 Endocrine disorders with mcc
  • 644 Endocrine disorders with cc
  • 645 Endocrine disorders without cc/mcc

Convert E21.3 to ICD-9-CM

Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
Code annotations containing back-references to E21.3:
  • Code First: G73.7
    ICD-10-CM Diagnosis Code G73.7

    Myopathy in diseases classified elsewhere

      2016 2017 2018 2019 2020 Billable/Specific Code Manifestation Code
    Code First
    • underlying disease, such as:
    • hyperparathyroidism (E21.0, E21.3)
    • hypoparathyroidism (E20.-)
    • glycogen storage disease (E74.0)
    • lipid storage disorders (E75.-)
    Type 1 Excludes
    • myopathy in:
    • rheumatoid arthritis (M05.32)
    • sarcoidosis (D86.87)
    • scleroderma (M34.82)
    • sicca syndrome [Sjögren] (M35.03)
    • systemic lupus erythematosus (M32.19)
  • Type 1 Excludes: E83.5
    ICD-10-CM Diagnosis Code E83.5

    Disorders of calcium metabolism

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Type 1 Excludes

Diagnosis Index entries containing back-references to E21.3:
  • Arthritis, arthritic (acute) (chronic) (nonpyogenic) (subacute) M19.90
    ICD-10-CM Diagnosis Code M19.90

    Unspecified osteoarthritis, unspecified site

      2016 2017 2018 2019 2020 Billable/Specific Code
    Applicable To
    • Arthrosis NOS
    • Arthritis NOS
    • Osteoarthritis NOS
    • in (due to)
      • hyperparathyroidism NEC E21.3 - see also subcategory M14.8-
  • Arthropathy M12.9
    - see also Arthritis
    ICD-10-CM Diagnosis Code M12.9

    Arthropathy, unspecified

      2016 2017 2018 2019 2020 Billable/Specific Code
    • hemophilic NEC D66
      ICD-10-CM Diagnosis Code D66

      Hereditary factor VIII deficiency

        2016 2017 2018 2019 2020 Billable/Specific Code
      Applicable To
      • Classical hemophilia
      • Deficiency factor VIII (with functional defect)
      • Hemophilia NOS
      • Hemophilia A
      Type 1 Excludes
      • factor VIII deficiency with vascular defect (D68.0)
      • in (due to)
        • hyperparathyroidism NEC E21.3
  • Hyperfunction
    • parathyroid E21.3 (gland)
  • Hyperparathyroidism E21.3
  • Myopathy G72.9
    ICD-10-CM Diagnosis Code G72.9

    Myopathy, unspecified

      2016 2017 2018 2019 2020 Billable/Specific Code
    • in (due to)
      • hyperparathyroidism NEC E21.3

ICD-10-CM Codes Adjacent To E21.3
E16.9 Disorder of pancreatic internal secretion, unspecified
E20 Hypoparathyroidism
E20.0 Idiopathic hypoparathyroidism
E20.1 Pseudohypoparathyroidism
E20.8 Other hypoparathyroidism
E20.9 Hypoparathyroidism, unspecified
E21 Hyperparathyroidism and other disorders of parathyroid gland
E21.0 Primary hyperparathyroidism
E21.1 Secondary hyperparathyroidism, not elsewhere classified
E21.2 Other hyperparathyroidism
E21.3 Hyperparathyroidism, unspecified
E21.4 Other specified disorders of parathyroid gland
E21.5 Disorder of parathyroid gland, unspecified
E22 Hyperfunction of pituitary gland
E22.0 Acromegaly and pituitary gigantism
E22.1 Hyperprolactinemia
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
E22.8 Other hyperfunction of pituitary gland
E22.9 Hyperfunction of pituitary gland, unspecified
E23 Hypofunction and other disorders of the pituitary gland
E23.0 Hypopituitarism

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.