2021 ICD-10-CM Diagnosis Code E22.2

Syndrome of inappropriate secretion of antidiuretic hormone

    2016 2017 2018 2019 2020 2021 Billable/Specific Code
  • E22.2 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2021 edition of ICD-10-CM E22.2 became effective on October 1, 2020.
  • This is the American ICD-10-CM version of E22.2 - other international versions of ICD-10 E22.2 may differ.
The following code(s) above E22.2 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to E22.2:
  • E00-E89
    2021 ICD-10-CM Range E00-E89

    Endocrine, nutritional and metabolic diseases

    • All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
    Type 1 Excludes
    • transitory endocrine and metabolic disorders specific to newborn (P70-P74)
    Endocrine, nutritional and metabolic diseases
  • E20-E35
    2021 ICD-10-CM Range E20-E35

    Disorders of other endocrine glands

    Type 1 Excludes
    Disorders of other endocrine glands
  • E22
    ICD-10-CM Diagnosis Code E22

    Hyperfunction of pituitary gland

      2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • Cushing's syndrome (E24.-)
    • Nelson's syndrome (E24.1)
    • overproduction of ACTH not associated with Cushing's disease (E27.0)
    • overproduction of pituitary ACTH (E24.0)
    • overproduction of thyroid-stimulating hormone (E05.8-)
    Hyperfunction of pituitary gland
Approximate Synonyms
  • Syndrome inappropriate antidiuretic hormone secretion
  • Syndrome of inappropriate vasopressin secretion
Clinical Information
  • A condition of hyponatremia and renal salt loss attributed to overexpansion of body fluids resulting from sustained release of antidiuretic hormones which stimulates renal resorption of water. It is characterized by normal kidney function, high urine osmolality, low serum osmolality, and neurological dysfunction. Etiologies include adh-producing neoplasms, injuries or diseases involving the hypothalamus, the pituitary gland, and the lung. This syndrome can also be drug-induced.
  • A syndrome characterized by abnormal secretion of antidiuretic hormone in conjunction with neoplastic growth occurring anywhere in the body.
ICD-10-CM E22.2 is grouped within Diagnostic Related Group(s) (MS-DRG v38.0):
  • 643 Endocrine disorders with mcc
  • 644 Endocrine disorders with cc
  • 645 Endocrine disorders without cc/mcc

Convert E22.2 to ICD-9-CM

Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change
Code annotations containing back-references to E22.2:
  • Type 1 Excludes: E87.1
    ICD-10-CM Diagnosis Code E87.1

    Hypo-osmolality and hyponatremia

      2016 2017 2018 2019 2020 2021 Billable/Specific Code
    Applicable To
    • Sodium [Na] deficiency
    Type 1 Excludes
    • syndrome of inappropriate secretion of antidiuretic hormone (E22.2)

Diagnosis Index entries containing back-references to E22.2:

ICD-10-CM Codes Adjacent To E22.2
E21 Hyperparathyroidism and other disorders of parathyroid gland
E21.0 Primary hyperparathyroidism
E21.1 Secondary hyperparathyroidism, not elsewhere classified
E21.2 Other hyperparathyroidism
E21.3 Hyperparathyroidism, unspecified
E21.4 Other specified disorders of parathyroid gland
E21.5 Disorder of parathyroid gland, unspecified
E22 Hyperfunction of pituitary gland
E22.0 Acromegaly and pituitary gigantism
E22.1 Hyperprolactinemia
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
E22.8 Other hyperfunction of pituitary gland
E22.9 Hyperfunction of pituitary gland, unspecified
E23 Hypofunction and other disorders of the pituitary gland
E23.0 Hypopituitarism
E23.1 Drug-induced hypopituitarism
E23.2 Diabetes insipidus
E23.3 Hypothalamic dysfunction, not elsewhere classified
E23.6 Other disorders of pituitary gland
E23.7 Disorder of pituitary gland, unspecified
E24 Cushing's syndrome

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.