2019 ICD-10-CM Diagnosis Code E23.0

Hypopituitarism

    2016 2017 2018 2019 Billable/Specific Code
  • E23.0 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2019 edition of ICD-10-CM E23.0 became effective on October 1, 2018.
  • This is the American ICD-10-CM version of E23.0 - other international versions of ICD-10 E23.0 may differ.
Applicable To
  • Fertile eunuch syndrome
  • Hypogonadotropic hypogonadism
  • Idiopathic growth hormone deficiency
  • Isolated deficiency of gonadotropin
  • Isolated deficiency of growth hormone
  • Isolated deficiency of pituitary hormone
  • Kallmann's syndrome
  • Lorain-Levi short stature
  • Necrosis of pituitary gland (postpartum)
  • Panhypopituitarism
  • Pituitary cachexia
  • Pituitary insufficiency NOS
  • Pituitary short stature
  • Sheehan's syndrome
  • Simmonds' disease
The following code(s) above E23.0 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to E23.0:
  • E00-E89
    2019 ICD-10-CM Range E00-E89

    Endocrine, nutritional and metabolic diseases

    Note
    • All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
    Type 1 Excludes
    • transitory endocrine and metabolic disorders specific to newborn (P70-P74)
    Endocrine, nutritional and metabolic diseases
  • E20-E35
    2019 ICD-10-CM Range E20-E35

    Disorders of other endocrine glands

    Type 1 Excludes
    Disorders of other endocrine glands
  • E23
    ICD-10-CM Diagnosis Code E23

    Hypofunction and other disorders of the pituitary gland

      2016 2017 2018 2019 Non-Billable/Non-Specific Code
    Includes
    • the listed conditions whether the disorder is in the pituitary or the hypothalamus
    Type 1 Excludes
    • postprocedural hypopituitarism (E89.3)
    Hypofunction and other disorders of the pituitary gland
Approximate Synonyms
  • Anterior pituitary hormone deficiency
  • Female infertility due to pituitary disorder
  • Female infertility of pituitary origin
  • Follicle stimulating hormone deficiency
  • Fsh - follicle stimulating hormone deficiency
  • Gonadotropin deficiency, isolated
  • Growth hormone deficiency
  • Growth hormone deficiency after bone marrow transplant
  • Growth hormone deficiency, bone marrow transplant
  • Growth hormone deficiency, isolated
  • Hypogonadism with anosmia
  • Hypogonadism, anosmia
  • Hypogonadotropic hypogonadism
  • Isolated gonadotropin deficiency
  • Isolated somatotropin deficiency
  • Lh - luteinizing hormone deficiency
  • Luteinizing hormone deficiency
  • Panhypopituitarism
  • Partial growth hormone deficiency
  • Partial hypopituitarism
  • Pituitary dwarfism
  • Somatotropin deficiency, partial
Clinical Information
  • A condition of diminution or cessation of secretion of one or more hormones from the anterior pituitary gland. This may result from surgical or radiation ablation, non-secretory pituitary neoplasms, metastatic tumors, infarction, pituitary apoplexy, infiltrative or granulomatous processes, and other conditions.
  • A form of dwarfism caused by complete or partial growth hormone deficiency, resulting from either the lack of growth hormone-releasing factor from the hypothalamus or from the mutations in the growth hormone gene (gh1) in the pituitary gland. It is also known as type i pituitary dwarfism. Human hypophysial dwarf is caused by a deficiency of human growth hormone during development.
  • A genetically heterogeneous disorder caused by hypothalamic gnrh deficiency and olfactory nerve defects. It is characterized by congenital hypogonadotropic hypogonadism and anosmia, possibly with additional midline defects. It can be transmitted as an x-linked (genetic diseases, x-linked), an autosomal dominant, or an autosomal recessive trait.
  • A syndrome, sometimes considered as three separate entities (kalmann syndromes 1, 2, and 3), characterized mainly by reduced hypothalamic function and reduced pituitary gonadotropic activity and deficiency of gonadotropin-releasing hormone with resulting hypogonadism and absent or reduced sense of smell due to agenesis of the olfactory bulbs. Associated anomalies include cleft palate, neurosensory hearing loss, congenital heart defect, intestinal malrotation, renal agenesis, hypertension, mental retardation, color blindness, and other defects. Most abnormalities occur in types 1 and 2; type 3 is marked mainly by hypogonadotropic hypogonadism, anosmia, and craniofacial abnormalities.
  • An x-linked or autosomal dominant genetic syndrome characterized by hypogonadotropic hypogonadism and anosmia.
  • Anosmia due to failure of the olfactory lobes to develop, with secondary hypogonadism due to gonadotropic hormone deficiency.
  • Diminution or cessation of secretion of one or more hormones from the anterior pituitary gland (including lh; follicle stimulating hormone; somatotropin; and corticotropin). This may result from surgical or radiation ablation, non-secretory pituitary neoplasms, metastatic tumors, infarction, pituitary apoplexy, infiltrative or granulomatous processes, and other conditions.
  • Diminution or cessation of secretion of one or more hormones from the anterior pituitary gland (including luteinizing hormone, follicle stimulating hormone, somatotropin; and corticotropin); may result from surgical or radiation ablation, non-secretory pituitary neoplasms, metastatic tumors, infarction, pituitary apoplexy, infiltrative or granulomatous processes, and other conditions.
  • Form of dwarfism due to deficient release of growth hormone which may result from dysfunction of the hypothalamus or anterior pituitary gland.
ICD-10-CM E23.0 is grouped within Diagnostic Related Group(s) (MS-DRG v36.0):
  • 643 Endocrine disorders with mcc
  • 644 Endocrine disorders with cc
  • 645 Endocrine disorders without cc/mcc

Convert E23.0 to ICD-9-CM

Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
Code annotations containing back-references to E23.0:
  • Type 1 Excludes: N97
    , E28
    , E29
    , E34.3
    , R62
    ICD-10-CM Diagnosis Code N97

    Female infertility

      2016 2017 2018 2019 Non-Billable/Non-Specific Code
    Includes
    • inability to achieve a pregnancy
    • sterility, female NOS
    Type 1 Excludes
    • female infertility associated with:
    • hypopituitarism (E23.0)
    • Stein-Leventhal syndrome (E28.2)
    Type 2 Excludes
    • incompetence of cervix uteri (N88.3)
    ICD-10-CM Diagnosis Code E28

    Ovarian dysfunction

      2016 2017 2018 2019 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • isolated gonadotropin deficiency (E23.0)
    • postprocedural ovarian failure (E89.4-)
    ICD-10-CM Diagnosis Code E29

    Testicular dysfunction

      2016 2017 2018 2019 Non-Billable/Non-Specific Code
    Type 1 Excludes
    ICD-10-CM Diagnosis Code E34.3

    Short stature due to endocrine disorder

      2016 2017 2018 2019 Billable/Specific Code
    Applicable To
    • Constitutional short stature
    • Laron-type short stature
    Type 1 Excludes
    • achondroplastic short stature (Q77.4)
    • hypochondroplastic short stature (Q77.4)
    • nutritional short stature (E45)
    • pituitary short stature (E23.0)
    • progeria (E34.8)
    • renal short stature (N25.0)
    • Russell-Silver syndrome (Q87.1)
    • short-limbed stature with immunodeficiency (D82.2)
    • short stature in specific dysmorphic syndromes - code to syndrome - see Alphabetical Index
    • short stature NOS (R62.52)
    ICD-10-CM Diagnosis Code R62

    Lack of expected normal physiological development in childhood and adults

      2016 2017 2018 2019 Non-Billable/Non-Specific Code
    Type 1 Excludes

Diagnosis Index entries containing back-references to E23.0:
  • Ahumada-del Castillo syndrome E23.0
  • Brissaud's
    • infantilism or dwarfism E23.0
  • Cachexia R64
    ICD-10-CM Diagnosis Code R64

    Cachexia

      2016 2017 2018 2019 Billable/Specific Code
    Applicable To
    • Wasting syndrome
    Code First
    • underlying condition, if known
    Type 1 Excludes
    • abnormal weight loss (R63.4)
    • nutritional marasmus (E41)
    • hypophyseal E23.0
    • hypopituitary E23.0
    • pituitary E23.0
    • Simmonds' E23.0
  • Decrease (d)
    • function
      • pituitary (gland) (anterior) (lobe) E23.0
        • posterior E23.0 (lobe)
      • ovary in hypopituitarism E23.0
  • Deficiency, deficient
    • hormone
    • gonadotropin E23.0 (isolated)
    • growth hormone E23.0 (idiopathic) (isolated)
    • pituitary hormone E23.0 (isolated)
  • Dwarfism E34.3
    ICD-10-CM Diagnosis Code E34.3

    Short stature due to endocrine disorder

      2016 2017 2018 2019 Billable/Specific Code
    Applicable To
    • Constitutional short stature
    • Laron-type short stature
    Type 1 Excludes
    • achondroplastic short stature (Q77.4)
    • hypochondroplastic short stature (Q77.4)
    • nutritional short stature (E45)
    • pituitary short stature (E23.0)
    • progeria (E34.8)
    • renal short stature (N25.0)
    • Russell-Silver syndrome (Q87.1)
    • short-limbed stature with immunodeficiency (D82.2)
    • short stature in specific dysmorphic syndromes - code to syndrome - see Alphabetical Index
    • short stature NOS (R62.52)
    • hypophyseal E23.0
    • Lorain E23.0 (-Levi)
    • pituitary E23.0
  • Eunuchoidism E29.1
    ICD-10-CM Diagnosis Code E29.1

    Testicular hypofunction

      2016 2017 2018 2019 Billable/Specific Code Male Dx
    Applicable To
    • Defective biosynthesis of testicular androgen NOS
    • 5-delta-Reductase deficiency (with male pseudohermaphroditism)
    • Testicular hypogonadism NOS
    Type 1 Excludes
    • postprocedural testicular hypofunction (E89.5)
    Use Additional
    • code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)
    • hypogonadotropic E23.0
  • Fertile eunuch syndrome E23.0
  • Hypoadrenocorticism E27.40
    ICD-10-CM Diagnosis Code E27.40

    Unspecified adrenocortical insufficiency

      2016 2017 2018 2019 Billable/Specific Code
    Applicable To
    • Adrenocortical insufficiency NOS
    • Hypoaldosteronism
    • pituitary E23.0
  • Hypofunction
    • pituitary E23.0 (gland) (anterior)
  • Hypogonadism
    • hypogonadotropic E23.0
    • pituitary E23.0
  • Hypophyseal, hypophysis - see also condition
    • dwarfism E23.0
  • Hypopituitarism (juvenile) E23.0
  • Hyposecretion
    • ACTH E23.0
  • Infancy, infantile, infantilism - see also condition
    • Lorain E23.0
    • pituitary E23.0
  • Infertility
    • female N97.9
      ICD-10-CM Diagnosis Code N97.9

      Female infertility, unspecified

        2016 2017 2018 2019 Billable/Specific Code Female Dx
  • Insufficiency, insufficient
    • pituitary E23.0
  • Kallmann's syndrome E23.0
  • Lorain E23.0 (-Levi)
  • Myopathy G72.9
    ICD-10-CM Diagnosis Code G72.9

    Myopathy, unspecified

      2016 2017 2018 2019 Billable/Specific Code
    • in (due to)
      • hypopituitarism E23.0
  • Necrosis, necrotic (ischemic) - see also Gangrene
  • Panhypopituitarism E23.0
    • prepubertal E23.0
  • Sheehan's disease or syndrome E23.0
  • Simmonds' cachexia or disease E23.0
  • Syndrome - see also Disease
    • fertile eunuch E23.0
    • hypopituitarism E23.0
    • infantilism E23.0 (pituitary)
    • postpartum panhypopituitary E23.0 (Sheehan)

ICD-10-CM Codes Adjacent To E23.0
E21.3 Hyperparathyroidism, unspecified
E21.4 Other specified disorders of parathyroid gland
E21.5 Disorder of parathyroid gland, unspecified
E22 Hyperfunction of pituitary gland
E22.0 Acromegaly and pituitary gigantism
E22.1 Hyperprolactinemia
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
E22.8 Other hyperfunction of pituitary gland
E22.9 Hyperfunction of pituitary gland, unspecified
E23 Hypofunction and other disorders of the pituitary gland
E23.0 Hypopituitarism
E23.1 Drug-induced hypopituitarism
E23.2 Diabetes insipidus
E23.3 Hypothalamic dysfunction, not elsewhere classified
E23.6 Other disorders of pituitary gland
E23.7 Disorder of pituitary gland, unspecified
E24 Cushing's syndrome
E24.0 Pituitary-dependent Cushing's disease
E24.1 Nelson's syndrome
E24.2 Drug-induced Cushing's syndrome
E24.3 Ectopic ACTH syndrome

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.