ICD-10-CM Codes
E00-E89 Endocrine, nutritional and metabolic diseases
E20-E35 Disorders of other endocrine glands
E25- Adrenogenital disorders
2022 ICD-10-CM Diagnosis Code E25.0

2022 ICD-10-CM Diagnosis Code E25.0

Congenital adrenogenital disorders associated with enzyme deficiency

2016

2017

2018

2019

2020

2021

2022

Billable/Specific Code

E25.0 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
Short description: Congenital adrenogenital disorders assoc w enzyme deficiency
The 2022 edition of ICD-10-CM E25.0 became effective on October 1, 2021.
This is the American ICD-10-CM version of E25.0 - other international versions of ICD-10 E25.0 may differ.

Applicable To

Congenital adrenal hyperplasia
21-Hydroxylase deficiency
Salt-losing congenital adrenal hyperplasia

The following code(s) above E25.0 contain annotation back-references

Annotation Back-References

In this context, annotation back-references refer to codes that contain:

Applicable To annotations, or
Code Also annotations, or
Code First annotations, or
Excludes1 annotations, or
Excludes2 annotations, or
Includes annotations, or
Note annotations, or
Use Additional annotations

that may be applicable to E25.0:

E00-E89
2022 ICD-10-CM Range E00-E89
Endocrine, nutritional and metabolic diseases
Note
- All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
Type 1 Excludes
- transitory endocrine and metabolic disorders specific to newborn (P70-P74)
Endocrine, nutritional and metabolic diseases
E20-E35
2022 ICD-10-CM Range E20-E35
Disorders of other endocrine glands
Type 1 Excludes
- galactorrhea (N64.3)
- gynecomastia (N62)
Disorders of other endocrine glands
E25
ICD-10-CM Diagnosis Code E25
Adrenogenital disorders
Includes
- adrenogenital syndromes, virilizing or feminizing, whether acquired or due to adrenal hyperplasia consequent on inborn enzyme defects in hormone synthesis
- Female adrenal pseudohermaphroditism
- Female heterosexual precocious pseudopuberty
- Male isosexual precocious pseudopuberty
- Male macrogenitosomia praecox
- Male sexual precocity with adrenal hyperplasia
- Male virilization (female)
Type 1 Excludes
- indeterminate sex and pseudohermaphroditism (Q56)
- chromosomal abnormalities (Q90-Q99)
Adrenogenital disorders

Approximate Synonyms

3 beta-hydroxysteroid dehydrogenase deficiency
Adrenal hyperplasia, congenital
Adrenal hyperplasia, congenital, simple virilizing
Adrenal hyperplasia, congenital, virilizing, non salt
Congenital adrenal hyperplasia
Congenital adrenal hyperplasia, undervirilized xy due to 17-alpha hydroxylase deficiency
Congenital adrenal hyperplasia, virilizing, non-salt-losing
Congenital adrenal hyperplasia, virilizing, salt-losing
Late onset congenital adrenal hyperplasia
Steroid 21-monooxygenase deficiency, simple virilizing type
Undervirilized xy, 3-beta hydroxysteroid deficiency
Undervirilized xy, congenital adrenal hyperplasis,

Clinical Information

A genetic disorder characterized by defects in the synthesis of cortisol and/or aldosterone, resulting in hyperplasia of the adrenal cortical cells.
A group of inherited disorders of the adrenal glands, caused by enzyme defects in the synthesis of cortisol (hydrocortisone) and/or aldosterone leading to accumulation of precursors for androgens. Depending on the hormone imbalance, congenital adrenal hyperplasia can be classified as salt-wasting, hypertensive, virilizing, or feminizing. Defects in steroid 21-hydroxylase; steroid 11-beta-hydroxylase; steroid 17-alpha-hydroxylase; 3-beta-hydroxysteroid dehydrogenase (3-hydroxysteroid dehydrogenases); testosterone 5-alpha-reductase; or steroidogenic acute regulatory protein; among others, underlie these disorders.
Group of syndromes caused by inherited defects in cortisol and/or aldosterone biosynthesis; acth elevation is caused by low levels of cortisol, whose production is impaired by absence or deficiency of one of the five enzymes necessary for its synthesis from cholesterol.

ICD-10-CM E25.0 is grouped within Diagnostic Related Group(s) (MS-DRG v39.0):

643 Endocrine disorders with mcc
644 Endocrine disorders with cc
645 Endocrine disorders without cc/mcc

Convert E25.0 to ICD-9-CM

Code History

2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
2017 (effective 10/1/2016): No change
2018 (effective 10/1/2017): No change
2019 (effective 10/1/2018): No change
2020 (effective 10/1/2019): No change
2021 (effective 10/1/2020): No change
2022 (effective 10/1/2021): No change

Code annotations containing back-references to E25.0:

Type 1 Excludes: E24
, E30.1
, Q89.1

ICD-10-CM Diagnosis Code E24
Cushing's syndrome
Type 1 Excludes
- congenital adrenal hyperplasia (E25.0)
ICD-10-CM Diagnosis Code E30.1
Precocious puberty
Applicable To
- Precocious menstruation
Type 1 Excludes
- Albright (-McCune) (-Sternberg) syndrome (Q78.1)
- central precocious puberty (E22.8)
- congenital adrenal hyperplasia (E25.0)
- female heterosexual precocious pseudopuberty (E25.-)
- male isosexual precocious pseudopuberty (E25.-)
ICD-10-CM Diagnosis Code Q89.1
Congenital malformations of adrenal gland
Type 1 Excludes
- adrenogenital disorders (E25.-)
- congenital adrenal hyperplasia (E25.0)

Diagnosis Index entries containing back-references to E25.0:

Adrenogenital syndrome E25.9
ICD-10-CM Diagnosis Code E25.9
Adrenogenital disorder, unspecified
Applicable To
Adrenogenital syndrome NOS
- congenital E25.0
- salt loss E25.0
Adrenogenitalism, congenital E25.0
Defect, defective Q89.9
ICD-10-CM Diagnosis Code Q89.9
Congenital malformation, unspecified
Applicable To
Congenital anomaly NOS
Congenital deformity NOS
- 3-beta-hydroxysteroid dehydrogenase E25.0
- 11-hydroxylase E25.0
- 21-hydroxylase E25.0
Deficiency, deficient
- 3-beta hydroxysteroid dehydrogenase E25.0
- 11-hydroxylase E25.0
- 21-hydroxylase E25.0
Hyperadrenocorticism E24.9
ICD-10-CM Diagnosis Code E24.9
Cushing's syndrome, unspecified
- congenital E25.0
Hyperfunction
- adrenal cortex, not associated with Cushing's syndrome E27.0
  ICD-10-CM Diagnosis Code E27.0
  Other adrenocortical overactivity
  2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
  Applicable To
  Overproduction of ACTH, not associated with Cushing's disease
  Premature adrenarche
  Type 1 Excludes
  Cushing's syndrome (E24.-)
  - virilism E25.9
    ICD-10-CM Diagnosis Code E25.9
    Adrenogenital disorder, unspecified
    2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
    Applicable To
    Adrenogenital syndrome NOS
    - congenital E25.0
Hyperplasia, hyperplastic
- adrenal (capsule) (cortex) (gland) E27.8
  ICD-10-CM Diagnosis Code E27.8
  Other specified disorders of adrenal gland
  2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
  Applicable To
  Abnormality of cortisol-binding globulin
  - with
    - sexual precocity (male) E25.9
      ICD-10-CM Diagnosis Code E25.9
      Adrenogenital disorder, unspecified
      2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
      Applicable To
      Adrenogenital syndrome NOS
      - congenital E25.0
    - virilism, adrenal E25.9
      ICD-10-CM Diagnosis Code E25.9
      Adrenogenital disorder, unspecified
      2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
      Applicable To
      Adrenogenital syndrome NOS
      - congenital E25.0
    - virilization (female) E25.9
      ICD-10-CM Diagnosis Code E25.9
      Adrenogenital disorder, unspecified
      2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
      Applicable To
      Adrenogenital syndrome NOS
      - congenital E25.0
  - congenital E25.0
    - salt-losing E25.0
Macrogenitosomia (adrenal) (male) (praecox) E25.9
ICD-10-CM Diagnosis Code E25.9
Adrenogenital disorder, unspecified
Applicable To
Adrenogenital syndrome NOS
- congenital E25.0
Masculinization (female) E25.9
ICD-10-CM Diagnosis Code E25.9
Adrenogenital disorder, unspecified
Applicable To
Adrenogenital syndrome NOS
- congenital E25.0
Precocity, sexual (constitutional) (cryptogenic) (female) (idiopathic) (male) E30.1
ICD-10-CM Diagnosis Code E30.1
Precocious puberty
Applicable To
Precocious menstruation
Type 1 Excludes
Albright (-McCune) (-Sternberg) syndrome (Q78.1)
central precocious puberty (E22.8)
congenital adrenal hyperplasia (E25.0)
female heterosexual precocious pseudopuberty (E25.-)
male isosexual precocious pseudopuberty (E25.-)
- with adrenal hyperplasia E25.9
  ICD-10-CM Diagnosis Code E25.9
  Adrenogenital disorder, unspecified
  2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
  Applicable To
  Adrenogenital syndrome NOS
  - congenital E25.0
Pseudohermaphroditism Q56.3
ICD-10-CM Diagnosis Code Q56.3
Pseudohermaphroditism, unspecified
- female Q56.2
  ICD-10-CM Diagnosis Code Q56.2
  Female pseudohermaphroditism, not elsewhere classified
  2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code POA Exempt
  Applicable To
  Female pseudohermaphroditism NOS
  - adrenal E25.0 (congenital)
Syndrome - see also Disease
- adrenogenital E25.9
  ICD-10-CM Diagnosis Code E25.9
  Adrenogenital disorder, unspecified
  2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
  Applicable To
  Adrenogenital syndrome NOS
  - congenital, associated with enzyme deficiency E25.0
Virilism (adrenal) E25.9
ICD-10-CM Diagnosis Code E25.9
Adrenogenital disorder, unspecified
Applicable To
Adrenogenital syndrome NOS
- congenital E25.0
Virilization (female) (suprarenal) E25.9
ICD-10-CM Diagnosis Code E25.9
Adrenogenital disorder, unspecified
Applicable To
Adrenogenital syndrome NOS
- congenital E25.0

ICD-10-CM Codes Adjacent To E25.0

E23.7 Disorder of pituitary gland, unspecified

E24 Cushing's syndrome

E24.0 Pituitary-dependent Cushing's disease

E24.1 Nelson's syndrome

E24.2 Drug-induced Cushing's syndrome

E24.3 Ectopic ACTH syndrome

E24.4 Alcohol-induced pseudo-Cushing's syndrome

E24.8 Other Cushing's syndrome

E24.9 Cushing's syndrome, unspecified

E25 Adrenogenital disorders

E25.0 Congenital adrenogenital disorders associated with enzyme deficiency

E25.8 Other adrenogenital disorders

E25.9 Adrenogenital disorder, unspecified

E26 Hyperaldosteronism

E26.0 Primary hyperaldosteronism

E26.01 Conn's syndrome

E26.02 Glucocorticoid-remediable aldosteronism

E26.09 Other primary hyperaldosteronism

E26.1 Secondary hyperaldosteronism

E26.8 Other hyperaldosteronism

E26.81 Bartter's syndrome

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.

2022 ICD-10-CM Diagnosis Code E25.0

Congenital adrenogenital disorders associated with enzyme deficiency

Endocrine, nutritional and metabolic diseases

Disorders of other endocrine glands

Adrenogenital disorders

Cushing's syndrome

Precocious puberty

Congenital malformations of adrenal gland

Adrenogenital disorder, unspecified

Congenital malformation, unspecified

Cushing's syndrome, unspecified

Other adrenocortical overactivity

Adrenogenital disorder, unspecified

Other specified disorders of adrenal gland

Adrenogenital disorder, unspecified

Adrenogenital disorder, unspecified

Adrenogenital disorder, unspecified

Adrenogenital disorder, unspecified

Adrenogenital disorder, unspecified

Precocious puberty

Adrenogenital disorder, unspecified

Pseudohermaphroditism, unspecified

Female pseudohermaphroditism, not elsewhere classified

Adrenogenital disorder, unspecified

Adrenogenital disorder, unspecified

Adrenogenital disorder, unspecified