2021 ICD-10-CM Diagnosis Code E25.8

Other adrenogenital disorders

    2016 2017 2018 2019 2020 2021 Billable/Specific Code
  • E25.8 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2021 edition of ICD-10-CM E25.8 became effective on October 1, 2020.
  • This is the American ICD-10-CM version of E25.8 - other international versions of ICD-10 E25.8 may differ.
Applicable To
  • Idiopathic adrenogenital disorder
Use Additional
Use Additional Help
Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. For such conditions the ICD-10-CM has a coding convention that requires the underlying condition be sequenced first followed by the manifestation. Wherever such a combination exists there is a "use additional code" note at the etiology code, and a "code first" note at the manifestation code. These instructional notes indicate the proper sequencing order of the codes, etiology followed by manifestation. In most cases the manifestation codes will have in the code title, "in diseases classified elsewhere." Codes with this title are a component of the etiology/manifestation convention. The code title indicates that it is a manifestation code. "In diseases classified elsewhere" codes are never permitted to be used as first listed or principle diagnosis codes. They must be used in conjunction with an underlying condition code and they must be listed following the underlying condition.
  • code for adverse effect, if applicable, to identify drug (T36-T50
    ICD-10-CM Range T36-T50

    Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances

    Code First
    • , for adverse effects, the nature of the adverse effect, such as:
    • adverse effect NOS (T88.7)
    • aspirin gastritis (K29.-)
    • blood disorders (D56-D76)
    • contact dermatitis (L23-L25)
    • dermatitis due to substances taken internally (L27.-)
    • nephropathy (N14.0-N14.2)
    Includes
    • adverse effect of correct substance properly administered
    • poisoning by overdose of substance
    • poisoning by wrong substance given or taken in error
    • underdosing by (inadvertently) (deliberately) taking less substance than prescribed or instructed
    Note
    • The drug giving rise to the adverse effect should be identified by use of codes from categories T36-T50 with fifth or sixth character 5.
    Type 1 Excludes
    • toxic reaction to local anesthesia in pregnancy (O29.3-)
    Type 2 Excludes
    • abuse and dependence of psychoactive substances (F10-F19)
    • abuse of non-dependence-producing substances (F55.-)
    • immunodeficiency due to drugs (D84.821)
    • drug reaction and poisoning affecting newborn (P00-P96)
    • pathological drug intoxication (inebriation) (F10-F19)
    Use Additional
    • code(s) to specify:
    • manifestations of poisoning
    • underdosing or failure in dosage during medical and surgical care (Y63.6, Y63.8-Y63.9)
    • underdosing of medication regimen (Z91.12-, Z91.13-)
    • T36 Poisoning by, adverse effect of and unde...
    • T37 Poisoning by, adverse effect of and unde...
    • T38 Poisoning by, adverse effect of and unde...
    • T39 Poisoning by, adverse effect of and unde...
    • T40 Poisoning by, adverse effect of and unde...
    • T41 Poisoning by, adverse effect of and unde...
    • T42 Poisoning by, adverse effect of and unde...
    • T43 Poisoning by, adverse effect of and unde...
    • T44 Poisoning by, adverse effect of and unde...
    • T45 Poisoning by, adverse effect of and unde...
    • T46 Poisoning by, adverse effect of and unde...
    • T47 Poisoning by, adverse effect of and unde...
    • T48 Poisoning by, adverse effect of and unde...
    • T49 Poisoning by, adverse effect of and unde...
    • T50 Poisoning by, adverse effect of and unde...
    with fifth or sixth character 5)
The following code(s) above E25.8 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to E25.8:
  • E00-E89
    2021 ICD-10-CM Range E00-E89

    Endocrine, nutritional and metabolic diseases

    Note
    • All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
    Type 1 Excludes
    • transitory endocrine and metabolic disorders specific to newborn (P70-P74)
    Endocrine, nutritional and metabolic diseases
  • E20-E35
    2021 ICD-10-CM Range E20-E35

    Disorders of other endocrine glands

    Type 1 Excludes
    Disorders of other endocrine glands
  • E25
    ICD-10-CM Diagnosis Code E25

    Adrenogenital disorders

      2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
    Includes
    • adrenogenital syndromes, virilizing or feminizing, whether acquired or due to adrenal hyperplasia consequent on inborn enzyme defects in hormone synthesis
    • Female adrenal pseudohermaphroditism
    • Female heterosexual precocious pseudopuberty
    • Male isosexual precocious pseudopuberty
    • Male macrogenitosomia praecox
    • Male sexual precocity with adrenal hyperplasia
    • Male virilization (female)
    Type 1 Excludes
    • indeterminate sex and pseudohermaphroditism (Q56)
    • chromosomal abnormalities (Q90-Q99)
    Adrenogenital disorders
Approximate Synonyms
  • Virilized female due to gestational hyperandrogenism
  • Virilized xx, gestational hyperandrogenism
ICD-10-CM E25.8 is grouped within Diagnostic Related Group(s) (MS-DRG v38.0):
  • 643 Endocrine disorders with mcc
  • 644 Endocrine disorders with cc
  • 645 Endocrine disorders without cc/mcc

Convert E25.8 to ICD-9-CM

Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change

Diagnosis Index entries containing back-references to E25.8:
  • Adrenogenital syndrome E25.9
    ICD-10-CM Diagnosis Code E25.9

    Adrenogenital disorder, unspecified

      2016 2017 2018 2019 2020 2021 Billable/Specific Code
    Applicable To
    • Adrenogenital syndrome NOS
    • acquired E25.8
  • Disorder (of) - see also Disease
    • adrenogenital E25.9
      ICD-10-CM Diagnosis Code E25.9

      Adrenogenital disorder, unspecified

        2016 2017 2018 2019 2020 2021 Billable/Specific Code
      Applicable To
      • Adrenogenital syndrome NOS
      • drug-induced E25.8
      • iatrogenic E25.8
      • idiopathic E25.8
  • Pseudohermaphroditism Q56.3
    ICD-10-CM Diagnosis Code Q56.3

    Pseudohermaphroditism, unspecified

      2016 2017 2018 2019 2020 2021 Billable/Specific Code POA Exempt
    • female Q56.2
      ICD-10-CM Diagnosis Code Q56.2

      Female pseudohermaphroditism, not elsewhere classified

        2016 2017 2018 2019 2020 2021 Billable/Specific Code POA Exempt
      Applicable To
      • Female pseudohermaphroditism NOS
      • with adrenocortical disorder E25.8
    • male Q56.1
      ICD-10-CM Diagnosis Code Q56.1

      Male pseudohermaphroditism, not elsewhere classified

        2016 2017 2018 2019 2020 2021 Billable/Specific Code Male Dx POA Exempt
      Applicable To
      • 46, XY with streak gonads
      • Male pseudohermaphroditism NOS
      • with
        • adrenocortical disorder E25.8
      • adrenal E25.8
    • adrenal E25.8
  • Pseudopuberty, precocious
    • female heterosexual E25.8
    • male isosexual E25.8
  • Puberty (development state) Z00.3
    ICD-10-CM Diagnosis Code Z00.3

    Encounter for examination for adolescent development state

      2016 2017 2018 2019 2020 2021 Billable/Specific Code Pediatric Dx (0-17 years) POA Exempt
    Applicable To
    • Encounter for puberty development state
    • premature E30.1
      ICD-10-CM Diagnosis Code E30.1

      Precocious puberty

        2016 2017 2018 2019 2020 2021 Billable/Specific Code Pediatric Dx (0-17 years)
      Applicable To
      • Precocious menstruation
      Type 1 Excludes
      • Albright (-McCune) (-Sternberg) syndrome (Q78.1)
      • central precocious puberty (E22.8)
      • congenital adrenal hyperplasia (E25.0)
      • female heterosexual precocious pseudopuberty (E25.-)
      • male isosexual precocious pseudopuberty (E25.-)
      • due to
        • adrenal cortical hyperfunction E25.8

ICD-10-CM Codes Adjacent To E25.8
E24 Cushing's syndrome
E24.0 Pituitary-dependent Cushing's disease
E24.1 Nelson's syndrome
E24.2 Drug-induced Cushing's syndrome
E24.3 Ectopic ACTH syndrome
E24.4 Alcohol-induced pseudo-Cushing's syndrome
E24.8 Other Cushing's syndrome
E24.9 Cushing's syndrome, unspecified
E25 Adrenogenital disorders
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
E25.8 Other adrenogenital disorders
E25.9 Adrenogenital disorder, unspecified
E26 Hyperaldosteronism
E26.0 Primary hyperaldosteronism
E26.01 Conn's syndrome
E26.02 Glucocorticoid-remediable aldosteronism
E26.09 Other primary hyperaldosteronism
E26.1 Secondary hyperaldosteronism
E26.8 Other hyperaldosteronism
E26.81 Bartter's syndrome
E26.89 Other hyperaldosteronism

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.