2022 ICD-10-CM Diagnosis Code E27.1

Primary adrenocortical insufficiency

    2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
  • E27.1 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2022 edition of ICD-10-CM E27.1 became effective on October 1, 2021.
  • This is the American ICD-10-CM version of E27.1 - other international versions of ICD-10 E27.1 may differ.
Applicable To
  • Addison's disease
  • Autoimmune adrenalitis
Type 1 Excludes
Type 1 Excludes Help
A type 1 excludes note is a pure excludes. It means "not coded here". A type 1 excludes note indicates that the code excluded should never be used at the same time as E27.1. A type 1 excludes note is for used for when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • Addison only phenotype adrenoleukodystrophy (
    ICD-10-CM Diagnosis Code E71.528

    Other X-linked adrenoleukodystrophy

      2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
    Applicable To
    • Addison only phenotype adrenoleukodystrophy
    • Addison-Schilder adrenoleukodystrophy
    E71.528
    )
  • amyloidosis (
    ICD-10-CM Diagnosis Code E85
    • E85 Amyloidosis
      • E85.0 Non-neuropathic heredofamilial amyloidosis
      • E85.1 Neuropathic heredofamilial amyloidosis
      • E85.2 Heredofamilial amyloidosis, unspecified
      • E85.3 Secondary systemic amyloidosis
      • E85.4 Organ-limited amyloidosis
      • E85.8 Other amyloidosis
        • E85.81 Light chain (AL) amyloidosis
        • E85.82 Wild-type transthyretin-related (ATTR) amyloi...
        • E85.89 Other amyloidosis
      • E85.9 Amyloidosis, unspecified
    E85.-
    )
  • tuberculous Addison's disease (
    ICD-10-CM Diagnosis Code A18.7

    Tuberculosis of adrenal glands

      2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
    Applicable To
    • Tuberculous Addison's disease
    A18.7
    )
  • Waterhouse-Friderichsen syndrome (
    ICD-10-CM Diagnosis Code A39.1

    Waterhouse-Friderichsen syndrome

      2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
    Applicable To
    • Meningococcal hemorrhagic adrenalitis
    • Meningococcic adrenal syndrome
    A39.1
    )
The following code(s) above E27.1 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to E27.1:
  • E00-E89
    2022 ICD-10-CM Range E00-E89

    Endocrine, nutritional and metabolic diseases

    Note
    • All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
    Type 1 Excludes
    • transitory endocrine and metabolic disorders specific to newborn (P70-P74)
    Endocrine, nutritional and metabolic diseases
  • E20-E35
    2022 ICD-10-CM Range E20-E35

    Disorders of other endocrine glands

    Type 1 Excludes
    Disorders of other endocrine glands
Approximate Synonyms
  • Addison's disease
  • Addison's disease, myopathy
  • Adrenal calcification
  • Adrenal insufficiency, primary
  • Myopathy in addison's disease
Clinical Information
  • A hormonal disorder that occurs when the adrenal glands fail to release adequate amounts of glucocorticoids (cortisol), mineralocorticoids (aldosterone, 11-deoxycorticosterone), and androgens (dehydroepiandrosterone) to meet physiologic needs, despite release of acth from the pituitary.
  • A rare endocrine or hormonal disorder that occurs when the adrenal glands do not produce enough of the hormone cortisol and in some cases, the hormone aldosterone. It may be due to a disorder of the adrenal glands themselves (primary adrenal insufficiency) or to inadequate secretion of acth by the pituitary gland (secondary adrenal insufficiency).
  • An adrenal disease characterized by the progressive destruction of the adrenal cortex, resulting in insufficient production of aldosterone and hydrocortisone. Clinical symptoms include anorexia; nausea; weight loss; muscle weakness; and hyperpigmentation of the skin due to increase in circulating levels of acth precursor hormone which stimulates melanocytes.
  • Disease characterized by hypotension, weight loss, anorexia, weakness, and sometimes a bronze-like melanotic hyperpigmentation of the skin; due to tuberculosis or autoimmune induced disease (hypofunction) of the adrenal glands that results in deficiency of aldosterone and cortisol.
  • Your adrenal glands are just above your kidneys. The outside layer of these glands makes hormones that help your body respond to stress and regulate your blood pressure and water and salt balance. Addison's disease happens if the adrenal glands don't make enough of these hormones. A problem with your immune system usually causes addison's disease. The immune system mistakenly attacks your own tissues, damaging your adrenal glands. Other causes include infections and cancer. Symptoms include
    • weight loss
    • muscle weakness
    • fatigue that gets worse over time
    • low blood pressure
    • patchy or dark skin
    lab tests can confirm that you have addison's disease. If you don't treat it, it can be fatal. You will need to take hormone pills for the rest of your life. If you have addison's disease, you should carry an emergency id. It should say that you have the disease, list your medicines and say how much you need in an emergency.
ICD-10-CM E27.1 is grouped within Diagnostic Related Group(s) (MS-DRG v39.0):
  • 643 Endocrine disorders with mcc
  • 644 Endocrine disorders with cc
  • 645 Endocrine disorders without cc/mcc

Convert E27.1 to ICD-9-CM

Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change
  • 2022 (effective 10/1/2021): No change

Diagnosis Index entries containing back-references to E27.1:
  • Addison's
  • Adrenalitis, adrenitis E27.8
    ICD-10-CM Diagnosis Code E27.8

    Other specified disorders of adrenal gland

      2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
    Applicable To
    • Abnormality of cortisol-binding globulin
    • autoimmune E27.1
  • Atrophy, atrophic (of)
    • adrenal (capsule) (gland) E27.49
      ICD-10-CM Diagnosis Code E27.49

      Other adrenocortical insufficiency

        2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
      Applicable To
      • Adrenal hemorrhage
      • Adrenal infarction
      • primary E27.1 (autoimmune)
    • suprarenal (capsule) (gland) E27.49
      ICD-10-CM Diagnosis Code E27.49

      Other adrenocortical insufficiency

        2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
      Applicable To
      • Adrenal hemorrhage
      • Adrenal infarction
      • primary E27.1
  • Deficiency, deficient
    • corticoadrenal E27.40
      ICD-10-CM Diagnosis Code E27.40

      Unspecified adrenocortical insufficiency

        2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
      Applicable To
      • Adrenocortical insufficiency NOS
      • Hypoaldosteronism
      • primary E27.1
  • Disease, diseased - see also Syndrome
  • Hypoadrenalism, hypoadrenia E27.40
    ICD-10-CM Diagnosis Code E27.40

    Unspecified adrenocortical insufficiency

      2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
    Applicable To
    • Adrenocortical insufficiency NOS
    • Hypoaldosteronism
    • primary E27.1
  • Hypoadrenocorticism E27.40
    ICD-10-CM Diagnosis Code E27.40

    Unspecified adrenocortical insufficiency

      2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
    Applicable To
    • Adrenocortical insufficiency NOS
    • Hypoaldosteronism
    • primary E27.1
  • Hypofunction
    • adrenocortical E27.40
      ICD-10-CM Diagnosis Code E27.40

      Unspecified adrenocortical insufficiency

        2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
      Applicable To
      • Adrenocortical insufficiency NOS
      • Hypoaldosteronism
      • primary E27.1
  • Insufficiency, insufficient
    • adrenal (gland) E27.40
      ICD-10-CM Diagnosis Code E27.40

      Unspecified adrenocortical insufficiency

        2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
      Applicable To
      • Adrenocortical insufficiency NOS
      • Hypoaldosteronism
      • primary E27.1
    • adrenocortical E27.40
      ICD-10-CM Diagnosis Code E27.40

      Unspecified adrenocortical insufficiency

        2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
      Applicable To
      • Adrenocortical insufficiency NOS
      • Hypoaldosteronism
      • primary E27.1
    • corticoadrenal E27.40
      ICD-10-CM Diagnosis Code E27.40

      Unspecified adrenocortical insufficiency

        2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
      Applicable To
      • Adrenocortical insufficiency NOS
      • Hypoaldosteronism
      • primary E27.1
    • suprarenal E27.40
      ICD-10-CM Diagnosis Code E27.40

      Unspecified adrenocortical insufficiency

        2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
      Applicable To
      • Adrenocortical insufficiency NOS
      • Hypoaldosteronism
      • primary E27.1
  • Melanosis L81.4
    ICD-10-CM Diagnosis Code L81.4

    Other melanin hyperpigmentation

      2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
    Applicable To
    • Lentigo
  • Melasma L81.1
    ICD-10-CM Diagnosis Code L81.1

    Chloasma

      2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
    • adrenal E27.1 (gland)
    • suprarenal E27.1 (gland)
  • Myopathy G72.9
    ICD-10-CM Diagnosis Code G72.9

    Myopathy, unspecified

      2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
    • in (due to)
      • Addison's disease E27.1

ICD-10-CM Codes Adjacent To E27.1
E26.01 Conn's syndrome
E26.02 Glucocorticoid-remediable aldosteronism
E26.09 Other primary hyperaldosteronism
E26.1 Secondary hyperaldosteronism
E26.8 Other hyperaldosteronism
E26.81 Bartter's syndrome
E26.89 Other hyperaldosteronism
E26.9 Hyperaldosteronism, unspecified
E27 Other disorders of adrenal gland
E27.0 Other adrenocortical overactivity
E27.1 Primary adrenocortical insufficiency
E27.2 Addisonian crisis
E27.3 Drug-induced adrenocortical insufficiency
E27.4 Other and unspecified adrenocortical insufficiency
E27.40 Unspecified adrenocortical insufficiency
E27.49 Other adrenocortical insufficiency
E27.5 Adrenomedullary hyperfunction
E27.8 Other specified disorders of adrenal gland
E27.9 Disorder of adrenal gland, unspecified
E28 Ovarian dysfunction
E28.0 Estrogen excess

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.