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ICD-10-CM Codes
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E00-E89
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E20-E35
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E28-
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2023 ICD-10-CM Diagnosis Code E28.0
2023 ICD-10-CM Diagnosis Code E28.0
Estrogen excess
2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code Female Dx
- E28.0 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
- The 2023 edition of ICD-10-CM E28.0 became effective on October 1, 2022.
- This is the American ICD-10-CM version of E28.0 - other international versions of ICD-10 E28.0 may differ.
ICD-10-CM Coding Rules
- E28.0 is applicable to female patients.
Use AdditionalUse Additional Help
Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. For such conditions the ICD-10-CM has a coding convention that requires the underlying condition be sequenced first followed by the manifestation. Wherever such a combination exists there is a "use additional code" note at the etiology code, and a "code first" note at the manifestation code. These instructional notes indicate the proper sequencing order of the codes, etiology followed by manifestation. In most cases the manifestation codes will have in the code title, "in diseases classified elsewhere." Codes with this title are a component of the etiology/manifestation convention. The code title indicates that it is a manifestation code. "In diseases classified elsewhere" codes are never permitted to be used as first listed or principle diagnosis codes. They must be used in conjunction with an underlying condition code and they must be listed following the underlying condition.
- code for adverse effect, if applicable, to identify drug (T36-T50
ICD-10-CM Range T36-T50
Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substancesCode First- , for adverse effects, the nature of the adverse effect, such as:
- adverse effect NOS (T88.7)
- aspirin gastritis (K29.-)
- blood disorders (D56-D76)
- contact dermatitis (L23-L25)
- dermatitis due to substances taken internally (L27.-)
- nephropathy (N14.0-N14.2)
Includes- adverse effect of correct substance properly administered
- poisoning by overdose of substance
- poisoning by wrong substance given or taken in error
- underdosing by (inadvertently) (deliberately) taking less substance than prescribed or instructed
Note- The drug giving rise to the adverse effect should be identified by use of codes from categories T36-T50 with fifth or sixth character 5.
Type 1 Excludes- toxic reaction to local anesthesia in pregnancy (O29.3-)
Type 2 Excludes- abuse and dependence of psychoactive substances (F10-F19)
- abuse of non-dependence-producing substances (F55.-)
- immunodeficiency due to drugs (D84.821)
- drug reaction and poisoning affecting newborn (P00-P96)
- pathological drug intoxication (inebriation) (F10-F19)
Use Additional- code(s) to specify:
- manifestations of poisoning
- underdosing or failure in dosage during medical and surgical care (Y63.6, Y63.8-Y63.9)
- underdosing of medication regimen (Z91.12-, Z91.13-)
- T36 Poisoning by, adverse effect of and unde...
- T37 Poisoning by, adverse effect of and unde...
- T38 Poisoning by, adverse effect of and unde...
- T39 Poisoning by, adverse effect of and unde...
- T40 Poisoning by, adverse effect of and unde...
- T41 Poisoning by, adverse effect of and unde...
- T42 Poisoning by, adverse effect of and unde...
- T43 Poisoning by, adverse effect of and unde...
- T44 Poisoning by, adverse effect of and unde...
- T45 Poisoning by, adverse effect of and unde...
- T46 Poisoning by, adverse effect of and unde...
- T47 Poisoning by, adverse effect of and unde...
- T48 Poisoning by, adverse effect of and unde...
- T49 Poisoning by, adverse effect of and unde...
- T50 Poisoning by, adverse effect of and unde...
The following code(s) above
E28.0 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
- Applicable To annotations, or
- Code Also annotations, or
- Code First annotations, or
- Excludes1 annotations, or
- Excludes2 annotations, or
- Includes annotations, or
- Note annotations, or
- Use Additional annotations
that may be applicable to
E28.0:
- E00-E89
2023 ICD-10-CM Range E00-E89
Endocrine, nutritional and metabolic diseasesNote- All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
Type 1 Excludes- transitory endocrine and metabolic disorders specific to newborn (P70-P74)
- E20-E35
2023 ICD-10-CM Range E20-E35
Disorders of other endocrine glands
- E28
ICD-10-CM Diagnosis Code E28
Ovarian dysfunction
2016 2017 2018 2019 2020 2021 2022 2023 Non-Billable/Non-Specific Code
Type 1 Excludes- isolated gonadotropin deficiency (E23.0)
- postprocedural ovarian failure (E89.4-)
- 742 Uterine and adnexa procedures for non-malignancy with cc/mcc
- 743 Uterine and adnexa procedures for non-malignancy without cc/mcc
- 760 Menstrual and other female reproductive system disorders with cc/mcc
- 761 Menstrual and other female reproductive system disorders without cc/mcc
Convert E28.0 to ICD-9-CM
Code History
- 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
- 2017 (effective 10/1/2016): No change
- 2018 (effective 10/1/2017): No change
- 2019 (effective 10/1/2018): No change
- 2020 (effective 10/1/2019): No change
- 2021 (effective 10/1/2020): No change
- 2022 (effective 10/1/2021): No change
- 2023 (effective 10/1/2022): No change
- Excess, excessive, excessively
- Hyperestrogenism E28.0 (drug-induced) (iatrogenic)
- Hypersecretion
- Increase, increased
- Puberty (development state) Z00.3
ICD-10-CM Diagnosis Code Z00.3
Encounter for examination for adolescent development state
2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code Pediatric Dx (0-17 years) POA Exempt
Applicable To- Encounter for puberty development state
- precocious (constitutional) (cryptogenic) (idiopathic) E30.1
ICD-10-CM Diagnosis Code E30.1
Precocious puberty
2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code Pediatric Dx (0-17 years)
Type 1 Excludes- Albright (-McCune) (-Sternberg) syndrome (Q78.1)
- central precocious puberty (E22.8)
- congenital adrenal hyperplasia (E25.0)
- female heterosexual precocious pseudopuberty (E25.-)
- male isosexual precocious pseudopuberty (E25.-)
- due to
- ovarian hyperfunction E28.1
ICD-10-CM Diagnosis Code E28.1
Androgen excess
2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code Female Dx
Applicable To- Hypersecretion of ovarian androgens
Use Additional- code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)
ICD-10-CM Codes Adjacent To E28.0
E27.1 Primary adrenocortical insufficiency
E27.3 Drug-induced adrenocortical insufficiency
E27.4 Other and unspecified adrenocortical insufficiency
E27.40 Unspecified adrenocortical insufficiency
E27.49 Other adrenocortical insufficiency
E27.5 Adrenomedullary hyperfunction
E27.8 Other specified disorders of adrenal gland
E27.9 Disorder of adrenal gland, unspecified
E28.0
Estrogen excess
E28.2 Polycystic ovarian syndrome
E28.3 Primary ovarian failure
E28.310 Symptomatic premature menopause
E28.319 Asymptomatic premature menopause
E28.39 Other primary ovarian failure
E28.8 Other ovarian dysfunction
E28.9 Ovarian dysfunction, unspecified
E29 Testicular dysfunction
Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.
