2020 ICD-10-CM Diagnosis Code E31.2

Multiple endocrine neoplasia [MEN] syndromes

    2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
  • E31.2 should not be used for reimbursement purposes as there are multiple codes below it that contain a greater level of detail.
  • The 2020 edition of ICD-10-CM E31.2 became effective on October 1, 2019.
  • This is the American ICD-10-CM version of E31.2 - other international versions of ICD-10 E31.2 may differ.
Applicable To
  • Multiple endocrine adenomatosis
Code Also
Code Also Help
A code also note instructs that 2 codes may be required to fully describe a condition but the sequencing of the two codes is discretionary, depending on the severity of the conditions and the reason for the encounter.
  • any associated malignancies and other conditions associated with the syndromes
The following code(s) above E31.2 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to E31.2:
  • E00-E89
    2020 ICD-10-CM Range E00-E89

    Endocrine, nutritional and metabolic diseases

    Note
    • All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
    Type 1 Excludes
    • transitory endocrine and metabolic disorders specific to newborn (P70-P74)
    Endocrine, nutritional and metabolic diseases
  • E20-E35
    2020 ICD-10-CM Range E20-E35

    Disorders of other endocrine glands

    Type 1 Excludes
    Disorders of other endocrine glands
  • E31
    ICD-10-CM Diagnosis Code E31

    Polyglandular dysfunction

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • ataxia telangiectasia [Louis-Bar] (G11.3)
    • dystrophia myotonica [Steinert] (G71.11)
    • pseudohypoparathyroidism (E20.1)
    Polyglandular dysfunction
Clinical Information
  • A group of autosomal dominant diseases characterized by the combined occurrence of tumors involving two or more endocrine glands that secrete peptide hormones or amines. These neoplasias are often benign but can be malignant. They are classified by the endocrine glands involved and the degree of aggressiveness. The two major forms are men1 and men2 with gene mutations on chromosome 11 and chromosome 10, respectively.
  • An autosomal dominant inherited neoplastic syndrome characterized by the development of various endocrine neoplasms and abnormalities in various anatomic sites. There are three types recognized: type 1 (men 1), caused by inactivation of the tumor suppressor gene men-1, type 2a (men 2a), caused by mutation of the ret gene, and type 2b (men 2b) also caused by mutation of the ret gene. Patients with men 1 may develop hyperparathyroidism and parathyroid gland adenomas, pituitary gland adenomas, pancreatic islet cell neoplasms, and carcinoid tumors. Patients with men 2a develop medullary thyroid carcinomas, and may also develop pheochromocytomas and parathyroid gland hyperplasia. Patients with men 2b develop medullary thyroid carcinomas and numerous neural defects including neuromas.
  • An inherited condition that may result in the development of cancers of the endocrine system. There are several types of multiple endocrine neoplasia syndrome, and patients with each type may develop different types of cancer. The altered genes that cause each type can be detected with a blood test.
  • Group of specific, familial syndromes characterized by simultaneous neoplastic transformation of multiple endocrine tissues, typically the parathyroid glands, pancreatic islets, and anterior pituitary.
Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
Code annotations containing back-references to E31.2:
  • Code Also: C7A
    , D3A
    ICD-10-CM Diagnosis Code C7A

    Malignant neuroendocrine tumors

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Code Also
    • any associated multiple endocrine neoplasia [MEN] syndromes (E31.2-)
    Type 2 Excludes
    • malignant pancreatic islet cell tumors (C25.4)
    • Merkel cell carcinoma (C4A.-)
    Use Additional
    • code to identify any associated endocrine syndrome, such as:
    • carcinoid syndrome (E34.0)
    ICD-10-CM Diagnosis Code D3A

    Benign neuroendocrine tumors

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Code Also
    • any associated multiple endocrine neoplasia [MEN] syndromes (E31.2-)
    Type 2 Excludes
    • benign pancreatic islet cell tumors (D13.7)
    Use Additional
    • code to identify any associated endocrine syndrome, such as:
    • carcinoid syndrome (E34.0)
  • Type 1 Excludes: Z15.81
    , D44
    , D44
    , E31.1
    , E31.1
    ICD-10-CM Diagnosis Code Z15.81

    Genetic susceptibility to multiple endocrine neoplasia [MEN]

      2016 2017 2018 2019 2020 Billable/Specific Code POA Exempt
    Type 1 Excludes
    • multiple endocrine neoplasia [MEN] syndromes (E31.2-)
    ICD-10-CM Diagnosis Code D44

    Neoplasm of uncertain behavior of endocrine glands

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • multiple endocrine adenomatosis (E31.2-)
    • multiple endocrine neoplasia (E31.2-)
    • neoplasm of uncertain behavior of endocrine pancreas (D37.8)
    • neoplasm of uncertain behavior of ovary (D39.1-)
    • neoplasm of uncertain behavior of testis (D40.1-)
    • neoplasm of uncertain behavior of thymus (D38.4)
    ICD-10-CM Diagnosis Code D44

    Neoplasm of uncertain behavior of endocrine glands

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • multiple endocrine adenomatosis (E31.2-)
    • multiple endocrine neoplasia (E31.2-)
    • neoplasm of uncertain behavior of endocrine pancreas (D37.8)
    • neoplasm of uncertain behavior of ovary (D39.1-)
    • neoplasm of uncertain behavior of testis (D40.1-)
    • neoplasm of uncertain behavior of thymus (D38.4)
    ICD-10-CM Diagnosis Code E31.1

    Polyglandular hyperfunction

      2016 2017 2018 2019 2020 Billable/Specific Code
    Type 1 Excludes
    • multiple endocrine adenomatosis (E31.2-)
    • multiple endocrine neoplasia (E31.2-)
    ICD-10-CM Diagnosis Code E31.1

    Polyglandular hyperfunction

      2016 2017 2018 2019 2020 Billable/Specific Code
    Type 1 Excludes
    • multiple endocrine adenomatosis (E31.2-)
    • multiple endocrine neoplasia (E31.2-)
ICD-10-CM Codes Adjacent To E31.2
E29.8 Other testicular dysfunction
E29.9 Testicular dysfunction, unspecified
E30 Disorders of puberty, not elsewhere classified
E30.0 Delayed puberty
E30.1 Precocious puberty
E30.8 Other disorders of puberty
E30.9 Disorder of puberty, unspecified
E31 Polyglandular dysfunction
E31.0 Autoimmune polyglandular failure
E31.1 Polyglandular hyperfunction
E31.2 Multiple endocrine neoplasia [MEN] syndromes
E31.20 Multiple endocrine neoplasia [MEN] syndrome, unspecified
E31.21 Multiple endocrine neoplasia [MEN] type I
E31.22 Multiple endocrine neoplasia [MEN] type IIA
E31.23 Multiple endocrine neoplasia [MEN] type IIB
E31.8 Other polyglandular dysfunction
E31.9 Polyglandular dysfunction, unspecified
E32 Diseases of thymus
E32.0 Persistent hyperplasia of thymus
E32.1 Abscess of thymus
E32.8 Other diseases of thymus

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.