1. ICD-10-CM Codes
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2. E00-E89
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3. E20-E35
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4. E31-
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5. 2023 ICD-10-CM Diagnosis Code E31.20

2023 ICD-10-CM Diagnosis Code E31.20

Multiple endocrine neoplasia [MEN] syndrome, unspecified

2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code

• E31.20 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
• The 2023 edition of ICD-10-CM E31.20 became effective on October 1, 2022.
• This is the American ICD-10-CM version of E31.20 - other international versions of ICD-10 E31.20 may differ.

• Multiple endocrine neoplasia syndrome
• Polyglandular activity in multiple endocrine adenomatosis

• A group of autosomal dominant diseases characterized by the combined occurrence of tumors involving two or more endocrine glands that secrete peptide hormones or amines. These neoplasias are often benign but can be malignant. They are classified by the endocrine glands involved and the degree of aggressiveness. The two major forms are men1 and men2 with gene mutations on chromosome 11 and chromosome 10, respectively.
• An autosomal dominant inherited neoplastic syndrome characterized by the development of various endocrine neoplasms and abnormalities in various anatomic sites. There are three types recognized: type 1 (men 1), caused by inactivation of the tumor suppressor gene men-1, type 2a (men 2a), caused by mutation of the ret gene, and type 2b (men 2b) also caused by mutation of the ret gene. Patients with men 1 may develop hyperparathyroidism and parathyroid gland adenomas, pituitary gland adenomas, pancreatic islet cell neoplasms, and carcinoid tumors. Patients with men 2a develop medullary thyroid carcinomas, and may also develop pheochromocytomas and parathyroid gland hyperplasia. Patients with men 2b develop medullary thyroid carcinomas and numerous neural defects including neuromas.
• An inherited condition that may result in the development of cancers of the endocrine system. There are several types of multiple endocrine neoplasia syndrome, and patients with each type may develop different types of cancer. The altered genes that cause each type can be detected with a blood test.
• Group of specific, familial syndromes characterized by simultaneous neoplastic transformation of multiple endocrine tissues, typically the parathyroid glands, pancreatic islets, and anterior pituitary.

• 643 Endocrine disorders with mcc
• 644 Endocrine disorders with cc
• 645 Endocrine disorders without cc/mcc

Convert E31.20 to ICD-9-CM

• 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
• 2017 (effective 10/1/2016): No change
• 2018 (effective 10/1/2017): No change
• 2019 (effective 10/1/2018): No change
• 2020 (effective 10/1/2019): No change
• 2021 (effective 10/1/2020): No change
• 2022 (effective 10/1/2021): No change
• 2023 (effective 10/1/2022): No change

• Adenomatosis
  • endocrine (multiple) E31.20
• Neoplasia
  • endocrine, multiple (MEN) E31.20

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.