1. ICD-10-CM Codes
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2. E00-E89
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3. E20-E35
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4. E31-
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5. 2023 ICD-10-CM Diagnosis Code E31.21

2023 ICD-10-CM Diagnosis Code E31.21

Multiple endocrine neoplasia [MEN] type I

2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code

• E31.21 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
• The 2023 edition of ICD-10-CM E31.21 became effective on October 1, 2022.
• This is the American ICD-10-CM version of E31.21 - other international versions of ICD-10 E31.21 may differ.

• Multiple endocrine neoplasia, type 1
• Multiple endocrine neoplasm type 1

• A form of multiple endocrine neoplasia that is characterized by the combined occurrence of tumors in the parathyroid glands, the pituitary gland, and the pancreatic islets. The resulting clinical signs include hyperparathyroidism; hypercalcemia; hyperprolactinemia; cushing disease; gastrinoma; and zollinger-ellison syndrome. This disease is due to loss-of-function of the men1 gene, a tumor suppressor gene (genes, tumor suppressor) on chromosome 11 (locus: 11q13).
• A rare, inherited disorder that affects the endocrine glands and can cause tumors in the parathyroid and pituitary glands and the pancreas. These tumors are usually benign (not cancer). They cause the glands to secrete high levels of hormones, which can lead to other medical problems, such as kidney stones, fertility problems, and severe ulcers. In some cases, tumors inside the pancreas can become malignant (cancer).
• Multiple endocrine neoplasia caused by inactivation of the tumor suppressor gene men-1. Patients may develop hyperparathyroidism and parathyroid gland adenomas, pituitary gland adenomas, pancreatic islet cell neoplasms, and carcinoid tumors.

• 643 Endocrine disorders with mcc
• 644 Endocrine disorders with cc
• 645 Endocrine disorders without cc/mcc

Convert E31.21 to ICD-9-CM

• 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
• 2017 (effective 10/1/2016): No change
• 2018 (effective 10/1/2017): No change
• 2019 (effective 10/1/2018): No change
• 2020 (effective 10/1/2019): No change
• 2021 (effective 10/1/2020): No change
• 2022 (effective 10/1/2021): No change
• 2023 (effective 10/1/2022): No change

• Disease, diseased - see also Syndrome
  • Wermer's E31.21
• Neoplasia
  • endocrine, multiple (MEN) E31.20
    ICD-10-CM Diagnosis Code E31.20

    Multiple endocrine neoplasia [MEN] syndrome, unspecified

    2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code

    Applicable To

    • Multiple endocrine adenomatosis NOS
    • Multiple endocrine neoplasia [MEN] syndrome NOS
    • type I E31.21
• Syndrome - see also Disease
  • Wermer's E31.21
• Wermer's disease or syndrome E31.21

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.