2023

  1. ICD-10-CM Codes
    2. ›
  2. E00-E89
    3. ›
  3. E20-E35
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  4. E34-
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  5. 2023 ICD-10-CM Diagnosis Code E34.321

2023 ICD-10-CM Diagnosis Code E34.321

Primary insulin-like growth factor-1 (IGF-1) deficiency

    2023 - New Code Billable/Specific Code
  • E34.321 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • ICD-10-CM E34.321 is a new 2023 ICD-10-CM code that became effective on October 1, 2022.
  • This is the American ICD-10-CM version of E34.321 - other international versions of ICD-10 E34.321 may differ.
Applicable To
  • Acid-labile subunit gene (IGFALS) defect
  • Growth hormone gene 1 (GH1) defect with growth hormone neutralizing antibodies
  • Growth hormone insensitivity syndrome (GHIS)
  • Insulin-like growth factor 1 gene (IGF1) defect
  • Laron type short stature
  • Severe primary insulin-like growth factor-1 deficiency (SPIGFD)
  • Signal transducer and activator of transcription 5B gene (STAT5b) defect
The following code(s) above E34.321 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to E34.321:
  • E00-E89
    2023 ICD-10-CM Range E00-E89

    Endocrine, nutritional and metabolic diseases

    Note
    • All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
    Type 1 Excludes
    • transitory endocrine and metabolic disorders specific to newborn (P70-P74)
    Endocrine, nutritional and metabolic diseases
  • E20-E35
    2023 ICD-10-CM Range E20-E35

    Disorders of other endocrine glands

    Type 1 Excludes
    Disorders of other endocrine glands
  • E34
    ICD-10-CM Diagnosis Code E34

    Other endocrine disorders

      2016 2017 2018 2019 2020 2021 2022 2023 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • pseudohypoparathyroidism (E20.1)
    Other endocrine disorders
  • E34.3
    ICD-10-CM Diagnosis Code E34.3

    Short stature due to endocrine disorder

      2016 2017 2018 2019 2020 2021 2022 2023 - Converted to Parent Code Non-Billable/Non-Specific Code
    Type 1 Excludes
    • achondroplastic short stature (Q77.4)
    • hypochondroplastic short stature (Q77.4)
    • nutritional short stature (E45)
    • pituitary short stature (E23.0)
    • progeria (E34.8)
    • renal short stature (N25.0)
    • Russell-Silver syndrome (Q87.19)
    • short-limbed stature with immunodeficiency (D82.2)
    • short stature (child) (R62.52)
    • short stature in specific dysmorphic syndromes - code to syndrome - see Alphabetical Index
    • short stature NOS (R62.52)
    Short stature due to endocrine disorder
ICD-10-CM E34.321 is grouped within Diagnostic Related Group(s) (MS-DRG v40.0):
  • 643 Endocrine disorders with mcc
  • 644 Endocrine disorders with cc
  • 645 Endocrine disorders without cc/mcc
Code History
  • 2023 (effective 10/1/2022): New code

Diagnosis Index entries containing back-references to E34.321:
  • Dwarfism E34.328
    - see also Stature, short
    ICD-10-CM Diagnosis Code E34.328

    Other genetic causes of short stature

      2023 - New Code Billable/Specific Code
    Applicable To
    • Short stature due to ACAN gene variant
    • Short stature due to aggrecan deficiency
    • Short stature due to NPR-2 gene variant
    • Laron-type E34.321 - see also Stature, short
  • Short, shortening, shortness
    • stature (child) (hereditary) (idiopathic) R62.52
      ICD-10-CM Diagnosis Code R62.52

      Short stature (child)

        2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
      Applicable To
      • Lack of growth
      • Physical retardation
      • Short stature NOS
      Type 1 Excludes
      • short stature due to endocrine disorder (E34.3-)
      • due to
        • genetic causes E34.329
          ICD-10-CM Diagnosis Code E34.329

          Unspecified genetic causes of short stature

            2023 - New Code Billable/Specific Code
          • acid-labile subunit gene E34.321 (IGFALS)
          • growth hormone gene 1 E34.321 (GH1)
          • growth hormone insensitivity syndrome E34.321 (GHIS)
          • insulin-like growth factor 1 gene E34.321 (IGF1)
          • primary insulin-like growth factor-1 E34.321 (IGF-1)
          • severe primary insulin-like growth factor-1 deficiency E34.321 (SPIGFD)
          • signal transducer and activator of transcription 5B gene E34.321 (STAT5b)
      • Laron-type E34.321

ICD-10-CM Codes Adjacent To E34.321
E32.8 Other diseases of thymus
E32.9 Disease of thymus, unspecified
E34 Other endocrine disorders
E34.0 Carcinoid syndrome
E34.1 Other hypersecretion of intestinal hormones
E34.2 Ectopic hormone secretion, not elsewhere classified
E34.3 Short stature due to endocrine disorder
E34.30 …… unspecified
E34.31 Constitutional short stature
E34.32 Genetic causes of short stature
E34.321 Primary insulin-like growth factor-1 (IGF-1) deficiency
E34.322 Insulin-like growth factor-1 (IGF-1) resistance
E34.328 Other genetic causes of short stature
E34.329 Unspecified genetic causes of short stature
E34.39 Other short stature due to endocrine disorder
E34.4 Constitutional tall stature
E34.5 Androgen insensitivity syndrome
E34.50 …… unspecified
E34.51 Complete androgen insensitivity syndrome
E34.52 Partial androgen insensitivity syndrome
E34.8 Other specified endocrine disorders

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.

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