ICD-10-CM Codes
E00-E89 Endocrine, nutritional and metabolic diseases
E50-E64 Other nutritional deficiencies
E52- Niacin deficiency [pellagra]
2022 ICD-10-CM Diagnosis Code E52

2022 ICD-10-CM Diagnosis Code E52

Niacin deficiency [pellagra]

2016

2017

2018

2019

2020

2021

2022

Billable/Specific Code

E52 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
The 2022 edition of ICD-10-CM E52 became effective on October 1, 2021.
This is the American ICD-10-CM version of E52 - other international versions of ICD-10 E52 may differ.

Applicable To

Niacin (-tryptophan) deficiency
Nicotinamide deficiency
Pellagra (alcoholic)

Type 1 Excludes

Type 1 Excludes Help

A type 1 excludes note is a pure excludes. It means "not coded here". A type 1 excludes note indicates that the code excluded should never be used at the same time as E52. A type 1 excludes note is for used for when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.

sequelae of niacin deficiency (
ICD-10-CM Diagnosis Code E64.8
Sequelae of other nutritional deficiencies
E64.8
)

The following code(s) above E52 contain annotation back-references

Annotation Back-References

In this context, annotation back-references refer to codes that contain:

Applicable To annotations, or
Code Also annotations, or
Code First annotations, or
Excludes1 annotations, or
Excludes2 annotations, or
Includes annotations, or
Note annotations, or
Use Additional annotations

that may be applicable to E52:

E00-E89
2022 ICD-10-CM Range E00-E89
Endocrine, nutritional and metabolic diseases
Note
- All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
Type 1 Excludes
- transitory endocrine and metabolic disorders specific to newborn (P70-P74)
Endocrine, nutritional and metabolic diseases
E50-E64
2022 ICD-10-CM Range E50-E64
Other nutritional deficiencies
Type 2 Excludes
- nutritional anemias (D50-D53)
Other nutritional deficiencies

Approximate Synonyms

Niacin deficiency
Pellagra

Clinical Information

A disease due to deficiency of niacin, a b-complex vitamin, or its precursor tryptophan. It is characterized by scaly dermatitis which is often associated with diarrhea and dementia (the three d's).

ICD-10-CM E52 is grouped within Diagnostic Related Group(s) (MS-DRG v39.0):

640 Miscellaneous disorders of nutrition, metabolism, fluids and electrolytes with mcc
641 Miscellaneous disorders of nutrition, metabolism, fluids and electrolytes without mcc

Convert E52 to ICD-9-CM

Code History

2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
2017 (effective 10/1/2016): No change
2018 (effective 10/1/2017): No change
2019 (effective 10/1/2018): No change
2020 (effective 10/1/2019): No change
2021 (effective 10/1/2020): No change
2022 (effective 10/1/2021): No change

Code annotations containing back-references to E52:

Code First: F02

ICD-10-CM Diagnosis Code F02
Dementia in other diseases classified elsewhere
Code First
- the underlying physiological condition, such as:
- Alzheimer's (G30.-)
- cerebral lipidosis (E75.4)
- Creutzfeldt-Jakob disease (A81.0-)
- dementia with Lewy bodies (G31.83)
- dementia with Parkinsonism (G31.83)
- epilepsy and recurrent seizures (G40.-)
- frontotemporal dementia (G31.09)
- hepatolenticular degeneration (E83.0)
- human immunodeficiency virus [HIV] disease (B20)
- Huntington's disease (G10)
- hypercalcemia (E83.52)
- hypothyroidism, acquired (E00-E03.-)
- intoxications (T36-T65)
- Jakob-Creutzfeldt disease (A81.0-)
- multiple sclerosis (G35)
- neurosyphilis (A52.17)
- niacin deficiency [pellagra] (E52)
- Parkinson's disease (G20)
- Pick's disease (G31.01)
- polyarteritis nodosa (M30.0)
- prion disease (A81.9)
- systemic lupus erythematosus (M32.-)
- traumatic brain injury (S06.-)
- trypanosomiasis (B56.-, B57.-)
- vitamin B deficiency (E53.8)
Includes
- Major neurocognitive disorder in other diseases classified elsewhere
Type 2 Excludes
- dementia in alcohol and psychoactive substance disorders (F10-F19, with .17, .27, .97)
- vascular dementia (F01.5-)

Diagnosis Index entries containing back-references to E52:

Acid
- deficiency
  - amide nicotinic E52
  - nicotinic E52
Alcohol, alcoholic, alcohol-induced
- pellagra E52
Avitaminosis (multiple) E56.9
- see also Deficiency, vitamin
ICD-10-CM Diagnosis Code E56.9
Vitamin deficiency, unspecified
- B E53.9
  ICD-10-CM Diagnosis Code E53.9
  Vitamin B deficiency, unspecified
  2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
  - with
    - pellagra E52
- nicotinic acid E52
Cheilosis (angular) K13.0
ICD-10-CM Diagnosis Code K13.0
Diseases of lips
Applicable To
Abscess of lips
Angular cheilitis
Cellulitis of lips
Cheilitis NOS
Cheilodynia
Cheilosis
Exfoliative cheilitis
Fistula of lips
Glandular cheilitis
Hypertrophy of lips
Perlèche NEC
Type 1 Excludes
ariboflavinosis (E53.0)
cheilitis due to radiation-related disorders (L55-L59)
congenital fistula of lips (Q38.0)
congenital hypertrophy of lips (Q18.6)
Perlèche due to candidiasis (B37.83)
Perlèche due to riboflavin deficiency (E53.0)
- with pellagra E52
Deficiency, deficient
- vitamin (multiple) E56.9
  ICD-10-CM Diagnosis Code E56.9
  Vitamin deficiency, unspecified
  2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
  - B (complex) E53.9
    ICD-10-CM Diagnosis Code E53.9
    Vitamin B deficiency, unspecified
    2016 2017 2018 2019 2020 2021 2022 Billable/Specific Code
    - with
      - pellagra E52
  - nicotinic E52
  - PP E52 (pellagra-preventing)
- niacin E52 (amide) (-tryptophan)
- nicotinamide E52
- nicotinic acid E52
Dementia (degenerative (primary)) (old age) (persisting) F03.90
ICD-10-CM Diagnosis Code F03.90
Unspecified dementia without behavioral disturbance
Applicable To
Dementia NOS
- in (due to)
  - niacin deficiency E52
    - with behavioral disturbance E52
  - pellagra E52
    - with behavioral disturbance E52
Dermatitis (eczematous) L30.9
ICD-10-CM Diagnosis Code L30.9
Dermatitis, unspecified
Applicable To
Eczema NOS
- pellagrous E52
Encephalopathy (acute) G93.40
ICD-10-CM Diagnosis Code G93.40
Encephalopathy, unspecified
- pellagrous E52
Erythema, erythematous (infectional) (inflammation) L53.9
ICD-10-CM Diagnosis Code L53.9
Erythematous condition, unspecified
Applicable To
Erythema NOS
Erythroderma NOS
- endemic E52
Gingivitis K05.10
ICD-10-CM Diagnosis Code K05.10
Chronic gingivitis, plaque induced
Applicable To
Chronic gingivitis NOS
Gingivitis NOS
- pellagrous E52
Glossitis (chronic superficial) (gangrenous) (Moeller's) K14.0
ICD-10-CM Diagnosis Code K14.0
Glossitis
Applicable To
Abscess of tongue
Ulceration (traumatic) of tongue
Type 1 Excludes
atrophic glossitis (K14.4)
- pellagrous E52
Niacin E52 (amide)
Nicotinic acid deficiency E52
Pellagra E52 (alcoholic) (with polyneuropathy)
Polioencephalopathy, superior hemorrhagic E51.2
ICD-10-CM Diagnosis Code E51.2
Wernicke's encephalopathy
- with
  - pellagra E52
Polyneuropathy (peripheral) G62.9
ICD-10-CM Diagnosis Code G62.9
Polyneuropathy, unspecified
Applicable To
Neuropathy NOS
- in (due to)
  - pellagra E52
Syndrome - see also Disease
- pellagroid E52

ICD-10-CM Codes Adjacent To E52

E50.7 Other ocular manifestations of vitamin A deficiency

E50.8 Other manifestations of vitamin A deficiency

E50.9 Vitamin A deficiency, unspecified

E51 Thiamine deficiency

E51.1 Beriberi

E51.11 Dry beriberi

E51.12 Wet beriberi

E51.2 Wernicke's encephalopathy

E51.8 Other manifestations of thiamine deficiency

E51.9 Thiamine deficiency, unspecified

E52 Niacin deficiency [pellagra]

E53 Deficiency of other B group vitamins

E53.0 Riboflavin deficiency

E53.1 Pyridoxine deficiency

E53.8 Deficiency of other specified B group vitamins

E53.9 Vitamin B deficiency, unspecified

E54 Ascorbic acid deficiency

E55 Vitamin D deficiency

E55.0 Rickets, active

E55.9 Vitamin D deficiency, unspecified

E56 Other vitamin deficiencies

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.

2022 ICD-10-CM Diagnosis Code E52

Niacin deficiency [pellagra]

Sequelae of other nutritional deficiencies

Endocrine, nutritional and metabolic diseases

Other nutritional deficiencies

Dementia in other diseases classified elsewhere

Vitamin deficiency, unspecified

Vitamin B deficiency, unspecified

Diseases of lips

Vitamin deficiency, unspecified

Vitamin B deficiency, unspecified

Unspecified dementia without behavioral disturbance

Dermatitis, unspecified

Encephalopathy, unspecified

Erythematous condition, unspecified

Chronic gingivitis, plaque induced

Glossitis

Wernicke's encephalopathy

Polyneuropathy, unspecified