2020 ICD-10-CM Diagnosis Code E53.1

Pyridoxine deficiency

    2016 2017 2018 2019 2020 Billable/Specific Code
  • E53.1 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2020 edition of ICD-10-CM E53.1 became effective on October 1, 2019.
  • This is the American ICD-10-CM version of E53.1 - other international versions of ICD-10 E53.1 may differ.
Applicable To
  • Vitamin B6 deficiency
Type 1 Excludes
Type 1 Excludes Help
A type 1 excludes note is a pure excludes. It means "not coded here". A type 1 excludes note indicates that the code excluded should never be used at the same time as E53.1. A type 1 excludes note is for used for when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • pyridoxine-responsive sideroblastic anemia (
    ICD-10-CM Diagnosis Code D64.3

    Other sideroblastic anemias

      2016 2017 2018 2019 2020 Billable/Specific Code
    Applicable To
    • Sideroblastic anemia NOS
    • Pyridoxine-responsive sideroblastic anemia NEC
    D64.3
    )
The following code(s) above E53.1 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to E53.1:
  • E00-E89
    2020 ICD-10-CM Range E00-E89

    Endocrine, nutritional and metabolic diseases

    Note
    • All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
    Type 1 Excludes
    • transitory endocrine and metabolic disorders specific to newborn (P70-P74)
    Endocrine, nutritional and metabolic diseases
  • E50-E64
    2020 ICD-10-CM Range E50-E64

    Other nutritional deficiencies

    Type 2 Excludes
    Other nutritional deficiencies
  • E53
    ICD-10-CM Diagnosis Code E53

    Deficiency of other B group vitamins

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • sequelae of vitamin B deficiency (E64.8)
    Deficiency of other B group vitamins
Approximate Synonyms
  • Vitamin b6 deficiency
Clinical Information
  • A nutritional condition produced by a deficiency of vitamin b 6 in the diet, characterized by dermatitis, glossitis, cheilosis, and stomatitis. Marked deficiency causes irritability, weakness, depression, dizziness, peripheral neuropathy, and seizures. In infants and children typical manifestations are diarrhea, anemia, and seizures. Deficiency can be caused by certain medications, such as isoniazid.
  • Condition due to deficiency of vitamin b6.
  • Deficiency of pyridoxine, one of the vitamin b 6 compounds. Although pyridoxine and vitamin b 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (ee snell; ann ny acad sci, vol 585 pg 1, 1990).
  • Deficiency of vitamin b6. It is usually caused by alcoholism, malabsorption, or as a side effect of medications. Signs and symptoms include stomatitis, glossitis, dermatitis, peripheral neuropathy, irritability, seizures, and anemia.
ICD-10-CM E53.1 is grouped within Diagnostic Related Group(s) (MS-DRG v37.0):
  • 640 Miscellaneous disorders of nutrition, metabolism, fluids and electrolytes with mcc
  • 641 Miscellaneous disorders of nutrition, metabolism, fluids and electrolytes without mcc

Convert E53.1 to ICD-9-CM

Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change

Diagnosis Index entries containing back-references to E53.1:
  • Avitaminosis (multiple) E56.9
    - see also Deficiency, vitamin
    ICD-10-CM Diagnosis Code E56.9

    Vitamin deficiency, unspecified

      2016 2017 2018 2019 2020 Billable/Specific Code
    • B6 E53.1
  • Deficiency, deficient
    • vitamin (multiple) E56.9
      ICD-10-CM Diagnosis Code E56.9

      Vitamin deficiency, unspecified

        2016 2017 2018 2019 2020 Billable/Specific Code
      • B6 E53.1
    • pyracin E53.1 (alpha) (beta)
    • pyridoxal E53.1
    • pyridoxamine E53.1
    • pyridoxine E53.1 (derivatives)
  • Dependence (on) (syndrome) F19.20
    ICD-10-CM Diagnosis Code F19.20

    Other psychoactive substance dependence, uncomplicated

      2016 2017 2018 2019 2020 Billable/Specific Code
    Applicable To
    • Other (or unknown) substance use disorder, moderate
    • Other (or unknown) substance use disorder, severe
    • vitamin B6 E53.1
  • Polyneuropathy (peripheral) G62.9
    ICD-10-CM Diagnosis Code G62.9

    Polyneuropathy, unspecified

      2016 2017 2018 2019 2020 Billable/Specific Code
    Applicable To
    • Neuropathy NOS
  • Syndrome - see also Disease
    • vitamin B6 deficiency E53.1

ICD-10-CM Codes Adjacent To E53.1
E51 Thiamine deficiency
E51.1 Beriberi
E51.11 Dry beriberi
E51.12 Wet beriberi
E51.2 Wernicke's encephalopathy
E51.8 Other manifestations of thiamine deficiency
E51.9 Thiamine deficiency, unspecified
E52 Niacin deficiency [pellagra]
E53 Deficiency of other B group vitamins
E53.0 Riboflavin deficiency
E53.1 Pyridoxine deficiency
E53.8 Deficiency of other specified B group vitamins
E53.9 Vitamin B deficiency, unspecified
E54 Ascorbic acid deficiency
E55 Vitamin D deficiency
E55.0 Rickets, active
E55.9 Vitamin D deficiency, unspecified
E56 Other vitamin deficiencies
E56.0 Deficiency of vitamin E
E56.1 Deficiency of vitamin K
E56.8 Deficiency of other vitamins

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.