ICD-10-CM Codes
E00-E89
E50-E64
E53-
2023 ICD-10-CM Diagnosis Code E53.8

2023 ICD-10-CM Diagnosis Code E53.8

Deficiency of other specified B group vitamins

2016

2017

2018

2019

2020

2021

2022

2023

Billable/Specific Code

E53.8 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
The 2023 edition of ICD-10-CM E53.8 became effective on October 1, 2022.
This is the American ICD-10-CM version of E53.8 - other international versions of ICD-10 E53.8 may differ.

Applicable To

Biotin deficiency
Cyanocobalamin deficiency
Folate deficiency
Folic acid deficiency
Pantothenic acid deficiency
Vitamin B12 deficiency

Type 1 Excludes

Type 1 Excludes Help

A type 1 excludes note is a pure excludes. It means "not coded here". A type 1 excludes note indicates that the code excluded should never be used at the same time as E53.8. A type 1 excludes note is for used for when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.

folate deficiency anemia (
ICD-10-CM Diagnosis Code D52
- D52 Folate deficiency anemia
  - D52.0 Dietary folate deficiency anemia
  - D52.1 Drug-induced folate deficiency anemia
  - D52.8 Other folate deficiency anemias
  - D52.9 Folate deficiency anemia, unspecified
D52.-
)
vitamin B12 deficiency anemia (
ICD-10-CM Diagnosis Code D51
- D51 Vitamin B12 deficiency anemia
  - D51.0 Vitamin B12 deficiency anemia due to intrinsi...
  - D51.1 Vitamin B12 deficiency anemia due to selectiv...
  - D51.2 Transcobalamin II deficiency
  - D51.3 Other dietary vitamin B12 deficiency anemia
  - D51.8 Other vitamin B12 deficiency anemias
  - D51.9 Vitamin B12 deficiency anemia, unspecified
D51.-
)

The following code(s) above E53.8 contain annotation back-references

Annotation Back-References

In this context, annotation back-references refer to codes that contain:

Applicable To annotations, or
Code Also annotations, or
Code First annotations, or
Excludes1 annotations, or
Excludes2 annotations, or
Includes annotations, or
Note annotations, or
Use Additional annotations

that may be applicable to E53.8:

E00-E89
2023 ICD-10-CM Range E00-E89
Endocrine, nutritional and metabolic diseases
Note
- All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
Type 1 Excludes
- transitory endocrine and metabolic disorders specific to newborn (P70-P74)
Endocrine, nutritional and metabolic diseases
E50-E64
2023 ICD-10-CM Range E50-E64
Other nutritional deficiencies
Type 2 Excludes
- nutritional anemias (D50-D53)
Other nutritional deficiencies
E53
ICD-10-CM Diagnosis Code E53
Deficiency of other B group vitamins
Type 1 Excludes
- sequelae of vitamin B deficiency (E64.8)
Deficiency of other B group vitamins

Approximate Synonyms

Cerebral degeneration due to vitamin b12 deficiency
Cobalamin deficiency
Folic acid deficiency
Neuropathy due to vitamin b12 deficiency
Peripheral nerve disorder due to vit b12 deficiency
Polyneuropathy (multiple nerve disorder)
Polyneuropathy due to vitamin b deficiency
Subacute combined degeneration of spinal cord
Subacute degeneration of spinal cord due to vitamin b12 deficiency
Vitamin b12 deficiency

Clinical Information

A nutritional condition produced by a deficiency of folic acid in the diet. Many plant and animal tissues contain folic acid, abundant in green leafy vegetables, yeast, liver, and mushrooms but destroyed by long-term cooking. Alcohol interferes with its intermediate metabolism and absorption. Folic acid deficiency may develop in long-term anticonvulsant therapy or with use of oral contraceptives. This deficiency causes anemia, macrocytic anemia, and megaloblastic anemia. It is indistinguishable from vitamin b 12 deficiency in peripheral blood and bone marrow findings, but the neurologic lesions seen in b 12 deficiency do not occur. (merck manual, 16th ed)
A nutritional condition produced by a deficiency of vitamin b 12 in the diet, characterized by megaloblastic anemia. Since vitamin b 12 is not present in plants, humans have obtained their supply from animal products, from multivitamin supplements in the form of pills, and as additives to food preparations. A wide variety of neuropsychiatric abnormalities is also seen in vitamin b 12 deficiency and appears to be due to an undefined defect involving myelin synthesis. (from cecil textbook of medicine, 19th ed, p848)
Condition due to a deficiency of vitamin b12.
State in which folate is absent or in diminished amount relative to the normal requirement of an organism or a biologic system.

ICD-10-CM E53.8 is grouped within Diagnostic Related Group(s) (MS-DRG v40.0):

640 Miscellaneous disorders of nutrition, metabolism, fluids and electrolytes with mcc
641 Miscellaneous disorders of nutrition, metabolism, fluids and electrolytes without mcc

Convert E53.8 to ICD-9-CM

Code History

2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
2017 (effective 10/1/2016): No change
2018 (effective 10/1/2017): No change
2019 (effective 10/1/2018): No change
2020 (effective 10/1/2019): No change
2021 (effective 10/1/2020): No change
2022 (effective 10/1/2021): No change
2023 (effective 10/1/2022): No change

Code annotations containing back-references to E53.8:

Code First: G32.0
, F02

ICD-10-CM Diagnosis Code G32.0
Subacute combined degeneration of spinal cord in diseases classified elsewhere
Applicable To
- Dana-Putnam syndrome
- Sclerosis of spinal cord (combined) (dorsolateral) (posterolateral)
Code First
- underlying disease, such as:
- anemia (D51.9)
- dietary (D51.3)
- pernicious (D51.0)
- vitamin B12 deficiency (E53.8)
Type 1 Excludes
- syphilitic combined degeneration of spinal cord (A52.11)
ICD-10-CM Diagnosis Code F02
Dementia in other diseases classified elsewhere
Code First
- the underlying physiological condition, such as:
- Alzheimer's (G30.-)
- cerebral lipidosis (E75.4)
- Creutzfeldt-Jakob disease (A81.0-)
- dementia with Lewy bodies (G31.83)
- dementia with Parkinsonism (G31.83)
- epilepsy and recurrent seizures (G40.-)
- frontotemporal dementia (G31.09)
- hepatolenticular degeneration (E83.0)
- human immunodeficiency virus [HIV] disease (B20)
- Huntington's disease (G10)
- hypercalcemia (E83.52)
- hypothyroidism, acquired (E00-E03.-)
- intoxications (T36-T65)
- Jakob-Creutzfeldt disease (A81.0-)
- multiple sclerosis (G35)
- neurosyphilis (A52.17)
- niacin deficiency [pellagra] (E52)
- Parkinson's disease (G20)
- Pick's disease (G31.01)
- polyarteritis nodosa (M30.0)
- prion disease (A81.9)
- systemic lupus erythematosus (M32.-)
- traumatic brain injury (S06.-)
- trypanosomiasis (B56.-, B57.-)
- vitamin B deficiency (E53.8)
Includes
- Major neurocognitive disorder in other diseases classified elsewhere
Type 1 Excludes
- mild neurocognitive disorder due to known physiological condition with or without behavioral disturbance (F06.7-)
Type 2 Excludes
- dementia in alcohol and psychoactive substance disorders (F10-F19, with .17, .27, .97)
- vascular dementia (F01.5-, F01.A-, F01.B-, F01.C-)
Type 1 Excludes: D51
, D52
, D81.81

ICD-10-CM Diagnosis Code D51
Vitamin B12 deficiency anemia
Type 1 Excludes
- vitamin B12 deficiency (E53.8)
ICD-10-CM Diagnosis Code D52
Folate deficiency anemia
Type 1 Excludes
- folate deficiency without anemia (E53.8)
ICD-10-CM Diagnosis Code D81.81
Biotin-dependent carboxylase deficiency
Applicable To
- Multiple carboxylase deficiency
Type 1 Excludes
- biotin-dependent carboxylase deficiency due to dietary deficiency of biotin (E53.8)

Diagnosis Index entries containing back-references to E53.8:

Acid
- deficiency
  - folic E53.8
  - pantothenic E53.8
Avitaminosis (multiple) E56.9
- see also Deficiency, vitamin
ICD-10-CM Diagnosis Code E56.9
Vitamin deficiency, unspecified
- B12 E53.8
Chacaleh E53.8
Deficiency, deficient
- vitamin (multiple) E56.9
  ICD-10-CM Diagnosis Code E56.9
  Vitamin deficiency, unspecified
  2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
  - group B E53.9
    ICD-10-CM Diagnosis Code E53.9
    Vitamin B deficiency, unspecified
    2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
    - specified NEC E53.8
  - B12 E53.8
  - folic acid E53.8
  - H E53.8 (biotin)
- biotin E53.8
- choline E53.8
- cyanocobalamin E53.8
- folate E53.8
- folic acid E53.8
- inositol E53.8 (B complex)
- pantothenic acid E53.8
Degeneration, degenerative
- brain (cortical) (progressive) G31.9
  ICD-10-CM Diagnosis Code G31.9
  Degenerative disease of nervous system, unspecified
  2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
  - in
    - vitamin B12 deficiency E53.8
- combined (spinal cord) (subacute) E53.8
  - in (due to)
    - vitamin B12 deficiency E53.8
Dementia (degenerative (primary)) (old age) (persisting) (unspecified severity) (without behavioral disturbance, psychotic disturbance, mood disturbance, and anxiety) F03.90
ICD-10-CM Diagnosis Code F03.90
Unspecified dementia, unspecified severity, without behavioral disturbance, psychotic disturbance, mood disturbance, and anxiety
Applicable To
Dementia NOS
- in (due to)
  - vitamin B12 deficiency E53.8 - see also Dementia, in, diseases specified elsewhere
    - with behavioral disturbance E53.8 - see also Dementia, in, diseases specified elsewhere
Electric feet syndrome E53.8
Lightning (effects) (stroke) (struck by) T75.00
ICD-10-CM Diagnosis Code T75.00
Unspecified effects of lightning
Applicable To
Struck by lightning NOS
- foot E53.8
Melalgia, nutritional E53.8
Myelopathy (spinal cord) G95.9
ICD-10-CM Diagnosis Code G95.9
Disease of spinal cord, unspecified
Applicable To
Myelopathy NOS
- vitamin B12 E53.8
Neuropathy, neuropathic G62.9
ICD-10-CM Diagnosis Code G62.9
Polyneuropathy, unspecified
Applicable To
Neuropathy NOS
- vitamin B12 E53.8
Painful - see also Pain
- feet syndrome E53.8
Polyneuropathy (peripheral) G62.9
ICD-10-CM Diagnosis Code G62.9
Polyneuropathy, unspecified
Applicable To
Neuropathy NOS
- in (due to)
  - vitamin B12 deficiency E53.8
Syndrome - see also Disease
- painful
  - feet E53.8
- electric feet E53.8
- Gopalan' E53.8 (burning feet)

ICD-10-CM Codes Adjacent To E53.8

E51.1 Beriberi

E51.11 Dry beriberi

E51.12 Wet beriberi

E51.2 Wernicke's encephalopathy

E51.8 Other manifestations of thiamine deficiency

E51.9 Thiamine deficiency, unspecified

E52 Niacin deficiency [pellagra]

E53 Deficiency of other B group vitamins

E53.0 Riboflavin deficiency

E53.1 Pyridoxine deficiency

E53.8 Deficiency of other specified B group vitamins

E53.9 Vitamin B deficiency, unspecified

E54 Ascorbic acid deficiency

E55 Vitamin D deficiency

E55.0 Rickets, active

E55.9 Vitamin D deficiency, unspecified

E56 Other vitamin deficiencies

E56.0 Deficiency of vitamin E

E56.1 Deficiency of vitamin K

E56.8 Deficiency of other vitamins

E56.9 Vitamin deficiency, unspecified

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.

2023 ICD-10-CM Diagnosis Code E53.8

Deficiency of other specified B group vitamins

Endocrine, nutritional and metabolic diseases

Other nutritional deficiencies

Deficiency of other B group vitamins

Subacute combined degeneration of spinal cord in diseases classified elsewhere

Dementia in other diseases classified elsewhere

Vitamin B12 deficiency anemia

Folate deficiency anemia

Biotin-dependent carboxylase deficiency

Vitamin deficiency, unspecified

Vitamin deficiency, unspecified

Vitamin B deficiency, unspecified

Degenerative disease of nervous system, unspecified

Unspecified dementia, unspecified severity, without behavioral disturbance, psychotic disturbance, mood disturbance, and anxiety

Unspecified effects of lightning

Disease of spinal cord, unspecified

Polyneuropathy, unspecified

Polyneuropathy, unspecified