2020 ICD-10-CM Diagnosis Code E53.8

Deficiency of other specified B group vitamins

    2016 2017 2018 2019 2020 Billable/Specific Code
  • E53.8 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2020 edition of ICD-10-CM E53.8 became effective on October 1, 2019.
  • This is the American ICD-10-CM version of E53.8 - other international versions of ICD-10 E53.8 may differ.
Applicable To
  • Biotin deficiency
  • Cyanocobalamin deficiency
  • Folate deficiency
  • Folic acid deficiency
  • Pantothenic acid deficiency
  • Vitamin B12 deficiency
Type 1 Excludes
Type 1 Excludes Help
A type 1 excludes note is a pure excludes. It means "not coded here". A type 1 excludes note indicates that the code excluded should never be used at the same time as E53.8. A type 1 excludes note is for used for when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • folate deficiency anemia (
    ICD-10-CM Diagnosis Code D52
    • D52 Folate deficiency anemia
      • D52.0 Dietary folate deficiency anemia
      • D52.1 Drug-induced folate deficiency anemia
      • D52.8 Other folate deficiency anemias
      • D52.9 Folate deficiency anemia, unspecified
    D52.-
    )
  • vitamin B12 deficiency anemia (
    ICD-10-CM Diagnosis Code D51
    • D51 Vitamin B12 deficiency anemia
      • D51.0 Vitamin B12 deficiency anemia due to intrinsi...
      • D51.1 Vitamin B12 deficiency anemia due to selectiv...
      • D51.2 Transcobalamin II deficiency
      • D51.3 Other dietary vitamin B12 deficiency anemia
      • D51.8 Other vitamin B12 deficiency anemias
      • D51.9 Vitamin B12 deficiency anemia, unspecified
    D51.-
    )
The following code(s) above E53.8 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to E53.8:
  • E00-E89
    2020 ICD-10-CM Range E00-E89

    Endocrine, nutritional and metabolic diseases

    Note
    • All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
    Type 1 Excludes
    • transitory endocrine and metabolic disorders specific to newborn (P70-P74)
    Endocrine, nutritional and metabolic diseases
  • E50-E64
    2020 ICD-10-CM Range E50-E64

    Other nutritional deficiencies

    Type 2 Excludes
    Other nutritional deficiencies
  • E53
    ICD-10-CM Diagnosis Code E53

    Deficiency of other B group vitamins

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • sequelae of vitamin B deficiency (E64.8)
    Deficiency of other B group vitamins
Approximate Synonyms
  • Cerebral degeneration due to vitamin b12 deficiency
  • Cobalamin deficiency
  • Folic acid deficiency
  • Neuropathy due to vitamin b12 deficiency
  • Peripheral nerve disorder due to vit b12 deficiency
  • Polyneuropathy (multiple nerve disorder)
  • Polyneuropathy due to vitamin b deficiency
  • Subacute combined degeneration of spinal cord
  • Subacute degeneration of spinal cord due to vitamin b12 deficiency
  • Vitamin b12 deficiency
Clinical Information
  • A nutritional condition produced by a deficiency of folic acid in the diet. Many plant and animal tissues contain folic acid, abundant in green leafy vegetables, yeast, liver, and mushrooms but destroyed by long-term cooking. Alcohol interferes with its intermediate metabolism and absorption. Folic acid deficiency may develop in long-term anticonvulsant therapy or with use of oral contraceptives. This deficiency causes anemia, macrocytic anemia, and megaloblastic anemia. It is indistinguishable from vitamin b 12 deficiency in peripheral blood and bone marrow findings, but the neurologic lesions seen in b 12 deficiency do not occur. (merck manual, 16th ed)
  • A nutritional condition produced by a deficiency of vitamin b 12 in the diet, characterized by megaloblastic anemia. Since vitamin b 12 is not present in plants, humans have obtained their supply from animal products, from multivitamin supplements in the form of pills, and as additives to food preparations. A wide variety of neuropsychiatric abnormalities is also seen in vitamin b 12 deficiency and appears to be due to an undefined defect involving myelin synthesis. (from cecil textbook of medicine, 19th ed, p848)
  • Condition due to a deficiency of vitamin b12.
  • State in which folate is absent or in diminished amount relative to the normal requirement of an organism or a biologic system.
ICD-10-CM E53.8 is grouped within Diagnostic Related Group(s) (MS-DRG v37.0):
  • 640 Miscellaneous disorders of nutrition, metabolism, fluids and electrolytes with mcc
  • 641 Miscellaneous disorders of nutrition, metabolism, fluids and electrolytes without mcc

Convert E53.8 to ICD-9-CM

Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
Code annotations containing back-references to E53.8:
  • Code First: G32.0
    , F02
    ICD-10-CM Diagnosis Code G32.0

    Subacute combined degeneration of spinal cord in diseases classified elsewhere

      2016 2017 2018 2019 2020 Billable/Specific Code Manifestation Code
    Applicable To
    • Dana-Putnam syndrome
    • Sclerosis of spinal cord (combined) (dorsolateral) (posterolateral)
    Code First
    • underlying disease, such as:
    • anemia (D51.9)
    • dietary (D51.3)
    • pernicious (D51.0)
    • vitamin B12 deficiency (E53.8)
    Type 1 Excludes
    • syphilitic combined degeneration of spinal cord (A52.11)
    ICD-10-CM Diagnosis Code F02

    Dementia in other diseases classified elsewhere

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Code First
    • the underlying physiological condition, such as:
    • Alzheimer's (G30.-)
    • cerebral lipidosis (E75.4)
    • Creutzfeldt-Jakob disease (A81.0-)
    • dementia with Lewy bodies (G31.83)
    • dementia with Parkinsonism (G31.83)
    • epilepsy and recurrent seizures (G40.-)
    • frontotemporal dementia (G31.09)
    • hepatolenticular degeneration (E83.0)
    • human immunodeficiency virus [HIV] disease (B20)
    • Huntington's disease (G10)
    • hypercalcemia (E83.52)
    • hypothyroidism, acquired (E00-E03.-)
    • intoxications (T36-T65)
    • Jakob-Creutzfeldt disease (A81.0-)
    • multiple sclerosis (G35)
    • neurosyphilis (A52.17)
    • niacin deficiency [pellagra] (E52)
    • Parkinson's disease (G20)
    • Pick's disease (G31.01)
    • polyarteritis nodosa (M30.0)
    • prion disease (A81.9)
    • systemic lupus erythematosus (M32.-)
    • traumatic brain injury (S06.-)
    • trypanosomiasis (B56.-, B57.-)
    • vitamin B deficiency (E53.8)
    Includes
    • Major neurocognitive disorder in other diseases classified elsewhere
    Type 2 Excludes
    • dementia in alcohol and psychoactive substance disorders (F10-F19, with .17, .27, .97)
    • vascular dementia (F01.5-)
  • Type 1 Excludes: D51
    , D52
    , D81.81
    ICD-10-CM Diagnosis Code D51

    Vitamin B12 deficiency anemia

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • vitamin B12 deficiency (E53.8)
    ICD-10-CM Diagnosis Code D52

    Folate deficiency anemia

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • folate deficiency without anemia (E53.8)
    ICD-10-CM Diagnosis Code D81.81

    Biotin-dependent carboxylase deficiency

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Applicable To
    • Multiple carboxylase deficiency
    Type 1 Excludes
    • biotin-dependent carboxylase deficiency due to dietary deficiency of biotin (E53.8)

Diagnosis Index entries containing back-references to E53.8:
  • Acid
  • Avitaminosis (multiple) E56.9
    - see also Deficiency, vitamin
    ICD-10-CM Diagnosis Code E56.9

    Vitamin deficiency, unspecified

      2016 2017 2018 2019 2020 Billable/Specific Code
    • B12 E53.8
  • Chacaleh E53.8
  • Deficiency, deficient
    • vitamin (multiple) E56.9
      ICD-10-CM Diagnosis Code E56.9

      Vitamin deficiency, unspecified

        2016 2017 2018 2019 2020 Billable/Specific Code
      • group B E53.9
        ICD-10-CM Diagnosis Code E53.9

        Vitamin B deficiency, unspecified

          2016 2017 2018 2019 2020 Billable/Specific Code
        • specified NEC E53.8
      • B12 E53.8
      • folic acid E53.8
      • H E53.8 (biotin)
    • biotin E53.8
    • choline E53.8
    • cyanocobalamin E53.8
    • folate E53.8
    • folic acid E53.8
    • inositol E53.8 (B complex)
    • pantothenic acid E53.8
  • Degeneration, degenerative
    • brain (cortical) (progressive) G31.9
      ICD-10-CM Diagnosis Code G31.9

      Degenerative disease of nervous system, unspecified

        2016 2017 2018 2019 2020 Billable/Specific Code
      • in
        • vitamin B12 deficiency E53.8
    • combined (spinal cord) (subacute) E53.8
  • Dementia (degenerative (primary)) (old age) (persisting) F03.90
    ICD-10-CM Diagnosis Code F03.90

    Unspecified dementia without behavioral disturbance

      2016 2017 2018 2019 2020 Billable/Specific Code Adult Dx (15-124 years)
    Applicable To
    • Dementia NOS
  • Electric feet syndrome E53.8
  • Lightning (effects) (stroke) (struck by) T75.00
    ICD-10-CM Diagnosis Code T75.00

    Unspecified effects of lightning

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Applicable To
    • Struck by lightning NOS
    • foot E53.8
  • Melalgia, nutritional E53.8
  • Myelopathy (spinal cord) G95.9
    ICD-10-CM Diagnosis Code G95.9

    Disease of spinal cord, unspecified

      2016 2017 2018 2019 2020 Billable/Specific Code
    Applicable To
    • Myelopathy NOS
    • vitamin B12 E53.8
  • Neuropathy, neuropathic G62.9
    ICD-10-CM Diagnosis Code G62.9

    Polyneuropathy, unspecified

      2016 2017 2018 2019 2020 Billable/Specific Code
    Applicable To
    • Neuropathy NOS
  • Painful - see also Pain
    • feet syndrome E53.8
  • Polyneuropathy (peripheral) G62.9
    ICD-10-CM Diagnosis Code G62.9

    Polyneuropathy, unspecified

      2016 2017 2018 2019 2020 Billable/Specific Code
    Applicable To
    • Neuropathy NOS
    • transthyretin-related (ATTR) E85.1
      ICD-10-CM Diagnosis Code E85.1

      Neuropathic heredofamilial amyloidosis

        2016 2017 2018 2019 2020 Billable/Specific Code
      Applicable To
      • Amyloid polyneuropathy (Portuguese)
      • Transthyretin-related (ATTR) familial amyloid polyneuropathy
  • Syndrome - see also Disease
    • painful
      • feet E53.8
    • electric feet E53.8
    • Gopalan' E53.8 (burning feet)

ICD-10-CM Codes Adjacent To E53.8
E51.1 Beriberi
E51.11 Dry beriberi
E51.12 Wet beriberi
E51.2 Wernicke's encephalopathy
E51.8 Other manifestations of thiamine deficiency
E51.9 Thiamine deficiency, unspecified
E52 Niacin deficiency [pellagra]
E53 Deficiency of other B group vitamins
E53.0 Riboflavin deficiency
E53.1 Pyridoxine deficiency
E53.8 Deficiency of other specified B group vitamins
E53.9 Vitamin B deficiency, unspecified
E54 Ascorbic acid deficiency
E55 Vitamin D deficiency
E55.0 Rickets, active
E55.9 Vitamin D deficiency, unspecified
E56 Other vitamin deficiencies
E56.0 Deficiency of vitamin E
E56.1 Deficiency of vitamin K
E56.8 Deficiency of other vitamins
E56.9 Vitamin deficiency, unspecified

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.