2019 ICD-10-CM Diagnosis Code E70.21

Tyrosinemia

    2016 2017 2018 2019 Billable/Specific Code
  • E70.21 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2019 edition of ICD-10-CM E70.21 became effective on October 1, 2018.
  • This is the American ICD-10-CM version of E70.21 - other international versions of ICD-10 E70.21 may differ.
Applicable To
  • Hypertyrosinemia
The following code(s) above E70.21 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to E70.21:
  • E00-E89
    2019 ICD-10-CM Range E00-E89

    Endocrine, nutritional and metabolic diseases

    Note
    • All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
    Type 1 Excludes
    • transitory endocrine and metabolic disorders specific to newborn (P70-P74)
    Endocrine, nutritional and metabolic diseases
  • E70-E88
    2019 ICD-10-CM Range E70-E88

    Metabolic disorders

    Type 1 Excludes
    • androgen insensitivity syndrome (E34.5-)
    • congenital adrenal hyperplasia (E25.0)
    • Ehlers-Danlos syndrome (Q79.6)
    • hemolytic anemias attributable to enzyme disorders (D55.-)
    • Marfan's syndrome (Q87.4)
    • 5-alpha-reductase deficiency (E29.1)
    Metabolic disorders
  • E70.2
    ICD-10-CM Diagnosis Code E70.2

    Disorders of tyrosine metabolism

      2016 2017 2018 2019 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • transitory tyrosinemia of newborn (P74.5)
    Disorders of tyrosine metabolism
Approximate Synonyms
  • Hypertyrosinemia
  • Hypertyrosinemia, richner hanhart type
  • Tyrosinemia type i
  • Tyrosinemia type iii
  • Tyrosinemia, type 3
Clinical Information
  • A group of disorders which have in common elevations of tyrosine in the blood and urine secondary to an enzyme deficiency. Type i tyrosinemia features episodic weakness, self-mutilation, hepatic necrosis, renal tubular injury, and seizures and is caused by a deficiency of the enzyme fumarylacetoacetase. Type ii tyrosinemia features intellectual disability, painful corneal ulcers, and keratoses of the palms and plantar surfaces and is caused by a deficiency of the enzyme tyrosine transaminase. Type iii tyrosinemia features intellectual disability and is caused by a deficiency of the enzyme 4-hydroxyphenylpyruvate dioxygenase. (menkes, textbook of child neurology, 5th ed, pp42-3)
  • An autosomal recessive inherited metabolic disorder caused by mutations in the fah, hpd, and tat genes. It is characterized by deficiency of one of the enzymes that are involved in the metabolism of tyrosine. It results in elevated blood tyrosine levels and accumulation of tyrosine and its byproducts in the liver, kidney, nervous system and other organs.
  • Group of disorders which have in common elevations of tyrosine in the blood and urine secondary to an enzyme deficiency.
ICD-10-CM E70.21 is grouped within Diagnostic Related Group(s) (MS-DRG v36.0):
  • 642 Inborn and other disorders of metabolism

Convert E70.21 to ICD-9-CM

Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change

Diagnosis Index entries containing back-references to E70.21:
  • Disorder (of) - see also Disease
    • metabolism NOS E88.9
      ICD-10-CM Diagnosis Code E88.9

      Metabolic disorder, unspecified

        2016 2017 2018 2019 Billable/Specific Code
      • amino-acid E72.9
        ICD-10-CM Diagnosis Code E72.9

        Disorder of amino-acid metabolism, unspecified

          2016 2017 2018 2019 Billable/Specific Code
        • aromatic E70.9
          ICD-10-CM Diagnosis Code E70.9

          Disorder of aromatic amino-acid metabolism, unspecified

            2016 2017 2018 2019 Billable/Specific Code
          • tyrosine E70.20
            ICD-10-CM Diagnosis Code E70.20

            Disorder of tyrosine metabolism, unspecified

              2016 2017 2018 2019 Billable/Specific Code
            • hypertyrosinemia E70.21
  • Hypertyrosinemia E70.21
  • Tyrosinemia E70.21
  • Tyrosinosis E70.21

ICD-10-CM Codes Adjacent To E70.21
E67.1 Hypercarotenemia
E67.2 Megavitamin-B6 syndrome
E67.3 Hypervitaminosis D
E67.8 Other specified hyperalimentation
E68 Sequelae of hyperalimentation
E70 Disorders of aromatic amino-acid metabolism
E70.0 Classical phenylketonuria
E70.1 Other hyperphenylalaninemias
E70.2 Disorders of tyrosine metabolism
E70.20 Disorder of tyrosine metabolism, unspecified
E70.21 Tyrosinemia
E70.29 Other disorders of tyrosine metabolism
E70.3 Albinism
E70.30 …… unspecified
E70.31 Ocular albinism
E70.310 X-linked ocular albinism
E70.311 Autosomal recessive ocular albinism
E70.318 Other ocular albinism
E70.319 …… unspecified
E70.32 Oculocutaneous albinism
E70.320 Tyrosinase negative oculocutaneous albinism

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.