2020 ICD-10-CM Diagnosis Code E72.02

Hartnup's disease

    2016 2017 2018 2019 2020 Billable/Specific Code
  • E72.02 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2020 edition of ICD-10-CM E72.02 became effective on October 1, 2019.
  • This is the American ICD-10-CM version of E72.02 - other international versions of ICD-10 E72.02 may differ.
The following code(s) above E72.02 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to E72.02:
  • E00-E89
    2020 ICD-10-CM Range E00-E89

    Endocrine, nutritional and metabolic diseases

    Note
    • All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
    Type 1 Excludes
    • transitory endocrine and metabolic disorders specific to newborn (P70-P74)
    Endocrine, nutritional and metabolic diseases
  • E70-E88
    2020 ICD-10-CM Range E70-E88

    Metabolic disorders

    Type 1 Excludes
    • androgen insensitivity syndrome (E34.5-)
    • congenital adrenal hyperplasia (E25.0)
    • Ehlers-Danlos syndrome (Q79.6-)
    • hemolytic anemias attributable to enzyme disorders (D55.-)
    • Marfan's syndrome (Q87.4)
    • 5-alpha-reductase deficiency (E29.1)
    Metabolic disorders
  • E72
    ICD-10-CM Diagnosis Code E72

    Other disorders of amino-acid metabolism

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • disorders of:
    • aromatic amino-acid metabolism (E70.-)
    • branched-chain amino-acid metabolism (E71.0-E71.2)
    • fatty-acid metabolism (E71.3)
    • purine and pyrimidine metabolism (E79.-)
    • gout (M1A.-, M10.-)
    Other disorders of amino-acid metabolism
  • E72.0
    ICD-10-CM Diagnosis Code E72.0

    Disorders of amino-acid transport

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • disorders of tryptophan metabolism (E70.5)
    Disorders of amino-acid transport
Approximate Synonyms
  • Hartnup disease
  • Neutral 1 amino acid transport defect
Clinical Information
  • An autosomal recessive disorder due to defective absorption of neutral amino acids by both the intestine and the proximal renal tubules. The abnormal urinary loss of tryptophan, a precursor of niacin, leads to a nicotinamide deficiency, pellagra-like light-sensitive rash, cerebellar ataxia, emotional instability, and aminoaciduria. Mutations involve the neurotransmitter transporter gene slc6a19.
  • An autosomal recessive inherited metabolic disorder caused by mutations in the slc6a19 gene. It is characterized by defective absorption of neutral amino acids. Signs and symptoms include skin eruptions reminiscent of pellagra, aminoaciduria, and cerebellar ataxia.
  • Disorder of amino acid transport characterized by the childhood (or rarely adult) onset of photosensitive dermatitis and intermittent neurologic symptoms; ataxia, personality changes, migraine headaches, and photophobia may occur periodically; results from impaired sodium-dependent transport of neutral amino acids across the brush border membrane of the small intestine and renal tubular epithelium.
ICD-10-CM E72.02 is grouped within Diagnostic Related Group(s) (MS-DRG v37.0):
  • 642 Inborn and other disorders of metabolism

Convert E72.02 to ICD-9-CM

Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change

Diagnosis Index entries containing back-references to E72.02:
  • Disease, diseased - see also Syndrome
    • H E72.02 (Hartnup's)
    • Hartnup E72.02 (pellagra-cerebellar ataxia-renal aminoaciduria)
    • Hart's E72.02 (pellagra-cerebellar ataxia-renal aminoaciduria)
  • H E72.02 (Hartnup's)
  • Hartnup's disease E72.02
  • Pellagra-cerebellar-ataxia-renal aminoaciduria syndrome E72.02
  • Syndrome - see also Disease
    • pellagra-cerebellar ataxia-renal aminoaciduria E72.02

ICD-10-CM Codes Adjacent To E72.02
E71.53 Other group 2 peroxisomal disorders
E71.54 Other peroxisomal disorders
E71.540 Rhizomelic chondrodysplasia punctata
E71.541 Zellweger-like syndrome
E71.542 Other group 3 peroxisomal disorders
E71.548 Other peroxisomal disorders
E72 Other disorders of amino-acid metabolism
E72.0 Disorders of amino-acid transport
E72.00 …… unspecified
E72.01 Cystinuria
E72.02 Hartnup's disease
E72.03 Lowe's syndrome
E72.04 Cystinosis
E72.09 Other disorders of amino-acid transport
E72.1 Disorders of sulfur-bearing amino-acid metabolism
E72.10 …… unspecified
E72.11 Homocystinuria
E72.12 Methylenetetrahydrofolate reductase deficiency
E72.19 Other disorders of sulfur-bearing amino-acid metabolism
E72.2 Disorders of urea cycle metabolism
E72.20 Disorder of urea cycle metabolism, unspecified

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.