2020 ICD-10-CM Diagnosis Code E72.03

Lowe's syndrome

    2016 2017 2018 2019 2020 Billable/Specific Code
  • E72.03 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2020 edition of ICD-10-CM E72.03 became effective on October 1, 2019.
  • This is the American ICD-10-CM version of E72.03 - other international versions of ICD-10 E72.03 may differ.
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Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. For such conditions the ICD-10-CM has a coding convention that requires the underlying condition be sequenced first followed by the manifestation. Wherever such a combination exists there is a "use additional code" note at the etiology code, and a "code first" note at the manifestation code. These instructional notes indicate the proper sequencing order of the codes, etiology followed by manifestation. In most cases the manifestation codes will have in the code title, "in diseases classified elsewhere." Codes with this title are a component of the etiology/manifestation convention. The code title indicates that it is a manifestation code. "In diseases classified elsewhere" codes are never permitted to be used as first listed or principle diagnosis codes. They must be used in conjunction with an underlying condition code and they must be listed following the underlying condition.
  • code for associated glaucoma (
    ICD-10-CM Diagnosis Code H42

    Glaucoma in diseases classified elsewhere

      2016 2017 2018 2019 2020 Billable/Specific Code Manifestation Code
    Code First
    Type 1 Excludes
    • glaucoma (in) onchocerciasis (B73.02)
    • glaucoma (in) syphilis (A52.71)
    • glaucoma (in) tuberculous (A18.59)
    H42
    )
The following code(s) above E72.03 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to E72.03:
  • E00-E89
    2020 ICD-10-CM Range E00-E89

    Endocrine, nutritional and metabolic diseases

    Note
    • All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
    Type 1 Excludes
    • transitory endocrine and metabolic disorders specific to newborn (P70-P74)
    Endocrine, nutritional and metabolic diseases
  • E70-E88
    2020 ICD-10-CM Range E70-E88

    Metabolic disorders

    Type 1 Excludes
    • androgen insensitivity syndrome (E34.5-)
    • congenital adrenal hyperplasia (E25.0)
    • Ehlers-Danlos syndrome (Q79.6-)
    • hemolytic anemias attributable to enzyme disorders (D55.-)
    • Marfan's syndrome (Q87.4)
    • 5-alpha-reductase deficiency (E29.1)
    Metabolic disorders
  • E72
    ICD-10-CM Diagnosis Code E72

    Other disorders of amino-acid metabolism

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • disorders of:
    • aromatic amino-acid metabolism (E70.-)
    • branched-chain amino-acid metabolism (E71.0-E71.2)
    • fatty-acid metabolism (E71.3)
    • purine and pyrimidine metabolism (E79.-)
    • gout (M1A.-, M10.-)
    Other disorders of amino-acid metabolism
  • E72.0
    ICD-10-CM Diagnosis Code E72.0

    Disorders of amino-acid transport

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • disorders of tryptophan metabolism (E70.5)
    Disorders of amino-acid transport
Approximate Synonyms
  • Lowe syndrome
Clinical Information
  • A sex-linked recessive disorder affecting multiple systems including the eye, the nervous system, and the kidney. Clinical features include congenital cataract; mental retardation; and renal tubular dysfunction (fanconi syndrome; renal tubular acidosis; x-linked hypophosphatemia or vitamin-d-resistant rickets) and scoliosis. This condition is due to a deficiency of phosphatidylinositol 4,5-bisphosphate-5-phosphatase leading to defects in phosphatidylinositol metabolism and inositol signaling pathway. (from menkes, textbook of child neurology, 5th ed, p60; am j hum genet 1997 jun;60(6):1384-8)
  • A syndrome of congenital cataracts, hydrophthalmia, delayed growth and mental development, vitamin d-resistant rickets, aminoaciduria, and reduced production of ammonia by the kidneys. Additional manifestations include areflexia, hypotonia, glaucoma, corneal keloid, and noninflammatory arthropathy.
  • An x-linked inherited multisystem metabolic disorder caused by mutations in the ocrl1 gene. The main manifestations of this disorder result from involvement of the eyes, nervous system and kidneys. Signs and symptoms include congenital cataracts, infantile glaucoma, intellectual disability, hypotonia, aminoaciduria and renal tubular dysfunction.
  • Sex-linked recessive disorder of amino acid transport which affects the eye, nervous system, and kidney; manifestations include cataract, glaucoma, aminoaciduria, hypophosphatemic rickets, developmental delay, myopathy, peripheral neuropathy, and hypotonia; associated with deficient activity of the enzyme phosphatidylinositol 4,5-bisphosphate-5-phosphatase.
ICD-10-CM E72.03 is grouped within Diagnostic Related Group(s) (MS-DRG v37.0):
  • 642 Inborn and other disorders of metabolism

Convert E72.03 to ICD-9-CM

Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
Code annotations containing back-references to E72.03:
  • Code First: H42
    ICD-10-CM Diagnosis Code H42

    Glaucoma in diseases classified elsewhere

      2016 2017 2018 2019 2020 Billable/Specific Code Manifestation Code
    Code First
    Type 1 Excludes
    • glaucoma (in) onchocerciasis (B73.02)
    • glaucoma (in) syphilis (A52.71)
    • glaucoma (in) tuberculous (A18.59)

Diagnosis Index entries containing back-references to E72.03:
  • Dystrophy, dystrophia
    • oculocerebrorenal E72.03
  • Glaucoma H40.9
    ICD-10-CM Diagnosis Code H40.9

    Unspecified glaucoma

      2016 2017 2018 2019 2020 Billable/Specific Code
    • in (due to)
      • Lowe's syndrome E72.03
  • Lowe's syndrome E72.03

ICD-10-CM Codes Adjacent To E72.03
E71.54 Other peroxisomal disorders
E71.540 Rhizomelic chondrodysplasia punctata
E71.541 Zellweger-like syndrome
E71.542 Other group 3 peroxisomal disorders
E71.548 Other peroxisomal disorders
E72 Other disorders of amino-acid metabolism
E72.0 Disorders of amino-acid transport
E72.00 …… unspecified
E72.01 Cystinuria
E72.02 Hartnup's disease
E72.03 Lowe's syndrome
E72.04 Cystinosis
E72.09 Other disorders of amino-acid transport
E72.1 Disorders of sulfur-bearing amino-acid metabolism
E72.10 …… unspecified
E72.11 Homocystinuria
E72.12 Methylenetetrahydrofolate reductase deficiency
E72.19 Other disorders of sulfur-bearing amino-acid metabolism
E72.2 Disorders of urea cycle metabolism
E72.20 Disorder of urea cycle metabolism, unspecified
E72.21 Argininemia

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.