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ICD-10-CM Codes
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E00-E89
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E70-E88
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E72-
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2023 ICD-10-CM Diagnosis Code E72.12
2023 ICD-10-CM Diagnosis Code E72.12
Methylenetetrahydrofolate reductase deficiency
2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
- E72.12 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
- The 2023 edition of ICD-10-CM E72.12 became effective on October 1, 2022.
- This is the American ICD-10-CM version of E72.12 - other international versions of ICD-10 E72.12 may differ.
The following code(s) above
E72.12 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
- Applicable To annotations, or
- Code Also annotations, or
- Code First annotations, or
- Excludes1 annotations, or
- Excludes2 annotations, or
- Includes annotations, or
- Note annotations, or
- Use Additional annotations
that may be applicable to
E72.12:
- E00-E89
2023 ICD-10-CM Range E00-E89
Endocrine, nutritional and metabolic diseasesNote- All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
Type 1 Excludes- transitory endocrine and metabolic disorders specific to newborn (P70-P74)
- E70-E88
2023 ICD-10-CM Range E70-E88
Metabolic disordersType 1 Excludes- androgen insensitivity syndrome (E34.5-)
- congenital adrenal hyperplasia (E25.0)
- hemolytic anemias attributable to enzyme disorders (D55.-)
- Marfan's syndrome (Q87.4)
- 5-alpha-reductase deficiency (E29.1)
Type 2 Excludes- Ehlers-Danlos syndromes (Q79.6-)
- E72
ICD-10-CM Diagnosis Code E72
Other disorders of amino-acid metabolism
2016 2017 2018 2019 2020 2021 2022 2023 Non-Billable/Non-Specific Code
Type 1 Excludes- disorders of:
- aromatic amino-acid metabolism (E70.-)
- branched-chain amino-acid metabolism (E71.0-E71.2)
- fatty-acid metabolism (E71.3)
- purine and pyrimidine metabolism (E79.-)
- gout (M1A.-, M10.-)
- E72.1
ICD-10-CM Diagnosis Code E72.1
Disorders of sulfur-bearing amino-acid metabolism
2016 2017 2018 2019 2020 2021 2022 2023 Non-Billable/Non-Specific Code
- 5,10-methylenetetrahydrofolate reductase deficiency
- Deficiency, methylenetetrahydrofolate reductase
- Heterozygous methylenetetrahydrofolate reductase mutation
- Homozygous methylenetetrahydrofolate reductase mutation
- Methylenetetrahydrofolate reductase mutation
ICD-10-CM E72.12 is grouped within Diagnostic Related Group(s) (MS-DRG v40.0):
- 642 Inborn and other disorders of metabolism
Convert E72.12 to ICD-9-CM
Code History
- 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
- 2017 (effective 10/1/2016): No change
- 2018 (effective 10/1/2017): No change
- 2019 (effective 10/1/2018): No change
- 2020 (effective 10/1/2019): No change
- 2021 (effective 10/1/2020): No change
- 2022 (effective 10/1/2021): No change
- 2023 (effective 10/1/2022): No change
- Deficiency, deficient
- methylenetetrahydrofolate reductase E72.12 (MTHFR)
- Disorder (of) - see also Disease
- metabolism NOS E88.9
ICD-10-CM Diagnosis Code E88.9
Metabolic disorder, unspecified
2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
- amino-acid E72.9
ICD-10-CM Diagnosis Code E72.9
Disorder of amino-acid metabolism, unspecified
2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
- sulfur-bearing E72.10
ICD-10-CM Diagnosis Code E72.10
Disorders of sulfur-bearing amino-acid metabolism, unspecified
2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
- methylenetetrahydrofolate reductase deficiency E72.12
ICD-10-CM Codes Adjacent To E72.12
E72.0 Disorders of amino-acid transport
E72.09 Other disorders of amino-acid transport
E72.1 Disorders of sulfur-bearing amino-acid metabolism
E72.12
Methylenetetrahydrofolate reductase deficiency
E72.19 Other disorders of sulfur-bearing amino-acid metabolism
E72.2 Disorders of urea cycle metabolism
E72.20 Disorder of urea cycle metabolism, unspecified
E72.22 Arginosuccinic aciduria
E72.29 Other disorders of urea cycle metabolism
E72.3 Disorders of lysine and hydroxylysine metabolism
E72.4 Disorders of ornithine metabolism
E72.5 Disorders of glycine metabolism
Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.
