1. ICD-10-CM Codes
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2. E00-E89
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3. E70-E88
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4. E72-
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5. 2023 ICD-10-CM Diagnosis Code E72.2

2023 ICD-10-CM Diagnosis Code E72.2

Disorders of urea cycle metabolism

2016 2017 2018 2019 2020 2021 2022 2023 Non-Billable/Non-Specific Code

• E72.2 should not be used for reimbursement purposes as there are multiple codes below it that contain a greater level of detail.
• The 2023 edition of ICD-10-CM E72.2 became effective on October 1, 2022.
• This is the American ICD-10-CM version of E72.2 - other international versions of ICD-10 E72.2 may differ.

• A genetic inborn error of metabolism characterized by the deficiency of one of the enzymes necessary for the urea cycle. It results in accumulation of ammonia in the body.
• Inherited errors in the metabolic reactions occurring in the liver that convert ammonia to urea, resulting from inborn genetic mutations.
• Rare congenital metabolism disorders of the urea cycle. The disorders are due to mutations that result in complete (neonatal onset) or partial (childhood or adult onset) inactivity of an enzyme, involved in the urea cycle. Neonatal onset results in clinical features that include irritability, vomiting, lethargy, seizures, neonatal hypotonia; respiratory alkalosis; hyperammonemia; coma, and death. Survivors of the neonatal onset and childhood/adult onset disorders share common risks for encephalopathies, metabolic, inborn; and respiratory alkalosis due to hyperammonemia.

• 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
• 2017 (effective 10/1/2016): No change
• 2018 (effective 10/1/2017): No change
• 2019 (effective 10/1/2018): No change
• 2020 (effective 10/1/2019): No change
• 2021 (effective 10/1/2020): No change
• 2022 (effective 10/1/2021): No change
• 2023 (effective 10/1/2022): No change

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.