2021 ICD-10-CM Diagnosis Code E72.2

Disorders of urea cycle metabolism

    2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
  • E72.2 should not be used for reimbursement purposes as there are multiple codes below it that contain a greater level of detail.
  • The 2021 edition of ICD-10-CM E72.2 became effective on October 1, 2020.
  • This is the American ICD-10-CM version of E72.2 - other international versions of ICD-10 E72.2 may differ.
Type 1 Excludes
Type 1 Excludes Help
A type 1 excludes note is a pure excludes. It means "not coded here". A type 1 excludes note indicates that the code excluded should never be used at the same time as E72.2. A type 1 excludes note is for used for when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • disorders of ornithine metabolism (
    ICD-10-CM Diagnosis Code E72.4

    Disorders of ornithine metabolism

      2016 2017 2018 2019 2020 2021 Billable/Specific Code
    Applicable To
    • Hyperammonemia-Hyperornithinemia-Homocitrullinemia syndrome
    • Ornithinemia (types I, II)
    • Ornithine transcarbamylase deficiency
    Type 1 Excludes
    • hereditary choroidal dystrophy (H31.2-)
    E72.4
    )
The following code(s) above E72.2 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to E72.2:
  • E00-E89
    2021 ICD-10-CM Range E00-E89

    Endocrine, nutritional and metabolic diseases

    Note
    • All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
    Type 1 Excludes
    • transitory endocrine and metabolic disorders specific to newborn (P70-P74)
    Endocrine, nutritional and metabolic diseases
  • E70-E88
    2021 ICD-10-CM Range E70-E88

    Metabolic disorders

    Type 1 Excludes
    • androgen insensitivity syndrome (E34.5-)
    • congenital adrenal hyperplasia (E25.0)
    • Ehlers-Danlos syndromes (Q79.6-)
    • hemolytic anemias attributable to enzyme disorders (D55.-)
    • Marfan's syndrome (Q87.4)
    • 5-alpha-reductase deficiency (E29.1)
    Metabolic disorders
  • E72
    ICD-10-CM Diagnosis Code E72

    Other disorders of amino-acid metabolism

      2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • disorders of:
    • aromatic amino-acid metabolism (E70.-)
    • branched-chain amino-acid metabolism (E71.0-E71.2)
    • fatty-acid metabolism (E71.3)
    • purine and pyrimidine metabolism (E79.-)
    • gout (M1A.-, M10.-)
    Other disorders of amino-acid metabolism
Clinical Information
  • A genetic inborn error of metabolism characterized by the deficiency of one of the enzymes necessary for the urea cycle. It results in accumulation of ammonia in the body.
  • Inherited errors in the metabolic reactions occurring in the liver that convert ammonia to urea, resulting from inborn genetic mutations.
  • Rare congenital metabolism disorders of the urea cycle. The disorders are due to mutations that result in complete (neonatal onset) or partial (childhood or adult onset) inactivity of an enzyme, involved in the urea cycle. Neonatal onset results in clinical features that include irritability, vomiting, lethargy, seizures, neonatal hypotonia; respiratory alkalosis; hyperammonemia; coma, and death. Survivors of the neonatal onset and childhood/adult onset disorders share common risks for encephalopathies, metabolic, inborn; and respiratory alkalosis due to hyperammonemia.
Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change
ICD-10-CM Codes Adjacent To E72.2
E72.01 Cystinuria
E72.02 Hartnup's disease
E72.03 Lowe's syndrome
E72.04 Cystinosis
E72.09 Other disorders of amino-acid transport
E72.1 Disorders of sulfur-bearing amino-acid metabolism
E72.10 …… unspecified
E72.11 Homocystinuria
E72.12 Methylenetetrahydrofolate reductase deficiency
E72.19 Other disorders of sulfur-bearing amino-acid metabolism
E72.2 Disorders of urea cycle metabolism
E72.20 Disorder of urea cycle metabolism, unspecified
E72.21 Argininemia
E72.22 Arginosuccinic aciduria
E72.23 Citrullinemia
E72.29 Other disorders of urea cycle metabolism
E72.3 Disorders of lysine and hydroxylysine metabolism
E72.4 Disorders of ornithine metabolism
E72.5 Disorders of glycine metabolism
E72.50 Disorder of glycine metabolism, unspecified
E72.51 Non-ketotic hyperglycinemia

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.