1. ICD-10-CM Codes
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2. E00-E89
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3. E70-E88
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4. E72-
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5. 2023 ICD-10-CM Diagnosis Code E72.23

2023 ICD-10-CM Diagnosis Code E72.23

Citrullinemia

2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code

• E72.23 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
• The 2023 edition of ICD-10-CM E72.23 became effective on October 1, 2022.
• This is the American ICD-10-CM version of E72.23 - other international versions of ICD-10 E72.23 may differ.

• A group of diseases related to a deficiency of the enzyme argininosuccinate synthase which causes an elevation of serum levels of citrulline. In neonates, clinical manifestations include lethargy, hypotonia, and seizures. Milder forms also occur. Childhood and adult forms may present with recurrent episodes of intermittent weakness, lethargy, ataxia, behavioral changes, and dysarthria. (from menkes, textbook of child neurology, 5th ed, p49)
• A rare autosomal recessive inherited disorder caused by mutations in the ass1 and slc25a13 genes. It is characterized by a defective urea cycle, resulting in the accumulation of ammonia and other toxic substances in the blood.
• Autosomal recessive aminoacidopathy characterized by marked elevation in plasma and urine levels of citrulline, with hyperammonemia and sometimes secondary oroticaciduria; clinical findings include mental retardation and neurologic abnormalities.

• 642 Inborn and other disorders of metabolism

Convert E72.23 to ICD-9-CM

• 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
• 2017 (effective 10/1/2016): No change
• 2018 (effective 10/1/2017): No change
• 2019 (effective 10/1/2018): No change
• 2020 (effective 10/1/2019): No change
• 2021 (effective 10/1/2020): No change
• 2022 (effective 10/1/2021): No change
• 2023 (effective 10/1/2022): No change

• Citrullinemia E72.23
• Citrullinuria E72.23
• Disorder (of) - see also Disease
  • urea cycle metabolism E72.20
    ICD-10-CM Diagnosis Code E72.20

    Disorder of urea cycle metabolism, unspecified

    2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code

    Applicable To

    • Hyperammonemia

    Type 1 Excludes

    • hyperammonemia-hyperornithinemia-homocitrullinemia syndrome E72.4
    • transient hyperammonemia of newborn (P74.6)
    • citrullinemia E72.23
• Disturbance(s) - see also Disease
  • metabolism E88.9
    ICD-10-CM Diagnosis Code E88.9

    Metabolic disorder, unspecified

    2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code
    • citrulline E72.23

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.