2023 ICD-10-CM Diagnosis Code E72.81

Disorders of gamma aminobutyric acid metabolism

    2019 - New Code 2020 2021 2022 2023 Billable/Specific Code
  • E72.81 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2023 edition of ICD-10-CM E72.81 became effective on October 1, 2022.
  • This is the American ICD-10-CM version of E72.81 - other international versions of ICD-10 E72.81 may differ.
Applicable To
  • 4-hydroxybutyric aciduria
  • Disorders of GABA metabolism
  • GABA metabolic defect
  • GABA transaminase deficiency
  • GABA-T deficiency
  • Gamma-hydroxybutyric aciduria
  • SSADHD
  • Succinic semialdehyde dehydrogenase deficiency
The following code(s) above E72.81 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to E72.81:
  • E00-E89
    2023 ICD-10-CM Range E00-E89

    Endocrine, nutritional and metabolic diseases

    Note
    • All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
    Type 1 Excludes
    • transitory endocrine and metabolic disorders specific to newborn (P70-P74)
    Endocrine, nutritional and metabolic diseases
  • E70-E88
    2023 ICD-10-CM Range E70-E88

    Metabolic disorders

    Type 1 Excludes
    • androgen insensitivity syndrome (E34.5-)
    • congenital adrenal hyperplasia (E25.0)
    • hemolytic anemias attributable to enzyme disorders (D55.-)
    • Marfan's syndrome (Q87.4)
    • 5-alpha-reductase deficiency (E29.1)
    Type 2 Excludes
    • Ehlers-Danlos syndromes (Q79.6-)
    Metabolic disorders
  • E72
    ICD-10-CM Diagnosis Code E72

    Other disorders of amino-acid metabolism

      2016 2017 2018 2019 2020 2021 2022 2023 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • disorders of:
    • aromatic amino-acid metabolism (E70.-)
    • branched-chain amino-acid metabolism (E71.0-E71.2)
    • fatty-acid metabolism (E71.3)
    • purine and pyrimidine metabolism (E79.-)
    • gout (M1A.-, M10.-)
    Other disorders of amino-acid metabolism
ICD-10-CM E72.81 is grouped within Diagnostic Related Group(s) (MS-DRG v40.0):
  • 642 Inborn and other disorders of metabolism
Code History
  • 2019 (effective 10/1/2018): New code
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change
  • 2022 (effective 10/1/2021): No change
  • 2023 (effective 10/1/2022): No change

Diagnosis Index entries containing back-references to E72.81:
  • Aciduria
    • 4-hydroxybutyric E72.81
    • gamma-hydroxybutyric E72.81
  • Defect, defective Q89.9
    ICD-10-CM Diagnosis Code Q89.9

    Congenital malformation, unspecified

      2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code POA Exempt
    Applicable To
    • Congenital anomaly NOS
    • Congenital deformity NOS
    • GABA E72.81 (gamma aminobutyric acid)
  • Deficiency, deficient
    • GABA E72.81 (gamma aminobutyric acid)
    • GABA-T E72.81 (gamma aminobutyric acid transaminase)
    • succinic semialdehyde dehydrogenase E72.81
  • Disorder (of) - see also Disease
    • gamma aminobutyric acid E72.81 (GABA)
  • SSADHD E72.81 (succinic semialdehyde dehydrogenase deficiency)

ICD-10-CM Codes Adjacent To E72.81
E72.29 Other disorders of urea cycle metabolism
E72.3 Disorders of lysine and hydroxylysine metabolism
E72.4 Disorders of ornithine metabolism
E72.5 Disorders of glycine metabolism
E72.50 Disorder of glycine metabolism, unspecified
E72.51 Non-ketotic hyperglycinemia
E72.52 Trimethylaminuria
E72.53 Primary hyperoxaluria
E72.59 Other disorders of glycine metabolism
E72.8 Other specified disorders of amino-acid metabolism
E72.81 Disorders of gamma aminobutyric acid metabolism
E72.89 Other specified disorders of amino-acid metabolism
E72.9 Disorder of amino-acid metabolism, unspecified
E73 Lactose intolerance
E73.0 Congenital lactase deficiency
E73.1 Secondary lactase deficiency
E73.8 Other lactose intolerance
E73.9 Lactose intolerance, unspecified
E74 Other disorders of carbohydrate metabolism
E74.0 Glycogen storage disease
E74.00 …… unspecified

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.