2020 ICD-10-CM Diagnosis Code E74.12

Hereditary fructose intolerance

    2016 2017 2018 2019 2020 Billable/Specific Code
  • E74.12 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2020 edition of ICD-10-CM E74.12 became effective on October 1, 2019.
  • This is the American ICD-10-CM version of E74.12 - other international versions of ICD-10 E74.12 may differ.
Applicable To
  • Fructosemia
The following code(s) above E74.12 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to E74.12:
  • E00-E89
    2020 ICD-10-CM Range E00-E89

    Endocrine, nutritional and metabolic diseases

    Note
    • All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
    Type 1 Excludes
    • transitory endocrine and metabolic disorders specific to newborn (P70-P74)
    Endocrine, nutritional and metabolic diseases
  • E70-E88
    2020 ICD-10-CM Range E70-E88

    Metabolic disorders

    Type 1 Excludes
    • androgen insensitivity syndrome (E34.5-)
    • congenital adrenal hyperplasia (E25.0)
    • Ehlers-Danlos syndrome (Q79.6-)
    • hemolytic anemias attributable to enzyme disorders (D55.-)
    • Marfan's syndrome (Q87.4)
    • 5-alpha-reductase deficiency (E29.1)
    Metabolic disorders
  • E74
    ICD-10-CM Diagnosis Code E74

    Other disorders of carbohydrate metabolism

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Type 1 Excludes
    Other disorders of carbohydrate metabolism
  • E74.1
    ICD-10-CM Diagnosis Code E74.1

    Disorders of fructose metabolism

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • muscle phosphofructokinase deficiency (E74.09)
    Disorders of fructose metabolism
Approximate Synonyms
  • Hereditary fructosuria
Clinical Information
  • A genetic disorder characterized by the absence of the enzyme aldolase-b from the liver. This enzyme is essential for the metabolism of fructose. Signs and symptoms from fructose ingestion are evident in infancy and include vomiting, abdominal pain and hypoglycemia. Long term complications include hepatic and renal failure.
  • An autosomal recessive fructose metabolism disorder due to deficient fructose-1-phosphate aldolase (ec 2.1.2.13) activity, resulting in accumulation of fructose-1-phosphate. The accumulated fructose-1-phosphate inhibits glycogenolysis and gluconeogenesis, causing severe hypoglycemia following ingestion of fructose. Prolonged fructose ingestion in infants leads ultimately to hepatic failure and death. Patients develop a strong distaste for sweet food, and avoid a chronic course of the disease by remaining on a fructose- and sucrose-free diet.
  • Autosomal recessive fructose metabolism disorder due to deficient fructose-1-phosphate aldolase (ec 2.1.2.13) activity, resulting in accumulation of fructose-1-phosphate; accumulated fructose-1-phosphate inhibits glycogenolysis and gluconeogenesis, causing severe hypoglycemia following ingestion of fructose; prolonged fructose ingestion in infants leads ultimately to hepatic failure and death; patients develop a strong distaste for sweet food, and avoid a chronic course of the disease by remaining on a fructose- and sucrose-free diet.
ICD-10-CM E74.12 is grouped within Diagnostic Related Group(s) (MS-DRG v37.0):
  • 391 Esophagitis, gastroenteritis and miscellaneous digestive disorders with mcc
  • 392 Esophagitis, gastroenteritis and miscellaneous digestive disorders without mcc

Convert E74.12 to ICD-9-CM

Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change

Diagnosis Index entries containing back-references to E74.12:
  • Disorder (of) - see also Disease
    • fructose metabolism E74.10
      ICD-10-CM Diagnosis Code E74.10

      Disorder of fructose metabolism, unspecified

        2016 2017 2018 2019 2020 Billable/Specific Code
      • hereditary fructose intolerance E74.12
  • Fructosemia E74.12 (benign) (essential)
  • Intolerance
    • fructose E74.10
      ICD-10-CM Diagnosis Code E74.10

      Disorder of fructose metabolism, unspecified

        2016 2017 2018 2019 2020 Billable/Specific Code
      • hereditary E74.12

ICD-10-CM Codes Adjacent To E74.12
E74.0 Glycogen storage disease
E74.00 …… unspecified
E74.01 von Gierke disease
E74.02 Pompe disease
E74.03 Cori disease
E74.04 McArdle disease
E74.09 Other glycogen storage disease
E74.1 Disorders of fructose metabolism
E74.10 Disorder of fructose metabolism, unspecified
E74.11 Essential fructosuria
E74.12 Hereditary fructose intolerance
E74.19 Other disorders of fructose metabolism
E74.2 Disorders of galactose metabolism
E74.20 …… unspecified
E74.21 Galactosemia
E74.29 Other disorders of galactose metabolism
E74.3 Other disorders of intestinal carbohydrate absorption
E74.31 Sucrase-isomaltase deficiency
E74.39 Other disorders of intestinal carbohydrate absorption
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
E74.8 Other specified disorders of carbohydrate metabolism

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.