2020 ICD-10-CM Diagnosis Code E74.21

Galactosemia

    2016 2017 2018 2019 2020 Billable/Specific Code
  • E74.21 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2020 edition of ICD-10-CM E74.21 became effective on October 1, 2019.
  • This is the American ICD-10-CM version of E74.21 - other international versions of ICD-10 E74.21 may differ.
The following code(s) above E74.21 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to E74.21:
  • E00-E89
    2020 ICD-10-CM Range E00-E89

    Endocrine, nutritional and metabolic diseases

    Note
    • All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
    Type 1 Excludes
    • transitory endocrine and metabolic disorders specific to newborn (P70-P74)
    Endocrine, nutritional and metabolic diseases
  • E70-E88
    2020 ICD-10-CM Range E70-E88

    Metabolic disorders

    Type 1 Excludes
    • androgen insensitivity syndrome (E34.5-)
    • congenital adrenal hyperplasia (E25.0)
    • Ehlers-Danlos syndrome (Q79.6-)
    • hemolytic anemias attributable to enzyme disorders (D55.-)
    • Marfan's syndrome (Q87.4)
    • 5-alpha-reductase deficiency (E29.1)
    Metabolic disorders
  • E74
    ICD-10-CM Diagnosis Code E74

    Other disorders of carbohydrate metabolism

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Type 1 Excludes
    Other disorders of carbohydrate metabolism
Approximate Synonyms
  • Classical galactosemia, homozygous duarte-type
  • Galactosemia (duarte)
Clinical Information
  • A group of inherited enzyme deficiencies which feature elevations of galactose in the blood. This condition may be associated with deficiencies of galactokinase; udpglucose-hexose-1-phosphate uridylyltransferase; or udpglucose 4-epimerase. The classic form is caused by udpglucose-hexose-1-phosphate uridylyltransferase deficiency, and presents in infancy with failure to thrive; vomiting; and intracranial hypertension. Affected individuals also may develop mental retardation; jaundice; hepatosplenomegaly; ovarian failure (primary ovarian insufficiency); and cataracts. (from menkes, textbook of child neurology, 5th ed, pp61-3)
  • An autosomal recessive inherited metabolic disorder caused by mutations in the gale, galk1, and galt genes. It is characterized by deficiency of the enzymes responsible for the metabolism of galactose. Signs and symptoms include intellectual disability, hepatomegaly, hepatic failure, and renal failure.
  • Group of inherited enzyme deficiencies which feature elevations of galactose in the blood; this condition may be associated with deficiencies of galactokinase, udp glucose-hexose-1-phosphate uridylyltransferase (classic form), or udp glucose 4-epimerase; the classic form presents in infancy with failure to thrive, vomiting, and intracranial hypertension; affected individuals also may develop mental retardation, jaundice, hepatosplenomegaly, ovarian failure and cataracts.
ICD-10-CM E74.21 is grouped within Diagnostic Related Group(s) (MS-DRG v37.0):
  • 642 Inborn and other disorders of metabolism

Convert E74.21 to ICD-9-CM

Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change

Diagnosis Index entries containing back-references to E74.21:
  • Cataract (cortical) (immature) (incipient) H26.9
    ICD-10-CM Diagnosis Code H26.9

    Unspecified cataract

      2016 2017 2018 2019 2020 Billable/Specific Code
  • Galactosemia E74.21 (classic) (congenital)
  • Jaundice (yellow) R17
    ICD-10-CM Diagnosis Code R17

    Unspecified jaundice

      2016 2017 2018 2019 2020 Billable/Specific Code
    Type 1 Excludes
    • newborn P59.9
      ICD-10-CM Diagnosis Code P59.9

      Neonatal jaundice, unspecified

        2016 2017 2018 2019 2020 Billable/Specific Code Code on Newborn Record
      Applicable To
      • Neonatal physiological jaundice (intense)(prolonged) NOS

ICD-10-CM Codes Adjacent To E74.21
E74.03 Cori disease
E74.04 McArdle disease
E74.09 Other glycogen storage disease
E74.1 Disorders of fructose metabolism
E74.10 Disorder of fructose metabolism, unspecified
E74.11 Essential fructosuria
E74.12 Hereditary fructose intolerance
E74.19 Other disorders of fructose metabolism
E74.2 Disorders of galactose metabolism
E74.20 …… unspecified
E74.21 Galactosemia
E74.29 Other disorders of galactose metabolism
E74.3 Other disorders of intestinal carbohydrate absorption
E74.31 Sucrase-isomaltase deficiency
E74.39 Other disorders of intestinal carbohydrate absorption
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
E74.8 Other specified disorders of carbohydrate metabolism
E74.9 Disorder of carbohydrate metabolism, unspecified
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
E75.0 GM2 gangliosidosis
E75.00 …… unspecified

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.