2020 ICD-10-CM Diagnosis Code E78.2

Mixed hyperlipidemia

    2016 2017 2018 2019 2020 Billable/Specific Code
  • E78.2 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2020 edition of ICD-10-CM E78.2 became effective on October 1, 2019.
  • This is the American ICD-10-CM version of E78.2 - other international versions of ICD-10 E78.2 may differ.
Applicable To
  • Broad- or floating-betalipoproteinemia
  • Combined hyperlipidemia NOS
  • Elevated cholesterol with elevated triglycerides NEC
  • Fredrickson's hyperlipoproteinemia, type IIb or III
  • Hyperbetalipoproteinemia with prebetalipoproteinemia
  • Hypercholesteremia with endogenous hyperglyceridemia
  • Hyperlipidemia, group C
  • Tubo-eruptive xanthoma
  • Xanthoma tuberosum
Type 1 Excludes
Type 1 Excludes Help
A type 1 excludes note is a pure excludes. It means "not coded here". A type 1 excludes note indicates that the code excluded should never be used at the same time as E78.2. A type 1 excludes note is for used for when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • cerebrotendinous cholesterosis [van Bogaert-Scherer- Epstein] (
    ICD-10-CM Diagnosis Code E75.5

    Other lipid storage disorders

      2016 2017 2018 2019 2020 Billable/Specific Code
    Applicable To
    • Cerebrotendinous cholesterosis [van Bogaert-Scherer-Epstein]
    • Wolman's disease
    E75.5
    )
  • familial combined hyperlipidemia (
    ICD-10-CM Diagnosis Code E78.49

    Other hyperlipidemia

      2019 - New Code 2020 Billable/Specific Code
    Applicable To
    • Familial combined hyperlipidemia
    E78.49
    )
The following code(s) above E78.2 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to E78.2:
  • E00-E89
    2020 ICD-10-CM Range E00-E89

    Endocrine, nutritional and metabolic diseases

    Note
    • All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
    Type 1 Excludes
    • transitory endocrine and metabolic disorders specific to newborn (P70-P74)
    Endocrine, nutritional and metabolic diseases
  • E70-E88
    2020 ICD-10-CM Range E70-E88

    Metabolic disorders

    Type 1 Excludes
    • androgen insensitivity syndrome (E34.5-)
    • congenital adrenal hyperplasia (E25.0)
    • Ehlers-Danlos syndrome (Q79.6-)
    • hemolytic anemias attributable to enzyme disorders (D55.-)
    • Marfan's syndrome (Q87.4)
    • 5-alpha-reductase deficiency (E29.1)
    Metabolic disorders
  • E78
    ICD-10-CM Diagnosis Code E78

    Disorders of lipoprotein metabolism and other lipidemias

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Type 1 Excludes
    Disorders of lipoprotein metabolism and other lipidemias
Approximate Synonyms
  • Diabetes type 1 with hyperliidemia
  • Diabetes type 2 with hyperlipidemia
  • Eruptive xanthoma
  • Hyperlipidemia, mixed (high blood fats)
  • Mixed hyperlipidemia associated with type 1 diabetes mellitus
  • Mixed hyperlipidemia associated with type 2 diabetes mellitus
  • Mixed hyperlipidemia due to type 1 diabetes mellitus
  • Mixed hyperlipidemia due to type 2 diabetes mellitus
  • Tuberous xanthoma
  • Xanthoma tuberosum
Clinical Information
  • A disorder of lipoprotein metabolism characterized by high levels of cholesterol and triglycerides in the blood. It is caused by elevation of low density and very low density lipoproteins.
  • A type of familial lipid metabolism disorder characterized by a variable pattern of elevated plasma cholesterol and/or triglycerides. Multiple genes on different chromosomes may be involved, such as the major late transcription factor (upstream stimulatory factors) on chromosome 1.
  • Type iib hyperlipoproteinemia is caused by mutation in the receptor-binding domain of apolipoprotein b-100 which is a major component of low-density lipoproteins and very-low-density lipoproteins resulting in reduced clearance of these lipoproteins. It is characterized by both hypercholesterolemia and hypertriglyceridemia (combined hyperlipidemia).
ICD-10-CM E78.2 is grouped within Diagnostic Related Group(s) (MS-DRG v37.0):
  • 642 Inborn and other disorders of metabolism

Convert E78.2 to ICD-9-CM

Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
Code annotations containing back-references to E78.2:
  • Type 1 Excludes: M67
    ICD-10-CM Diagnosis Code M67

    Other disorders of synovium and tendon

      2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • palmar fascial fibromatosis [Dupuytren] (M72.0)
    • tendinitis NOS (M77.9-)
    • xanthomatosis localized to tendons (E78.2)

Diagnosis Index entries containing back-references to E78.2:
  • Betalipoproteinemia, broad or floating E78.2
  • Broad - see also condition
    • beta disease E78.2
  • Broad- or floating-betalipoproteinemia E78.2
  • Cholesterol
    • elevated (high) E78.00
      ICD-10-CM Diagnosis Code E78.00

      Pure hypercholesterolemia, unspecified

        2017 - New Code 2018 2019 2020 Billable/Specific Code
      Applicable To
      • Fredrickson's hyperlipoproteinemia, type IIa
      • Hyperbetalipoproteinemia
      • Low-density-lipoprotein-type [LDL] hyperlipoproteinemia
      • (Pure) hypercholesterolemia NOS
      • with elevated E78.2 (high)
  • Cirrhosis, cirrhotic (hepatic) (liver) K74.60
    ICD-10-CM Diagnosis Code K74.60

    Unspecified cirrhosis of liver

      2016 2017 2018 2019 2020 Billable/Specific Code
    Applicable To
    • Cirrhosis (of liver) NOS
    • due to
      • xanthomatosis E78.2
    • xanthomatous (biliary) K74.5
      ICD-10-CM Diagnosis Code K74.5

      Biliary cirrhosis, unspecified

        2016 2017 2018 2019 2020 Billable/Specific Code
      • due to xanthomatosis E78.2 (familial) (metabolic) (primary)
  • Disease, diseased - see also Syndrome
  • Dysbetalipoproteinemia E78.2 (familial)
  • Elevated, elevation
    • cholesterol E78.00
      ICD-10-CM Diagnosis Code E78.00

      Pure hypercholesterolemia, unspecified

        2017 - New Code 2018 2019 2020 Billable/Specific Code
      Applicable To
      • Fredrickson's hyperlipoproteinemia, type IIa
      • Hyperbetalipoproteinemia
      • Low-density-lipoprotein-type [LDL] hyperlipoproteinemia
      • (Pure) hypercholesterolemia NOS
      • with high triglycerides E78.2
    • triglycerides E78.1
      ICD-10-CM Diagnosis Code E78.1

      Pure hyperglyceridemia

        2016 2017 2018 2019 2020 Billable/Specific Code
      Applicable To
      • Elevated fasting triglycerides
      • Endogenous hyperglyceridemia
      • Fredrickson's hyperlipoproteinemia, type IV
      • Hyperlipidemia, group B
      • Hyperprebetalipoproteinemia
      • Very-low-density-lipoprotein-type [VLDL] hyperlipoproteinemia
      • with high cholesterol E78.2
  • Findings, abnormal, inconclusive, without diagnosis - see also Abnormal
    • cholesterol E78.9
      ICD-10-CM Diagnosis Code E78.9

      Disorder of lipoprotein metabolism, unspecified

        2016 2017 2018 2019 2020 Billable/Specific Code
      • high E78.00
        ICD-10-CM Diagnosis Code E78.00

        Pure hypercholesterolemia, unspecified

          2017 - New Code 2018 2019 2020 Billable/Specific Code
        Applicable To
        • Fredrickson's hyperlipoproteinemia, type IIa
        • Hyperbetalipoproteinemia
        • Low-density-lipoprotein-type [LDL] hyperlipoproteinemia
        • (Pure) hypercholesterolemia NOS
        • with high triglycerides E78.2
    • triglycerides E78.9
      ICD-10-CM Diagnosis Code E78.9

      Disorder of lipoprotein metabolism, unspecified

        2016 2017 2018 2019 2020 Billable/Specific Code
      • high E78.1
        ICD-10-CM Diagnosis Code E78.1

        Pure hyperglyceridemia

          2016 2017 2018 2019 2020 Billable/Specific Code
        Applicable To
        • Elevated fasting triglycerides
        • Endogenous hyperglyceridemia
        • Fredrickson's hyperlipoproteinemia, type IV
        • Hyperlipidemia, group B
        • Hyperprebetalipoproteinemia
        • Very-low-density-lipoprotein-type [VLDL] hyperlipoproteinemia
        • with high cholesterol E78.2
  • Frederickson's hyperlipoproteinemia, type
    • IIB and III E78.2
  • High
    • cholesterol E78.00
      ICD-10-CM Diagnosis Code E78.00

      Pure hypercholesterolemia, unspecified

        2017 - New Code 2018 2019 2020 Billable/Specific Code
      Applicable To
      • Fredrickson's hyperlipoproteinemia, type IIa
      • Hyperbetalipoproteinemia
      • Low-density-lipoprotein-type [LDL] hyperlipoproteinemia
      • (Pure) hypercholesterolemia NOS
      • with high triglycerides E78.2
    • triglycerides E78.1
      ICD-10-CM Diagnosis Code E78.1

      Pure hyperglyceridemia

        2016 2017 2018 2019 2020 Billable/Specific Code
      Applicable To
      • Elevated fasting triglycerides
      • Endogenous hyperglyceridemia
      • Fredrickson's hyperlipoproteinemia, type IV
      • Hyperlipidemia, group B
      • Hyperprebetalipoproteinemia
      • Very-low-density-lipoprotein-type [VLDL] hyperlipoproteinemia
      • with high cholesterol E78.2
  • Hyperbetalipoproteinemia (familial) E78.00
    ICD-10-CM Diagnosis Code E78.00

    Pure hypercholesterolemia, unspecified

      2017 - New Code 2018 2019 2020 Billable/Specific Code
    Applicable To
    • Fredrickson's hyperlipoproteinemia, type IIa
    • Hyperbetalipoproteinemia
    • Low-density-lipoprotein-type [LDL] hyperlipoproteinemia
    • (Pure) hypercholesterolemia NOS
    • with prebetalipoproteinemia E78.2
  • Hypercholesterolemia (essential) (primary) (pure) E78.00
    ICD-10-CM Diagnosis Code E78.00

    Pure hypercholesterolemia, unspecified

      2017 - New Code 2018 2019 2020 Billable/Specific Code
    Applicable To
    • Fredrickson's hyperlipoproteinemia, type IIa
    • Hyperbetalipoproteinemia
    • Low-density-lipoprotein-type [LDL] hyperlipoproteinemia
    • (Pure) hypercholesterolemia NOS
    • with hyperglyceridemia, endogenous E78.2
  • Hyperlipemia, hyperlipidemia E78.5
    ICD-10-CM Diagnosis Code E78.5

    Hyperlipidemia, unspecified

      2016 2017 2018 2019 2020 Billable/Specific Code
  • Hyperlipoproteinemia E78.5
    ICD-10-CM Diagnosis Code E78.5

    Hyperlipidemia, unspecified

      2016 2017 2018 2019 2020 Billable/Specific Code
  • Lipoproteinemia E78.5
    ICD-10-CM Diagnosis Code E78.5

    Hyperlipidemia, unspecified

      2016 2017 2018 2019 2020 Billable/Specific Code
    • broad-beta E78.2
    • floating-beta E78.2
  • Xanthelasmatosis E78.2 (essential)
  • Xanthoma(s), xanthomatosis (primary) (familial) (hereditary) E75.5
    ICD-10-CM Diagnosis Code E75.5

    Other lipid storage disorders

      2016 2017 2018 2019 2020 Billable/Specific Code
    Applicable To
    • Cerebrotendinous cholesterosis [van Bogaert-Scherer-Epstein]
    • Wolman's disease
    • with
    • disseminatum E78.2 (skin)
    • eruptive E78.2
    • multiple E78.2 (skin)
    • tubo-eruptive E78.2
    • tuberosum E78.2
    • tuberous E78.2

ICD-10-CM Codes Adjacent To E78.2
E77 Disorders of glycoprotein metabolism
E77.0 Defects in post-translational modification of lysosomal enzymes
E77.1 Defects in glycoprotein degradation
E77.8 Other disorders of glycoprotein metabolism
E77.9 Disorder of glycoprotein metabolism, unspecified
E78 Disorders of lipoprotein metabolism and other lipidemias
E78.0 Pure hypercholesterolemia
E78.00 …… unspecified
E78.01 Familial hypercholesterolemia
E78.1 Pure hyperglyceridemia
E78.2 Mixed hyperlipidemia
E78.3 Hyperchylomicronemia
E78.4 Other hyperlipidemia
E78.41 Elevated Lipoprotein(a)
E78.49 Other hyperlipidemia
E78.5 Hyperlipidemia, unspecified
E78.6 Lipoprotein deficiency
E78.7 Disorders of bile acid and cholesterol metabolism
E78.70 Disorder of bile acid and cholesterol metabolism, unspecified
E78.71 Barth syndrome
E78.72 Smith-Lemli-Opitz syndrome

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.