2021 ICD-10-CM Diagnosis Code E84

Cystic fibrosis

    2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
  • E84 should not be used for reimbursement purposes as there are multiple codes below it that contain a greater level of detail.
  • The 2021 edition of ICD-10-CM E84 became effective on October 1, 2020.
  • This is the American ICD-10-CM version of E84 - other international versions of ICD-10 E84 may differ.
Code Also
Code Also Help
A code also note instructs that 2 codes may be required to fully describe a condition but the sequencing of the two codes is discretionary, depending on the severity of the conditions and the reason for the encounter.
  • exocrine pancreatic insufficiency (
    ICD-10-CM Diagnosis Code K86.81

    Exocrine pancreatic insufficiency

      2017 - New Code 2018 2019 2020 2021 Billable/Specific Code
    K86.81
    )
Includes
Includes Help
"Includes" further defines, or give examples of, the content of the code or category.
  • mucoviscidosis
The following code(s) above E84 contain annotation back-references
Annotation Back-References
In this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to E84:
  • E00-E89
    2021 ICD-10-CM Range E00-E89

    Endocrine, nutritional and metabolic diseases

    Note
    • All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
    Type 1 Excludes
    • transitory endocrine and metabolic disorders specific to newborn (P70-P74)
    Endocrine, nutritional and metabolic diseases
  • E70-E88
    2021 ICD-10-CM Range E70-E88

    Metabolic disorders

    Type 1 Excludes
    • androgen insensitivity syndrome (E34.5-)
    • congenital adrenal hyperplasia (E25.0)
    • Ehlers-Danlos syndromes (Q79.6-)
    • hemolytic anemias attributable to enzyme disorders (D55.-)
    • Marfan's syndrome (Q87.4)
    • 5-alpha-reductase deficiency (E29.1)
    Metabolic disorders
Clinical Information
  • A common hereditary disease in which exocrine (secretory) glands produce abnormally thick mucus. This mucus can cause problems in digestion, breathing, and body cooling.
  • A congenital metabolic disorder affecting the exocrine glands, inherited as an autosomal trait. The secretions of exocrine glands are abnormal, resulting in excessively viscid mucus production which causes obstruction of passageways (including pancreatic and bile ducts, intestines, and bronchi). The sweat sodium and chloride content are increased. Symptoms usually appear in childhood and include meconium ileus, poor growth despite good appetite, malabsorption and foul bulky stools, chronic bronchitis with cough, recurrent pneumonia, bronchiectasis, emphysema, clubbing of the fingers, and salt depletion in hot weather.
  • An autosomal recessive genetic disease of the exocrine glands. It is caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator expressed in several organs including the lung, the pancreas, the biliary system, and the sweat glands. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in airway obstruction; chronic respiratory infections; pancreatic insufficiency; maldigestion; salt depletion; and heat prostration.
  • Cystic fibrosis (cf) is an inherited disease of the mucus and sweat glands. It affects mostly your lungs, pancreas, liver, intestines, sinuses and sex organs. Cf causes your mucus to be thick and sticky. The mucus clogs the lungs, causing breathing problems and making it easy for bacteria to grow. This can lead to problems such as repeated lung infections and lung damage. The symptoms and severity of cf vary widely. Some people have serious problems from birth. Others have a milder version of the disease that doesn't show up until they are teens or young adults. Although there is no cure for cf, treatments have improved greatly in recent years. Until the 1980s, most deaths from cf occurred in children and teenagers. Today, with improved treatments, some people who have cf are living into their forties, fifties, or older.
  • Most common potentially lethal autosomal recessive disease affecting caucasians; characterized by chronic pulmonary, intestinal, liver, pancreatic, and exocrine gland dysfunction; caused by mutations of the cftr chloride channel.
Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change
Code annotations containing back-references to E84:
  • Code First: J93.12
    , E08
    , Q55.3
    ICD-10-CM Diagnosis Code J93.12

    Secondary spontaneous pneumothorax

      2016 2017 2018 2019 2020 2021 Billable/Specific Code
    Code First
    • underlying condition, such as:
    • catamenial pneumothorax due to endometriosis (N80.8)
    • cystic fibrosis (E84.-)
    • eosinophilic pneumonia (J82)
    • lymphangioleiomyomatosis (J84.81)
    • malignant neoplasm of bronchus and lung (C34.-)
    • Marfan's syndrome (Q87.4)
    • pneumonia due to Pneumocystis carinii (B59)
    • secondary malignant neoplasm of lung (C78.0-)
    • spontaneous rupture of the esophagus (K22.3)
    ICD-10-CM Diagnosis Code E08

    Diabetes mellitus due to underlying condition

      2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
    Code First
    • the underlying condition, such as:
    • congenital rubella (P35.0)
    • Cushing's syndrome (E24.-)
    • cystic fibrosis (E84.-)
    • malignant neoplasm (C00-C96)
    • malnutrition (E40-E46)
    • pancreatitis and other diseases of the pancreas (K85-K86.-)
    Type 1 Excludes
    • drug or chemical induced diabetes mellitus (E09.-)
    • gestational diabetes (O24.4-)
    • neonatal diabetes mellitus (P70.2)
    • postpancreatectomy diabetes mellitus (E13.-)
    • postprocedural diabetes mellitus (E13.-)
    • secondary diabetes mellitus NEC (E13.-)
    • type 1 diabetes mellitus (E10.-)
    • type 2 diabetes mellitus (E11.-)
    Use Additional
    • code to identify control using:
    • insulin (Z79.4)
    • oral antidiabetic drugs (Z79.84)
    • oral hypoglycemic drugs (Z79.84)
    ICD-10-CM Diagnosis Code Q55.3

    Atresia of vas deferens

      2016 2017 2018 2019 2020 2021 Billable/Specific Code Male Dx POA Exempt
    Code First
    • any associated cystic fibrosis (E84.-)
  • Type 1 Excludes: Q45.3
    ICD-10-CM Diagnosis Code Q45.3

    Other congenital malformations of pancreas and pancreatic duct

      2016 2017 2018 2019 2020 2021 Billable/Specific Code POA Exempt
    Applicable To
    • Accessory pancreas
    • Congenital malformation of pancreas or pancreatic duct NOS
    Type 1 Excludes
    • congenital diabetes mellitus (E10.-)
    • cystic fibrosis (E84.0-E84.9)
    • fibrocystic disease of pancreas (E84.-)
    • neonatal diabetes mellitus (P70.2)
  • Type 2 Excludes: K86
    ICD-10-CM Diagnosis Code K86

    Other diseases of pancreas

      2016 2017 2018 2019 2020 2021 Non-Billable/Non-Specific Code
    Type 2 Excludes
    • fibrocystic disease of pancreas (E84.-)
    • islet cell tumor (of pancreas) (D13.7)
    • pancreatic steatorrhea (K90.3)
ICD-10-CM Codes Adjacent To E84
E83.49 Other disorders of magnesium metabolism
E83.5 Disorders of calcium metabolism
E83.50 Unspecified disorder of calcium metabolism
E83.51 Hypocalcemia
E83.52 Hypercalcemia
E83.59 Other disorders of calcium metabolism
E83.8 Other disorders of mineral metabolism
E83.81 Hungry bone syndrome
E83.89 Other disorders of mineral metabolism
E83.9 Disorder of mineral metabolism, unspecified
E84 Cystic fibrosis
E84.0 Cystic fibrosis with pulmonary manifestations
E84.1 Cystic fibrosis with intestinal manifestations
E84.11 Meconium ileus in cystic fibrosis
E84.19 Cystic fibrosis with other intestinal manifestations
E84.8 Cystic fibrosis with other manifestations
E84.9 Cystic fibrosis, unspecified
E85 Amyloidosis
E85.0 Non-neuropathic heredofamilial amyloidosis
E85.1 Neuropathic heredofamilial amyloidosis
E85.2 Heredofamilial amyloidosis, unspecified

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.